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10-hydroxydecenoic acid
2-decenoic acid, 10-hydroxy-

Supplier Sponsors

Name:10-hydroxydec-2-enoic acid
CAS Number: 765-01-5Picture of molecule3D/inchi
FDA UNII: 76B519G7TJ
MDL:MFCD00204506
XlogP3-AA:2.20 (est)
Molecular Weight:186.25106000
Formula:C10 H18 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 339.00 to 340.00 °C. @ 760.00 mm Hg (est)
Flash Point: 344.00 °F. TCC ( 173.10 °C. ) (est)
logP (o/w): 1.808 (est)
Soluble in:
 alcohol
 water, 4173 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
10-hydroxydec-2-enoic acid 95%
Jiangyin Healthway
10-hydroxydec-2-enoic Acid
New functional food ingredients
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for 10-hydroxydecenoic acid usage levels up to:
 not for fragrance use.
 
Recommendation for 10-hydroxydecenoic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92837
National Institute of Allergy and Infectious Diseases:Data
10-hydroxydec-2-enoic acid
Chemidplus:0000765015
 
References:
 10-hydroxydec-2-enoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):92837
Pubchem (sid):135050717
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
2-decenoic acid, 10-hydroxy-
10-hydroxy-2-decenoic acid
10-hydroxy-trans-2-decenoic acid
 

Articles:

PubMed:Geographical influences on content of 10-hydroxy-trans-2-decenoic acid in royal jelly in China.
PubMed:Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages.
PubMed:10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5'-AMP-activated protein kinase in L6 myotubes and mice.
PubMed:Hypoallergenicity and immunological characterization of enzyme-treated royal jelly from Apis mellifera.
PubMed:Oriental orchid (Cymbidium floribundum) attracts the Japanese honeybee (Apis cerana japonica) with a mixture of 3-hydroxyoctanoic acid and 10-hydroxy- (E)-2-decenoic acid.
PubMed:Contribution of lipids in honeybee (Apis mellifera) royal jelly to health.
PubMed:Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production.
PubMed:Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses.
PubMed:10-Hydroxy-2-decenoic acid prevents ultraviolet A-induced damage and matrix metalloproteinases expression in human dermal fibroblasts.
PubMed:Hydroxy decenoic acid down regulates gtfB and gtfC expression and prevents Streptococcus mutans adherence to the cell surfaces.
PubMed:Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression.
PubMed:Effects of Hydroxydecine(®) (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis.
PubMed:Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans.
PubMed:Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis.
PubMed:Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production.
PubMed:Specific hydroxy fatty acids in royal jelly activate TRPA1.
PubMed:Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.
PubMed:10-Hydroxy-2-decenoic acid from Royal jelly: a potential medicine for RA.
PubMed:Drones of the dwarf honey bee Apis florea are attracted to (2E)-9-oxodecenoic acid and (2E)-10-hydroxydecenoic acid.
PubMed:Comparison of bee products based on assays of antioxidant capacities.
PubMed:10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.
PubMed:Estrogenic activities of Fatty acids and a sterol isolated from royal jelly.
PubMed:Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro.
PubMed:Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera).
PubMed:Determination of (E)-10-hydroxy-2-decenoic acid content in pure royal jelly: a comparison between a new CZE method and HPLC.
PubMed:Optimized determination method for trans-10-hydroxy-2-decenoic acid content in royal jelly by high-performance liquid chromatography with an internal standard.
PubMed:Beyond 9-ODA: sex pheromone communication in the European honey bee Apis mellifera L.
PubMed:Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera).
PubMed:Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism.
PubMed:[The research of 10-hydroxy-2-decenoic acid on experiment hyperlipoidemic rat].
PubMed:[Determination of 10-HDA in honeybee body by HPLC].
PubMed:Insight into some of the signaling pathways triggered by a lipid immunomodulator.
PubMed:Antifatigue effect of fresh royal jelly in mice.
PubMed:[Features of fatty acid composition of queen bee jelly].
PubMed:[Determination of 10-hydroxy-2-decenoic acid (10-HDA) in Chinese traditional medicine preparations by high performance liquid chromatography].
PubMed:Storage-dependent degradation of 57-kDa protein in royal jelly: a possible marker for freshness.
PubMed:Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography.
PubMed:Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro.
PubMed:Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly.
PubMed:[Effects of royal jelly and 10-hydroxy decenoic acid on the sebaceous glands of hamster ear].
PubMed:[The physiological dispositions of 10-hydroxy-delta 2-decenoic acid (10-HDA) in rats and mice].
PubMed:[Establishment of human glioma cell line--nude mice solid tumor model NHG-1 and its characteristics].
PubMed:[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography].
PubMed:[Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography].
PubMed:New synthesis of royal jelly acid.
PubMed:Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly.
PubMed:Biological origin and configuration of 10-hydroxy-2-decenoic acid.
PubMed:Activity of 10-hydroxydecenoic acid from royal jelly against experimental leukaemia and ascitic tumours.
 
Notes:
None found
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