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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | chocolate brown powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 135.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 507.39 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 501.00 °F. TCC ( 260.70 °C. ) (est)
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| logP (o/w): | 2.899 (est) |
| Soluble in: |
| | water, 196.4 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 35 mg/kg
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 5, Pg. 163, 1946.
unreported-mouse LD50 2750 mg/kg
Herba Polonica. Vol. 25, Pg. 209, 1979.
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| Dermal Toxicity: |
subcutaneous-cat LD50 140 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 135, 1960.
subcutaneous-dog LD50 500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 135, 1960.
subcutaneous-frog LD50 160 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 135, 1960.
subcutaneous-mouse LD50 125 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 135, 1960.
subcutaneous-rabbit LD50 360 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 135, 1960.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for chelidonine usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for chelidonine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :197810 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol |
| Chemidplus:0000476324 |
| RTECS:FL9450000 for cas# 476-32-4 |
References:
| | (1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 197810 |
| Pubchem (sid): | 134973497 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| [1,3] | benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-13-methyl-, (5bR,6S,12bS)- | | | chelidonin | | | helidonine | | [5bR-(5ba,6b,12b4a)]-5b,6,7,12b,13,14- | hexahydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-di oxolo[4,5-i]phenanthridin-6-ol | | | khelidonin | | (5bR,6S,12bS)-13- | methyl-5b,6,7,12b,13,14-hexahydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol | | (5bR,6S,12bS)-13- | methyl-5b,6,7,12b,13,14-hexahydro[1,3]dioxolo[4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol | | | stylophorin | | | stylophorine | | (1S,12S,13R)-24- | methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol |
Articles:
| PubMed:Poly (lactide-co-glycolide) nano-encapsulation of chelidonine, an active bioingredient of greater celandine (Chelidonium majus), enhances its ameliorative potential against cadmium induced oxidative stress and hepatic injury in mice. |
| PubMed:Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo. |
| PubMed:[The reactivity of liver monoamine oxidase in the ringed seal Phoca hispida ladogensis]. |
| PubMed:[Study on the separation process of pharmacological active total alkaloids from Chelidonium majus L. growing in Georgia]. |
| PubMed:Capillary electrophoretic study of the synergistic biological effects of alkaloids from Chelidonium majus L. in normal and cancer cells. |
| PubMed:A sensitive and selective liquid chromatography-tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. in rat plasma and its application to a pharmacokinetic study. |
| PubMed:Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids. |
| PubMed:Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways. |
| PubMed:Total syntheses of chelidonine and norchelidonine via an enamide-benzyne-[2 + 2] cycloaddition cascade. |
| PubMed:The in vivo effect of chelidonine on the stem cell system of planarians. |
| PubMed:Chelidonium majus leaves methanol extract and its chelidonine alkaloid ingredient reduce cadmium-induced nephrotoxicity in rats. |
| PubMed:Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells. |
| PubMed:Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L. |
| PubMed:In vivo anthelmintic activity of chelidonine from Chelidonium majus L. against Dactylogyrus intermedius in Carassius auratus. |
| PubMed:Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. |
| PubMed:Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). |
| PubMed:[Comparative substrate-inhibitor analysis of liver monoamine oxidases of minks]. |
| PubMed:Simultaneous determination of seven main alkaloids of Chelidonium majus L. by ultra-performance LC with photodiode-array detection. |
| PubMed:Transcriptional down regulation of hTERT and senescence induction in HepG2 cells by chelidonine. |
| PubMed:A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids. |
| PubMed:Concise enantioselective total syntheses of (+)-homochelidonine, (+)-chelamidine, (+)-chelidonine, (+)-chelamine and (+)-norchelidonine by a Pd II-catalyzed ring-opening strategy. |
| PubMed:Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells. |
| PubMed:Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects. |
| PubMed:Ukrain modulates glial fibrillary acidic protein, but not connexin 43 expression, and induces apoptosis in human cultured glioblastoma cells. |
| PubMed:[Effect of alkaloids from celandine on calcium accumulation and oxidative phosphorylation in mitochondria depending on their DNA intercalating properties]. |
| PubMed:[Experimental study of the inhibitory effects of Chelidonium majus L. extractive on Streptococcus mutans in vitro]. |
| PubMed:Intestinal spasmolytic effects of STW 5 (Iberogast) and its components. |
| PubMed:Effect of Ukrain on matrix metalloproteinase-2 and Secreted Protein Acidic and Rich in Cysteine (SPARC) expression in human glioblastoma cells. |
| PubMed:Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. |
| PubMed:[Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase]. |
| PubMed:Identification and quantification of isoquinoline alkaloids in the genus Sarcocapnos by GC-MS. |
| PubMed:Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. |
| PubMed:[Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their derivative drugs]. |
| PubMed:Preliminary evaluation of CNS effects of 6-O-substituted chelidonine derivatives. |
| PubMed:Cytotoxic activity and quality control determinations on Chelidonium majus. |
| PubMed:Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens. |
| PubMed:[Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood]. |
| PubMed:NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. |
| PubMed:[The inhibition enzymatic hydrolysis of acetylthiocholine by acetylcholinesterase using principal alkaloids isolated from celandine and macleya and their derivatives]. |
| PubMed:Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives. |
| PubMed:A method for determination of Ukrain in blood plasma for monitoring and pharmacokinetic study. |
| PubMed:Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain. |
| PubMed:Synthesis of a [18F]labeled chelidonine derivative as a possible antitumor agent. |
| PubMed:The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways. |
| PubMed:Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure. |
| PubMed:[Minor alkaloids from the capsule of Papaver nudicaule L]. |
| PubMed:Effect of sample handling on alkaloid and mineral content of aqueous extracts of greater celandine (Chelidonium majus L.). |
| PubMed:Inhibition of Candida rugosa lipase by berberine and structurally related alkaloids, evaluated by high-performance liquid chromatography. |
| PubMed:Antispasmodic and relaxant activity of chelidonine, protopine, coptisine, and Chelidonium majus extracts on isolated guinea-pig ileum. |
| PubMed:Benzophenanthridine alkaloids of Chelidonium majus; II. Potent inhibitory action against the growth of human keratinocytes. |
| PubMed:Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism. |
| PubMed:Pharmacological activities of Chelidonium majus L. (Papaveraceae). |
| PubMed:Ukrain therapy in a frontal anaplastic grade III astrocytoma (case report). |
| PubMed:[The greater celandine (Chelidonium majus L.)--review of present knowledge]. |
| PubMed:Antimicrotubule properties of benzophenanthridine alkaloids. |
| PubMed:[HPTLC separation and fluorodensitometric determination of isoquinoline alkaloids in Chelidonine majus L]. |
| PubMed:Chelidonium majus L. (Ukrain) in the treatment of cancer patients. |
| PubMed:Stepwise gradient in thin-layer chromatography of Chelidonium alkaloids. |
| PubMed:Studies on the participation of the dopaminergic system in the central effects of chelidonine. |
| PubMed:Preliminary pharmacological evaluation of chelidonine in rodents. |
| PubMed:Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1. |
| PubMed:[Basic electron optical characteristics of chelidonine hydrochloride]. |
| PubMed:THE ANTITUMOR FACTORS PRESENT IN CHELIDONIUM MAJUS L. I. CHELIDONINE AND PROTOPINE. |
| PubMed:[Partition of chelidonine and protopine by means of countercurrent cascade extraction]. |
| PubMed:[On the pharmacology of chelidonine and sanguinarine]. |
| PubMed:[Recent data on the pharmacology of chelidonine and sanguinarine]. |
| PubMed:[The configurations of chelidonine and homchelidonine]. |
| PubMed:Separation and determination of the dissociation constants of chelidonine and protopine by paper chromatography. |
| PubMed:[Chelidonine in liver and gallbladder diseases]. |
| PubMed:[Studies on paper electrophoresis; paper electrophoresis of morphine and chelidonine in natural mixtures]. |
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3D/inchi