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neohesperidin
hesperetin-7-neohesperidoside

Supplier Sponsors

Name:(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyph
CAS Number: 13241-33-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:236-216-9
FDA UNII: OA5C88H3L0
Beilstein Number:0074945
MDL:MFCD16661259
XlogP3-AA:-0.50 (est)
Molecular Weight:610.56698000
Formula:C28 H34 O15
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 933.70 °C. @ 760.00 mm Hg (est)
Flash Point: 584.00 °F. TCC ( 306.70 °C. ) (est)
logP (o/w): 2.440 (est)
Soluble in:
 water, 2041 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Neohesperidin 98%
BOC Sciences
For experimental / research use only.
neohesperidin
ExtraSynthese
For experimental / research use only.
neoHesperidin (HPLC) ≥99%
Layn Natural ingredients
Bitter Orange Extract Neohesperidin
M&U International
NAT. neoHESPERIDIN
Santa Cruz Biotechnology
For experimental / research use only.
neoHesperidin
Sigma-Aldrich
For experimental / research use only.
neoHesperidin
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for neohesperidin usage levels up to:
 not for fragrance use.
 
Recommendation for neohesperidin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :73395
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyph
Chemidplus:0013241333
 
References:
 (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyph
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):73395
Pubchem (sid):135032826
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):C09806
HMDB (The Human Metabolome Database):HMDB30748
FooDB:FDB002679
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 citrus aurantium peel
Search Trop Picture
 lemon pericarp
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 mandarin fruit juice
Search Trop Picture
 mandarin pericarp
Search Trop Picture
 orange fruit juice
Search Trop Picture
 orange pericarp
Search Trop Picture
 
Synonyms:
 hesperetin-7-neohesperidoside
 

Articles:

PubMed:Systematic Analysis of Main Constituents in Rat Biological Samples after Oral Administration of the Methanol Extract of Fructus Aurantii by HPLC-ESI-MS/MS.
PubMed:Flavonoid profiles of immature and mature fruit tissues of Citrus grandis Osbeck (Dangyuja) and overall contribution to the antioxidant effect.
PubMed:Development of new reference material neohesperidin for quality control of dietary supplements.
PubMed:[Study on HPLC fingerprint of Ganershu intermediate and determination of three active components].
PubMed:Sweet taste receptor expression in ruminant intestine and its activation by artificial sweeteners to regulate glucose absorption.
PubMed:Evaluation of bioactive components and antioxidant and anticancer properties of citrus wastes generated during bioethanol production.
PubMed:Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties.
PubMed:Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats.
PubMed:[Studies on pharmacokinetics features of characteristic active ingredients of daidai flavone extract in different physiological status].
PubMed:Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats.
PubMed:Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma.
PubMed:Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.
PubMed:Sonochemical effects on 14 flavonoids common in citrus: relation to stability.
PubMed:[Substrate specificity of Cryptococcus albidus and Eupenicillium erubescens alpha-L-rhamnosidases].
PubMed:Dietary supplementation with lactose or artificial sweetener enhances swine gut Lactobacillus population abundance.
PubMed:Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, bioavailability and tissue distribution of neohesperidin dihydrochalcone in rats.
PubMed:Identification and Simultaneous Determination of Twelve Active Components in the Methanol Extract of Traditional Medicine Weichang'an Pill by HPLC-DAD-ESI-MS/MS.
PubMed:Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
PubMed:4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells.
PubMed:Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway.
PubMed:[Study on screening cardioprotective components from Zhishi Xiebai Guizhi Tang].
PubMed:[Study on all-time multi-wavelength fusion fingerprint of Qizhiweitong granules and multi-component quantitative analysis].
PubMed:The ethanol extract isolated from Weiqi Decoction induces G₂/M arrest and apoptosis in AGS cells.
PubMed:Analysis of major constituents in Fructus aurantii-Magnolia bark decoction by UPLC-PDA.
PubMed:Occurrence of seven artificial sweeteners in the aquatic environment and precipitation of Tianjin, China.
PubMed:[Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS].
PubMed:Fragmentation characterization and differentiation of isomeric diglycosyl flavonoids using ultra-high-performance liquid chromatography electrospray ionization quadrupole time-of-flight tandem mass spectrometry in negative ion mode.
PubMed:[About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs].
PubMed:Evaluation of taste-masking effects of pharmaceutical sweeteners with an electronic tongue system.
PubMed:[Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC].
PubMed:Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San.
PubMed:Simultaneous determination of 10 components in traditional Chinese medicine Dachaihu Granule by reversed-phase-high-performance liquid chromatographic-diode array detector.
PubMed:2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.
PubMed:Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector.
PubMed:Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.
PubMed:Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway.
PubMed:The influence of compatibility of traditional Chinese medicine on the pharmacokinetic of main components in Fructus aurantii.
PubMed:Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.
PubMed:Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.
PubMed:HPLC-PDA-MS and NMR characterization of a hydroalcoholic extract of Citrus aurantium L. var. amara peel with antiedematogenic activity.
PubMed:Degreening and postharvest storage influences 'Star Ruby' grapefruit (Citrus paradisi Macf.) bioactive compounds.
PubMed:Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells.
PubMed:The content of high-intensity sweeteners in different categories of foods available on the Polish market.
PubMed:The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.
PubMed:In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.
PubMed:Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-γ and histamine exposed human keratinocytes.
PubMed:Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones.
PubMed:Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD-MS/MS.
PubMed:[Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].
PubMed:Phenolic composition and antioxidant effect of aqueous extract of Arisaema cum Bile, the Oriental Herb Medicine, in human fibroblast cells.
PubMed:Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography.
PubMed:Dihydrochalcone glycosides from Oxytropis myriophylla.
PubMed:Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.
PubMed:Secondary metabolites of ponderosa lemon (Citrus pyriformis) and their antioxidant, anti-inflammatory, and cytotoxic activities.
PubMed:Development and validation of a UHPLC method for the determination of flavonoids in red wine.
PubMed:Simultaneous determination of flavanones, hydroxycinnamic acids and alkaloids in citrus fruits by HPLC-DAD-ESI/MS.
PubMed:Chemical composition and biological activity of Citrus jambhiri Lush.
PubMed:Optimization of flavanones extraction by modulating differential solvent densities and centrifuge temperatures.
PubMed:[Flavonoids--bioactive compounds in fruits juice].
PubMed:Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.
PubMed:[Comprehensive quality control method for total flavonoid of Fructus Aurantii].
PubMed:Binding capacity of ER-α ligands and SERMs: comparison of the human, dog and cat.
PubMed:Study of the polyphenolic composition and antioxidant activity of new sherry vinegar-derived products by maceration with fruits.
PubMed:[Intestinal absorption properties of flavones and extract of fructus aurantii immaturus in rats].
PubMed:Analysis of isoflavones and flavonoids in human urine by UHPLC.
PubMed:Retention behaviour of some high-intensity sweeteners on different SPE sorbents.
PubMed:Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners.
PubMed:Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.
PubMed:Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography.
PubMed:Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines.
PubMed:Major phytochemical composition of 3 native Korean citrus varieties and bioactive activity on V79-4 cells induced by oxidative stress.
PubMed:Quasi-MSn identification of flavanone 7-glycoside isomers in Da Chengqi Tang by high performance liquid chromatography-tandem mass spectrometry.
PubMed:Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.
PubMed:Application of an efficient strategy based on MAE, HPLC-DAD-MS/MS and HSCCC for the rapid extraction, identification, separation and purification of flavonoids from Fructus Aurantii Immaturus.
PubMed:[Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice].
PubMed:Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).
PubMed:[Studies on chemical constituents in stems of Zanthoxylum dissitum].
PubMed:Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.
PubMed:Inhibitory effects of Citrus hassaku extract and its flavanone glycosides on melanogenesis.
PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.
PubMed:Hydrolysis of flavanone glycosides and degradation of the corresponding aglycones from dried immature Citrus fruit by human fecal flora in vitro.
PubMed:Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of new compounds.
PubMed:Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.
PubMed:Estimating bergamot juice adulteration of lemon juice by high-performance liquid chromatography (HPLC) analysis of flavanone glycosides.
PubMed:Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities.
PubMed:Inhibition of oral carcinogenesis by citrus flavonoids.
PubMed:Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells.
PubMed:Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.
PubMed:Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet.
PubMed:The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.
PubMed:Origin identification on the commercial samples of Aurantii Fructus.
PubMed:[Identification of jizhi syrup using HPLC fingerprint].
PubMed:HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines.
PubMed:Racemization at C-2 of naringin in sour oranges with increasing maturity determined by chiral high-performance liquid chromatography.
PubMed:Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death.
PubMed:Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods.
PubMed:Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry.
PubMed:Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.
PubMed:Central nervous system depressant action of flavonoid glycosides.
PubMed:Stereoisomeric separation of flavanones and flavanone-7-O-glycosides by capillary electrophoresis and determination of interconversion barriers.
PubMed:Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry.
PubMed:Application of LC/MS and ICP/MS for establishing the fingerprint spectrum of the traditional Chinese medicinal preparation Gan-Lu-Yin.
PubMed:Flavonoid composition of fruit tissues of citrus species.
PubMed:An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'.
PubMed:Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC.
PubMed:[Historical and pharmalogical study of Citrus hassaku.].
PubMed:Separation of some chiral flavonoids by microbial cyclosophoraoses and their sulfated derivatives in micellar electrokinetic chromatography.
PubMed:[History and therapeutic evaluation of Citrus hassaku HORT. Tanaka].
PubMed:[Study on quality control of effective fraction in qixue bingzhi decoction].
PubMed:HPLC separation of hesperidin and the C-2 epimer in commercial hesperidin samples and herbal medicines.
PubMed:Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP.
PubMed:Antioxidant activity of citrus limonoids, flavonoids, and coumarins.
PubMed:Degradation of neohesperidin dihydrochalcone by human intestinal bacteria.
PubMed:Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme.
PubMed:Separation of flavanone-7-O-glycoside diastereomers and analysis in citrus juices by multidimensional liquid chromatography coupled with mass spectrometry.
PubMed:High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara.
PubMed:Crystal architecture and conformational properties of the inclusion complex, neohesperidin dihydrochalcone-cyclomaltoheptaose (beta-cyclodextrin), by X-ray diffraction.
PubMed:Oral zinc sulfate solutions inhibit sweet taste perception.
PubMed:Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats.
PubMed:LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii.
PubMed:Separation of some chiral flavanones by micellar electrokinetic chromatography.
PubMed:Influence of solvents on the antioxidant property of flavonoids.
PubMed:Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.
PubMed:[Studies on chemical constituents of processed green tangerine peel].
PubMed:Sense of taste in a new world monkey, the common marmoset: recordings from the chorda tympani and glossopharyngeal nerves.
PubMed:[Studies on chemical constituents from the flower of Citrus aurantium].
PubMed:Sweetener preference of C57BL/6ByJ and 129P3/J mice.
PubMed:Chiral separation of six diastereomeric flavanone-7-O-glycosides by capillary electrophoresis and analysis of lemon juice.
PubMed:[Determination of neohesperidin dihydrochalcone in foods].
PubMed:Purification and identification of active antibacterial components in Carpobrotus edulis L.
PubMed:Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.
PubMed:PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine,sucrose, neohesperidin dihydrochalcone and chocolate.
PubMed:Dissolution profiles of principal ingredients in Kampo medicinal powders by high-performance liquid chromatography.
PubMed:Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study.
PubMed:Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions.
PubMed:Molecular topology: a useful tool for the search of new antibacterials.
PubMed:Synergism among ternary mixtures of fourteen sweeteners.
PubMed:Variance of common flavonoids by brand of grapefruit juice.
PubMed:Inhibitory effect of herbal medicines on rotavirus infectivity.
PubMed:Effect of temperature, pH, and ions on sweet taste.
PubMed:Transglycosylation of neohesperidin dihydrochalcone by Bacillus stearothermophilus maltogenic amylase.
PubMed:An estimation of the detection and quantitation limits of neohesperidine DC by high-performance liquid chromatography.
PubMed:Double functionality of sweeteners: a case of study.
PubMed:Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.
PubMed:Validation of a liquid chromatography ionspray mass spectrometry method for the analysis of flavanones, flavones and flavonols.
PubMed:[Standardization of the sour orange flower and leaf].
PubMed:Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.
PubMed:Analytical monitoring of citrus juices by using capillary electrophoresis.
PubMed:In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone.
PubMed:Simultaneous separation of flavanone glycosides and polymethoxylated flavones in citrus juices using liquid chromatography.
PubMed:Lowering effect of phenolic glycosides on the rise in postprandial glucose in mice.
PubMed:Validated high-performance liquid chromatographic method for quantitation of neohesperidine dihydrochalcone in foodstuffs.
PubMed:Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas.
PubMed:Synthesis of neohesperidin glycosides and naringin glycosides by cyclodextrin glucanotransferase from an alkalophilic Bacillus species.
PubMed:Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds.
PubMed:Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid.
PubMed:Bitterness of sweeteners as a function of concentration.
PubMed:Investigation of synergism in binary mixtures of sweeteners.
PubMed:Adaptation of sweeteners in water and in tannic acid solutions.
PubMed:Gustatory neural coding in the monkey cortex: the quality of sweetness.
PubMed:Bioproduction of neohesperidin and naringin in callus cultures of Citrus aurantium.
PubMed:Naringin and Neohesperidin Levels during Development of Leaves, Flower Buds, and Fruits of Citrus aurantium.
PubMed:UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase. Purification and characterization of an enzyme catalyzing the production of bitter compounds in citrus.
PubMed:[Studies on the preparation and evaluation of Kijitsu, the immature citrus fruits. IV. Biological activities of immature fruits of different citrus species].
PubMed:Subchronic (13-week) oral toxicity of neohesperidin dihydrochalcone in rats.
PubMed:High-potency sweeteners and dental health.
PubMed:Sweet tastants stimulate adenylate cyclase coupled to GTP-binding protein in rat tongue membranes.
PubMed:Liquid chromatographic determination of naringin and neohesperidin as a detector of grapefruit juice in orange juice.
PubMed:Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides.
PubMed:Caffeine intensifies taste of certain sweeteners: role of adenosine receptor.
PubMed:Gustatory reaction time to various sweeteners in human adults.
PubMed:In vivo exposure to plant flavonols. Influence on frequencies of micronuclei in mouse erythrocytes and sister-chromatid exchange in rabbit lymphocytes.
PubMed:Taste responses to neohesperidin dihydrochalcone in rats and baboon monkeys.
PubMed:Genetic toxicological of some plant flavonoids by the micronucleus test.
PubMed:Dihydrochalcone sweeteners. A study of the atypical temporal phenomena.
PubMed:Sweeteners--an overview. Part. 1.
PubMed:An exponential model for adaptation in taste.
PubMed:Qualitative differences among sweeteners.
PubMed:Saccharin and other sweeteners: mutagenic properties.
PubMed:Nonnutritive sweeteners: taste-structure relationships for some new simple dihydrochalcones.
PubMed:Liquid chromatography of neohesperidin dihydrochalcone.
 
Notes:
Constit. of Seville orange peel (Citrus aurantium) and other Citrus spp. Very bitter flavouring agent
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