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5'-inosinic acid
inosine-5'-monophosphoric acid

Supplier Sponsors

CAS Number: 131-99-7Picture of molecule3D/inchi
FDA UNII: TAO7US05G5
Nikkaji Web:J9.493E
Beilstein Number:0630517
MDL:MFCD00066754
XlogP3:-3.70 (est)
Molecular Weight:348.20897200
Formula:C10 H13 N4 O8 P
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
JECFA Food Additive: 5'-Inosinic Acid
GSFA Codex: Inosinic acid (630)
DG SANTE Food Additives:5'-inosinic acid
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 851.37 °C. @ 760.00 mm Hg (est)
Flash Point: 876.00 °F. TCC ( 468.70 °C. ) (est)
logP (o/w): -3.707 (est)
Soluble in:
 water, 5921 mg/L @ 25 °C (est)
 alcohol, slightly
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
5'-Inosinic acid ≥98%
Carbosynth
For experimental / research use only.
Inosine 5'-monophosphate
Santa Cruz Biotechnology
For experimental / research use only.
Inosine 5'-monophosphate from Saccharomyces cerevisiae ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Inosine 5'-monophosphate from Saccharomyces cerevisiae Grade V, ≥98%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 16000 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

intravenous-rat LD50 2730 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

intraperitoneal-rat LD50 4850 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

oral-mouse LD50 12000 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

intravenous-mouse LD50 3300 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

intraperitoneal-mouse LD50 5400 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

Dermal Toxicity:
subcutaneous-rat LD50 3900 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

subcutaneous-mouse LD50 5480 mg/kg
Archives of Toxicology. Vol. 47, Pg. 77, 1981.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavor enhancers
Recommendation for 5'-inosinic acid usage levels up to:
 not for fragrance use.
 
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):131-99-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8582
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
Chemidplus:0000131997
 
References:
  [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:131-99-7
Pubchem (cid):8582
Pubchem (sid):134973915
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00130
HMDB (The Human Metabolome Database):HMDB00175
FooDB:FDB021901
YMDB (Yeast Metabolome Database):YMDB00352
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
 inosine-5'-monophosphoric acid
 

Articles:

Google Patents:Production of 5'-inosinic acid by fermentation
PubMed:Enzymatic production of 5'-inosinic acid by a newly synthesised acid phosphatase/phosphotransferase.
Google Patents:Microorganism producing 5'-inosinic acid and process for producing 5'-inosinic acid using the same
PubMed:Improving the pyrophosphate-inosine phosphotransferase activity of Escherichia blattae acid phosphatase by sequential site-directed mutagenesis.
PubMed:Surface imprinting polymers for the recognition of nucleotides.
PubMed:Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus.
PubMed:Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
PubMed:Nucleotide dimers suppress HIV expression in vitro.
PubMed:[Effect of antibiotics on 5'-inosinic acid biosynthesis by a Brevibacterium ammoniagenes mutant].
PubMed:[Adenine effect on the biosynthesis of 5'-inosinic acid by the mutant Brevibacterium ammoniagenes 225-5].
PubMed:[Effect of medium components on the metabolism of Brevibacterium ammoniagenes-producer of 5'-inosinic acid].
PubMed:Inhibition of ribonucleotide reductase activity and nucleic acid synthesis in tumor cells by the dialdehyde derivatives of inosine (NSC 118994) and inosinic acid.
PubMed:[Study of inosine transformation into 5'-inosinic acid by the culture of Pseudomonas trifoli].
PubMed:Production of nucleic acid-related substances by fermentation processes. 33. Accumulation of inosine by a mutant of Brevibacterium ammoniagenes.
PubMed:Production of nucleic acid-related substances by fermentative processes. 28. Accumulation of 5' inosinic acid by a manganese-insensitive mutant of Brevibacterium ammoniagenes.
PubMed:Unbalanced growth death due to depletion of Mn2+ in Brevibacterium ammoniagenes.
PubMed:Production of nucleic acid-related substances by fermentative processes. XIX. Accumulation of 5'-inosinic acid by a mutant of Brevibacterium ammoniagenes.
PubMed:REMOVAL OF INTERFERING NUCLEOTIDES FROM BRAIN EXTRACTS CONTAINING SUBSTANCE P. EFFECT OF DRUGS ON BRAIN CONCENTRATIONS OF SUBSTANCE P.
 
Notes:
A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Inosinic acid is a nucleotide present in muscle and other tissues. It is formed by the deamination of AMP and when hydrolysed produces inosine. Inosinic acid is the ribonucleotide of hypoxanthine and is the first compound formed during the synthesis of purine. (Wikipedia) [HMDB]
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