EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

buflomedil
2',4',6'-trimethoxy-4-(1-pyrrolidinyl)butyrophenone

Supplier Sponsors

CAS Number: 55837-25-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:259-851-3
FDA UNII: V7I71DQ432
Nikkaji Web:J11.045K
MDL:MFCD00242740
XlogP3-AA:2.30 (est)
Molecular Weight:307.39005000
Formula:C17 H25 N O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 454.48 °C. @ 760.00 mm Hg (est)
Flash Point: 444.00 °F. TCC ( 228.70 °C. ) (est)
logP (o/w): 3.131 (est)
Soluble in:
 water, 326.4 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Buflomedil > 95%
Odor: characteristic
Use: Buflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease.
George Uhe Company
Buflomedil
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for buflomedil usage levels up to:
 not for fragrance use.
 
Recommendation for buflomedil flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2467
National Institute of Allergy and Infectious Diseases:Data
4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
Chemidplus:0055837257
 
References:
 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):2467
Pubchem (sid):135047752
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D07176
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 buflomedilum
1-butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-
4-pyrrolidin-1-yl-1-(2,4,6-trimethoxy-phenyl)-butan-1-one
4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
4-pyrrolidin-1-yl-1-[2,4,6-tris(methyloxy)phenyl]butan-1-one
4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
4-pyrrolidinyl-1-(2,4,6-trimethoxyphenyl)butan-1-one
4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
2',4',6'-trimethoxy-4-(1-pyrrolidinyl)butyrophenone
(2,4,6-trimethoxyphenyl) (3-pyrrolidinopropyl) ketone
 

Articles:

PubMed:Comparative bio-safety and in vivo evaluation of native or modified locust bean gum-PVA IPN microspheres.
PubMed:Huoxue Rongluo Tablet reduces matrix metalloproteinase-9 expression in infarcted brain tissue.
PubMed:Combined study of biphasic and zero-order release formulations with dissolution tests and ATR-FTIR spectroscopic imaging.
PubMed:Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery.
PubMed:Application of a high performance liquid chromatography-tandem mass spectrometry method for determination of buflomedil in human plasma for a bioequivalence study.
PubMed:Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.
PubMed:Buflomedil for intermittent claudication.
PubMed:[Long-term functional outcomes of digital ischemia under tourniquet: observations in three cases].
PubMed:Vasoactive agent buflomedil up-regulated expression of vascular endothelial growth factor in a rat model of sciatic nerve crush injury.
PubMed:[Microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153].
PubMed:Safety profile assessment of buflomedil: an overview of adverse reactions between 1975 and 2011.
PubMed:Oral vasodilators for primary Raynaud's phenomenon.
PubMed:The value of population pharmacokinetics and simulation for postmarketing safety evaluation of dosing guidelines for drugs with a narrow therapeutic index: buflomedil as a case study.
PubMed:Safety of subcutaneous microinjections (mesotherapy) in musicians.
PubMed:Buflomedil: still too many fatal cardiac and neurological events.
PubMed:Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes.
PubMed:Effects of buflomedil on skin blood flow in patients with type 2 diabetes mellitus without overt micro- or macroangiopathy.
PubMed:A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite.
PubMed:Influence of pharmacological treatment on blood flow and muscle perfusion in patients with obliterative atheromatosis assessed with isotopic methods. A pilot study.
PubMed:Quantification of the Vasoactive Agent Buflomedil HCl in Pharmaceutical Formulation and Human Serum by Stripping Voltammetry and Liquid Chromatography.
PubMed:[Addition of antithrombosis in situ in the case of digital replantation: preliminary prospective study of 13 cases].
PubMed:[Multicentric study of thrombosis prevention in upper-extremity microsurgery. Survey at the Fesum centers].
PubMed:Effects of buflomedil and pentoxifylline on hamster skin-flap microcirculation: prediction of flap viability using orthogonal polarization spectral imaging.
PubMed:Effectiveness of interventions of specific complaints of the arm, neck, or shoulder (CANS): musculoskeletal disorders of the hand.
PubMed:Silence of the limbs pharmacological symptomatic treatment of intermittent claudication.
PubMed:Pharmacologic therapy for intermittent claudication.
PubMed:Bias in benefit-risk appraisal in older products: the case of buflomedil for intermittent claudication.
PubMed:Cutaneous granulomatous reaction from mesotherapy.
PubMed:Buflomedil: potential new indications for an old agent.
PubMed:Buflomedil reduced cardiovascular events in peripheral arterial disease.
PubMed:Letter by De Backer et al regarding article, "Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study".
PubMed:Oral vasodilators for primary Raynaud's phenomenon.
PubMed:Effectiveness of mesotherapy on body contouring.
PubMed:Buflomedil in peripheral arterial disease: trials and tribulations.
PubMed:Buflomedil for intermittent claudication.
PubMed:Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study.
PubMed:The use of buflomedil in reduction mammaplasty for a previously irradiated breast: a case report.
PubMed:Long-term follow-up of hypothenar hammer syndrome: a series of 47 patients.
PubMed:Buflomedil for intermittent claudication.
PubMed:Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release.
PubMed:Sensitive and rapid LC-ESI-MS method for the determination of trimetazidine in human plasma.
PubMed:Detailed documentation of one lipolysis treatment: blood values, histology, and ultrasound findings.
PubMed:Buflomedil: still seizures and cardiac disorders. Too many patients are exposed to an unjustified risk of serious adverse effects.
PubMed:[Adenosine for treatment of ischemic pain in thromboangiitis obliterans. A case report].
PubMed:The effects of prostaglandin E-1 in patients with intermittent claudication.
PubMed:Buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with nicotine.
PubMed:Comparison between intravenous iloprost and vasoactive drugs in limb ischemia IIB severe. A retrospective analysis.
PubMed:Assemblage of novel release modules for the development of adaptable drug delivery systems.
PubMed:[Severe peripheral ischemia of rare origin].
PubMed:Facilitated column selection in pharmaceutical analyses using a simple column classification system.
PubMed:[Pharmaceutical analysis and validation of hospital prescriptions, a 5-year study].
PubMed:Protective effect of buflomedil in a rat model of moderate cerebral ischemia.
PubMed:Effect of loading on a swelling-controlled drug delivery system studied by optical techniques.
PubMed:Continuous peripheral nerve blocks at home for treatment of recurrent complex regional pain syndrome I in children.
PubMed:Does Danshen improve disability after acute ischaemic stroke?
PubMed:Inhibitory effect of buflomedil on prostate alpha1A adrenoceptor in the Wistar rat.
PubMed:[Pharmacokinetics and bioequivalence of eperisone hydrochloride tablet in healthy subjects].
PubMed:Suicide by buflomedil HCl: a case report.
PubMed:Drug treatment of intermittent claudication.
PubMed:[Secondary prevention and conservative therapy of obliterative arteriosclerosis].
PubMed:Rapid and sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the determination of eperisone in human plasma: method and clinical applications.
PubMed:[Suicidal buflomedil intoxication].
PubMed:Development of pulsatile release tablets with swelling and rupturable layers.
PubMed:Effects of PGE-1 in patients suffering from peripheral arterial occlusive disease.
PubMed:[Sudden hearing loss. Clinical case].
PubMed:[Clinical study of the effect of buflomedil on peripheral neuropathy in diabetic patients].
PubMed:Rapid HPLC measurement of buflomedil in plasma in poisoning cases.
PubMed:Rheological and biochemical examination of red blood cells after treatment with different pharmacological and toxic substances.
PubMed:Highlights of the 22nd French pharmacovigilance meeting.
PubMed:[Bullous pemphigoid induced by spironolactone].
PubMed:Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication.
PubMed:[Retrograde venous perfusion (RVP in ulcero-mutilating neuropathy].
PubMed:Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients.
PubMed:[Myoclonic coma and severe cardiac insufficiency in a patient with arteritis].
PubMed:Buflomedil for intermittent claudication.
PubMed:Heparin protects local skin microcirculation in 210 minutes-long intravital microscopy observations under general anaesthesia.
PubMed:Adenosine and chronic ischemia of the lower limbs.
PubMed:Buflomedil poisoning: a potentially life-threatening intoxication.
PubMed:Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate.
PubMed:[Morphometric analysis of erythrocyte aggregates in vitro: pharmacological application with buflomedil].
PubMed:Oral vasoactive medication in intermittent claudication: utile or futile?
PubMed:Warning! One buflomedil may hide another one!
PubMed:Assessment of collateral perfusion: a pharmacodynamic study with buflomedil hydrochloride.
PubMed:Tissular oxygenation and venoarteriolar reflex disturbances in diabetes mellitus: vasoregulator effect of Buflomedil.
PubMed:[Value of vasoactive drugs in conservative therapy of peripheral arterial occlusive disease].
PubMed:Acceleration of wound healing by topical drug delivery via liposomes.
PubMed:[Fatal poisoning caused by buflomedil].
PubMed:Nitrite plasma levels in normolipemic and hypercholesterolemic arteriopathics after vasoactive and lipid-lowering treatment.
PubMed:Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethyl cellulose matrices containing a soluble drug.
PubMed:Effects of prostaglandin E1 and buflomedil on left ventricular function in patients with severe chronic occlusive arterial disease: a prospective, randomized, double-blind trial.
PubMed:Anaphylactic reactions to buflomedil.
PubMed:[Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?].
PubMed:[Third degree atrio-ventricular block induced by interferon alpha. Report of a case].
PubMed:Buflomedil hydrochloride reduces systemic activation of polymorphonuclear leukocytes during hyperdynamic endotoxemia.
PubMed:Reduction of skin flap necrosis by transdermal application of buflomedil bound to liposomes.
PubMed:Multicriteria decision analysis for determining drug therapy for intermittent claudication.
PubMed:Buflomedil is a potent interfering substance in immunoassays of tricyclic antidepressants.
PubMed:[Intermittent claudication: review of a disease of growing prevalence. II. Treatment].
PubMed:A placebo-controlled study of the effects of intravenous Buflomedil on foot skin microcirculation in patients with severe intermittent claudication.
PubMed:Differential modulation of IL-8 and TNF-alpha expression in human keratinocytes by buflomedil chlorhydrate and pentoxifylline.
PubMed:Effects of a calcium antagonist and of the adrenergic system on spontaneous vasomotion and mean arteriolar diameter in the hamster cheek pouch: influence of buflomedil.
PubMed:State of the art--treatment of peripheral occlusive arterial disease (POAD) with drugs vs. vascular reconstruction or amputation.
PubMed:Buflomedil interference with the monoclonal EMIT d.a.u. amphetamine/methamphetamine immunoassay.
PubMed:Pharmacological preconditioning of ischaemia.
PubMed:Effect of buflomedil on the neutrophil-endothelial cell interaction under inflammatory and hypoxia conditions.
PubMed:Failure of buflomedil to improve wound healing in ischaemic skin flaps.
PubMed:Dialysis clearance of buflomedil in hemodialysed patients.
PubMed:Buflomedil poisoning: five cases with cardiotoxicity.
PubMed:Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases.
PubMed:Drug diffusion front movement is important in drug release control from swellable matrix tablets.
PubMed:[Severe intoxications by buflomedil. 2 cases].
PubMed:The treatment of severe or recurrent deep venous thrombosis. Beneficial effect of the co-administration of antiplatelet agents with or without rheological effects, and anticoagulants.
PubMed:[Disordered cutaneous microcirculation in diabetic neuropathic foot ulcer. Is modification by retrograde transvenous perfusion therapy possible?].
PubMed:[Physicochemical incompatibility of injectable drugs: practical considerations].
PubMed:Acute buflomedil intoxication: a critically life-threatening condition.
PubMed:[Treatment of chronic obliterative arteriopathy of the legs in the second Fontaine's stage. Personal experience with a buflomedil-pentoxifylline-defibrotide combination].
PubMed:A fatal case of buflomedil self-poisoning: toxicological data and literature review.
PubMed:The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study.
PubMed:[Severe acute buflomedil poisoning].
PubMed:A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication.
PubMed:Increase in plasma levels of adenosine and adenine nucleotides after intravenous infusion of buflomedil in humans.
PubMed:[Action of Buflomedil on the cutaneous microcirculation studies by a cold provocation test. Multicenter, double-blind, placebo controlled trial].
PubMed:[Effects of buflomedil and naftidrofuryl on the human cochlear microcirculation measured by laser-Doppler].
PubMed:The use of buflomedil in peripheral angiography.
PubMed:Visualization of nutritive perfusion following tourniquet ischemia in arterial pattern skin flaps: effect of vasoactive medication.
PubMed:Effects of buflomedil on spontaneous vasomotion and mean arteriolar internal diameter in the hamster cheek pouch.
PubMed:Buflomedil hydrochloride attenuates tourniquet-induced microvascular reperfusion injury in striated muscle.
PubMed:Comparative evaluation of pentoxifylline, buflomedil, and nifedipine in the treatment of intermittent claudication of the lower limbs.
PubMed:Disturbances of cutaneous microcirculation in patients with diabetic legs: additional parameters for a new therapeutic concept?
PubMed:Evaluation of two buflomedil tablet formulations in patients with atherosclerotic disease.
PubMed:[The effects of terazosin hydrochloride and buflomedil in patients with hemicrania without aura].
PubMed:[Effect of buflomedil perfusion on peripheral tissue oxygenation during transluminal angioplasty in patients with advanced arteriopathy of the lower limbs].
PubMed:Acute buflomedil intoxication: a life-threatening condition.
PubMed:[Can vasomotion be modified by vasoactive substances or hemodilution?].
PubMed:[Value of buflomedil in vascular radiology of hepatoma].
PubMed:Improvement of microcirculation abnormalities in sickle cell patients upon buflomedil treatment.
PubMed:Optimization of distal artery opacification in peripheral arteriography: comparison between nitroglycerin, tolazoline and buflomedyl.
PubMed:Effect of buflomedil on in vitro prostacyclin and endothelin synthesis by vascular (rat and human) and penile (rat) tissue and calcium uptake by isolated human platelets.
PubMed:Treatment of the Raynaud's phenomenon with piracetam.
PubMed:Buflomedil: one-year oral safety evaluation in rats.
PubMed:Impact of ischemia on tissue oxygenation and wound healing: intravital microscopic studies on the hairless mouse ear model.
PubMed:[Nuclear medicine studies of tissue concentration and hemodynamic effects of retrograde intravenous pressure infusions].
PubMed:[Systemic infusion therapy versus retrograde intravenous perfusion: comparative results in patients with diabetic neuropathic plantar ulcer].
PubMed:[Pioneer experience with buflomedil in the form of retrograde venous pulse therapy for treatment of ischemia and severe extremity infections].
PubMed:[Status epilepticus following voluntary poisoning with buflomedil].
PubMed:Walk training and drug treatment in patients with peripheral arterial occlusive disease stage II. A review.
PubMed:Vascular manifestations in homocystinuria.
PubMed:The effect of oral buflomedil on microalbuminuria in non-insulin-dependent diabetic patients.
PubMed:Pharmacokinetics of a sustained release formulation of pyridoxal phosphate of buflomedil after single or repeated oral doses in healthy volunteers.
PubMed:Pretreatment with buflomedil enhances ventricular function by reducing the dysfunctional area after transient coronary artery occlusion.
PubMed:Multicentre clinical placebo-controlled study with buflomedil in the treatment of mild dementia of vascular origin.
PubMed:[Use of vasoactive substances in prevention of skin necroses].
PubMed:[Poisoning by buflomedil (Fonzylane)].
PubMed:Buflomedil intoxication: the little-known risk.
PubMed:Effect of intensive walking exercise on skeletal muscle blood flow in intermittent claudication.
PubMed:Impact of ischemia on tissue oxygenation and wound healing: improvement by vasoactive medication.
PubMed:[Fatal suicide by buflomedil poisoning].
PubMed:Gas chromatographic-mass spectrometric analysis of buflomedil hydrochloride in biological samples after acute intoxication.
PubMed:Vasodilator and angioprotective activity of 1-ethyl-1-hydroxyalkyl-octahydroindolo[2,3a]quinolizine derivates.
PubMed:Double-blind placebo-controlled trial of buflomedil in the treatment of Raynaud's phenomenon: six-month follow-up.
PubMed:Increase in skin-flap survival by the vasoactive drug buflomedil.
PubMed:Effects of buflomedil on microvascular disorders in diabetic patients.
PubMed:Exercise-induced variations in muscle tissue oxygen pressure in claudicants: effects of buflomedil.
PubMed:Microvascular motricity and haemorheology effects of buflomedil. Symposium held during the International Congress on Angiology. Rome, September 21, 1989. Proceedings.
PubMed:Rheological activity of propionyl L-carnitine.
PubMed:Drug therapy of diabetic neuropathic foot ulcers: transvenous retrograde perfusion versus systemic regimen.
PubMed:[Possibilities and limits of physical training therapy of intermittent claudication patients with simultaneous drug therapy].
PubMed:[Retrograde venous perfusion in treatment of diabetic gangrene].
PubMed:Effect of buflomedil, dipyridamole and indobufene on hemorrheologic and blood coagulation parameters in patients who underwent vascular surgery for severe atherosclerosis.
PubMed:Reduction of postischemic reperfusion injury by the vasoactive drug buflomedil.
PubMed:Norepinephrine, phentolamine and buflomedil influence on arteriolar vasomotion in the hamster skinfold preparation.
PubMed:Hemorheological effects of buflomedil: action on shape and functions of the human neutrophils.
PubMed:[Action and tolerability of delayed-action buflomedil in obliterating arteriopathies of the lower limbs. A multicenter study].
PubMed:High-performance liquid chromatographic method for the measurement of buflomedil in plasma and serum.
PubMed:[Cerebral vasodilators].
PubMed:[Local application of buflomedil. Value in the treatment of subcutaneous tissue loss].
PubMed:A review of long-term safety data with buflomedil.
PubMed:Effects of torbafylline, pentoxifylline and buflomedil on vascularisation and fibre type of rat skeletal muscles subjected to limited blood supply.
PubMed:Effects of buflomedil and its two derivatives, CRL40634 and CRL40598, on pancreatic exocrine secretion in the rat.
PubMed:[Acral skin circulation following intra-arterial infusion of vasodilating substances in patients with intermittent claudication].
PubMed:Current therapy of peripheral obstructive arterial disease. The non-surgical approach.
PubMed:Quantitation and ultraviolet spectrum identification of buflomedil in whole blood and plasma by HPLC.
PubMed:Effect of CRL 41034 on the adrenergic neuroeffector interaction in the canine saphenous vein.
PubMed:In vitro studies of the effect of buflomedil on platelet responsiveness.
PubMed:[Local intravenous treatment of algodystrophy of the hand: buflomedil versus guanethidine, long term follow-up].
PubMed:[Bencyclane in stage II arterial occlusive disease. Results of a controlled study].
PubMed:[Multi-infarct dementia. Current knowledge concerning pathogenesis and therapy].
PubMed:[Whole blood filterability in chronic cerebrovascular disorders: effects of the use of buflomedil hydrochloride].
PubMed:[Acute and chronic cerebrovascular diseases. A therapeutic approach].
PubMed:Cardiovascular actions of buflomedil and possible mechanisms involved.
PubMed:Effect of buflomedil chlorhydrate on local oxygen delivery in peripheral vascular disease.
PubMed:Rapid, sensitive high-performance liquid chromatographic method for the analysis of buflomedil hydrochloride and its potential by-products.
PubMed:Pharmacokinetics of buflomedil after various dosage forms.
PubMed:An evaluation of the ability of the peripheral vasodilator buflomedil to improve vascular patency after acute frostbite.
PubMed:Effect of buflomedil (4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy phenyl)-1-butanone hydrochloride) on the function of striatal dopaminergic neurons.
PubMed:The influence of buflomedil on blood viscosity parameters in insulin-dependent diabetic patients: a preliminary study.
PubMed:Computer-assisted development of modified-release dosage forms.
PubMed:[A study using laser-Doppler velocimetry of modifications of the labyrinthine microcirculation induced by chemical and physical stimuli].
PubMed:Ticlopidine-pentoxifylline combination in the treatment of atherosclerosis and the prevention of cerebrovascular accidents.
PubMed:[Comparison of the effectiveness of intra-arterial and intravenous administration of buflomedil in patients with intermittent claudication].
PubMed:[Effects of buflomedil hydrochloride on the rheological properties of the blood in chronic cerebrovascular diseases].
PubMed:[Myoclonus during a course with buflomedil treatment].
PubMed:[Emetic and catalepsy-inducing actions of buflomedil].
PubMed:Effect of long-term administration of buflomedil on regional cerebral blood flow in chronic cerebral infarction.
PubMed:Effect of buflomedil on cell metabolism in ischemic muscle.
PubMed:[Acute severe coronary insufficiency during intravenous therapy with buflomedil hydrochloride. Description of 4 cases].
PubMed:[Acute fatal poisoning with buflomedil].
PubMed:[Decrease of blood viscosity induced by buflomedil in healthy volunteers].
PubMed:Effect of buflomedil [4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride] on neurotransmitters in the striatum and substantia nigra.
PubMed:Gas chromatographic evaluation of buflomedil in biological samples employing the thermoionic specific detector.
PubMed:[Effect of buflomedil on cerebral acetylcholine, neuroactive amino acids contents and energy metabolism: analysis using spontaneously hypertensive rat (SHR)].
PubMed:[Digital blood flow in peripheral vascular diseases. Action of drugs: buflomedil].
PubMed:[The use of buflomedil in the treatment of post-traumatic cerebral edema].
PubMed:[Effects of buflomedil on peripheral arteriopathies. An open clinical study].
PubMed:Effect of vasodilators on hepatic microcirculation: a study of the inhibition of norepinephrine-induced vasoconstriction in the isolated perfused rat liver.
PubMed:[Effects of buflomedil on ambulatory activity and discrete avoidance responses in mice].
PubMed:[Nutritive skin circulation in partial ischemia: effect of various vasoactive substances].
PubMed:[Diagnostic value of intra-arterial buflomedil, during arteriography of the limbs].
PubMed:Double-blind placebo-controlled trial of buflomedil in intermittent claudication.
PubMed:[Effects of buflomedil on survival rate, local cerebral blood flow and glucose utilization after cerebral ischemia in spontaneously hypertensive rats].
PubMed:[Scintigraphy with thallium-201 in the evaluation of vasoactive treatment in subjects with obliterative arteriopathies of the lower limbs].
PubMed:[Evaluation of pharmacologic treatment associated with motor-activation therapy in the prevention of senile impairment].
PubMed:Effect of buflomedil on epinephrine-enhanced platelet aggregation in vitro and ex vivo.
PubMed:The effect of buflomedil in diabetic retinopathy estimated by ocular fluorophotometry.
PubMed:Buflomedil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in peripheral and cerebral vascular diseases.
PubMed:[Changes in erythrocyte ATP after the oral administration of buflomedil hydrochloride].
PubMed:[Buflomedil and the speed of glycolysis. Note I].
PubMed:[Buflomedil chlorhydrate in the treatment of retinopathies].
PubMed:[Clinical picture and treatment of the Raynaud syndrome of the upper extremities].
PubMed:Vasoactive effects of buflomedil assessed by fluorescein angiography.
PubMed:The pharmacological effects of buflomedil in patients with multi-cerebral infarcts dementia: an open, preliminary assessment.
PubMed:[Recent drug therapy of senile dementia].
PubMed:[Buflomedil chlorhydrate in peripheral vasculopathies].
PubMed:[Study of carotid flow and cerebral circulatory impedance using Doppler computerized spectral analysis. Evaluation of the effect of buflomedil].
PubMed:[Vascular and hemorheologic effects of buflomedil chlorhydrate in chronic obliterative arteriopathies of the legs].
PubMed:[Multicenter study on the therapeutic activity of buflomedil chlorhydrate in obliterative arteriopathies of the legs].
PubMed:[Buflomedil: new findings on its mechanism of action].
PubMed:Buflomedil kinetics in patients with liver disease.
PubMed:[Clinical experience and instrumental evaluation of buflomedil hydrochloride in the therapy of chronic obliterative arteriopathies of the legs].
PubMed:[Treatment of circulatory insufficiency with buflomedil chlorhydrate in chronic hemodialysis patients].
PubMed:[Randomized clinical study of the efficacy of buflomedil in the prevention of recurrence of cerebral ischemia in comparison with anti-platelet aggregation agents].
PubMed:Cardiorespiratory and metabolic effects of buflomedil: case reports.
PubMed:[Protective effect of buflomedil hydrochloride on erythrocyte sickling. In vitro study].
PubMed:[Hemorheologic therapy applications in coronary heart disease].
PubMed:Effects of buflomedil hydrochloride in occlusive arterial disease of the lower limbs stage IV.
PubMed:The effect of buflomedilhydrochloride (Loftyl) on temporary hearing threshold shift.
PubMed:[Acute toxicity of (2,4,6-trimethoxy) phenyl-3 (pyrrolidinyl-1) propyl-ketone chlorhydrate (buflomedil) and of metacrylic copolymers (eudragit) both alone and in association in the mouse and rat].
PubMed:[Myoclonus during treatment with buflomedil].
PubMed:[Clinical evaluation of the activity of buflomedil in ischemic processes in the legs].
PubMed:[Doppler flowmeter evaluation of the effects of the administration of buflomedil (irrodan) on peripheral circulation in patients with obstructive chronic arteriopathy].
PubMed:[Epidemiologic study of peripheral obstructive arteriopathies: clinical effects of treatment with buflomedil chlorhydrate (Loftyl). Processing of data furnished by a polycenter study].
PubMed:[The combination of repeated anesthetic "bathing" of the cervico-thoracic system and buflomedil in analgesic therapy of in Raynaud's syndrome of the arm].
PubMed:[Platelet function after the single administration of buflomedil].
PubMed:[Treatment of chronic cerebrovascular insufficiency and chronic obliterating arteriopathy of the lower extremities with buflomedil hydrochloride].
PubMed:Effect of buflomedil on behaviour, memory, and intellectual capacity in patients with dementia. A placebo-controlled study.
PubMed:[Vasoactive drugs in peripheral arterial perfusion disorders. Problems, principles and results of the determination of therapeutic efficacy].
PubMed:[Stroke and post-ictal states].
PubMed:Microcirculation in the elderly.
PubMed:[Use of buflomedil chlorhydrate in vertiginous patients. Vertigo].
PubMed:[Buflomedil and nicergoline in the targeted treatment of acute cerebral ischemia. Randomized comparative double blind study].
PubMed:[Buflomedil in the treatment of chronic peripheral arterial diseases. Case contribution].
PubMed:[Flowmetric, thermometric and rheologic studies in obliterating arterial diseases of the lower extremities treated with buflomedil].
PubMed:[Reversible neurologic toxicity of buflomedil overdosage].
PubMed:[Effect of buflomedil on microcirculation of the skin in acral gangrene].
PubMed:Effects of buflomedil in a group of patients with chronic peripheral arterial diseases. Clinical and hemorheological evaluation.
PubMed:[Does conjunctival biomicroscopy enable one to assess the microcirculatory activity of buflomedil?].
PubMed:Microcirculatory changes in patients with primary Raynaud's phenomenon after treatment with buflomedil.
PubMed:The treatment of senile dementia associated with cerebrovascular insufficiency: a comparative study of buflomedil and dihydrogenated ergot alkaloids.
PubMed:In-vitro effects of buflomedil on parameters regulating hemostatic balance via the prostaglandin-system.
PubMed:Metabolic effects of buflomedil hydrochloride.
PubMed:Pharmacokinetics of buflomedil after intravenous administration in patients with chronic renal failure.
PubMed:Buflomedil in arterial occlusive disease: results of a controlled multicenter study.
PubMed:[Comparative study of various schedules of buflomedil treatment in peripheral arterial insufficiency of the lower limbs. Evaluation of its therapeutic efficacy].
PubMed:[Use of buflomedil in the treatment of obliterative arteriopathies of the lower extremities. Clinical and functional study].
PubMed:[Effectiveness of buflomedil in arterial occlusive disease. Modification of transcutaneous oxygen pressure in a placebo-controlled double-blind study].
PubMed:[Latent or evident microangiopathies in rheumatology: proposal of a pharmacologic test].
PubMed:[Acute affect of buflomedil hydrochloride (bufedil) on transcutaneously measured oxygen pressures in patients with peripheral arterial occlusive disease].
PubMed:Positive effect of oral buflomedil on exercise-induced haemorheological damage and on claudication distance in peripheral obliterative arterial disease patients.
PubMed:Oral buflomedil in diabetic background retinopathy: results of a preliminary controlled study.
PubMed:Our experience with the use of buflomedil chlorhydrate in a mixed population of vasculopathic patients.
PubMed:Buflomedil concentrations in blood and viscera in a case of fatal intoxication.
PubMed:Encephalotropic and psychotropic effects of intravenous buflomedil in the elderly: double-blind, placebo-controlled pharmaco-EEG and psychometric studies.
PubMed:Cardiovascular pharmacology of buflomedil.
PubMed:Effects of buflomedil on the responsiveness of canine vascular smooth muscle.
PubMed:Effects of buflomedil on isolated dog arteries.
PubMed:[Vasoactive drugs and microcirculation in old age].
PubMed:[Clinical pharmacokinetics of buflomedil].
PubMed:[Effects of the administration of buflomedil-hydrochloride on the arterial circulation of the legs in patients with obliterative arteriopathies].
PubMed:[Effect of buflomedil on the behavior of platelet aggregation and its clinical evaluation in elderly patients with chronic cerebrovascular insufficiency].
PubMed:[Monitoring therapy in the treatment of cerebrovascular insufficiency].
PubMed:[Myoclonic encephalopathy in a patient treated with an excessive dose of buflomedil].
PubMed:[Arterio-vascular diseases. New trends in diagnosis and therapy].
PubMed:[Myoclonic encephalopathy in a patient treated with an excessive dose of buflomedil].
PubMed:[Buflomedil in the patient with renal insufficiency].
PubMed:[Buflomedil in arterial occlusive disease. Results of a controlled study].
PubMed:[Microcirculation in the conjunctiva and the nail bed in the aged. Symptomatic and clinico-pharmacologic aspects].
PubMed:[Effect of the vasoactive drug buflomedil in arterial occlusive disease].
PubMed:[Comparative vasodilator action of 5 vasodilators: dihydroergotoxine, nicergoline, papaverine, naftidrofuryl and buflomedil on the femoral artery of the dog].
PubMed:Analysis of buflomedil in mouse, rat and rabbit plasma by reversed-phase ion-pair high-performance liquid chromatography.
PubMed:Buflomedil: three month intravenous safety evaluation in rats.
PubMed:Improvements in the rheologic properties of blood induced by medium-term treatment with buflomedil in diabetic patients.
PubMed:Protective effects of buflomedil against exercise-induced reductions in regional erythrocyte deformability of patients with peripheral arterial disease.
PubMed:Haemodynamic and haemorheological effects of buflomedil in patients with peripheral occlusive arterial disease.
PubMed:[Acute poisoning by buflomedil].
PubMed:[Improved microcirculation and collateral circulation in arterial occlusive diseases of the lower extremity].
PubMed:Double blind comparative study of cinnarizine and buflomedil in patients suffering from cerebrovascular insufficiency.
PubMed:Tissue pO2 and transcutaneous pO2 as guidelines in experimental and clinical drug evaluation.
PubMed:Experience with buflomedil in peripheral arterial occlusive disease.
PubMed:Double-blind capillaroscopic study of the activity of buflomedil in Raynaud's syndrome: a report on 80 cases.
PubMed:Evaluation of buflomedil in geriatric patients suffering from vascular cerebral insufficiency.
PubMed:Effects of buflomedil on erythrocyte deformability.
PubMed:Comparative evaluation of the effectiveness of buflomedil and pentoxifylline in patients with arterial occlusive disease.
PubMed:An experimental overview of a new vasoactive drug: buflomedil HCl.
PubMed:Comparison of safety and efficacy of buflomedil and naftidrofuryl in the treatment of intermittent claudication.
PubMed:[Use of buflomedil hydrochloride in ocular pathology].
PubMed:The clinical pharmacokinetics of buflomedil in normal subjects after intravenous and oral administration.
PubMed:Pharmacokinetics of buflomedil after intravenous and oral administration.
PubMed:[Treatment of frostbites. Analysis of results in twenty patients with buflomedil chlorhydrate (author's transl)].
PubMed:Determination of buflomedil hydrochloride [2',4',6'-trimethoxy-4-(pyrrolidinyl)butyrophenone hydrochloride] by reversed-phase ion-pair high-performance liquid chromatography.
PubMed:[Assay of buflomedil in biologic media. Determination of different pharmacokinetic parameters].
 
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