EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

platycodin D

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CAS Number: 58479-68-8Picture of molecule3D/inchi
FDA UNII: CWJ06TA2GI
XlogP3-AA:-3.70 (est)
Molecular Weight:1225.33784000
Formula:C57 H92 O28
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.690 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Platycodin D 98%
BOC Sciences
For experimental / research use only.
Platycodin D >98%
Odor: characteristic
Use: Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases. Platycodin D and D3 increased mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization Hypolipidemic
Coompo
For experimental / research use only.
Platycodin D from Plants ≥98%
Odor: characteristic
Use: Platycodin D suppressed prostaglandin E2 production at 10 and 30 µM in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA). Western blot analysis revealed that the induction of COX-2 protein by TPA was inhibited by platycodin D in parallel with the inhibition of prostaglandin E2 production. Platycodin D showed no direct effect on COX-1 and COX-2 activities. TPA-induced release of [3H]arachidonic acid from pre-labeled macrophages was also not inhibited by platycodin D. Platycodin D may stimulate TNF-a synthesis or inhibit degradation of TNF-a mRNA. Platycodin D and D3 increased mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization. The effect of platycodin D3 was stronger than that of ATP, a potent mucin secretagogue and also of ambroxole, a mucolytic drug. The results from the present study suggest that platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for platycodin D usage levels up to:
 not for fragrance use.
 
Recommendation for platycodin D flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
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EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :162859
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0058479688
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):162859
Pubchem (sid):135117090
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 platycodon grandiflorum root
Search Trop Picture
 
Synonyms:
 platycodin D
 

Articles:

PubMed:Platycodon grandiflorus - An Ethnopharmacological, phytochemical and pharmacological review.
PubMed:Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity.
PubMed:The inhibition of Platycodin D on Mycoplasma pneumoniae proliferation and its effect on promoting cell growth after anti-Mycoplasma pneumoniae treatment.
PubMed:Solubilization of menthol by platycodin D in aqueous solution: an integrated study of classical experiments and dissipative particle dynamics simulation.
PubMed:Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells.
PubMed:Platycodin D Attenuates Airway Inflammation in a Mouse Model of Allergic Asthma by Regulation NF-κB Pathway.
PubMed:Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action.
PubMed:Effects of platycodin D on proliferation, apoptosis and PI3K/Akt signal pathway of human glioma U251 cells.
PubMed:In vivo and in vitro antitumor effects of platycodin d, a saponin purified from platycodi radix on the h520 lung cancer cell.
PubMed:Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo.
PubMed:Platycodin D inhibits tumor growth by antiangiogenic activity via blocking VEGFR2-mediated signaling pathway.
PubMed:Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits.
PubMed:Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells.
PubMed:Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1.
PubMed:Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells.
PubMed:An HPLC-MS/MS method for the quantitative determination of platycodin D in rat plasma and its application to the pharmacokinetics of Platycodi Radix extract.
PubMed:Determination of platycodin D and platycodin D3 in rat plasma using liquid chromatography-tandem mass spectrometry.
PubMed:Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
PubMed:The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis.
PubMed:Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication.
PubMed:Glycosylated platycosides: identification by enzymatic hydrolysis and structural determination by LC-MS/MS.
PubMed:Evaluation of the spermicidal and contraceptive activity of Platycodin D, a Saponin from Platycodon grandiflorum.
PubMed:Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro.
PubMed:Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway.
PubMed:Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways.
PubMed:Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines.
PubMed:Antiproliferative and apoptotic activities of triterpenoid saponins from the roots of Platycodon grandiflorum and their structure-activity relationships.
PubMed:Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.
PubMed:[Mechanism of platycodin D-induced apoptosis in A549 human lung cancer cells].
PubMed:Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice.
PubMed:Protective effect of the aqueous extract from the root of Platycodon grandiflorum on cholestasis-induced hepatic injury in mice.
PubMed:Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells.
PubMed:Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice.
PubMed:Anti-atherosclerotic activity of platycodin D derived from roots of Platycodon grandiflorum in human endothelial cells.
PubMed:Platycodin D induces reactive oxygen species-mediated apoptosis signal-regulating kinase 1 activation and endoplasmic reticulum stress response in human breast cancer cells.
PubMed:Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice.
PubMed:Response surface methodology to optimize enzymatic preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi.
PubMed:Platycodon grandiflorum modifies adipokines and the glucose uptake in high-fat diet in mice and L6 muscle cells.
PubMed:[Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines].
PubMed:Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells.
PubMed:Quantitative analysis and simulation of anti-inflammatory effects from the active components of Paino Powder () in rats.
PubMed:Single oral dose toxicity test of platycodin d, a saponin from platycodin radix in mice.
PubMed:A sensitive method for determination of platycodin d in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
PubMed:[Study on industrialization production technology of decoction pieces shuangfei of Platycodon grandiflorum].
PubMed:Depigmenting action of platycodin D depends on the cAMP/Rho-dependent signalling pathway.
PubMed:Pharmacokinetic pilot study of the antiangiogenic activity of standardized platycodi radix.
PubMed:Structure-function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity.
PubMed:WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum.
PubMed:[Mechanism for sperm immobilization activity of extract from Platycodon grandiflorum in vitro].
PubMed:Platycoside N: a new oleanane-type triterpenoid saponin from the roots of Platycodon grandiflorum.
PubMed:Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.
PubMed:Enzymatic transformation of platycosides and one-step separation of platycodin D by high-speed countercurrent chromatography.
PubMed:Platycodin D induces apoptosis in MCF-7 human breast cancer cells.
PubMed:Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice.
PubMed:Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice.
PubMed:Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating Kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma.
PubMed:Platycodin D and 2''-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus.
PubMed:[Dynamic research of density on Platycodon grandiflorum dry material accumulation and platycodin D content in Platycodon grandiflorum].
PubMed:Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen.
PubMed:Platyconic acid A, a genuine triterpenoid saponin from the roots of Platycodon grandiflorum.
PubMed:Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition.
PubMed:Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells.
PubMed:Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea.
PubMed:Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses.
PubMed:Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum.
PubMed:Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells.
PubMed:Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells.
PubMed:Enzymatic modification of saponins from Platycodon grandiflorum with Aspergillus niger.
PubMed:[Advances in studies on Platycodon grandiflorum].
PubMed:[Chemical constituents from roots of Platycodon grandiflorum].
PubMed:Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes.
PubMed:Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice.
PubMed:Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines.
PubMed:In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase.
PubMed:Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells.
PubMed:Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay.
PubMed:Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay.
PubMed:Antinociceptive profiles of platycodin D in the mouse.
PubMed:Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells.
PubMed:[Evaluations of saponin properties of HPLC analysis of Platycodon grandiflorum A.DC].
PubMed:Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse.
PubMed:Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice.
PubMed:Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters.
PubMed:Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.
PubMed:Requirement of the glycosyl parts in platycodin D to stimulate pancreatic exocrine secretion.
PubMed:Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats.
PubMed:Enhancement and suppression in production of IgM-antibody in mice treated with purified saponins.
PubMed:Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D.
 
Notes:
triterpenoid saponin from a root of platycodon grandiflorum.
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