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Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 107.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 479.13 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 2.590000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 470.00 °F. TCC ( 243.60 °C. ) (est)
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| logP (o/w): | 2.900 |
| Soluble in: |
| | water, 140 mg/L @ 25 °C (exp) | | | water, 148 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 352 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 22, Pg. 263, 1997.
oral-quail LD50 150 mg/kg
Pesticide Manual. Vol. 9, Pg. 215, 1991.
oral-rat LD50 1020 mg/kg
Pesticide Manual. Vol. 9, Pg. 215, 1991.
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| Dermal Toxicity: |
skin-rat LD50 > 2000 mg/kg
Pesticide Manual. Vol. 9, Pg. 215, 1991.
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| Inhalation Toxicity: |
inhalation-rat LC50 > 5650 mg/m3/4H
Pesticide Manual. Vol. 9, Pg. 215, 1991.
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Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for cyproconazole usage levels up to: | | | not for fragrance use.
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| Recommendation for cyproconazole flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Reasoned opinion on the modification of the existing MRLs for cyproconazole in mustard seed and gold of pleasure
View page or View pdf
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Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment of confirmatory data for the active substance cyproconazole
View page or View pdf
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Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
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Modification of the existing maximum residue levels for cyproconazole in pulses, barley and oat
View page or View pdf
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Review of the existing maximum residue levels for cyproconazole according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :86132 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-(4-chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazol-1-yl)butan-2-ol |
| Chemidplus:0094361065 |
References:
| | 2-(4-chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazol-1-yl)butan-2-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 86132 |
| Pubchem (sid): | 135143299 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C18456 |
| HMDB (The Human Metabolome Database): | Search |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•cyproconazole 360 sl contains two decay preventing fungicides, cyproconazole and didecyldimethylammonium chloride (ddac). cyproconazole comprises 6.08% of the product by weight and ddac is 31.6% by weight.
•sentinel 40wg turf fungicide; active ingredient 40.00% cyproconazole
•cyproconazole technical; active ingredient 96.60% cyproconazole
•quadris xtra fungicide; active ingredients 18.20% azoxystrobin and 7.30% cyproconazole
•alto 100sl fungicide; active ingredient 8.90% cyproconazole
•cypro-shield; active ingredient 8.90% cyproconazole
•evipol 360sl; active ingredients 31.60% didecyl ammonium chloride and 6.08% cyproconazole
•evipol technical; active ingredient 96.60% cyproconazole
•xamox 3 ol; active ingredients 0.50% thiamethoxam, 2.50% cyproconazole
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | atemi C | | 2-(4- | chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazol-1-yl)butan-2-ol | | 2-(4- | chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazolyl)butan-2-ol | | 2-(4- | chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol | | (2RS,3RS)-2-(4- | chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | | 2-(4- | chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | | 1H-1,2,4- | triazole-1-ethanol, a-(4-chlorophenyl)-a-(1-cyclopropylethyl)- |
Articles:
| PubMed:Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery. |
| PubMed:Pathogenesis-Related Protein Expression in the Apoplast of Wheat Leaves Protected Against Leaf Rust Following Application of Plant Extracts. |
| PubMed:Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice. |
| PubMed:Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides. |
| PubMed:Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. |
| PubMed:Dynamics and mitigation of six pesticides in a "Wet" forest buffer zone. |
| PubMed:Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola. |
| PubMed:Effects of mixtures of azole fungicides in postimplantation rat whole-embryo cultures. |
| PubMed:Direct enantioseparation of nitrogen-heterocyclic pesticides on amylose-tris-(5-chloro-2-methylphenylcarbamate) by reversed-phase high-performance liquid chromatography. |
| PubMed:Triazole induced concentration-related gene signatures in rat whole embryo culture. |
| PubMed:Triazole-induced gene expression changes in the zebrafish embryo. |
| PubMed:HPLC-MS/MS enantioseparation of triazole fungicides using polysaccharide-based stationary phases. |
| PubMed:Toxicity assessment of 45 pesticides to the epigeic earthworm Eisenia fetida. |
| PubMed:Residues behavior of some fungicides applied on two greenhouse tomato varieties different in shape and weight. |
| PubMed:The hepatocarcinogenic conazoles: cyproconazole, epoxiconazole, and propiconazole induce a common set of toxicological and transcriptional responses. |
| PubMed:Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). |
| PubMed:Environmental fate of fungicides in surface waters of a horticultural-production catchment in southeastern Australia. |
| PubMed:Is the amphibian X. laevis WEC a good alternative method to rodent WEC teratogenicity assay? The example of the three triazole derivative fungicides Triadimefon, Tebuconazole, Cyproconazole. |
| PubMed:Determination of azoles in sewage sludge from Spanish wastewater treatment plants by liquid chromatography-tandem mass spectrometry. |
| PubMed:Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles. |
| PubMed:Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies. |
| PubMed:Fungicide dissipation and impact on metolachlor aerobic soil degradation and soil microbial dynamics. |
| PubMed:Occurrence and removal of fungicides in municipal sewage treatment plant. |
| PubMed:Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD-modified MEKC. |
| PubMed:In vitro toxicity of selected fungicides from the groups of benzimidazoles and demethylation inhibitors to Cladobotryum dendroides and Agaricus bisporus. |
| PubMed:The effect of fungicides on seed yield and disease control in Italian ryegrass. |
| PubMed:Development of monoclonal immunoassays for the determination of triazole fungicides in fruit juices. |
| PubMed:The toxicity study of a systemic fungicide: artea 330 EC on the physiology and the respiratory metabolism of the tadpole (Rana saharica). |
| PubMed:Photocatalytic degradation of pesticides in pure water and a commercial agricultural solution on TiO2 coated media. |
| PubMed:[Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates]. |
| PubMed:Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. |
| PubMed:Control of Mycosphaerella graminicola on wheat seedlings by medical drugs known to modulate the activity of ATP-binding cassette transporters. |
| PubMed:Capabilities of different liquid chromatography tandem mass spectrometry systems in determining pesticide residues in food. Application to estimate their daily intake. |
| PubMed:Sexual reproduction facilitates the adaptation of parasites to antagonistic host environments: Evidence from empirical study in the wheat-Mycosphaerella graminicola system. |
| PubMed:Use of SPE-GC/EIMS for residue analysis in wine elaborated from musts spiked with formulations of chlorpyriphos-methyl, methiocarb, dicofol, and cyproconazol. |
| PubMed:Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.). |
| PubMed:Testing estrogenicity of known and novel (xeno-)estrogens in the MolDarT using developing zebrafish (Danio rerio). |
| PubMed:Bioaccumulation and biotransformation of chiral triazole fungicides in rainbow trout (Oncorhynchus mykiss). |
| PubMed:MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides. |
| PubMed:Fungicides affect the production of extracellular mucilaginous material (ECMM) and the peripheral growth unit (PGU) in two wood-rotting basidiomycetes. |
| PubMed:Influence of pH on the stereoselective degradation of the fungicides epoxiconazole and cyproconazole in soils. |
| PubMed:Selection for increased cyproconazole tolerance in Mycosphaerella graminicola through local adaptation and in response to host resistance. |
| PubMed:MgSlt2, a cellular integrity MAP kinase gene of the fungal wheat pathogen Mycosphaerella graminicola, is dispensable for penetration but essential for invasive growth. |
| PubMed:In vitro selection of an effective fungicide against Armillaria mellea and control of white root rot of grapevine in the field. |
| PubMed:Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry. |
| PubMed:Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. |
| PubMed:Capillary electrophoresis for analyzing pesticides in fruits and vegetables using solid-phase extraction and stir-bar sorptive extraction. |
| PubMed:Application of solid-phase extraction to quantitatively determine cyproconazole and tebuconazole in treated wood using liquid chromatography with UV detection. |
| PubMed:Liquid chromatography-electrospray quadrupole ion-trap mass spectrometry of nine pesticides in fruits. |
| PubMed:Chiral separation of some triazole pesticides by supercritical fluid chromatography. |
| PubMed:Evaluation of a method based on liquid chromatography/electrospray tandem mass spectrometry for analyzing eight triazolic and pyrimidine fungicides in extracts of processed fruits and vegetables. |
| PubMed:Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola. |
| PubMed:Triazole fungicide degradation in peaches in the field and in model systems. |
| PubMed:ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola. |
| PubMed:Molecular cloning and characterisation of three new ATP-binding cassette transporter genes from the wheat pathogen Mycosphaerella graminicola. |
| PubMed:High-performance chiral separation of fourteen triazole fungicides by sulfated beta-cyclodextrin-mediated capillary electrophoresis. |
| PubMed:Characterization of the ABC transporter genes MgAtr1 and MgAtr2 from the wheat pathogen Mycosphaerella graminicola. |
| PubMed:Pesticide residues in grapes, wine, and their processing products. |
| PubMed:Multiresidue determination of 19 fungicides in processed fruits and vegetables by capillary gas chromatography after gel permeation chromatography. |
| PubMed:Developmental toxicity of cyproconazole, an inhibitor of fungal ergosterol biosynthesis, in the rat. |
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