choline, 62-49-7

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CODE160051 CODE160051
Product(s):
160051 Choline

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CODE160051 CODE160051
Product(s):
62-49-7 Choline

CAS Number:	62-49-7	3D/inchi
Other(deleted CASRN):	139741-81-4
ECHA EINECS - REACH Pre-Reg:	200-535-1
FDA UNII:	N91BDP6H0X
Nikkaji Web:	J4.822D
Beilstein Number:	1736748
MDL:	MFCD00002831
XlogP3-AA:	-0.40 (est)
Molecular Weight:	104.17278000
Formula:	C5 H14 N O
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:flavoring agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
FEMA Number:	4500 choline
FDA:	No longer provide for the use of these seven synthetic flavoring substances

Physical Properties:

Food Chemicals Codex Listed:	No
Shelf Life:	12.00 month(s) or longer if stored properly.
Storage:	refrigerate in tightly sealed containers.
Soluble in:
	water, 1e+006 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

American International Chemical, LLC.

Choline

Axsyn

For experimental / research use only.

Ethanaminium,2-hydroxy-N,N,N-trimethyl-

Balchem

Memor-C™

Flavor: characteristic

Choline is an essential nutrient; it is important for the healthy structure and function of your body, acting as a chemical “building block”, an agent of cell-to-cell communication and transportation, and part of a regulatory system for your genes.

Balchem

VitaCholine™

Flavor: characteristic

Choline is an essential nutrient important to the healthy structure and function of the human body.

BOC Sciences

For experimental / research use only.

Choline

Sigma-Aldrich: Sigma

For experimental / research use only.

Choline base solution ∼50 % (w/w) in H2O

sds

Safety Information:

Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 34 - Causes burns. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 35 mg/kg "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 358, 1948. intraperitoneal-guinea pig LDLo 450 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 642, 1954. intravenous-rabbit LDLo 70 mg/kg Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920.
Dermal Toxicity:
subcutaneous-cat LDLo 150 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. subcutaneous-frog LDLo 1500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. subcutaneous-rabbit LDLo 500 mg/kg "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 358, 1948.
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavoring agents
Recommendation for choline usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24. Update in publication number(s): 26
Click here to view publication 24
		average usual ppm	average maximum ppm
baked goods:		4000.00000	6000.00000
beverages(nonalcoholic):		-	-
beverages(alcoholic):		-	-
breakfast cereal:		4000.00000	6000.00000
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		600.00000	1200.00000
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		4000.00000	6000.00000
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		4000.00000	6000.00000
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		4000.00000	6000.00000
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		4000.00000	6000.00000
snack foods:		4000.00000	6000.00000
soft candy:		-	-
soups:		2500.00000	4000.00000
sugar substitutes:		-	-
sweet sauces:		-	-

Safety References:

European Food Safety Authority (EFSA) reference(s):

Literature search and review related to specific preparatory work in the establishment of Dietary References Values for Thiamin, Pantothenic Acid and Choline
View page or View pdf

Scientific Opinion on the substantiation of a health claim related to choline and "development of brain" pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf

Dietary Reference Values for choline
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for choline
View page or View pdf

EPI System: View

ClinicalTrials.gov:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):62-49-7

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :305

National Institute of Allergy and Infectious Diseases:Data

WISER:UN 3267

WGK Germany:3

2-hydroxyethyl(trimethyl)azanium

Chemidplus:0000062497

References:

	2-hydroxyethyl(trimethyl)azanium
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	62-49-7
Pubchem (cid):	305
Pubchem (sid):	134971369

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Metabolomics Database:	Search
KEGG (GenomeNet):	C00114
HMDB (The Human Metabolome Database):	HMDB00097
FooDB:	FDB000710
YMDB (Yeast Metabolome Database):	YMDB00227
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

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Synonyms:

	bilineurine
	biocoline
	choline base solution
	choline cation
	choline ion
	cholinum
	ethanaminium,2-hydroxy-N,N,N-trimethyl-
	hepacholine
	hormocline
2-	hydroxyethyl(trimethyl)azanium
(2-	hydroxyethyl)trimethyl ammonium
(2-	hydroxyethyl)trimethylammonium
(beta-	hydroxyethyl)trimethylammonium
	lipotril
	nemor-C
	neocolina
	vitacholine

Articles:

PubMed:Quail FMO3 gene cloning, tissue expression profiling, polymorphism detection and association analysis with fishy taint in eggs.

PubMed:An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.

PubMed:Trimethylamine deposition in the egg yolk from laying hens with different FMO3 genotypes.

PubMed:Determination of trimethylamine in spinach, cabbage, and lettuce at alkaline pH by headspace solid-phase microextraction.

PubMed:Fungal aryl-alcohol oxidase: a peroxide-producing flavoenzyme involved in lignin degradation.

PubMed:Overaccumulation of higher polyamines in ripening transgenic tomato fruit revives metabolic memory, upregulates anabolism-related genes, and positively impacts nutritional quality.

Notes:

a basic constituent of lecithin that is found in many plants and animal organs. it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. Nutritional supplement. Occurs free and combined in many animal and vegetable foods with highest concentrations found in egg yolk, meat, fish, milk, cereaks and legumes Choline is a water-soluble essential nutrient. It is usually grouped within the B-complex vitamins. Choline generally refers to the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation. (Wikipedia)

choline 2-hydroxyethyl(trimethyl)azanium

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2-hydroxyethyl(trimethyl)azanium