trans-limonene oxide, 4959-35-7

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Name:	(1R,4S,6S)-1-methyl-4-prop-1-en-2-yl-7-oxabicyclo[4.1.0]heptane
CAS Number:	4959-35-7	3D/inchi
FDA UNII:	Search
Nikkaji Web:	J350.262G
XlogP3-AA:	2.50 (est)
Molecular Weight:	152.23672000
Formula:	C10 H16 O
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Soluble in:
	water, 137.2 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor Description:fresh citrus

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
IFRA Critical Effect:
Sensitization
IFRA Other Specification:		< 20 mmoles / liter peroxides
IFRA fragrance material specification:
	d-, l-and dl-Limonene and natural products containing substantial amounts of it, should only be used when the level of peroxides is kept to the lowest practical level, for instance by adding antioxidants at the time of production. Such products should have a peroxide value of less than 20 millimoles peroxides per liter, determined according to the FMA method, which can be downloaded from the IFRA website (see Analytical Methods).
Recommendation for trans-limonene oxide usage levels up to:
	not for fragrance use.

Recommendation for trans-limonene oxide flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

(1R,4S,6S)-1-methyl-4-prop-1-en-2-yl-7-oxabicyclo[4.1.0]heptane

References:

	(1R,4S,6S)-1-methyl-4-prop-1-en-2-yl-7-oxabicyclo[4.1.0]heptane
NIST Chemistry WebBook:	Search Inchi
Pubchem (cas):	4959-35-7
Flavornet:	4959-35-7
Pherobase:	View

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB029684
Typical G.C.
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

	aloysia triphylla oil turkey @ 0.22% Data GC Search Trop Picture
	bergamot oil @ 0.001-0.015% Data GC Search Trop Picture
	caraway seed Search Trop Picture
	carum carvi fruit oil @ 0.05-1.00% Data GC Search Trop Picture
	chenopodium ambrosioldes var. anthelminthicum oil america @ 0.09% Data GC Search Trop Picture
	citrus aurantifolia swingle oil distilled peru @ trace% Data GC Search Trop Picture
	citrus grandis peel oil @ 0.02% Data GC Search Trop Picture
	citrus limon peel oil c.p. california @ 0.007% Data GC Search Trop Picture
	citrus reticulata nova var. mandarin oil uruguay @ 0.01-0.04% Data GC Search Trop Picture
	citrus reticulata peel Search Trop Picture
	citrus sinensis var. biondo comune c.p. blond italy @ 0.019% Data GC Search Trop Picture
	citrus sinensis var. moro oil @ 0.014% Data GC Search Trop Picture
	citrus sinensis var. navelina c.p. oil blond italy @ 0.013% Data GC Search Trop Picture
	citrus sinensis var. ovale c.p. oil blond italy @ 0.010% Data GC Search Trop Picture
	citrus sinensis var. sanguinello oil italy @ 0.017% Data GC Search Trop Picture
	citrus sinensis var. tarocco oil italy @ 0.011% Data GC Search Trop Picture
	citrus sinensis var. valencia late c.p. oil blond italy @ 0.012% Data GC Search Trop Picture
	citrus sinensis var. washington navel c.p. oil blond italy @ 0.016% Data GC Search Trop Picture
	citrus unshiu peel oil @ trace% Data GC Search Trop Picture
	conyza canadensis (l.) cronq. oil @ 0.30% Data GC Search Trop Picture
	cymbopogon giganteus chiov. leaf oil @ 0.50% Data GC Search Trop Picture
	cymbopogon laniger extract @ 0.70-1.20% Data GC Search Trop Picture
	dracocephalum kotschyi Search Trop Picture
	ducrosia flabellifolia flower Search Trop Picture

Synonyms:

(E)-1,2-	epoxy-para-menth-8-ene
trans-1,2-	epoxy-para-menth-8-ene
(E)-1,2-para-	epoxymenth-8-ene
trans-	limonene
(E)-	limonene epoxide
trans-	limonene epoxide
(E)-	limonene oxide
(1R,4S,6S)-1-	methyl-4-prop-1-en-2-yl-7-oxabicyclo[4.1.0]heptane

Articles:

PubMed:Chemical Composition, Antimicrobial Activity, and Mode of Action of Essential Oils against Paenibacillus larvae, Etiological Agent of American Foulbrood on Apis mellifera.

PubMed:Chicken volatiles repel host-seeking malaria mosquitoes.

PubMed:Synthesis and structural revision of a brominated sesquiterpenoid, aldingenin C.

Notes:

Flavouring compound [Flavornet]

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