EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

aloe emodin
1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthraquinone

Supplier Sponsors

CAS Number: 481-72-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-571-7
FDA UNII: C8IYT9CR7C
Nikkaji Web:J5.780K
Beilstein Number:2059062
MDL:MFCD00017373
XlogP3-AA:1.80 (est)
Molecular Weight:270.24070000
Formula:C15 H10 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 223.50 °C. @ 760.00 mm Hg
Boiling Point: 568.82 °C. @ 760.00 mm Hg (est)
Flash Point: 593.00 °F. TCC ( 311.90 °C. ) (est)
logP (o/w): 3.254 (est)
Soluble in:
 water, 45.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Aloe emodin 98%
BOC Sciences
For experimental / research use only.
3-Hydroxymethylchrysazine >98%
Carbosynth
For experimental / research use only.
Aloe-emodin
Coompo
For experimental / research use only.
Aloeemodin from Plants ≥96%
ExtraSynthese
For experimental / research use only.
Aloe-emodin (HPLC) ≥98.5%
Santa Cruz Biotechnology
For experimental / research use only.
Aloe-emodin
Sigma-Aldrich: Sigma
For experimental / research use only.
Aloe-emodin ≥95% (HPLC)
sds
TCI AMERICA
For experimental / research use only.
Aloe Emodin >97.0%(HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for aloe emodin usage levels up to:
 not for fragrance use.
 
Recommendation for aloe emodin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of hydroxyanthracene derivatives for use in food
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10207
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
Chemidplus:0000481721
RTECS:CB6712200 for cas# 481-72-1
 
References:
 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):10207
Pubchem (sid):134974698
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10294
HMDB (The Human Metabolome Database):HMDB30829
FooDB:FDB002785
Export Tariff Code:2914.69.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 rhubarb
Search Trop Picture
 
Synonyms:
 aloe-emodin
 aloe-emodine
 aloeemodin
 aloeemodin:9,10-Anthracenedione,1,8-dihydroxy-3-(hydroxymethyl)-,
9,10-anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
9,10-anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- (9CI)
 anthraquinone, 1,8-dihydroxy-3-hydroxymethyl-
1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthraquinone
1,8-dihydroxy-3-(hydroxymethyl)anthra-9,10-quinone
1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
1,8-dihydroxy-3-(hydroxymethyl)anthraquinone
1,8-dihydroxy-3-hydroxymethyl-anthraquinone
1,8-dihydroxy-3-hydroxymethylanthraquinone
 emodine
3-hydroxymethylchrysazine
 rhabarberone
 

Articles:

PubMed:Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D.
PubMed:Assessment of antibacterial properties and the active ingredient of plant extracts and its effect on the performance of crucian carp (Carassius auratus gibelio var. E'erqisi, Bloch).
PubMed:Comment on "The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells by Zhu et al. (2012).
PubMed:Cell-type dependent response of melanoma cells to aloe emodin.
PubMed:Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis.
PubMed:The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells.
PubMed:A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode.
PubMed:Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models.
PubMed:Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages.
PubMed:Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
PubMed:Anti-angiogenic effects of rhubarb and its anthraquinone derivatives.
PubMed:Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice.
PubMed:Aloe-emodin-induced apoptosis in human gastric carcinoma cells.
PubMed:Chemical constituents of cape aloe and their synergistic growth-inhibiting effect on Ehrlich ascites tumor cells.
PubMed:Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography.
PubMed:Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway.
PubMed:Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2).
PubMed:Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungi.
PubMed:Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells.
PubMed:In vitro studies on the photobiological properties of aloe emodin and aloin A.
PubMed:[Contents of barbaloin-related compounds in aloe drinks and their change during storage].
PubMed:Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated?
 
Notes:
Found in aloes, also bark of cascara sagrada Rhamnus purshiana, Chinese rhubarb Rheum palmatum and Rheum undulatum (rhubarb) Aloe emodin is an anthraquinone present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action. (Wikipedia)
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