EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

genkwanin
7-O-methylapigenin

Supplier Sponsors

Name:5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
CAS Number: 437-64-9Picture of molecule3D/inchi
FDA UNII: 5K3I5D6B2B
Nikkaji Web:J61.256A
Beilstein Number:0292549
MDL:MFCD00017452
XlogP3:2.10 (est)
Molecular Weight:284.26764000
Formula:C16 H12 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 546.50 °C. @ 760.00 mm Hg (est)
Flash Point: 409.00 °F. TCC ( 209.70 °C. ) (est)
logP (o/w): 2.360 (est)
Soluble in:
 water, 71.1 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Gengkwanin 98%
BOC Sciences
For experimental / research use only.
Genkwanin 0.99
Odor: characteristic
Use: Genkwanin isolated from the herbs of Lobelia chinensis. It is transported by both passive diffusion and multidrug resistance protein (MDR)-mediated efflux mechanisms. anti-inflammatory effect
Carbosynth
For experimental / research use only.
Genkwanin
Coompo
For experimental / research use only.
Genkwanin from Plants ≥96%
ExtraSynthese
For experimental / research use only.
Genkwanin (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
Genkwanin
Sigma-Aldrich
For experimental / research use only.
Genkwanin analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for genkwanin usage levels up to:
 not for fragrance use.
 
Recommendation for genkwanin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281617
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
Chemidplus:0000437649
 
References:
 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281617
Pubchem (sid):135024489
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10046
HMDB (The Human Metabolome Database):Search
FooDB:FDB006932
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 basil
Search Trop Picture
 rosemary leaf
Search Trop Picture
 sage leaf
Search Trop Picture
 savory winter savory shoot
Search Trop Picture
 thyme leaf
Search Trop Picture
 
Synonyms:
 apigenin 7-methyl ether
 apigenin-7-methylether
4H-1-benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
4',5-dihydroxy-7-methoxyflavone
5,4'-dihydroxy-7-methoxyflavone
 flavone, 4',5-dihydroxy-7-methoxy-
 gengkwanin
 henquanin
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
7-methoxyapigenin
7-methylapigenin
7-O-methylapigenin
 

Articles:

PubMed:Comparative investigation of in vitro biotransformation of 14 components in Ginkgo biloba extract in normal, diabetes and diabetic nephropathy rat intestinal bacteria matrix.
PubMed:A characterization of content, composition and scavenging capacity of phenolic compounds in parsnip roots of various weight.
PubMed:Interactions of pharmacokinetic profile of different parts from Ginkgo biloba extract in rats.
PubMed:Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages.
PubMed:[Chemical constituents from tubers of Cremastra appendiculata].
PubMed:Intestinal absorptive transport of Genkwanin from Flos genkwa using a single-pass intestinal perfusion rat model.
PubMed:Antioxidant effects of Genkwa flos flavonoids on Freund׳s adjuvant-induced rheumatoid arthritis in rats.
PubMed:STUDIES ON A SIMPLE AND EFFICIENT METHOD FOR LARGE-SCALE PREPARATION OF GENKWANIN FROM DAPHNE GENKWA SIEB. ET ZUCC. USING NORMAL-PHASE FLASH CHROMATOGRAPHY.
PubMed:Investigation of solute-solvent interactions in phenol compounds: accurate ab initio calculations of solvent effects on 1H NMR chemical shifts.
PubMed:Isolation of anticancer constituents from flos genkwa (Daphne genkwa Sieb.et Zucc.) through bioassay-guided procedures.
PubMed:Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit.
PubMed:Determination of iriflophenone 3-C-β-d-glucoside from Aquilaria spp. by an indirect competitive enzyme-linked immunosorbent assay using a specific polyclonal antibody.
PubMed:Determination of genkwanin in rat plasma by liquid chromatography-tandem mass spectrometry: application to a bioavailability study.
PubMed:The small molecule genkwanine M induces single mode, mesenchymal tumor cell motility.
PubMed:Discrimination of raw and vinegar-processed Genkwa Flos using metabolomics coupled with multivariate data analysis: a discrimination study with metabolomics coupled with PCA.
PubMed:Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves.
PubMed:In vitro cytotoxic activity of novel protoflavone analogs - selectivity towards a multidrug resistant cancer cell line.
PubMed:[Constituents from the leaves of Aquilaria sinensis].
PubMed:α-glucosidase inhibitors from Brickellia cavanillesii.
PubMed:Cytotoxic fraction from Artemisia sacrorum Ledeb. against three human cancer cell lines and separation and identification of its compounds.
PubMed:Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: a structure-activity relationship study.
PubMed:Comparison of different extraction procedures for the comprehensive characterization of bioactive phenolic compounds in Rosmarinus officinalis by reversed-phase high-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight mass spectrometry.
PubMed:PREPARATIVE ISOLATION AND PURIFICATION OF FOUR FLAVONOIDS FROM DAPHNE GENKWA SIEB. ET ZUCC. BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY.
PubMed:Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice.
PubMed:New iridoid diesters of glucopyranose from Linaria canadensis (L.) Dum.
PubMed:Introduction of distillate rosemary leaves into the diet of the Murciano-Granadina goat: transfer of polyphenolic compounds to goats' milk and the plasma of suckling goat kids.
PubMed:Evaluation of estrogen receptor Beta binding of pruni cortex and its constituents.
PubMed:[Chemical constituents from flowers of Chrysanthemum indicum].
PubMed:A simple and efficient protocol for large-scale preparation of three flavonoids from the flower of Daphne genkwa by combination of macroporous resin and counter-current chromatography.
PubMed:Flavonoids from the aerial parts of Diplomorpha canescens.
PubMed:[Studies on the chemical constituents from Daphne tangutica].
PubMed:Two new coumarins from the chloroform extract of Angelica urumiensis from Iran.
PubMed:Flavonoids and phenolic compounds from Rosmarinus officinalis.
PubMed:Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells.
PubMed:Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order.
PubMed:[Chemical constituents and antitumor activity on leukemia K562 cell of Leonurus heterophyllus].
PubMed:Sesquiterpenoids from Teucrium ramosissimum.
PubMed:CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.
PubMed:[Studies on chemical constituents of Daphne genkwa].
PubMed:[Studies on chemical constituents of leaves of Aquilaria sinensis].
PubMed:Biological synthesis of 7-O-methyl Apigenin from naringenin using escherichia coli expressing two genes.
PubMed:Quantitative determination of flavonoids by column high-performance liquid chromatography with mass spectrometry and ultraviolet absorption detection in Artemisia afra and comparative studies with various species of Artemisia plants.
PubMed:Flavonoids from Daphne giraldii Nitsche.
PubMed:[Chemical constituents from herb of Gueldenstaedtia stenophylla].
PubMed:Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
PubMed:[Studies on chemical constituents from herbs of Taraxacum mongolicum].
PubMed:Laxative effect of agarwood leaves and its mechanism.
PubMed:Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
PubMed:[Studies on chemical constituents in spikes of Schizonepeta tenuifolia].
PubMed:Rosemary (Rosmarinus officinalis) diterpenes affect lipid polymorphism and fluidity in phospholipid membranes.
PubMed:Rumex induratus leaves: interesting dietary source of potential bioactive compounds.
PubMed:Prostaglandin inhibitory and antioxidant components of Cistus laurifolius, a Turkish medicinal plant.
PubMed:Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity.
PubMed:[A new dicoumarin from stem bark of Wikstroemia indica].
PubMed:[Studies on flavonoids from herb of Artemisia ordosica].
PubMed:[Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation].
PubMed:New labdane-type diterpenoids from Leonurus heterophyllus SW.
PubMed:Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli.
PubMed:[Studies on the chemical constituents in roots of Daphne odora var. atrocaulis].
PubMed:Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.
PubMed:Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae).
PubMed:Labdane diterpenes of Leonurus sibiricus.
PubMed:Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity.
PubMed:Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.).
PubMed:Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity.
PubMed:In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe.
PubMed:Subcritical water extraction of antioxidant compounds from rosemary plants.
PubMed:[Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey].
PubMed:[Comprehensive evaluation and practical confirmation on processing technology of Daphne genkwa Sieb. et Zucc].
PubMed:In vitro antiplasmodial investigation of medicinal plants from El Salvador.
PubMed:Flavonoid glycosides from Salvia moorcroftiana wall.
PubMed:Flavone aglycones in glandular hairs of Origanum x intercedens.
PubMed:[Effects of processing on toxicity and pharmacological action of flos Genkwa].
PubMed:Antimicrobial evaluation of coumarins and flavonoids from the stems of Daphne gnidium L.
PubMed:Protective effects of some flavonoids on the renal cellular membrane.
PubMed:A flavonoid 7-O-methyltransferase is expressed in barley leaves in response to pathogen attack.
PubMed:Chlorogenic acid, an antioxidant principle from the aerial parts ofArtemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical.
PubMed:[Quality of processed samples of Daphne genkwa Sieb. et Zucc].
PubMed:[HPLC analysis of the influence of processing on the contents of genkwanin in flos Genkwa].
PubMed:[HPLC analysis of mimic vinegar-processing of genkwanin].
PubMed:DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis.
PubMed:[Determination of genkwanin in flos Genkwa by HPLC].
PubMed:[Isolation and identification of a new cinnamate ester from liaoxi propolis].
PubMed:[Influence of processing on contents of genkwanin in flos Genkwa].
PubMed:Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model.
PubMed:[Quantitative determination of genkwanin in flos Genkwa by TLC-densitometry].
PubMed:[Chemical constituents of Eupolyphaga sinensis Walkre].
PubMed:Flavone glycosides from Asplenium normale.
PubMed:[Determination of hydroxygenkwanin and genkwanin in flos Genkwa before and after processing by a TLC-scanner].
PubMed:Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence.
PubMed:Chemical constituents of gentianaceae XXVIII: flavonoids of Enicostemma hyssopifolium (Willd.) Verd.
PubMed:Flavonoids from Vernonia fasciculata Michx. Isolation of genkwanin and a new flavone disaccharide, fasciculatin.
PubMed:The partial demethylation of flavones. I. Preparation of genkwanin.
 
Notes:
None found
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