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lactupicrin
lactucopicrin

Supplier Sponsors

Name:	[(3aR,4S,9aS,9bR)-9-(hydroxymethyl)-6-methyl-3-methylidene-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-(4-hydroxyphenyl)acetate
CAS Number:	65725-11-3	3D/inchi
Other(deleted CASRN):	81249-29-8
FDA UNII:	Search
Nikkaji Web:	J1.583.455B
XlogP3-AA:	1.10 (est)
Molecular Weight:	410.42274000
Formula:	C23 H22 O7
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	686.00 °C. @ 760.00 mm Hg (est)
Flash Point:	467.00 °F. TCC ( 241.80 °C. ) (est)
logP (o/w):	2.240 (est)
Soluble in:
	water, 3777 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

For experimental / research use only.

Lactucopicrin (HPLC) ≥95%

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for lactupicrin usage levels up to:
	not for fragrance use.

Recommendation for lactupicrin flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :174880

National Institute of Allergy and Infectious Diseases:Data

[(3aR,4S,9aS,9bR)-9-(hydroxymethyl)-6-methyl-3-methylidene-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-(4-hydroxyphenyl)acetate

Chemidplus:0065725113

References:

	[(3aR,4S,9aS,9bR)-9-(hydroxymethyl)-6-methyl-3-methylidene-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-(4-hydroxyphenyl)acetate
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	174880
Pubchem (sid):	135153533

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
KEGG (GenomeNet):	C09490
HMDB (The Human Metabolome Database):	HMDB35828
FooDB:	FDB014592
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
EFSA Update of results on the monitoring of furan levels in food:	Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:	Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:	Read Report

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

	chicory fruit juice Search Trop Picture
	chicory latex Search Trop Picture
	chicory plant Search Trop Picture
	chicory root Search Trop Picture
	endive Search Trop Picture
	lettuce plant Search Trop Picture

Synonyms:

[(3aR,4S,9aS,9bR)-9-(	hydroxymethyl)-6-methyl-3-methylidene-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-(4-hydroxyphenyl)acetate
	lactucopicrin

Articles:

PubMed:Sesquiterpene lactone content and overall quality of fresh-cut witloof chicory (Cichorium intybus L. var. foliosum Hegi) as affected by different washing procedures.

PubMed:Reversed-phase ultra-high-performance liquid chromatography coupled to electrospray ionization-quadrupole-time-of-flight mass spectrometry as a powerful tool for metabolic profiling of vegetables: Lactuca sativa as an example of its application.

PubMed:Introducing Cichorium Pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats.

PubMed:In vitro analysis of the anthelmintic activity of forage chicory (Cichorium intybus L.) sesquiterpene lactones against a predominantly Haemonchus contortus egg population.

PubMed:[Comparative studies in content of major active compositions in different parts of Cichorium glandulosum].

PubMed:Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography.

PubMed:Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice.

PubMed:Influence of cultivation site on sesquiterpene lactone composition of forage chicory (Cichorium intybus L.).

PubMed:Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus.

PubMed:Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

PubMed:Sesquiterpene lactones in a hairy root culture of Cichorium intybus.

PubMed:Guaianolides from Cichorium intybus and structure revision of Cichorium sesquiterpene lactones.

PubMed:Metabolite profiling of sesquiterpene lactones from Lactuca species. Major latex components are novel oxalate and sulfate conjugates of lactucin and its derivatives.

PubMed:(+)-Germacrene A biosynthesis . The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory

PubMed:Guaianolides from Lactuca saligna.

PubMed:[Oxidation of lactucopicrin and p-hydroxyphenylacetic acid by peroxydase].

PubMed:[Research on the preparation of lactucin and lactucopicrin from Lactuca virosa plants. 15. On the enzymatic and non-enzymatic oxidation of therapeutically active plant substances].

PubMed:[Fermentative destruction of lactucopicrin. 1. On oxydation of vegetable substances].

Notes:

Constit. of Lactuca sativa (lettuce), Cichorium intybus (chicory) and Cichorium endivia (endive)

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