peg-450
poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- (450 mol EO average molar ratio)

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CAS Number: 25322-68-3 3D/inchi Other(deleted CASRN): 101677-86-5 ECHA ELINCS - REACH Pre-Reg: 500-038-2 FDA UNII: Search Formula: (C2 H4 O)mult-H2 O Category:binding, emulsion stabilising agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: binding agents emulsion stabilisers   Suppliers:   None found   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intravenous-dog LDLo 3000 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951. oral-guinea pig LD50 15700 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-guinea pig LD50 17000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-guinea pig LD50 19600 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-guinea pig LD50 22500 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950. oral-guinea pig LD50 28000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-guinea pig LD50 28900 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-guinea pig LD50 50000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-guinea pig LD50 50900 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-mouse LD50 473 mg/kg Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 21, Pg. 387, 1986. intraperitoneal-mouse LD50 2000 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951. intraperitoneal-mouse LD50 7500 mg/kg National Technical Information Service. Vol. AD628-313 intraperitoneal-mouse LD50 8000 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951. intravenous-mouse LD50 7900 ug/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970. intravenous-mouse LD50 8550 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976. intravenous-mouse LD50 16000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-mouse LD50 28915 mg/kg Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976. oral-mouse LD50 31000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-mouse LD50 34000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-mouse LD50 36000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. intravenous-rabbit LD50 8000 mg/kg BLOOD: CHANGE IN CLOTTING FACTORS Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 4, Pg. 71, 1978. oral-rabbit LD50 14000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-rabbit LD50 17300 mg/kg International Journal of Toxicology. Vol. 18(Suppl oral-rabbit LD50 17300 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rabbit LD50 19000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-rabbit LD50 26800 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rabbit LD50 28900 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rabbit LD50 76000 mg/kg International Journal of Toxicology. Vol. 18(Suppl oral-rabbit LD50 76000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD > 4000 mg/kg Union Carbide Data Sheet. Vol. 9/25/1969 intraperitoneal-rat LD50 6790 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-rat LD50 9000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-rat LD50 9700 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982. intraperitoneal-rat LD50 9708 mg/kg Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976. intraperitoneal-rat LD50 12600 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-rat LD50 14100 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982. intraperitoneal-rat LD50 15390 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-rat LD50 15570 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-rat LD50 16000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intraperitoneal-rat LD50 17000 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950. intraperitoneal-rat LD50 17700 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. intravenous-rat LD50 7130 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982. intravenous-rat LD50 7312 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976. intravenous-rat LD50 7500 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982. intravenous-rat LD50 13000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD50 600 mg/kg Dow Chemical Company Reports. Vol. MSD-94 oral-rat LD50 1054 mg/kg Dow Chemical Company Reports. Vol. MSD-95 oral-rat LD50 > 4000 mg/kg Dow Chemical Company Reports. Vol. MSD-938 oral-rat LD50 22000 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969. oral-rat LD50 27500 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD50 28000 mg/kg Dow Chemical Company Reports. Vol. MSD-1112 oral-rat LD50 30000 mg/kg Dow Chemical Company Reports. Vol. MSD-2203 oral-rat LD50 30200 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950. oral-rat LD50 31600 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969. oral-rat LD50 31640 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD50 32000 mg/kg Dow Chemical Company Reports. Vol. MSD-937 oral-rat LD50 44200 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD50 45000 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982. oral-rat LD50 50000 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969. oral-rat LD50 > 50000 mg/kg Dow Chemical Company Reports. Vol. MSD-935 oral-rat LD50 > 50000 mg/kg Dow Chemical Company Reports. Vol. MSD-940 oral-rat LD50 50000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD50 51200 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. oral-rat LD50 51310 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. unreported-rat LD50 7800 mg/kg United States Patent Document. Vol. #4767763 intravenous-rat LDLo 3 mg/kg Toxicology and Applied Pharmacology. Vol. 16, Pg. 442, 1970. intravenous-rat LDLo 22000 mg/kg KIDNEY, URETER, AND BLADDER: HEMATURIA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1087, 1973. Dermal Toxicity: subcutaneous-mouse LD50 18000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. skin-rabbit LD > 1000 mg/kg Union Carbide Data Sheet. Vol. 9/25/1969 skin-rabbit LD50 > 20 mL/kg International Journal of Toxicology. Vol. 18(Suppl skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-1112 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-2202 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-96 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-2203 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-937 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-939 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-935 skin-rabbit LD50 > 20000 mg/kg Dow Chemical Company Reports. Vol. MSD-940 subcutaneous-rat LD50 16000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953. Inhalation Toxicity: Not determined   Safety in Use Information: Category: binding, emulsion stabilising agents Recommendation for peg-450 usage levels up to:   not for fragrance use.   Recommendation for peg-450 flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search NIOSH International Chemical Safety Cards:search Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA GENetic TOXicology:Search EPA Substance Registry Services (TSCA):25322-68-3 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry National Institute of Allergy and Infectious Diseases:Data WGK Germany:1 Chemidplus:0025322683 EPA/NOAA CAMEO:hazardous materials   References: Canada Domestic Sub. List: 25322-68-3 Pubchem (sid): 134996364   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements HMDB (The Human Metabolome Database): Search MedlinePlusSupp: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms:   poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- (450 mol EO average molar ratio)   polyethylene glycol (450)   polyoxyethylene (450)   Articles:   None found yet. Try the PubMed Search.

Notes: a tasteless laxative composed of peg3350; miralax is tradename. polymers of ethylene oxide and water and their ethers. they vary in consistency from liquid to solid, depending on the molecular weight, indicated by a number following the name. they are used as surfactants, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. some specific groups are lauromagrogols, nonoxynols, octoxynols and poloxamers.

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