EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

(E)-polydatin
(E)-3,4,5-trihydroxystilbene-3-beta-monoglucoside

Supplier Sponsors

Name:(2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS Number: 27208-80-6Picture of molecule3D/inchi
Other(deleted CASRN):28759-35-5
FDA UNII: XM261C37CQ
MDL:MFCD00210592
XlogP3:1.70 (est)
Molecular Weight:390.38894000
Formula:C20 H22 O8
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 707.70 °C. @ 760.00 mm Hg (est)
Flash Point: 719.00 °F. TCC ( 381.80 °C. ) (est)
logP (o/w): 0.412 (est)
Soluble in:
 water, 1616 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Polydatin 98%
BOC Sciences
For experimental / research use only.
Resveratrol 3-O-β-D-Glucopyranoside >98%
Carbosynth
For experimental / research use only.
trans-Resveratrol 3-O-b-D-glucuronide
Coompo
For experimental / research use only.
Polydatin from Plants ≥98%
Odor: characteristic
Use: Polydatin has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels. Polydatin preconditioning (PPC) has been reported to be protective against brain and intestine ischemia/reperfusion injury. It also exerts cardioprotective effect by the activation of PKC-K(ATP)-dependent signaling and the direct anti-oxidative stress mechanisms. Polydatin affects lipopolysaccharide‘s induction on VEC ICAM-1;Polydatin affects the neutrophils’s chemotaxis reaction inspired by lipopolysaccharide; Polydatin affects smooth muscle and Cardiomyocytes PKC under the situation of ischemia, hypoxia, burn serum, and LPS; Polydatin was used in treating severe Acute Pancreatitis in the early stage; Polydatin affects TLR4 when reducing the injury occurred during perfusing blood to ischemic Rabbit lung; Experiments and researches both in vitro and in vivo on of Polydatin curing Viral Myocarditis.
Nacalai USA
For experimental / research use only.
trans-Polydatin
TCI AMERICA
For experimental / research use only.
Piceid >95.0%(HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for (E)-polydatin usage levels up to:
 not for fragrance use.
 
Recommendation for (E)-polydatin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281718
National Institute of Allergy and Infectious Diseases:Data
(2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Chemidplus:0027208806
 
References:
 (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281718
Pubchem (sid):135032843
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):C10275
HMDB (The Human Metabolome Database):HMDB30564
FooDB:FDB002449
Export Tariff Code:2938.90.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 grape fruit
Search Trop Picture
 grape skin
Search Trop Picture
 polygonum cuspidatum
Search Trop Picture
 sorghum
Search Trop Picture
 wine red wine
Search Picture
 
Synonyms:
(2S,3R,4S,5S,6R)-2-(3-hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(3S,4R,6S)-2-{3-hydroxy-5-[(E)-2-(4-hydroxy-phenyl)-vinyl]-phenoxy}-6-((S)-(R)-1-hydroxymethyl)-tetrahydro-pyran-3,4,5-triol
(2S,3R,4S,5S,6R)-2-{3-hydroxy-5-[(E)-2-(4-hydroxy-phenyl)-vinyl]-phenoxy}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
(2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
(E)-piceid
(E)-resveratrol 3-beta-mono-dextro-glucoside
(E)-3,4,5-trihydroxystilbene-3-beta-monoglucoside
 

Articles:

PubMed:Natural stilbenoids isolated from grapevine exhibiting inhibitory effects against HIV-1 integrase and eukaryote MOS1 transposase in vitro activities.
PubMed:Stilbenoid profiles of canes from Vitis and Muscadinia species.
PubMed:Targeted isolation and structure elucidation of stilbene glycosides from the bark of Lysidice brevicalyx Wei guided by biological and chemical screening.
PubMed:A stilbene and dihydrochalcones with radical scavenging activities from Loiseleuria procumbens.
 
Notes:
Present in grapeskins and red wine. Isol. from Polygonum cuspidatum (Japanese knotweed) Piceid is a stilbenoid glucoside and is a major resveratrol derivative in grape juices.
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