EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

protamine sulfate
vasorelax

Supplier Sponsors

CAS Number: 9009-65-8
FDA UNII: 0DE9724IHC
MDL:MFCD00132091
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Protamines, sulfates 95%
Maypro Industries
Protamine Sulfate
Sigma-Aldrich: Sigma
For experimental / research use only.
Protamine Sulfate, meets USP testing specifications
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-guinea pig LD50 120 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

intravenous-guinea pig LD50 120 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

intravenous-man LDLo 2174 ug/kg/25M
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 211, 1988.

intraperitoneal-mouse LD50 94 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

intravenous-mouse LD50 38 mg/kg
Russian Pharmacology and Toxicology Vol. 38, Pg. 73, 1975.

intraperitoneal-rat LD50 120 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

intravenous-rat LD50 75 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 374, 1967.

Dermal Toxicity:
subcutaneous-guinea pig LD50 200 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

subcutaneous-mouse LD50 200 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

subcutaneous-rabbit LD50 200 mg/kg
Drugs in Japan Vol. 6, Pg. 726, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for protamine sulfate usage levels up to:
 not for fragrance use.
 
Recommendation for protamine sulfate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9009-65-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0009009658
RTECS:VO9470000 for cas# 9009-65-8
 
References:
Pubchem (sid):135354089
 
Other Information:
HMDB (The Human Metabolome Database):Search
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 protamine sulphate
 vasorelax
 

Articles:

PubMed:Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon.
PubMed:Identification of site-specific heterogeneity in peptide drugs using intact mass spectrometry with electron transfer dissociation.
PubMed:Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use.
PubMed:A 1-year drug utilization evaluation of protamine in hospitalized patients to identify possible future roles of heparin and low molecular weight heparin reversal agents.
PubMed:Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase.
PubMed:Application of quality by design elements for the development and optimization of an analytical method for protamine sulfate.
PubMed:Purification and characterisation of proteases A and D from Debaryomyces hansenii.
PubMed:Protease B from Debaryomyces hansenii: purification and biochemical properties.
PubMed:Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI.
PubMed:Methods for determination of milt protein and epsilon-polylysine in food additive preparations and processed foods by capillary zone electrophoresis.
PubMed:Fatal anaphylactoid shock associated with protamine for heparin reversal during anesthesia.
PubMed:Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition.
PubMed:A nationwide investigation of a possible protamine drug-product defect.
PubMed:Lack of cross-reactivity between IgE to salmon and protamine sulfate.
PubMed:Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: implications for human gene therapy.
PubMed:Lipoprotein lipase is produced, regulated, and functional in rat brain.
PubMed:Partial Purification and Some Properties of Tyrosine Phenol-Lyase from Aeromonas phenologenes ATCC 29063.
PubMed:Letter: Protamine sulfate and fish allergy.
PubMed:Death of Staphylococcus aureus in liquid whole egg near pH 8.
 
Notes:
a group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. protamines contain very few kinds of amino acids. protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (from merck index, 11th ed; martindale, the extra pharmacopoeia, 30th ed, p692)
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