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procyanidin B2
(2R-(2alpha,3alpha,4beta(2'R*,3'R*)))-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-(4,8'-Bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol

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Name:(2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
CAS Number: 29106-49-8Picture of molecule3D/inchi
FDA UNII: L88HKE854X
Nikkaji Web:J56.253J
MDL:MFCD01861513
XlogP3-AA:2.40 (est)
Molecular Weight:578.52762000
Formula:C30 H26 O12
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 955.30 °C. @ 760.00 mm Hg (est)
Flash Point: 989.00 °F. TCC ( 531.60 °C. ) (est)
logP (o/w): 0.300 (est)
Soluble in:
 water, 20.86 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Procyanidin B2 98%
BOC Sciences
For experimental / research use only.
Procyanidin B2 >98%
Odor: characteristic
Use: Procyanidin B2 has been shown to inhibit the formation of the advanced glycation end-products pentosidine, carboxymethyllysine (CML), and methylglyoxal (MGO). anti-hypertension
ExtraSynthese
For experimental / research use only.
Procyanidin B2 (HPLC) ≥90%
Glentham Life Sciences
Procyanidin B2
Layn Natural ingredients
Grape Seed Extract Proanthocyanidins | Polyphenols 60% - 90%
Santa Cruz Biotechnology
For experimental / research use only.
Procyanidin B2 ≥90%
Sigma-Aldrich
For experimental / research use only.
Procyanidin B2
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for procyanidin B2 usage levels up to:
 not for fragrance use.
 
Recommendation for procyanidin B2 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :122738
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
Chemidplus:0029106498
 
References:
 (2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):122738
Pubchem (sid):135078310
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C17639
HMDB (The Human Metabolome Database):HMDB33973
FooDB:FDB012204
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 apple fruit
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 apple fruit juice
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 apple leaf
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 apple pericarp
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 bay laurel
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 bay laurel leaf
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 bilberry fruit
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 bilberry leaf
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 buckwheat root
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 buckwheat tissue culture
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 cacao
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 cassia bark
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 cinnamomum spp.
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 cinnamon ceylon cinnamon bark
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 cranberry
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 grape leaf
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 grape pericarp
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 grape seed
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 guava leaf
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 loquat
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 malus spp.
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 peanut
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 pomegranate fruit
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 star fruit
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 tea leaf
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 wine red wine
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Synonyms:
(4,8'-bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R-(2alpha,3alpha,4beta(2'R*,3'R*)))-
(2R-(2alpha,3alpha,4beta(2'R*,3'R*)))-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-(4,8'-Bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol
(2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
 proanthocyanidin
 

Articles:

PubMed:Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2.
PubMed:3-O-Galloylated Procyanidins from Rumex acetosa L. Inhibit the Attachment of Influenza A Virus.
PubMed:Chemical composition, antioxidant and antinociceptive properties of Litchi chinensis leaves.
PubMed:Quantitative proteomics study of protective effects of grape seed procyanidin B2 on diabetic cardiomyopathy in db/db mice.
PubMed:Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats.
PubMed:Degradation of (-)-Epicatechin and Procyanidin B2 in Aqueous and Lipidic Model Systems. First Evidence of "Chemical" Flavan-3-ol Oligomers in Processed Cocoa.
PubMed:Microbial catabolism of procyanidins by human gut microbiota.
PubMed:Rapid screening and identification of new soluble tannin-salivary protein aggregates in saliva by mass spectrometry (MALDI-TOF-TOF and FIA-ESI-MS).
PubMed:Analysis of different European hazelnut (Corylus avellana L.) cultivars: authentication, phenotypic features, and phenolic profiles.
PubMed:Chemical constituents from Gouania longipetala and Glyphaea brevis.
PubMed:Red wine and oenological extracts display antimicrobial effects in an oral bacteria biofilm model.
PubMed:Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS.
PubMed:Variation of quantitative composition of phenolic compounds in rowan (Sorbus aucuparia L.) leaves during the growth season.
PubMed:Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro.
PubMed:Antioxidant and anti-lipid peroxidation activities of Tamarindus indica seed coat in human fibroblast cells.
PubMed:The phenolic content and its involvement in the graft incompatibility process of various pear rootstocks (Pyrus communis L.).
PubMed:Polyphenol compounds belonging to flavonoids inhibit activity of coagulation factor X.
PubMed:Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis.
PubMed:Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice.
PubMed:Procyanidin B2 3,3(″)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-κB, Stat3, and AP1 transcription factors.
PubMed:Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats.
PubMed:Comparative analysis of Tunisian wild Crataegus azarolus (yellow azarole) and Crataegus monogyna (red azarole) leaf, fruit, and traditionally derived syrup: phenolic profiles and antioxidant and antimicrobial activities of the aqueous-acetone extracts.
PubMed:Polyphenols and triterpenes from Chaenomeles fruits: chemical analysis and antioxidant activities assessment.
PubMed:Effect of growing zone and vintage on the prediction of extractable flavanols in winegrape seeds by a FT-NIR method.
PubMed:Isolation of a reduced form of cyanidin 3-O-β-D-glucoside from immature black soybean (Glycine max (L.) Merr.) and its reducing properties.
PubMed:PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2.
PubMed:Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages.
PubMed:Characterisation of proanthocyanidins from black soybeans: isolation and characterisation of proanthocyanidin oligomers from black soybean seed coats.
PubMed:Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities.
PubMed:HPLC-DAD determination of seven antioxidants and caffeine in different phytopharmaceuticals.
PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed:Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats.
PubMed:Procyanidin b2 cytotoxicity to mcf-7 human breast adenocarcinoma cells.
PubMed:Development and validation studies for determination of phenylpropanoid-substituted flavan-3-ols in semipurified extract of Trichilia catigua by high-performance liquid chromatography with photodiode array detection.
PubMed:Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy.
PubMed:Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis.
PubMed:Polyphenolic composition, antioxidant activity, and polyphenol oxidase (PPO) activity of quince (Cydonia oblonga Miller) varieties.
PubMed:Antioxidant activity and HPLC analysis of polyphenol-enriched extracts from industrial apple pomace.
PubMed:Phenolic profile and antioxidant capacity of the principal apples produced in Brazil.
PubMed:Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage.
PubMed:In vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents.
PubMed:Phenolic profiles and antioxidant activity of litchi (Litchi Chinensis Sonn.) fruit pericarp from different commercially available cultivars.
PubMed:Polyphenolic profile and biological activity of Chinese hawthorn (Crataegus pinnatifida BUNGE) fruits.
PubMed:Rapid and simultaneous determination of antioxidant markers and caffeine in commercial teas and dietary supplements by HPLC-DAD.
PubMed:Cocoa polyphenols are absorbed in Caco-2 cell model of intestinal epithelium.
PubMed:Ultrasound-assisted extraction, HPLC analysis, and antioxidant activity of polyphenols from unripe apple.
PubMed:A procyanidin trimer, C1, promotes NO production in rat aortic endothelial cells via both hyperpolarization and PI3K/Akt pathways.
PubMed:In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells.
PubMed:[Qualitative and quantitative analysis of flavonoids in Chinese hawthorn fruit].
PubMed:Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(dimethylamino)cinnamaldehyde assay.
PubMed:Apple pomace, a by-product from the asturian cider industry, inhibits herpes simplex virus types 1 and 2 in vitro replication: study of its mechanisms of action.
PubMed:Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans.
PubMed:The relationship between antiglycation activity and procyanidin and phenolic content in commercial grape seed products.
PubMed:HPLC-DAD-ESI-MS analysis of flavonoid compounds in 5 seedless table grapes grown in Apulian Region.
PubMed:Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae).
PubMed:Characterization of procyanidin B2 oxidation products in an apple juice model solution and confirmation of their presence in apple juice by high-performance liquid chromatography coupled to electrospray ion trap mass spectrometry.
PubMed:Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver.
PubMed:Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress.
PubMed:Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation.
PubMed:Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells.
PubMed:Simple solution for a complex problem: proanthocyanidins, galloyl glucoses and ellagitannins fit on a single calibration curve in high performance-gel permeation chromatography.
PubMed:Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products.
PubMed:The effect of postharvest 1-MCP treatment and storage atmosphere on 'Cripps Pink' apple phenolics and antioxidant activity.
PubMed:Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.
PubMed:Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea.
PubMed:Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol.
PubMed:Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway.
PubMed:Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation.
PubMed:Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
PubMed:Intestinal transit and systemic metabolism of apple polyphenols.
PubMed:Optimization of microwave-assisted extraction of polyphenols from apple pomace using response surface methodology and HPLC analysis.
PubMed:Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells.
PubMed:Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity.
PubMed:Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption.
PubMed:Sweet cherry pomological and biochemical characteristics influenced by rootstock.
PubMed:Determination of total procyanidins in selected chocolate and confectionery products using DMAC.
PubMed:Procyanidin B2 catabolism by human fecal microflora: partial characterization of 'dimeric' intermediates.
PubMed:Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells.
PubMed:Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90.
PubMed:A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota.
PubMed:In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats.
PubMed:Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease.
PubMed:Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation.
PubMed:Influence of apple polyphenols on inflammatory gene expression.
PubMed:Degradation and metabolism of catechin, epigallocatechin-3-gallate (EGCG), and related compounds by the intestinal microbiota in the pig cecum model.
PubMed:Polyphenol contents and antioxidant activities of extracts from flowers of two Crataegus azarolus L. varieties.
PubMed:Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats.
PubMed:Screening antioxidants using LC-MS: case study with cocoa.
PubMed:Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo.
PubMed:Densitometric determination of (+)-catechin and (-)-epicatechin by 4-dimethylaminocinnamaldehyde reagent.
PubMed:Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats.
PubMed:Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity.
PubMed:Pyrogallol structure in polyphenols is involved in apoptosis-induction on HEK293T and K562 cells.
PubMed:Procyanidins from Myrothamnus flabellifolia.
PubMed:An analysis on flavonoids, phenolics and organic acids contents in brewed red wines of both non-skin contact and skin contact fermentation techniques of Mao Luang ripe fruits (Antidesma bunius) harvested from Phupan Valley in Northeast Thailand.
PubMed:An analysis on flavonoids contents in Mao Luang fruits of fifteen cultivars (Antidesma bunius), grown in northeast Thailand.
PubMed:[Phenols from the rhizomes of Arachniodes exilis].
PubMed:Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase.
PubMed:Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry.
PubMed:[Antioxidant activity of tinctures prepared from hawthorn fruits and motherwort herb].
PubMed:Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities.
PubMed:Rapid preparation of procyanidins B2 and C1 from Granny Smith apples by using low pressure column chromatography and identification of their oligomeric procyanidins.
PubMed:Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts.
PubMed:Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations.
PubMed:Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK.
PubMed:Cacao procyanidins reduce plasma cholesterol and increase fecal steroid excretion in rats fed a high-cholesterol diet.
PubMed:Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase.
PubMed:Content of polyphenolic compounds in the Nigerian stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and their antioxidant capacity.
PubMed:Litchi flavonoids: isolation, identification and biological activity.
PubMed:Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3.
PubMed:Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary alpha-amylase (HSA) by fluorescence quenching.
PubMed:[Studies on chemical constituents from roots of Craibiodendron henryi].
PubMed:High-performance liquid chromatography/electrospray ionization mass spectrometric characterization of new products formed by the reaction between flavanols and malvidin 3-glucoside in the presence of acetaldehyde.
PubMed:Antidepressant-like effect of Cecropia glazioui Sneth and its constituents - in vivo and in vitro characterization of the underlying mechanism.
PubMed:Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes.
PubMed:A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans.
PubMed:Concentrations and characteristics of procyanidins and other phenolics in apples during fruit growth.
PubMed:Ex vivo evaluation of the percutaneous penetration of proanthocyanidin extracts from Guazuma ulmifolia using photoacoustic spectroscopy.
PubMed:Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate.
PubMed:Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
PubMed:Inhibitory effects of procyanidin B(2) dimer on lipid-laden macrophage formation.
PubMed:Degradation of procyanidins by Aspergillus fumigatus: identification of a novel aromatic ring cleavage product.
PubMed:Influence of different phenolic copigments on the color of malvidin 3-glucoside.
PubMed:A 3D structural and conformational study of procyanidin dimers in water and hydro-alcoholic media as viewed by NMR and molecular modeling.
PubMed:Quantification of the polyphenols and triterpene acids in chinese hawthorn fruit by high-performance liquid chromatography.
PubMed:Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms.
PubMed:Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells.
PubMed:Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols.
PubMed:Polyphenol contents in grape-seed extracts correlate with antipica effects in cisplatin-treated rats.
PubMed:HPLC coupled on-line to ESI-MS and a DPPH-based assay for the rapid identification of anti-oxidants in Butea superba.
PubMed:Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage.
PubMed:Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia.
PubMed:Isolation and structure elucidation of phenolic compounds from longan (Dimocarpus longan Lour.) seed by high-performance liquid chromatography-electrospray ionization mass spectrometry.
PubMed:Separation of eight selected flavan-3-ols on cellulose thin-layer chromatographic plates.
PubMed:Isolation and structure elucidation of phenolic antioxidants from Tamarind (Tamarindus indica L.) seeds and pericarp.
PubMed:Which polyphenolic compounds contribute to the total antioxidant activities of apple?
PubMed:Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases.
PubMed:Effects of phenolics in Empire apples on hydrogen peroxide-induced inhibition of gap-junctional intercellular communication.
PubMed:Effect of mash maceration on the polyphenolic content and visual quality attributes of cloudy apple juice.
PubMed:Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis.
PubMed:Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition.
PubMed:Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column.
PubMed:Hawthorn extracts inhibit LDL oxidation.
PubMed:Phenolic constituents and antioxidant capacities of Crataegus monogyna (Hawthorn) callus extracts.
PubMed:Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
PubMed:Isolation and structural elucidation of some procyanidins from apple by low-temperature nuclear magnetic resonance.
PubMed:Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats.
PubMed:Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS.
PubMed:Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.
PubMed:Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen species.
PubMed:Influence of procyanidins on the color stability of oenin solutions.
PubMed:Immunomodulatory proanthocyanidins from Ecdysanthera utilis.
PubMed:Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures.
PubMed:Quantification of procyanidins in oral herbal medicinal products containing extracts of Crataegus species.
PubMed:Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro.
PubMed:Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment.
PubMed:Antioxidant activity of polyphenols from seeds of Vitis amurensis in vitro.
PubMed:Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC.
PubMed:Quantitative analysis of flavan-3-ols in Spanish foodstuffs and beverages.
PubMed:A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli.
PubMed:Studies in polyphenol chemistry and bioactivity. 2. Establishment of interflavan linkage regio- and stereochemistry by oxidative degradation of an O-alkylated derivative of procyanidin B2 to (R)-(-)-2,4-diphenylbutyric acid.
PubMed:Gel permeation chromatography of anthocyanin pigments from Rosé cider and red wine.
PubMed:Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent.
PubMed:Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test.
PubMed:Anti-HIV activity of flavonoids and proanthocyanidins from Crataegus sinaica.
PubMed:Procyanidin Production by Fagopyrum esculentum Callus Culture.
 
Notes:
Present in red wine
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