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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellow powder (est) |
| Assay: | 92.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 499.00 to 503.00 °C. @ 760.00 mm Hg
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| Flash Point: | 525.00 °F. TCC ( 273.89 °C. )
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| logP (o/w): | 5.405 (est) |
| Shelf Life: | 6.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: |
| | alcohol | | | water, 2.727 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Carnosic acid 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Carnosic Acid >98%
Odor: characteristic Use: Carnosic acid is a natural diterpenoid compound isolated from the herb of Rosmarinus officinalis L. Carnosic acid has protection against carcinogens in animals' studies and shows the activities of
antimicrobial and antioxidant.
antimicrobial, antioxidant |
| Coompo |
| For experimental / research use only. |
| Carnosic Acid from Plants ≥98%
Odor: characteristic Use: Carnosic acid has medicinal properties, is a potent antioxidant and protects skin cells against UV-A radiation (photoprotection). Studies in animals have also found a protection against carcinogens. They found that cells treated with carnosic acid triggered antioxidant enzyme production in the cells, which in turn lowered levels of reactive oxygen and nitrogen species (cell-damaging free radicals and peroxides).
carnosic acid substantially inhibited pancreatic lipase activity with IC50 values of 12 g/mL (36 M). Carnosic acid significantly inhibited triglyceride elevation in olive oil-loaded mice at doses of 5-20 mg/kg (p.o.). Furthermore, carnosic acid (20 mg/kg/day, p.o.) reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days. |
| ExtraSynthese |
| For experimental / research use only. |
| Carnosic Acid (HPLC) ≥90%
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| Foreverest Resources |
| Carnosic Acid 10∼90%
Odor: characteristic Use: Carnosic acid (Salvin), is a natural benzenediol abietane diterpene found in rosemary and common sage. It used as an efficient and stable (high temperature durable) green food additive with non-toxic oil-soluble antioxidants. It can be added into oil and fatty food, pharmaceutical, chemical, cosmetics and feed, etc. |
| Jiangyin Healthway |
| Carnosic Acid
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| New functional food ingredients |
| Jiangyin Healthway |
| Deoxypicrosalvinic acid ( Carnosic acid)
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| Layn Natural ingredients |
| Rosemary Extract Carnosic Acid / Rosmarinic Acid / Ursolic Acid
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Carnosic Acid ≥95%
|
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Carnosic acid from Rosmarinus officinalis ≥91%, powder
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for carnosic acid usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for carnosic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Use of rosemary extracts as a food additive - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :65126 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid |
| Chemidplus:0003650097 |
References:
| | (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 65126 |
| Pubchem (sid): | 135022653 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (4aR,10aS)-5,6- | dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid | | (4aR,10aS)-5,6- | dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid | | | salvin |
Articles:
| PubMed:Carnosic acid attenuates obesity-induced glucose tolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J-ob/ob mice. |
| J-Stage:Antiangiogenic Effect of Carnosic Acid and Carnosol, Neuroprotective Compounds in Rosemary Leaves |
| PubMed:Competitive reduction of perferrylmyoglobin radicals by protein thiols and plant phenols. |
| PubMed:Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes. |
| PubMed:Carnosic acid induces apoptosis associated with mitochondrial dysfunction and Akt inactivation in HepG2 cells. |
| PubMed:Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity. |
| PubMed:Comprehensive foodomics study on the mechanisms operating at various molecular levels in cancer cells in response to individual rosemary polyphenols. |
| PubMed:Improving the sensory and oxidative stability of cooked and chill-stored lamb using dietary rosemary diterpenes. |
| PubMed:Stability of α-tocotrienol and α-tocopherol in salami-type sausages and curing brine depending on nitrite and pH. |
| PubMed:Carnosic acid inhibits the epithelial-mesenchymal transition in B16F10 melanoma cells: a possible mechanism for the inhibition of cell migration. |
| PubMed:Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. |
| PubMed:A rosemary extract rich in carnosic acid selectively modulates caecum microbiota and inhibits β-glucosidase activity, altering fiber and short chain fatty acids fecal excretion in lean and obese female rats. |
| PubMed:The mechanisms of carnosic acid attenuates tumor necrosis factor-α-mediated inflammation and insulin resistance in 3T3-L1 adipocytes. |
| PubMed:Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. |
| PubMed:A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype. |
| PubMed:Relevance of the carnosic acid/carnosol ratio for the level of rosemary diterpene transfer and for improving lamb meat antioxidant status. |
| PubMed:Shelf life of meat from lambs given essential oil-free rosemary extract containing carnosic acid plus carnosol at 200 or 400 mg kg⁻¹. |
| PubMed:Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice. |
| PubMed:Anticholinesterase activity of phenolic acids and their derivatives. |
| PubMed:Relationship between the solubility, dosage and antioxidant capacity of carnosic acid in raw and cooked ground buffalo meat patties and chicken patties. |
| PubMed:Antioxidant activity of carnosic acid and rosmarinic acid in raw and cooked ground chicken patties. |
| PubMed:Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. |
| PubMed:Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. |
| PubMed:Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. |
| PubMed:Effect of dietary carnosic acid on the fatty acid profile and flavour stability of meat from fattening lambs. |
| PubMed:Isolation of carnosic acid from rosemary extracts using semi-preparative supercritical fluid chromatography. |
| PubMed:Anti-Campylobacter activities and resistance mechanisms of natural phenolic compounds in Campylobacter. |
| PubMed:Carnosic acid attenuates lipopolysaccharide-induced liver injury in rats via fortifying cellular antioxidant defense system. |
| PubMed:Phenolic antioxidant scavenging of myosin radicals generated by hypervalent myoglobin. |
| PubMed:Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. |
| PubMed:Effects of optimized mixtures containing phenolic compounds on the oxidative stability of sausages. |
| PubMed:Effect of Rosemarinus officinalis L. on MMP-9, MCP-1 levels, and cell migration in RAW 264.7 and smooth muscle cells. |
| PubMed:Acute and 30-day oral toxicity studies of administered carnosic acid. |
| PubMed:Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts. |
| PubMed:Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC. |
| PubMed:Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid. |
| PubMed:Concentration of antioxidant polyphenols from Thymus capitatus extracts by membrane process technology. |
| PubMed:Meat texture and antioxidant status are improved when carnosic acid is included in the diet of fattening lambs. |
| PubMed:Optimization of ultrasound assisted extraction of antioxidant compounds from marjoram (Origanum majorana L.) using response surface methodology. |
| PubMed:Carnosic acid dietary supplementation at 0.12% rates slows down meat discoloration in gluteus medius of fattening lambs. |
| PubMed:Effects of heat and ultraviolet radiation on the oxidative stability of pine nut oil supplemented with carnosic acid. |
| PubMed:Rosemary and cancer prevention: preclinical perspectives. |
| PubMed:Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. |
| PubMed:Oxidative stability of fish oil supplemented with carnosic acid compared with synthetic antioxidants during long-term storage. |
| PubMed:Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from Fe-catalyzed oxidation of resveratrol. |
| PubMed:Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet. |
| PubMed:Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC/DAD/MS study. |
| PubMed:The canine sand maze: an appetitive spatial memory paradigm sensitive to age-related change in dogs. |
| PubMed:Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage. |
| PubMed:Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves. |
| PubMed:Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice. |
| PubMed:Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. |
| PubMed:Importance of extract standardization and in vitro/ex vivo assay selection for the evaluation of antioxidant activity of botanicals: a case study on three Rosmarinus officinalis L. extracts. |
| PubMed:Introduction of distillate rosemary leaves into the diet of the Murciano-Granadina goat: transfer of polyphenolic compounds to goats' milk and the plasma of suckling goat kids. |
| PubMed:Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. |
| PubMed:Flavonoids and phenolic compounds from Rosmarinus officinalis. |
| PubMed:Investigation of antioxidant and rosmarinic acid variation in the sage collection of the genebank in Gatersleben. |
| PubMed:Testing and enhancing the in vitro bioaccessibility and bioavailability of Rosmarinus officinalis extracts with a high level of antioxidant abietanes. |
| PubMed:Bactericidal activity of glutaraldehyde-like compounds from olive products. |
| PubMed:Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order. |
| PubMed:Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L. |
| PubMed:In vitro antimicrobial and antioxidant activity of commercial rosemary extract formulations. |
| PubMed:The immature stages and natural history of Veladyris pardalis (Salvin, 1869) in Eastern Ecuador (Lepidoptera: Nymphalidae: Lthomiinae). |
| PubMed:Effect of marinades on the formation of heterocyclic amines in grilled beef steaks. |
| PubMed:Antioxidant effect rosemary (Rosmarinus officinalis L.) and oregano (Origanum vulgare L.) extracts on TBARS and colour of model raw pork batters. |
| PubMed:Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia. |
| PubMed:Polyphenolic transmission to Segureno lamb meat from ewes' diet supplemented with the distillate from rosemary (Rosmarinus officinalis) leaves. |
| PubMed:[Enhancement of differentiation induction of HL-60 cells by 1,25-dihydroxyvitamin D3 in combination with carnosic acid]. |
| PubMed:Direct determination of carnosic acid in a new active packaging based on natural extract of rosemary. |
| PubMed:Enhanced carnosic acid levels in two rosemary accessions exposed to cold stress conditions. |
| PubMed:Characterization of two unknown compounds in methanol extracts of rosemary oil. |
| PubMed:Low-density lipoprotein, collagen, and thrombin models reveal that Rosemarinus officinalis L. exhibits potent antiglycative effects. |
| PubMed:Potential of rosemary (Rosemarinus officinalis L.) diterpenes in preventing lipid hydroperoxide-mediated oxidative stress in Caco-2 cells. |
| PubMed:Carnosic acid from rosemary extracts: a potential chemoprotective agent against aflatoxin B1. An in vitro study. |
| PubMed:Rosemary (Rosmarinus officinalis) diterpenes affect lipid polymorphism and fluidity in phospholipid membranes. |
| PubMed:Isolation of functional ingredients from rosemary by preparative-supercritical fluid chromatography (Prep-SFC). |
| PubMed:Liquid chromatograpic-mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material. |
| PubMed:Radioprotective-antimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by gamma-rays. |
| PubMed:Antioxidant activity of a catechol derived from abietic acid. |
| PubMed:Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. |
| PubMed:Pressurized liquid extraction-capillary electrophoresis-mass spectrometry for the analysis of polar antioxidants in rosemary extracts. |
| PubMed:Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. |
| PubMed:Relevance of carnosic acid concentrations to the selection of rosemary, Rosmarinus officinalis (L.), accessions for optimization of antioxidant yield. |
| PubMed:Potential for the use of ultrasound in the extraction of antioxidants from Rosmarinus officinalis for the food and pharmaceutical industry. |
| PubMed:Antioxidant activity of organic extracts from aqueous infusions of sage. |
| PubMed:Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity. |
| PubMed:Rapid quantitative enrichment of carnosic acid from rosemary (Rosmarinus officinalis L.) by isoelectric focused adsorptive bubble chromatography. |
| PubMed:Subcritical water extraction of antioxidant compounds from rosemary plants. |
| PubMed:Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant. |
| PubMed:Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. |
| PubMed:Apianane terpenoids from Salvia officinalis. |
| PubMed:Antioxidant mechanism of carnosic acid: structural identification of two oxidation products. |
| PubMed:Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents. |
| PubMed:Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary. |
| PubMed:Activities of antioxidants are affected by colloidal properties of oil-in-water and water-in-oil emulsions and bulk oils. |
| PubMed:Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention. |
| PubMed:An evaluation of the antioxidant and antiviral action of extracts of rosemary and Provençal herbs. |
| PubMed:Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes. |
| PubMed:Protection by albumin against the pro-oxidant actions of phenolic dietary components. |
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