kempferol, 520-18-3

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CODE158899 CODE158899
Product(s):
520-18-3 Kaempferol >98%
Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier
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With a Glentham Life Sciences account you can view more product details, request quotes and order products online.
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CODE158899 CODE158899
Product(s):
GP7425 Kaempferol

Name:	3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
CAS Number:	520-18-3	3D/inchi
ECHA EINECS - REACH Pre-Reg:	208-287-6
FDA UNII:	731P2LE49E
Nikkaji Web:	J1.575J
Beilstein Number:	0304401
MDL:	MFCD00016938
XlogP3:	1.90 (est)
Molecular Weight:	286.23990000
Formula:	C15 H10 O6
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:cosmetic agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Appearance:	yellow needles (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	277.00 °C. @ 760.00 mm Hg
Boiling Point:	582.00 to 583.00 °C. @ 860.00 mm Hg (est)
Flash Point:	439.00 °F. TCC ( 226.10 °C. ) (est)
logP (o/w):	2.685 (est)
Soluble in:
	alcohol
	water, 1191 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	antioxidants skin conditioning - emollient

Suppliers:

Alfa Biotechnology

For experimental / research use only.

Kaempferol 98%

BOC Sciences

For experimental / research use only.

Kaempferol >98%

Odor: characteristic

Use: Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.

Changzhou Longo Chemical

Kempferol

Coompo

For experimental / research use only.

Kempferol from Plants ≥96%

Odor: characteristic

Use: Kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, antiosteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic, and antiallergic activities. Keampferol is a strong antioxidant and helps to prevent oxidative damage of our cells, lipids and DNA. Kaempferol seems to prevent arteriosclerosis by inhibiting the oxidation of low density lipoprotein and the formation of platelets in the blood. Studies have also confirmed that kaempferol acts as a chemopreventive agent, which means that it inhibits the formation of cancer cells. Kaempferol inhibits monocyte chemoattractant protein (MCP-1). MCP-1 plays a role in the initial steps of atherosclerotic plaque formation. Kaempferol can help to fight cancer because it reduces the resistance of cancer cells to anti-cancer drugs such as vinbalstine and paclitaxel. Kaempferol consumption is also correlated with a reduced lung cancer incidence. Kaempferol may be a potent prophylactic against NOX-mediated neurodegeneration.

ExtraSynthese

For experimental / research use only.

Kaempferol (HPLC) ≥90%

Glentham Life Sciences

Kaempferol

Santa Cruz Biotechnology

For experimental / research use only.

Kempferol ≥98%

Shaanxi Y-Herb Biotechnology

CAS 520-18-3 Kaempferia Galanga Extract Kaempferol Powder 30% 50% 70% 90% 98%

Sigma-Aldrich: Sigma

For experimental / research use only.

Kempferol ≥97.0% (HPLC)

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
cosmetic agents
Recommendation for kempferol usage levels up to:
	not for fragrance use.

Recommendation for kempferol flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

Carcinogenic Potency Database:Search

EPA GENetic TOXicology:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :5280863

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Chemidplus:0000520183

References:

	3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	5280863
Pubchem (sid):	134976840

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Golm Metabolome Database:	Search
KEGG (GenomeNet):	C05903
HMDB (The Human Metabolome Database):	HMDB05801
FooDB:	FDB000633
YMDB (Yeast Metabolome Database):	YMDB01722
MedlinePlusSupp:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

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Synonyms:

	campherol
	kaempferol
	nimbecetin
	pelargidenolon
	populnetin
	rhamnolutein
	robigenin
	swartziol
3,4',5,7-	tetrahydroxyflavone
	trifolitin
3,5,7-	trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
3,5,7-	trihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Articles:

PubMed:Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.

PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.

PubMed:Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay.

PubMed:Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study.

PubMed:3,4-Dihydroxy-7,8-dihydro-beta-ionone 3-O-beta-D-glucopyranoside and other glycosidic constituents from apple leaves.

Notes:

Very widespread in the plant world, e.g. in Brassicaceae, Apocynaceae, Dilleniaceae, Ranunculaceae, Leguminosae, etc. Found esp. in broccoli, capers, chives, kale, garden cress, fennel, lovage, dill weed and tarragon [CCD] Kaempferol is a natural flavonol, a type of flavonoid. Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. Kaempferol consumption in tea and broccoli has been associated with reduced risk of heart disease. [Wikipedia]