| Name: | 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one |
| CAS Number: | 4773-96-0 |  3D/inchi
|
| Other(deleted CASRN): | 99331-60-9 |
| FDA UNII: | 1M84LD0UMD |
| Nikkaji Web: | J15.735J |
| MDL: | MFCD00075656 |
| XlogP3-AA: | -0.40 (est) |
| Molecular Weight: | 422.34366000 |
| Formula: | C19 H18 O11 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:cosmetic ingredient for skin protecting
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 842.70 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 578.00 °F. TCC ( 303.60 °C. ) (est)
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| logP (o/w): | 0.130 (est) |
| Soluble in: |
| | water, 467.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 2300 ug/kg
Problemi na Vutreshnata Meditsina. Problems of Internal Medicine. Vol. 8(2), Pg. 109, 1980.
intraperitoneal-rat LD50 365 mg/kg
Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1838, 1972.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic ingredient for skin protecting |
| Recommendation for mangiferin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for mangiferin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281647 |
| Pubchem (sid): | 135023010 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | alpizarin | | | aphloiol | | | chinomin | | | chinonin | | | hedysarid | | 1,3,6,7- | tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | | 9H- | xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy- (9CI) |
Articles:
| PubMed:The Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis Ameliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation. |
| PubMed:Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets. |
| PubMed:Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways. |
| PubMed:Evaluation of extraction methods for preparative scale obtention of mangiferin and lupeol from mango peels (Mangifera indica L.). |
| PubMed:Iriflophenone-3-C-glucoside from Cyclopia genistoides: isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays. |
| PubMed:The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology. |
| PubMed:Ultrasound-assisted extraction of Mangiferin from Mango (Mangifera indica L.) leaves using response surface methodology. |
| PubMed:Antioxidant properties and hyphenated HPLC-PDA-MS profiling of Chilean Pica mango fruits (Mangifera indica L. Cv. piqueño). |
| PubMed:Beneficial effects of mangiferin isolated from Salacia chinensis on biochemical and hematological parameters in rats with streptozotocin-induced diabetes. |
| PubMed:Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats. |
| PubMed:Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics. |
| PubMed:Mangiferin from Salacia chinensis prevents oxidative stress and protects pancreatic β-cells in streptozotocin-induced diabetic rats. |
| PubMed:Comparison of microwave-assisted and conventional extraction of mangiferin from mango (Mangifera indica L.) leaves. |
| PubMed:Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment. |
| PubMed:Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity. |
| PubMed:Polyphenolic and vitamin C contents and antioxidant activities of aqueous extracts from mature-green and ripe fruit fleshes of Mangifera sp. |
| PubMed:Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract. |
| PubMed:Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage. |
| PubMed:Development and application of an enzyme-linked immunosorbent assay for specific detection of mangiferin content in various cultivars of Mangifera indica leaves using anti-mangiferin polyclonal antibody. |
| PubMed:Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. |
| PubMed:Mangiferin glucuronidation: important hepatic modulation of antioxidant activity. |
| PubMed:Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters. |
| PubMed:Anti-diabetic effects of TongGuanWan, a Chinese traditional herbal formula, in C57BL/KsJ-db/db mice. |
| PubMed:Identification and quantification of phenolic compounds in bambangan (Mangifera pajang Kort.) peels and their free radical scavenging activity. |
| PubMed:Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts. |
| PubMed:The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea). |
| PubMed:Mango extracts and the mango component mangiferin promote endothelial cell migration. |
| PubMed:Influences of harvest date and location on the levels of beta-carotene, ascorbic acid, total phenols, the in vitro antioxidant capacity, and phenolic profiles of five commercial varieties of mango (Mangifera indica L.). |
| PubMed:Effect of pre-drying treatments and storage on color and phenolic composition of green honeybush (Cyclopia subternata) herbal tea. |
| PubMed:In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity. |
| PubMed:Cytoprotective and antigenotoxic potential of Mangiferin, a glucosylxanthone against cadmium chloride induced toxicity in HepG2 cells. |
| PubMed:Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract. |
| PubMed:Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). |
| PubMed:Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity. |
| PubMed:Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. |
| PubMed:Effect of species variation and processing on phenolic composition and in vitro antioxidant activity of aqueous extracts of Cyclopia spp. (Honeybush Tea). |
| PubMed:A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas. |
| PubMed:Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity. |
| PubMed:Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material. |
| PubMed:Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia. |
| PubMed:Phenolic metabolites from honeybush tea (Cyclopia subternata). |
| PubMed:Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. Cv. "Tommy Atkins") peels by high-performance liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed:Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. |
| PubMed:Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement. |
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