EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hydroxypropyl methylcellulose phthalate
cellulose phthalate hydroxypropyl methyl ether

Supplier Sponsors

CAS Number: 9050-31-1
Other(deleted CASRN):168395-88-8
FDA UNII: G4U024CQK6
MDL:MFCD00147216
Category:oral care agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: oral care agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
(Hydroxypropyl)methyl cellulose phthalate
Sigma-Aldrich
For experimental / research use only.
Hypromellose phthalate
European Pharmacopoeia (EP) Reference Standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD > 15000 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1017, 1970.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
oral care agents
Recommendation for hydroxypropyl methylcellulose phthalate usage levels up to:
 not for fragrance use.
 
Recommendation for hydroxypropyl methylcellulose phthalate flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9050-31-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0009050311
 
References:
Pubchem (sid):135029952
 
Other Information:
HMDB (The Human Metabolome Database):Search
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 cellulose phthalate hydroxypropyl methyl ether
 HP 55
 HP 55 F
 hydroxypropyl methyl cellulose phthalate
2-hydroxypropyl methyl cellulose phthalate
 hydroxypropylmethylcellulose phthalate
 

Articles:

PubMed:Enteric-coated capsule containing β-galactosidase-loaded polylactic acid nanocapsules: enzyme stability and milk lactose hydrolysis under simulated gastrointestinal conditions.
PubMed:pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation.
PubMed:Instantaneous enteric nano-encapsulation of omeprazole: pharmaceutical and pharmacological evaluation.
PubMed:Stability and viscoelasticity of magneto-Pickering foams.
PubMed:Preparation, characterization, and evaluation in vivo of Ins-SiO₂-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin.
PubMed:Highly efficient miniaturized coprecipitation screening (MiCoS) for amorphous solid dispersion formulation development.
PubMed:A novel once daily microparticulate dosage form comprising lansoprazole to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease: preparation, pharmacokinetic and pharmacodynamic evaluation.
PubMed:A practical method to predict physical stability of amorphous solid dispersions.
PubMed:Solvent mediated microstructures and release behavior of insulin from pH-sensitive nanoparticles.
PubMed:HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
PubMed:Development of enteric submicron particle formulation of papain for oral delivery.
PubMed:Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus.
PubMed:Development of enteric submicron particles formulation of α-amylase for oral delivery.
PubMed:Magnetically responsive pickering foams.
PubMed:Preparation and characterization of tablet formulation based on solid dispersion of glimepiride and poly(ester amide) hyperbranched polymer.
PubMed:Comparison of HPMC based polymers performance as carriers for manufacture of solid dispersions using the melt extruder.
PubMed:Enteric microsphere formulations of papain for oral delivery.
PubMed:Differences in crystallization rate of nitrendipine enantiomers in amorphous solid dispersions with HPMC and HPMCP.
PubMed:Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery.
PubMed:Adsorption and desorption of Sr(II) ions in the gels based on polysaccharide derivates.
PubMed:Quality by design: optimization of a liquid filled pH-responsive macroparticles using Draper-Lin composite design.
PubMed:Development of tablets containing probiotics: Effects of formulation and processing parameters on bacterial viability.
PubMed:Development and in vitro evaluation of pantoprazole-loaded microspheres.
PubMed:Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies.
PubMed:Preparation of rapidly disintegrating tablets containing itraconazole solid dispersions.
PubMed:Influence of water soluble additives and HPMCP on drug release from Surelease-coated pellets containing tamsulosin hydrochloride.
PubMed:Mechanistic investigations of phase behavior in Eudragit E blends.
PubMed:Statistical optimization of tamsulosin hydrochloride controlled release pellets coated with the blend of HPMCP and HPMC.
PubMed:Development and optimization of a novel oral controlled delivery system for tamsulosin hydrochloride using response surface methodology.
PubMed:Optimization of tamsulosin hydrochloride controlled release pellets coated with Surelease and neutralized HPMCP.
PubMed:Designing a self-associated cationic polymer for enhanced compatibility, palatability, and gastric release of cefuroxime axetil.
PubMed:Blends of reverse enteric polymer with Enteric and pH-independent polymers: mechanistic investigations for tailoring drug release.
PubMed:Solid dispersions of itraconazole and enteric polymers made by ultra-rapid freezing.
PubMed:Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique.
PubMed:Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery.
PubMed:Colonic drug delivery: influence of cross-linking agent on pectin beads properties and role of the shell capsule type.
PubMed:A new solution for a chronic problem; aqueous enteric coating.
PubMed:Pharmacokinetics of two novel bicalutamide formulations in healthy male volunteers.
PubMed:Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder.
PubMed:Preparation of enteric microsphere of oleanolic acid dihemiphthalate sodium by salting-out action using spherical crystallization technique.
PubMed:[Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method].
PubMed:Preparation and evaluation of pH-dependent gradient-release pellets for TCM.
PubMed:A novel pH-dependent gradient-release delivery system for nitrendipine II. Investigations of the factors affecting the release behaviors of the system.
PubMed:[Relative bioavailability of cyclosporine A-loaded hydroxypropyl methylcellulose phthalate nanoparticles for oral administration in rats].
PubMed:A novel pH-dependent gradient-release delivery system for nitrendipine: I. Manufacturing, evaluation in vitro and bioavailability in healthy dogs.
PubMed:Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
PubMed:[Influence of suspending agents on relative bioavailability of cyclosporine A-loaded HPMCP nanoparticles for oral administration to rats].
PubMed:Gastrointestinal absorption enhancement of insulin by administration of enteric microspheres and SNAC to rats.
PubMed:Molecular weight determination of hypromellose phthalate (HPMCP) using size exclusion chromatography with a multi-angle laser light scattering detector.
PubMed:Swelling and drug release behavior of tablets coated with aqueous hydroxypropyl methylcellulose phthalate (HPMCP) nanoparticles.
PubMed:Physical stability and enthalpy relaxation of drug-hydroxypropyl methylcellulose phthalate solvent change co-precipitates.
PubMed:Factors affecting incorporation of drug into solid solution with HPMCP during solvent change co-precipitation.
PubMed:Solvent change co-precipitation with hydroxypropyl methylcellulose phthalate to improve dissolution characteristics of a poorly water-soluble drug.
PubMed:The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder.
PubMed:Retention and transit of intestinal mucoadhesive films in rat small intestine.
PubMed:Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping method.
PubMed:Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method.
PubMed:Design, optimization and evaluation of domperidone coevaporates.
PubMed:[Evaluation of film forming properties of a hydroxypropylmethylcellulose phthalate (HP 55) pseudolatex].
PubMed:Design of a "microbicide" for prevention of sexually transmitted diseases using "inactive" pharmaceutical excipients.
PubMed:Influence of aqueous coatings on the stability of enteric coated pellets and tablets.
PubMed:Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique.
PubMed:Characterization of impurities formed by interaction of duloxetine HCl with enteric polymers hydroxypropyl methylcellulose acetate succinate and hydroxypropyl methylcellulose phthalate.
PubMed:Passage of chicken egg yolk antibody treated with hydroxypropyl methylcellulose phthalate in the gastrointestinal tract of calves.
PubMed:The bioavailability of oral dosage forms of a new HIV-1 protease inhibitor, KNI-272, in beagle dogs.
PubMed:Oral absorption improvement of poorly soluble drug using solid dispersion technique.
PubMed:Preparation, characterization and in vitro drug release of poly-epsilon-caprolactone and hydroxypropyl methylcellulose phthalate ketoprofen loaded microspheres.
PubMed:Improved oral absorption of enteric coprecipitates of a poorly soluble drug.
PubMed:Influence of physical aging on mechanical properties of polymer free films: the prediction of long-term aging effects on the water permeability and dissolution rate of polymer film-coated tablets.
PubMed:A polymer carrier system for taste masking of macrolide antibiotics.
PubMed:Comparison of enteric-coated capsules and liquid formulation of Ty21a typhoid vaccine in randomised controlled field trial.
PubMed:The effect of physical aging on the dissolution rate of anionic polyelectrolytes.
PubMed:Influence of relative humidity on the adhesive properties of a model interactive system.
PubMed:[Effect of film formers and plasticizers on the stability of resistance and disintegration behavior. 4. Pharmaceutical-technological and analytical studies of gastric juice-resistant commercial preparations].
PubMed:[Fabrication and coating of microgranules of acetylsalicylic acid: use of HP55].
PubMed:[Analysis of traces of organic solvents in microgranules of acetylsalicylic acid coated with HP55].
PubMed:Sustained release of nifedipine from granules.
PubMed:Radiotelemetric method for evaluating enteric coatings in vivo.
PubMed:Dosage form design for improvement of bioavailability of levodopa VI: formulation of effervescent enteric-coated tablets.
 
Notes:
used to coat microgranules.
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