EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

protodioscin
furost-5-ene-3,22,26-triol 3-chacotrioside-26-glucopyranoside

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CAS Number: 55056-80-9Picture of molecule3D/inchi
Other(deleted CASRN):221527-54-4
FDA UNII: D0LC3PH24P
Nikkaji Web:J445.547I
XlogP3-AA:-1.30 (est)
Molecular Weight:1049.21288000
Formula:C51 H84 O22
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 0.232 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Protodioscin 98%
BOC Sciences
For experimental / research use only.
Protodioscin
Carbosynth
For experimental / research use only.
Protodioscin
Changsha Organic Herb
Tribulus Terrestris Extract Protodioscin
Coompo
For experimental / research use only.
Protodioscin from Plants ≥98%
Odor: characteristic
Use: Protodioscin has been demonstrated to trigger release of nitric oxide in corpus cavernosum tissue, and also to produce statistically significant increases in the levels of the hormones testosterone, dihydrotestosterone and dehydroepiandrosterone in animal studies.
Jiangyin Healthway
Protodioscin 98%
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
Protodioscin
Sigma-Aldrich: Sigma
For experimental / research use only.
Protodioscin from Dioscorea sinoparviflora, ≥98% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for protodioscin usage levels up to:
 not for fragrance use.
 
Recommendation for protodioscin flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :441891
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0090288441
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):441891
Pubchem (sid):135267363
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C08907
HMDB (The Human Metabolome Database):Search
FooDB:FDB012311
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 asparagus
Search Trop Picture
 beet
Search Trop Picture
 
Synonyms:
 furost-5-ene-3,22,26-triol 3-chacotrioside-26-glucopyranoside
 furostanol I
 

Articles:

PubMed:A Comparative Tissue-specific Metabolite Analysis and Determination of Protodioscin Content in Asparagus Species used in Traditional Chinese Medicine and Ayurveda by use of Laser Microdissection, UHPLC-QTOF/MS and LC-MS/MS.
J-Stage:Effects of Various Asparagus Production Methods on Rutin and Protodioscin Contents in Spears and Cladophylls
PubMed:Poisoning by Brachiaria brizantha in flocks of naïve and experienced sheep.
J-Stage:A New Spirostanol Glycoside from Fruits of Solanum indicum L.
PubMed:Performance of sheep grazing in pastures of Brachiaria decumbens, Brachiaria brizantha, Panicum maximum, and Andropogon gayanus with different protodioscin concentrations.
J-Stage:A New Steroidal Saponin from Dioscorea cayenensis
PubMed:Saponin profile of green asparagus genotypes.
J-Stage:Effects of Two Saponins Extracted from the Polygonatum Zanlanscianense Pamp on the Human Leukemia (HL-60) Cells
PubMed:Hepatic photosensitization in buffaloes intoxicated by Brachiaria decumbens in Minas Gerais state, Brazil.
PubMed:Optimization of a method for the profiling and quantification of saponins in different green asparagus genotypes.
PubMed:Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
PubMed:Potential nephrotoxic effects produced by steroidal saponins from hydro alcoholic extract of Tribulus terrestris in STZ-induced diabetic rats.
PubMed:Protodioscin-glycosidase-1 hydrolyzing 26-O-β-D-glucoside and 3-O-(1 → 4)-α-L-rhamnoside of steroidal saponins from Aspergillus oryzae.
PubMed:Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS.
PubMed:Development of an analytical method for yam saponins using HPLC with pulsed amperometric detection at different column temperatures.
PubMed:Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.
PubMed:Fenugreek with reduced bitterness prevents diet-induced metabolic disorders in rats.
PubMed:Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
PubMed:Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.
PubMed:Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears.
PubMed:Differential activity of multiple saponins against omnivorous insects with varying feeding preferences.
PubMed:[Determination by high performance chromatography, steroid saponins in a biologically active food supplements containing the extract of Tribulus terrestris].
PubMed:Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC-MS/MS.
PubMed:[Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].
PubMed:Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.
PubMed:The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.
PubMed:Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles.
PubMed:Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.
PubMed:Pharmacokinetics of methyl protodioscin in rats.
PubMed:[Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].
PubMed:A new spirostanol glycoside from fruits of Solanum indicum L.
PubMed:Steroidal saponins from Smilax excelsa rhizomes.
PubMed:[Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].
PubMed:New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.
PubMed:Pregnane glycosides and steroid saponins from Smilax bockii Warb. and their NGF-potentiating activity.
PubMed:The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat.
PubMed:Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.
PubMed:Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
PubMed:Distribution of steroidal saponins in Tribulus terrestris from different geographical regions.
PubMed:Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:[Study on steroidal saponins of Dioscorea septemloba thunb].
PubMed:Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.
PubMed:Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
PubMed:Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.
PubMed:Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
PubMed:[Study on chemical constituents in total saponin from Trigonella foenum-graecum].
PubMed:Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.
PubMed:A new steroidal saponin from Dioscorea cayenensis.
PubMed:Microbial metabolism of pseudoprotodioscin.
PubMed:Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.
PubMed:Steroidal saponins from Dioscorea panthaica and their cytotoxic activity.
PubMed:In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.
PubMed:Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).
PubMed:Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.
PubMed:Furostanol saponins from Tribulus terrestris.
PubMed:The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.
PubMed:Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.
PubMed:Total synthesis of methyl protodioscin: a potent agent with antitumor activity.
PubMed:Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.
PubMed:Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.
PubMed:Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.
PubMed:Two new sulfated furostanol saponins from Tribulus terrestris.
PubMed:Determination of steroidal saponins in Tribulus terrestris by reversed-phase high-performance liquid chromatography and evaporative light scattering detection.
PubMed:Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
PubMed:Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions.
PubMed:Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum.
PubMed:Steroidal saponins from Asparagus officinalis and their cytotoxic activity.
PubMed:Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
PubMed:Steroidal saponins from the rhizomes of Smilax menispermoidea.
PubMed:Experimental antitumor agents from Solanum indicum L.
PubMed:[beta-Glucosidases from fungus Geotrichum candidum].
 
Notes:
From Asparagus officinalis (asparagus) Protodioscin is a steroidal saponin compound found in a number of plant species, most notably in the Tribulus, Trigonella and Dioscorea families. It is best known as the putative active component of the herbal aphrodisiac plant Tribulus terrestris.
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