EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

glabratic acid
4-(2,4-dihydroxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoic acid

Supplier Sponsors

Name:4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
CAS Number: 480-56-8Picture of molecule3D/inchi
FDA UNII: D0M65TKS0F
Nikkaji Web:J13.181D
Beilstein Number:2172778
MDL:MFCD00210524
XlogP3-AA:3.60 (est)
Molecular Weight:318.28198000
Formula:C16 H14 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 557.10 °C. @ 760.00 mm Hg (est)
Flash Point: 407.00 °F. TCC ( 208.30 °C. ) (est)
logP (o/w): 4.390 (est)
Soluble in:
 water, 16.08 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Lecanoric acid >97%
Odor: characteristic
Use: Lecanoric acid, a natural phenol from the herbs of Parmelia tinctorum Despr,
Carbosynth
For experimental / research use only.
Lecanoric acid
Coompo
For experimental / research use only.
Lecanoric Acid from Plants ≥96%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD > 200 mg/kg
Journal of Antibiotics. Vol. 27, Pg. 587, 1974.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for glabratic acid usage levels up to:
 not for fragrance use.
 
Recommendation for glabratic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :99613
National Institute of Allergy and Infectious Diseases:Data
4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
Chemidplus:0000480568
 
References:
 4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):99613
Pubchem (sid):135056308
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C02868
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Wikipedia2:View2
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 benzoic acid, 4-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-
4-carboxy-3-hydroxy-5-methyl phenyl 2,4-dihydroxy-6-methyl benzoate
2,4-dihydroxy-6-methyl benzoic acid 4-carboxy-3-hydroxy-5-methyl phenyl ester
4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
4-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoic acid
4-(2,4-dihydroxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoic acid
 lecanoric acid
 lecanoricacid
 

Articles:

PubMed:Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells.
PubMed:Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review.
PubMed:Lichen secondary metabolites affect growth of Physcomitrella patens by allelopathy.
PubMed:Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens.
PubMed:Lichen acids may be used as a potential drug for cancer therapy; by inhibiting mitochondrial thioredoxin reductase purified from rat lung.
PubMed:Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity.
PubMed:Protective effects of isolecanoric acid on neurodegenerative in vitro models.
PubMed:A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.
PubMed:Growth promoting effects of some lichen metabolites on probiotic bacteria.
PubMed:Qualitative and spatial metabolite profiling of lichens by a LC-MS approach combined with optimised extraction.
PubMed:[Study on the chemical constituents of two lichen plants from Meng Mountain].
PubMed:Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans.
PubMed:Antioxidant activity of some lichen metabolites.
PubMed:Characterisation of phenols and antioxidant and hypolipidaemic activities of Lethariella cladonioides.
PubMed:Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.
PubMed:The In vitro antioxidant properties of chinese highland lichens.
PubMed:Molecular structural studies of lichen substances with antimicrobial, antiproliferative, and cytotoxic effects from Parmelia subrudecta.
PubMed:In vitro antitumour activity of orsellinates.
PubMed:Lichen metabolites modulate hydrogen peroxide and nitric oxide in mouse macrophages.
PubMed:Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.
PubMed:PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica.
PubMed:Radical-scavenging activity of orsellinates.
PubMed:Metabolites from the Lichen Ochrolechia parella growing under two different heliotropic conditions.
PubMed:Cytotoxic activity of orsellinates.
PubMed:A study of the genetic variability of Rhizoplaca chrysoleuca using DNA sequences and secondary metabolic substances.
PubMed:[Studies on chemical constituents of Umbilicaria esculenta (Miyoshi) minks].
PubMed:Phenolic constituents from the lichen Parmotrema stuppeum (Nyl.) Hale and their antioxidant activity.
PubMed:Lichen biodeterioration of the Convento de la Peregrina, Sahagún, Spain.
PubMed:Destruction of lichen chemical defenses by a fungal.
PubMed:Inhibition of tumor promotion by a lecanoric acid analogue.
PubMed:Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.
PubMed:Isolation of lecanoric acid, an inhibitor of histidine decarboxylase from a fungus.
PubMed:[On the occurrence of erythrine and lecanoric acid in some Dinaria species. 51. On the lichen contents].
PubMed:Biosynthesis of lichen depsides, lecanoric acid and atranorin.
 
Notes:
from a strain of pyricularia (deuteromycetes).
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