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Category:antioxidants and preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to dark yellow powder (est) |
| Assay: | 97.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 226.00 to 228.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 916.00 to 917.00 °C. @ 760.00 mm Hg
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| Flash Point: | 612.00 °F. TCC ( 322.22 °C. )
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| logP (o/w): | 0.049 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: |
| | alcohol | | | water, slightly | | | water, 5581 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 36 - Wear suitable protective clothing.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants and preservatives |
| Recommendation for isoquercetin usage levels up to: | | | not for fragrance use.
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| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 22. Update in publication number(s): 23 |
| Click here to view publication 22 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | 150.00000 | 200.00000 |
| beverages(alcoholic): | 150.00000 | 200.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | 1500.00000 | 2000.00000 |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | 150.00000 | 200.00000 |
| fruit ices: | - | - |
| gelatins / puddings: | 150.00000 | 200.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | 150.00000 | 200.00000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5484006 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 3-[(2S,3R,4R,5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one |
| Chemidplus:0021637252 |
| RTECS:LK8960000 for cas# 21637-25-2 |
References:
| | 3-[(2S,3R,4R,5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5484006 |
| Pubchem (sid): | 135046247 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy- | | 3-[[(2S,3R,4R,5R)-5-[(1R)-1,2- | dihydroxyethyl]-3,4-dihydroxy-2-oxolanyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyran-4-one | | 3-[(2S,3R,4R,5R)-5-[(1R)-1,2- | dihydroxyethyl]-3,4-dihydroxyoxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one | | 2-(3,4- | dihydroxyphenyl)-3-(b-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-3-(beta-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-3-(beta-dextro-glucofuranosyl oxy)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl beta-D-glucofuranoside | | alpha- | glycosyl isoquercitrin | | 3,3',4',5,7- | pentahydroxyflavone 3-b-D-glucofuranoside | | 3,3',4',5,7- | pentahydroxyflavone 3-beta-D-glucofuranoside | | 3,3',4',5,7- | pentahydroxyflavone 3-beta-dextro-glucofuranoside | | | quercetin 3-β-D-glucoside | | iso | quercetin, enzymatically modified | | iso | quercitrin | | iso | quercitroside | | | sanmelm | | | trifoliin A | | iso | trifolin |
Articles:
| PubMed:Research on the bioactivity of isoquercetin extracted from marestail on bladder cancer EJ cell and the mechanism of its occurrence. |
| PubMed:Persimmon (Diospyros kaki L.) leaves: a review on traditional uses, phytochemistry and pharmacological properties. |
| PubMed:Neuroprotective Effect of Prenylated Arylbenzofuran and Flavonoids from Morus alba Fruits on Glutamate-Induced Oxidative Injury in HT22 Hippocampal Cells. |
| PubMed:Bioprospecting medicinal plants for antioxidant components. |
| PubMed:[Study of screening nephroprotective bioactive substances based on triple-color fluorescence probes in Carthami flos]. |
| PubMed:Identification of phenylpropanoids in fig (Ficus carica L.) leaves. |
| PubMed:[Study on chemical constituents from twig and leaf of Juniperus sabina]. |
| PubMed:Induction of hepatic apolipoprotein A-I gene expression by the isoflavones quercetin and isoquercetrin. |
| PubMed:Comparative analysis of antioxidant activity and functional components of the ethanol extract of lotus (Nelumbo nucifera) from various growing regions. |
| PubMed:Unconventional approaches to the prevention of cancer associated thrombosis. |
| PubMed:Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells. |
| PubMed:Antiplatelet Activity of Morus alba Leaves Extract, Mediated via Inhibiting Granule Secretion and Blocking the Phosphorylation of Extracellular-Signal-Regulated Kinase and Akt. |
| PubMed:Thiol isomerases in thrombus formation. |
| PubMed:Estimation of flavoniods, antimicrobial, antitumor and anticancer activity of Carissa opaca fruits. |
| PubMed:Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae). |
| PubMed:Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea. |
| PubMed:Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-кB signal pathway. |
| PubMed:First identification of α-glucosidase inhibitors from okra (Abelmoschus esculentus) seeds. |
| PubMed:Antioxidant and α-glucosidase inhibitory activities of cucurbit fruit vegetables and identification of active and major constituents from phenolic-rich extracts of Lagenaria siceraria and Sechium edule. |
| PubMed:Simultaneous HPLC quantitative analysis of active compounds in leaves of Moringa oleifera Lam. |
| PubMed:Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation. |
| PubMed:Anti-H5N1 virus flavonoids from Capparis sinaica Veill. |
| PubMed:Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses. |
| PubMed:Simultaneous Determination of Crypto-Chlorogenic Acid, Isoquercetin, and Astragalin Contents in Moringa oleifera Leaf Extracts by TLC-Densitometric Method. |
| PubMed:[Analysis of fingerprint and bioactive components of Bidens biternata by HPLC]. |
| PubMed:The environmental and human effects of ptaquiloside-induced enzootic bovine hematuria: a tumorous disease of cattle. |
| PubMed:1,25-Dihydroxyvitamin D3-glycoside of herbal origin exhibits delayed release pharmacokinetics when compared to its synthetic counterpart. |
| PubMed:Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba. |
| PubMed:Chemical composition of currant seed extracts and their protective effect on human lymphocytes DNA. |
| PubMed:Palynological origin, phenolic content, and antioxidant properties of honeybee-collected pollen from Bahia, Brazil. |
| PubMed:Flavonoid compounds identified in Alchemilla L. species collected in the north-eastern Black Sea region of Turkey. |
| PubMed:Antidiabetic activity of isoquercetin in diabetic KK -Ay mice. |
| PubMed:Synthesis and antiviral activity of substituted quercetins. |
| PubMed:Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. |
| PubMed:Chemical composition and antioxidant activities of extracts from Apocyni Veneti Folium. |
| PubMed:The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. |
| PubMed:Effect of mixed flavonoids, n-3 fatty acids, and vitamin C on oxidative stress and antioxidant capacity before and after intense cycling. |
| PubMed:Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. |
| PubMed:[Simultaneous determination of six flavonoids in Apocynum venetum by HPLC]. |
| PubMed:A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells. |
| PubMed:Comprehensive separation and identification of chemical constituents from Apocynum venetum leaves by high-performance counter-current chromatography and high performance liquid chromatography coupled with mass spectrometry. |
| PubMed:Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity. |
| PubMed:Inhibition of influenza virus replication by plant-derived isoquercetin. |
| PubMed:Solvent gradient elution for comprehensive separation of constituents with wide range of polarity in Apocynum venetum leaves by high-speed counter-current chromatography. |
| PubMed:Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. |
| PubMed:Phenylpropanoid glycosides from Heterosmilax erythrantha and their antioxidant activity. |
| PubMed:Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. |
| PubMed:Study on the interaction between 3 flavonoid compounds and alpha-amylase by fluorescence spectroscopy and enzymatic kinetics. |
| PubMed:Simultaneous determination of seven active flavonols in the flowers of Abelmoschus manihot by HPLC. |
| PubMed:Level of catechin, myricetin, quercetin and isoquercitrin in buckwheat (Fagopyrum esculentum Moench), changes of their levels during vegetation and their effect on the growth of selected weeds. |
| PubMed:Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb. |
| PubMed:Flavonoids in onion cultivars (Allium cepa L.). |
| PubMed:Calpain inhibitory flavonoids isolated from Orostachys japonicus. |
| PubMed:[Chemical constituents of flavonoids from Apocynum venetum]. |
| PubMed:In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. |
| PubMed:[Isolation and preparation of flavonoids from the leaves of Nelumbo nucifera Gaertn by preparative reversed-phase high performance liquid chromatography]. |
| PubMed:Quantitative phytochemical analyses of six hypericum species growing in slovenia. |
| PubMed:Determining the binding affinities of phenolic compounds to proteins by quenching of the intrinsic tryptophan fluorescence. |
| PubMed:Binding of selected phenolic compounds to proteins. |
| PubMed:[Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method]. |
| PubMed:Constituents of the underground parts of Glehnia littoralis. |
| PubMed:[Oxyanthraquinones and flavonoids from garland chrysanthenum]. |
| PubMed:Hepatoprotective effect of Apocynum venetum and its active constituents. |
| PubMed:Quercetin glycosides in Psidium guajava L. leaves and determination of a spasmolytic principle. |
| PubMed:Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases. |
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3D/inchi