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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 518.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 403.00 °F. TCC ( 206.00 °C. ) (est)
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| logP (o/w): | 11.440 (est) |
| Soluble in: |
| | water, 1.069e-006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for dextro-gamma-tocopherol usage levels up to: | | | not for fragrance use.
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| Recommendation for dextro-gamma-tocopherol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Scientific Opinion on the re-evaluation of tocopherol-rich extract (E 306), a-tocopherol (E 307), ?-tocopherol (E 308) and d-tocopherol (E 309) as food additives
View page or View pdf
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| EPI System: View |
| ClinicalTrials.gov:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):54-28-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :92729 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol |
| Chemidplus:0000054284 |
References:
| | (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 54-28-4 |
| Pubchem (cid): | 92729 |
| Pubchem (sid): | 135051177 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2H-1- | benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)- | | 2H-1- | benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)- | | (2R(2R*(4R*,8R*)))-3,4- | dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol | | (2R)-3,4- | dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol | | D-gamma- | tocopherol | | (2R)-2,7,8- | trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol | | (2R)-2,7,8- | trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol | | (2R)-2,7,8- | trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-6-chromanol | | (2R)-2,7,8- | trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol |
Articles:
| PubMed:Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan. |
| PubMed:Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCĪ± in human microvascular endothelial cells. |
| PubMed:Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells. |
| PubMed:Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. |
| PubMed:A pharmacological action of vitamin E unrelated to its antioxidant capacity. |
| PubMed:Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats. |
| PubMed:Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors. |
| PubMed:Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC. |
| PubMed:Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells. |
| PubMed:The vitamin E nutritional status of rats fed on diets high in fish oil, linseed oil or sunflower seed oil. |
| PubMed:NO2-induced DNA single strand breaks are inhibited by antioxidative vitamins in V79 cells. |
| PubMed:Mammary transfer of vitamin E in dairy cows. |
| PubMed:Mechanisms of absorption, transport and tissue uptake of RRR-alpha-tocopherol and d-gamma-tocopherol in the white rat. |
| PubMed:Biopotency of vitamin E in barley. |
| PubMed:Relative antioxidant effectiveness of alpha-tocopherol and gamma-tocopherol in iron-loaded rats. |
| PubMed:Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds. |
| PubMed:EFFECT OF D-GAMMA-TOCOPHEROL ON THE INCIDENCE OF TERATOGENY IN VITAMIN E-DEFICIENT RATS. |
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3D/inchi