Category:emollients, humectants, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 620.20 °C. @ 760.00 mm Hg (est)
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Flash Point: | 624.00 °F. TCC ( 328.90 °C. ) (est)
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logP (o/w): | -1.600 (est) |
Soluble in: |
| water, 1.136e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | emollients, humectants, skin conditioning |
Recommendation for acetyl histidine usage levels up to: | | not for fragrance use.
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Recommendation for acetyl histidine flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
| (2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoic acid |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 75619 |
Pubchem (sid): | 135031072 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(S)-2- | acetamido-3-(1H-imidazol-4-yl)propanoic acid | (2S)-2- | acetamido-3-(1H-imidazol-5-yl)propanoic acid | N- | acetyl histidine | N- | acetyl-L-histidine | N(2)- | acetyl-L-histidine | (2S)-2-( | acetylamino)-3-imidazol-4-ylpropanoic acid | N- | acetylhistidine | N2- | acetylhistidine | L- | histidine, N-acetyl- | L- | histidine, N-acetyl- (9CI) | L- | histidine, N-acetyl-, | | histidine, N-acetyl-, L- | | histidine, N-acetyl-, L- (8CI) |
Articles:
PubMed:Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus. |
PubMed:An epidemiological study of cataracts in wild and farmed lumpfish (Cyclopterus lumpus L.) and the relation to nutrition. |
PubMed:Lens metabolomic profiling as a tool to understand cataractogenesis in Atlantic salmon and rainbow trout reared at optimum and high temperature. |
PubMed:The metabolic response in fish to mildly elevated water temperature relates to species-dependent muscular concentrations of imidazole compounds and free amino acids. |
PubMed:Synthesis and evaluation of pH-sensitive, self-assembled chitosan-based nanoparticles as efficient doxorubicin carriers. |
PubMed:Tumor microenvironment-responsive micelles for pinpointed intracellular release of doxorubicin and enhanced anti-cancer efficiency. |
PubMed:Novel self-assembled pH-responsive biomimetic nanocarriers for drug delivery. |
PubMed:Active Tumor Permeation and Uptake of Surface Charge-Switchable Theranostic Nanoparticles for Imaging-Guided Photothermal/Chemo Combinatorial Therapy. |
PubMed:Microhydration of Protonated Nα-Acetylhistidine: A Theoretical Approach. |
PubMed:The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex. |
PubMed:N-acetyl-L-histidine, a Prominent Biomolecule in Brain and Eye of Poikilothermic Vertebrates. |
PubMed:Importance of polarization transfer in reaction products for interpreting and analyzing CIDNP at low magnetic fields. |
PubMed:Imidazole catalyzes chlorination by unreactive primary chloramines. |
PubMed:Dietary histidine requirement to reduce the risk and severity of cataracts is higher than the requirement for growth in Atlantic salmon smolts, independently of the dietary lipid source. |
PubMed:Coherent transfer of nuclear spin polarization in field-cycling NMR experiments. |
PubMed:An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for Nα-acetylhistidine synthesis. |
PubMed:HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantation. |
PubMed:Preservation of endothelial vascular function of saphenous vein grafts after long-time storage with a recently developed potassium-chloride and N-acetylhistidine enriched storage solution. |
PubMed:Synthesis of catecholamine conjugates with nitrogen-centered bionucleophiles. |
PubMed:Creating Long-Lived Spin States at Variable Magnetic Field by Means of Photochemically Induced Dynamic Nuclear Polarization. |
PubMed:Effects of chronic and periodic exposures to ammonia on the eye health in juvenile Atlantic halibut (Hippoglossus hippoglossus). |
PubMed:Synthesis of allylic hydroperoxides and EPR spin-trapping studies on the formation of radicals in iron systems as potential initiators of the sensitizing pathway. |
PubMed:Susceptibility of Atlantic salmon lenses to hydrogen peroxide oxidation ex vivo after being fed diets with vegetable oil and methylmercury. |
PubMed:Even short-time storage in physiological saline solution impairs endothelial vascular function of saphenous vein grafts. |
PubMed:N-acetylhistidine, a novel osmolyte in the lens of Atlantic salmon (Salmo salar L.). |
PubMed:Tumor targeting efficiency of bare nanoparticles does not mean the efficacy of loaded anticancer drugs: importance of radionuclide imaging for optimization of highly selective tumor targeting polymeric nanoparticles with or without drug. |
PubMed:Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents. |
PubMed:Prostate cancer-targeted imaging using magnetofluorescent polymeric nanoparticles functionalized with bombesin. |
PubMed:Influence of histidine on the release of all-trans retinoic acid from self-assembled glycol chitosan nanoparticles. |
PubMed:Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens. |
PubMed:Deferoxamine, the newly developed iron chelator LK-614 and N-alpha-acetyl-histidine in myocardial protection. |
PubMed:Myocardial protection with the use of L-arginine and N-alpha-acetyl-histidine. |
PubMed:Improved vessel preservation after 4 days of cold storage: experimental study in rat arteries. |
PubMed:Genome-wide transcription analysis of histidine-related cataract in Atlantic salmon (Salmo salar L). |
PubMed:Histidine-containing radicals in the gas phase. |
PubMed:Occurrence of a novel acetylated amino acid, N(alpha)-acetylhistidine, in skeletal muscle of freshwater fish and other ectothermic vertebrates. |
PubMed:Solution interactions between the uranyl cation [UO2(2+)] and histidine, N-acetyl-histidine, tyrosine, and N-acetyl-tyrosine. |
PubMed:Efficient preparation of xanthine-containing oligodeoxynucleotide from oxanine-containing oligodeoxynucleotide, catalyzed by N alpha-acetyl-L-histidine. |
PubMed:Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines. |
PubMed:The melatonin metabolite N-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger. |
PubMed:Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE. |
PubMed:Attenuated cold storage injury of rat livers using a modified HTK solution. |
PubMed:Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments. |
PubMed:Magnetic assembly and patterning of vesicle/nanoparticle aggregates. |
PubMed:Detection of kynurenine modifications in proteins using a monoclonal antibody. |
PubMed:Possible bioactivation pathways of lamotrigine. |
PubMed:pH-tunable equilibria in azocrown ethers with histidine moieties. |
PubMed:N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release. |
PubMed:Purification and sequence identification of anserinase. |
PubMed:Histidine nutrition and genotype affect cataract development in Atlantic salmon, Salmo salar L. |
PubMed:Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation. |
PubMed:3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody. |
PubMed:Anti-crosslinking properties of carnosine: significance of histidine. |
PubMed:Synthesis of N tau-arylhistidine derivatives via direct N-arylation. |
PubMed:Model studies on protein side chain modification by 4-oxo-2-nonenal. |
PubMed:Ultraviolet spectrophotometric characterization of copper(II) complexes with imidazole N-methyl derivatives of L-histidine in aqueous solution. |
PubMed:Structural basis of protein-bound endogenous aldehydes. Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. |
PubMed:Mechanisms of reactions of flavin mononucleotide triplet with aromatic amino acids. |
PubMed:Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells. |
PubMed:Characterization of sterically stabilized cisplatin liposomes by nuclear magnetic resonance. |
PubMed:Novel mechanism of surface catalysis of protein adduct formation. NMR studies of the acetylation of ubiquitin. |
PubMed:Modification of histidine residues by 4,5-epoxy-2-alkenals. |
PubMed:The existence of molecular water pumps in the nervous system: a review of the evidence. |
PubMed:Mass spectrometric analysis of catechol-histidine adducts from insect cuticle. |
PubMed:Function of the N-acetyl-L-histidine system in the vertebrate eye. Evidence in support of a role as a molecular water pump. |
PubMed:Toward understanding tryptophan fluorescence in proteins. |
PubMed:Canavan disease. Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms. |
PubMed:Hydrazide as a ligand moiety in immobilized metal ion affinity chromatography. Separation of BO-IMI and BODIPY-hydrazide. |
PubMed:A review of phylogenetic and metabolic relationships between the acylamino acids, N-acetyl-L-aspartic acid and N-acetyl-L-histidine, in the vertebrate nervous system. |
PubMed:Identification of N-acetylaspartate in the lens of the vertebrate eye: a new model for the investigation of the function of N-acetylated amino acids in vertebrates. |
PubMed:Profiling peptide adducts of oxidized N-acetyldopamine by electrospray mass spectrometry. |
PubMed:Effect of histidine-containing dipeptides on isolated heart under ischemia/reperfusion. |
PubMed:Characterization of products from the reactions of N-acetyldopamine quinone with N-acetylhistidine. |
PubMed:The reaction of 4-hydroxy-2-nonenal with N alpha-acetyl-L-histidine. |
PubMed:Reaction of malondialdehyde (MDA) with alpha-N-acetylhistidine in the presence of alkanal. |
PubMed:Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. |
PubMed:Detection and identification of the cross-linking amino acids N tau- and N pi-(2'-amino-2'-carboxy-ethyl)-L-histidine ("histidinoalanine", HAL) in heated milk products. |
PubMed:DNA cleavage photoinduced by new water-soluble zinc porphyrins linked to 9-methoxyellipticine. |
PubMed:Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscle. |
PubMed:Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. |
PubMed:Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methods. |
PubMed:Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. |
PubMed:Formation of difluorothionoacetyl-protein adducts by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine metabolites: nucleophilic catalysis of stable lysyl adduct formation by histidine and tyrosine. |
PubMed:N-acetylhistidine, glutamate, and beta-alanine are concentrated in a receptor cell layer of the trout inner ear. |
PubMed:Chemical modification of chalcone isomerase by diethyl pyrocarbonate: histidine residues are not essential for catalysis. |
PubMed:LHRH interaction with Zn(II) ions. |
PubMed:Detection, characterisation, and quantification of carnosine and other histidyl derivatives in cardiac and skeletal muscle. |
PubMed:Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum. |
PubMed:Development and characterization of a polymer gel with an immobilized enzyme to measure L-glutamate. |
PubMed:Synaptic transmission in amphibian retinae during conditions unfavourable for calcium entry into presynaptic terminals. |
PubMed:Chemical modification of sheep-liver 6-phosphogluconate dehydrogenase by diethylpyrocarbonate. Evidence for an essential histidine residue. |
PubMed:Reactivities of tyrosine, histidine, tryptophan, and methionine in radical pair formation in flavin triplet induced protein nuclear magnetic polarization. |
PubMed:[Determination of the antihistaminic properties of histidine derivatives on models of guinea pig T- and B-lymphocyte rosette formation]. |
PubMed:Evidence for the identification of synaptic transmitters released by photoreceptors of the toad retina. |
PubMed:Catalysis of peptide bond formation by histidyl-histidine in a fluctuating clay environment. |
PubMed:In vivo deacetylation of N-acetyl amino acids by kidney acylases in mice and rats. A possible role of acylase system in mammalian kidneys. |
PubMed:Conformation of cobrotoxin in aqueous solution as studied by nuclear magnetic resonance. |
PubMed:A new arylating agent, 2-carboxy-4,6-dinitrochlorobenzene. Reaction with model compounds and bovine pancreatic ribonuclease. |
PubMed:Similarity of tuna N-acetylhistidine deacetylase and cod fish anserinase. |
PubMed:Studies on the heterotropic interaction of hemoglobin. I. Mass spectrometric method for determination of the pKa of the beta-146 histidine residue in human hemoglobin. |
PubMed:Model ligands for copper proteins. Proton magnetic resonance study of acetylhistamine and acetylhistidine complexes with copper(I). |
PubMed:Haem ligands of the ferricytochrome c of Ustilago sphaerogena. |
PubMed:Crystal structure of L-N-acetylhistidine monohydrate: an open and closed case. |
PubMed:Acetylhistidine as substrate for acetylornithinase: a new system for the selection of arginine regulation mutants in Escherichia coli. |
PubMed:N-acetylhistidine metabolism in the brain, heart and lens of the goldfish, Carassius auratus, in vivo: evidence of rapid turnover and a possible intermediate. |
PubMed:Phospholipid reactivation of plasmalogen metabolism. |
PubMed:N-acetylhistidine in developing embryos of the killifish, Fundulus heteroclitus and the zebrafish, Brachydanio rerio. |
PubMed:N-acetylhistidine isolated from frog heart. |
PubMed:[N-acetylhistidine as a donor of acetyl in the biosynthesis of acetylcholine in the brain in fish]. |
PubMed:[Differences in N-acetylhistidine level in fresh water and sea water fish]. |
PubMed:OCCURRENCE AND DISTRIBUTION OF N-ACETYLHISTIDINE IN BRAIN AND EXTRACEREBRAL TISSUES OF POIKILOTHERMAL VERTEBRATES. |
PubMed:OCCURRENCE OF N-ACETYLHISTIDINE IN THE CENTRAL NERVOUS SYSTEM AND THE EYE OF RANA ESCULENTA. |
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