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Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 76.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 547.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 544.00 °F. TCC ( 284.60 °C. ) (est)
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| logP (o/w): | 4.300 |
| Soluble in: |
| | water, 0.5956 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-duck LD50 > 2150 mg/kg
Pesticide Manual. Vol. 9, Pg. 277, 1991.
oral-rat LD50 1453 mg/kg
Pesticide Manual. Vol. 9, Pg. 277, 1991.
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| Dermal Toxicity: |
skin-rabbit LD50 > 2010 mg/kg
Pesticide Manual. Vol. 9, Pg. 277, 1991.
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| Inhalation Toxicity: |
inhalation-rat LC50 > 45 mg/m3/4H
Pesticide Manual. Vol. 9, Pg. 277, 1991.
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Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for difenoconazole usage levels up to: | | | not for fragrance use.
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| Recommendation for difenoconazole flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Reasoned opinion on the modification of the existing MRLs for difenoconazole in various crops
View page or View pdf
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Reasoned opinion on the modification of the existing MRLs for difenoconazole in peppers and aubergines
View page or View pdf
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Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment of confirmatory data for the active substance difenoconazole
View page or View pdf
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Reasoned opinion on the modification of the existing MRLs for difenoconazole in lettuce and other salad plants including Brassicaceae and in basil (mint)
View page or View pdf
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Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
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Modification of the existing maximum residue levels for difenoconazole in various crops
View page or View pdf
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Modification of the existing maximum residue levels for difenoconazole in various crops
View page or View pdf
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Outcome of the consultation with Member States and EFSA on the basic substance application for approval of caffeine to be used in plant protection as insecticide in cabbage, potatoes and buxus and as molluscicide in all edible and non-edible crops
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :86173 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole |
| Chemidplus:0119446683 |
References:
| | 1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 86173 |
| Pubchem (sid): | 135043115 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1-[[2-[2- | chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole | | 1-((2-[2- | chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole | | 1-[[2-[2- | chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole | | 1-({2-[2- | chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole | | cis-trans-3- | chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl]phenyl 4-chlorophenyl ether | | 1-[2-[4-(4- | chlorophenoxy)-2-chlorophenyl]-4-methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole | | | difenconazole | | | dividend | | | plover | | | score | | 1H-1,2,4- | triazole, 1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]- |
Articles:
| PubMed:Development of a new microextraction method based on elevated temperature dispersive liquid-liquid microextraction for determination of triazole pesticides residues in honey by gas chromatography-nitrogen phosphorus detection. |
| PubMed:Determination of fungicides in sediments using a dispersive liquid-liquid microextraction procedure based on solidification of floating organic drop. |
| PubMed:Pesticide exposure on sloths (Bradypus variegatus and Choloepus hoffmanni) in an agricultural landscape of Northeastern Costa Rica. |
| PubMed:An in situ immobilized pipette tip solid phase microextraction method based on molecularly imprinted polymer monolith for the selective determination of difenoconazole in tap water and grape juice. |
| PubMed:Transfer of difenoconazole and azoxystrobin residues from chrysanthemum flower tea to its infusion. |
| PubMed:A computational approach to structural properties of glycoside hydrolase family 4 from bacteria. |
| PubMed:Effects of ozone fumigation treatment on the removal of residual difenoconazole from strawberries and on their quality. |
| PubMed:Dissipation and residues of difenoconazole and azoxystrobin in bananas and soil in two agro-climatic zones of China. |
| PubMed:Pesticide residues in berries harvested from South-Eastern Poland (2009-2011). |
| PubMed:MSPD sample preparation approach for reversed-phase liquid chromatographic analysis of pesticide residues in stem of coconut palm. |
| PubMed:Environmental fungicides and triazole resistance in Aspergillus. |
| PubMed:[Occurrence and control of Cercospora leaf spot on Lonicera macrathoides]. |
| PubMed:Effect on enzymes and histopathology in earthworm (Eisenia foetida) induced by triazole fungicides. |
| PubMed:Non-target effects of three formulated pesticides on microbially-mediated processes in a clay-loam soil. |
| PubMed:Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. |
| PubMed:Assessment of silicone as support to investigate the transformation routes of organic chemicals under environmental conditions and UV exposure. Application to selected fungicides. |
| PubMed:Evaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assays. |
| PubMed:Experimental exposure of red-legged partridges (Alectoris rufa) to seeds coated with imidacloprid, thiram and difenoconazole. |
| PubMed:Comparison of the selectivity of different sorbent phases for bar adsorptive microextraction--application to trace level analysis of fungicides in real matrices. |
| PubMed:Dissipation of difenoconazole in rice, paddy soil, and paddy water under field conditions. |
| PubMed:Simultaneous enantioselective determination of triazole fungicide difenoconazole and its main chiral metabolite in vegetables and soil by normal-phase high-performance liquid chromatography. |
| PubMed:Degradation of terbuthylazine, difenoconazole and pendimethalin pesticides by selected fungi cultures. |
| PubMed:Comparison of greenhouse and field degradation behaviour of isoprocarb, hexaflumuron and difenoconazole in Perilla frutescens. |
| PubMed:Development of a difenoconazole/propiconazole microemulsion and its antifungal activities against Rhizoctonia solani AG1-IA. |
| PubMed:Cladosporium cladosporioides LPSC 1088 produces the 1,8-dihydroxynaphthalene-melanin-like compound and carries a putative pks gene. |
| PubMed:Enantiomeric resolution of five chiral pesticides on a Chiralpak IB-H column by SFC. |
| PubMed:HPLC-MS/MS enantioseparation of triazole fungicides using polysaccharide-based stationary phases. |
| PubMed:Occurrence and distribution study of residues from pesticides applied under controlled conditions in the field during rice processing. |
| PubMed:Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China. |
| PubMed:Chemosensitization of plant pathogenic fungi to agricultural fungicides. |
| PubMed:Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. |
| PubMed:Pre-harvest treatments with fungicides and post-harvest dips in sodium bicarbonate to control postharvest decay in stone fruit. |
| PubMed:Characterization of CbCyp51 from field isolates of Cercospora beticola. |
| PubMed:Environmental fate of fungicides in surface waters of a horticultural-production catchment in southeastern Australia. |
| PubMed:Orchard factors associated with resistance and cross resistance to sterol demethylation inhibitor fungicides in populations of Venturia inaequalis from Pennsylvania. |
| PubMed:Dissipation and distribution behavior of azoxystrobin, carbendazim, and difenoconazole in pomegranate fruits. |
| PubMed:Dissipation study of difenoconazole in/on chili fruit and soil in India. |
| PubMed:Extraction and preconcentration technique for triazole pesticides from cow milk using dispersive liquid-liquid microextraction followed by GC-FID and GC-MS determinations. |
| PubMed:Determination of azoles in sewage sludge from Spanish wastewater treatment plants by liquid chromatography-tandem mass spectrometry. |
| PubMed:Determination of fungicides in wine by mixed-mode solid phase extraction and liquid chromatography coupled to tandem mass spectrometry. |
| PubMed:Determination and safety evaluation of difenoconazole residues in apples and soils. |
| PubMed:Temperature, moisture, and fungicide effects in managing Rhizoctonia root and crown rot of sugar beet. |
| PubMed:Development, validation and application of a methodology based on solid-phase micro extraction followed by gas chromatography coupled to mass spectrometry (SPME/GC-MS) for the determination of pesticide residues in mangoes. |
| PubMed:Efficacy of osthol, a potent coumarin compound, in controlling powdery mildew caused by Sphaerotheca fuliginea. |
| PubMed:Pesticide sequestration in passive samplers (SPMDs): considerations for deployment time, biofouling, and stream flow in a tropical watershed. |
| PubMed:Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of selected fungicides in wine. |
| PubMed:Residues of Pesticides in honeybee (Apis mellifera carnica) bee bread and in pollen loads from treated apple orchards. |
| PubMed:Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives. |
| PubMed:[Study on safe use of 10% difenoconazole in GAP of Gentiana scabra]. |
| PubMed:Acquisition of Resistance to Sterol Demethylation Inhibitors by Populations of Venturia inaequalis. |
| PubMed:Rational Management of Didymella rabiei in Chickpea by Integration of Genotype Resistance and Postinfection Application of Fungicides. |
| PubMed:Simultaneous determination of eight pesticide residues in coconut using MSPD and GC/MS. |
| PubMed:Enantiomer separation of triazole fungicides by high-performance liquid chromatography. |
| PubMed:Effectiveness of pressurized liquid extraction and solvent extraction for the simultaneous quantification of 14 pesticide residues in green tea using GC. |
| PubMed:Management of apple scab (Venturia inaequalis) in Romania based on electronic warnings. |
| PubMed:Degradation kinetics and safety evaluation of tetraconazole and difenoconazole residues in grape. |
| PubMed:[Determination of difenoconazole residue in foods by gas chromatography-negative chemical ionization mass spectrometry]. |
| PubMed:[Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates]. |
| PubMed:Safe apples for baby-food production: survey of pesticide treatment regimes leaving minimum residues. |
| PubMed:A novel substitution I381V in the sterol 14alpha-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides. |
| PubMed:Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances. |
| PubMed:Behavior of pesticides in sediment/water systems in outdoor mesocosms. |
| PubMed:Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry. |
| PubMed:High temperature liquid chromatography of triazole fungicides on polybutadiene-coated zirconia stationary phase. |
| PubMed:Evaluation of the systemic activity of simeconazole in comparison with that of other DMI fungicides. |
| PubMed:Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds. |
| PubMed:The influence of lipophilicity and formulation on the distribution of pesticides in laboratory-scale sediment/water systems. |
| PubMed:Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. |
| PubMed:High-performance chiral separation of fourteen triazole fungicides by sulfated beta-cyclodextrin-mediated capillary electrophoresis. |
| PubMed:[The effect of biostimulants and fungicides on the growth parameters of natural associations of soil microorganisms]. |
| PubMed:Joint actions of deltamethrin and azole fungicides on honey bee thermoregulation. |
| PubMed:3-Acetyl deoxynivalenol and esterase production in a fungicideinsensitive strain ofFusarium culmorum. |
| PubMed:3-Acetyl deoxynivalenol production in a strain ofFusarium culmorum insensitive to the fungicide difenoconazole. |
| PubMed:Degradation of the fungicide difenoconazole in a silt loam soil as affected by pretreatment and organic amendment. |
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3D/inchi