deoxynivalenol
vomitoxin

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  CODE168086 CODE168086
  Product(s):
  51481-10-8 Deoxynivalenol ≥98.0%
  Vomitoxin is a type B trichothecene, an epoxy-sesquiterpenoid. This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects. It inhibits protein biosynthesis, binds to peptidyl transferase, Potent protein synthesis inhibitor; Exhibits cytotoxic activity in vivo via the ribotoxic stress response;

CAS Number: 51481-10-8 3D/inchi Other(deleted CASRN): 115825-61-1 FDA UNII: JT37HYP23V MDL: MFCD09039270 XlogP3-AA: -0.70 (est) Molecular Weight: 296.31960000 Formula: C15 H20 O6 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:toxic natural substances   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 152.00 °C. @ 760.00 mm Hg Boiling Point: 543.88 °C. @ 760.00 mm Hg (est) Vapor Pressure: 6.800000 mmHg (est) Flash Point: 404.00 °F. TCC ( 206.90 °C. ) (est) logP (o/w): -1.250 (est) Soluble in:   water, 5.175e+004 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Deoxynivalenol ≥98.0% Odor: characteristic Use: Vomitoxin is a type B trichothecene, an epoxy-sesquiterpenoid. This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects. It inhibits protein biosynthesis, binds to peptidyl transferase, Potent protein synthesis inhibitor; Exhibits cytotoxic activity in vivo via the ribotoxic stress response; Santa Cruz Biotechnology For experimental / research use only. Deoxynivalenol ≥98% Sigma-Aldrich: Sigma For experimental / research use only. Deoxynivalenol sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-chicken LD50 140 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Poultry Science. Vol. 60, Pg. 1412, 1981. intraperitoneal-mouse LD50 43 mg/kg Toxicon. Vol. 24, Pg. 985, 1986. oral-mouse LD50 46 mg/kg GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Fundamental and Applied Toxicology. Vol. 4, Pg. S124, 1984. Dermal Toxicity: subcutaneous-dog LD50 27 mg/kg Veterinary and Human Toxicology. Vol. 25, Pg. 335, 1983. subcutaneous-mouse LD50 45 mg/kg Toxicon. Vol. 24, Pg. 985, 1986. Inhalation Toxicity: Not determined   Safety in Use Information: Category: toxic natural substances Recommendation for deoxynivalenol usage levels up to:   not for fragrance use.   Recommendation for deoxynivalenol flavor usage levels up to:   not for flavor use.   Safety References: European Food Safety Authority (EFSA) reference(s): Deoxynivalenol in food and feed: occurrence and exposure View page or View pdf Statement on the risks for public health related to a possible increase of the maximum level of deoxynivalenol for certain semi-processed cereal products View page or View pdf Evaluation of the increase of risk for public health related to a possible temporary derogation from the maximum level of deoxynivalenol, zearalenone and fumonisins for maize and maize products View page or View pdf The in vivo genotoxicity studies on nivalenol and deoxynivalenol View page or View pdf Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed View page or View pdf EPI System: View Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search Carcinogenic Potency Database:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :442408 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 Chemidplus:0051481108 RTECS:YD0167000 for cas# 51481-10-8   References: NIST Chemistry WebBook: Search Inchi Pubchem (cid): 442408 Pubchem (sid): 135002057   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View KEGG (GenomeNet): C09747 HMDB (The Human Metabolome Database): HMDB36156 FooDB: FDB015009 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   found in nature   Synonyms:   vomitoxin   Articles:   None found yet. Try the PubMed Search.

Notes: Prod. by Fusarium graminearum and Fusarium roseum, responsible for headblight in cereals Vomitoxin, also known as deoxynivalenol (DON), is a type B trichothecene, an epoxy-sesquiterpeneoid. This mycotoxin occurs predominantly in grains such as wheat, barley, oats, rye, and maize, and less often in rice, sorghum, and triticale. The occurrence of deoxynivalenol is associated primarily with Fusarium graminearum (Gibberella zeae) and F. culmorum, both of which are important plant pathogens which cause Fusarium head blight in wheat and Gibberella ear rot in maize. A direct relationship between the incidence of Fusarium head blight and contamination of wheat with deoxynivalenol has been established. The incidence of Fusarium head blight is strongly associated with moisture at the time of flowering (anthesis), and the timing of rainfall, rather than the amount, is the most critical factor. Furthermore, deoxynivalenol contents are significantly affected by the susceptibility of cultivars towards Fusarium species, previous crop, tillage practices, and fungicide use