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Category:antioxidants, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 836.62 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 567.00 °F. TCC ( 297.20 °C. ) (est)
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| logP (o/w): | 1.431 (est) |
| Soluble in: |
| | water, 907 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants, skin conditioning |
| Recommendation for baicalin usage levels up to: | | | not for fragrance use.
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| Recommendation for baicalin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 64982 |
| Pubchem (sid): | 135022168 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | baicalein-7-D-glucuronide | | 4H-1- | benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-phenyl- | | 5,6- | dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid | | (2S,3S,4S,5R,6S)-6-((5,6- | dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid | | (2S,3S,4S,5R,6S)-6-(5,6- | dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | | 5,6,7- | trihydroxyflavone 7-O-b-D-glucuronide | | 5,6,7- | trihydroxyflavone-7-O-b-D-glucopyranosideuronic acid |
Articles:
| PubMed:Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats. |
| PubMed:[Effect of different developmental stage on plant growth and active compounds in Scutellaria baicalensis]. |
| PubMed:Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia. |
| PubMed:Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization. |
| PubMed:Baicalin Inhibits the Lethality of Shiga-Like Toxin 2 in Mice. |
| PubMed:The effect of baicalin in a mouse model of retinopathy of prematurity. |
| PubMed:Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation. |
| PubMed:Purification and antioxidant activities of baicalin isolated from the root of huangqin (Scutellaria baicalensis gcorsi). |
| PubMed:Inhibitory effect of baicalin and baicalein on ovarian cancer cells. |
| PubMed:The role of intestinal microflora in anti-inflammatory effect of baicalin in mice. |
| PubMed:Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin. |
| PubMed:Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. |
| PubMed:Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles. |
| PubMed:Variation of pathways and network profiles reveals the differential pharmacological mechanisms of each effective component to treat middle cerebral artery ischemia-reperfusion mice. |
| PubMed:Spectroscopic investigation on the food components-drug interaction: the influence of flavonoids on the affinity of nifedipine to human serum albumin. |
| PubMed:Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats. |
| PubMed:Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats. |
| PubMed:Baicalin in radical scavenging and its synergistic effect with beta-carotene in antilipoxidation. |
| PubMed:A Scutellaria baicalensis radix water extract inhibits morphine-induced conditioned place preference. |
| PubMed:Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts. |
| PubMed:Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats. |
| PubMed:Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. |
| PubMed:Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. |
| PubMed:Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. |
| PubMed:Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress. |
| PubMed:Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. |
| PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. |
| PubMed:Identification of a nitric oxide generation-stimulative principle in Scutellariae radix. |
| PubMed:Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke. |
| PubMed:Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury. |
| PubMed:Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis. |
| PubMed:HPLC and chemometrics for the quality consistency evaluation of Shuanghuanglian injection. |
| PubMed:Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley rats. |
| PubMed:Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells. |
| PubMed:Wnt signaling in liver fibrosis: progress, challenges and potential directions. |
| PubMed:Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. |
| PubMed:Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. |
| PubMed:Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods. |
| PubMed:90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. |
| PubMed:Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. |
| PubMed:Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. |
| PubMed:Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay. |
| PubMed:Rapid in vivo screening system for anti-oxidant activity using bacterial redox sensor strains. |
| PubMed:An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. |
| PubMed:[Intestinal absorption and secretion mechanism of carboxylate drugs]. |
| PubMed:Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. |
| PubMed:Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products. |
| PubMed:Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats. |
| PubMed:Effect of Sho-saiko-to extract on HGF and TGF-beta levels of intraorgans in liver-injured rats after partial hepatectomy. |
| PubMed:Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes. |
| PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. |
| PubMed:A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. |
| PubMed:Glycosylation of dietary flavonoids decreases the affinities for plasma protein. |
| PubMed:Development of the chromatographic fingerprint of herbal preparations Shuang-Huang-Lian oral liquid. |
| PubMed:Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. |
| PubMed:Ultrasound-assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang. |
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3D/inchi