lidocaine hydrochloride, 73-78-9

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CODE154673 CODE154673
Product(s):
154673 Lidocaine Hydrochloride USP

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CODE154673 CODE154673
Product(s):
73-78-9 Lidocaine hydrochloride 98%
Lidocaine hydrochloride is the first amino amide type local anesthetic and antiarrhythmic drug, which has anti-inflammatory properties in vitro and in vivo. It was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. Lidocaine hydrochloride is used topically to relieve itching, burning and pain from skin inflammations,

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CODE154673 CODE154673
Product(s):
12-38500 LIDOCAINE HYDROCHLORIDE ANHYDROUS USP

Name:	2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
CAS Number:	73-78-9	3D/inchi
ECHA EINECS - REACH Pre-Reg:	200-803-8
FDA UNII:	EC2CNF7XFP
Beilstein Number:	3917968
MDL:	MFCD00150329
Molecular Weight:	270.80251000
Formula:	C14 H23 Cl N2 O
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:pharmaceuticals / chemical synthisis

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	350.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure:	0.000043 mmHg @ 25.00 °C. (est)
Flash Point:	331.00 °F. TCC ( 166.00 °C. ) (est)
logP (o/w):	2.359 (est)
Soluble in:
	water, 1473 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

American International Chemical, LLC.

Lidocaine Hydrochloride USP

BOC Sciences

For experimental / research use only.

Lidocaine hydrochloride 98%

Odor: characteristic

Use: Lidocaine hydrochloride is the first amino amide type local anesthetic and antiarrhythmic drug, which has anti-inflammatory properties in vitro and in vivo. It was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. Lidocaine hydrochloride is used topically to relieve itching, burning and pain from skin inflammations,

Maypro Industries

Lidocaine HCl

Penta International

LIDOCAINE HYDROCHLORIDE ANHYDROUS USP

Santa Cruz Biotechnology

For experimental / research use only.

Lidocaine Hydrochloride ≥99%

Sigma-Aldrich

For experimental / research use only.

Lidocaine Hydrochloride

European Pharmacopoeia (EP) Reference Standard

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-child TDLo 60 mg/kg/1H BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 51, 1986. intravenous-dog LDLo 65700 ug/kg Journal de Pharmacologie. Vol. 2, Pg. 240, 1971. parenteral-frog LD50 159 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 289, Pg. 278, 1987. intravenous-guinea pig LD50 24500 ug/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. intravenous-man TDLo 7143 ug/kg CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP Chest. Vol. 61, Pg. 682, 1972. intravenous-man TDLo 9 mg/kg/4H-C CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION Drug Intelligence and Clinical Pharmacy. Vol. 19, Pg. 669, 1985. intramuscular-mouse LD50 177 mg/kg Drug Development Research. Vol. 21, Pg. 277, 1990. intraperitoneal-mouse LD50 63 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985. intravenous-mouse LD50 15 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 48T, 1962. oral-mouse LD50 220 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. intratracheal-rabbit LD50 28 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. intravenous-rabbit LD50 25600 ug/kg Drugs in Japan Vol. 6, Pg. 879, 1982. intraperitoneal-rat LD50 122 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 224, 1954. intravenous-rat LD50 21 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.
Dermal Toxicity:
subcutaneous-mouse LD50 163 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 103, Pg. 353, 1960. subcutaneous-rat LD50 570 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
pharmaceuticals / chemical synthisis
Recommendation for lidocaine hydrochloride usage levels up to:
	not for fragrance use.

Recommendation for lidocaine hydrochloride flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

ClinicalTrials.gov:search

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):73-78-9

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :6314

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride

Chemidplus:0000073789

RTECS:AN7700000 for cas# 73-78-9

References:

	2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	6314
Pubchem (sid):	134972951

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEMBL:	View
KEGG (GenomeNet):	D02086
HMDB (The Human Metabolome Database):	Search
MedlinePlusSupp:	View
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, chloride, hydrogen salt (1:1)
	acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
	acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride
2',6'-	acetoxylidide, 2-(diethylamino)-, hydrochloride
2',6'-	acetoxylidide, 2-(diethylamino)-, monohydrochloride
	anestacon hydrochloride
a-	diethylamino-2,6-acetoxylidine hydrochloride
2-	diethylamino-2',6'-acetoxylidide hydrochloride
(	diethylamino)-2',6'-acetoxylidide monohydrochloride
2-(	diethylamino)-n-(2,6-dimethylphenyl)-acetamide hydrochloride
2-(	diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
2-(	diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride
2-(	diethylamino)-N-(2,6-dimethylphenyl)acetamide, hydrochloride (1:1)
2-(	diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
2-(	diethylamino)-N-(2,6-dimethylphenyl)acetamidhydrochlorid
N-(	diethylaminoacetyl)-2,6-dimethylaniline hydrochloride
N-(2,6-	dimethylphenyl)-N(2),N(2)-diethylglycinamide hydrochloride
N-(2,6-	dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride
	duncaine hydrochloride
	gravocain hydrochloride
	isicaine hydrochloride
	leostesin hydrochloride
	lidocain hydrochloride
	lidocaine HCl
	lidothesin hydrochloride
	lignocaine hydrochloride
	linocaine hydrochloride
	metaclopramide hydrochloride
	rucaina hydrochloride
	xilina hydrochloride
	xycaine hydrochloride
	xylestesin hydrochloride
	xylocaine hydrochloride
	xylocaine MPF
	xylocitin hydrochloride
	xylotox hydrochloride

Articles:

PubMed:Study on patients who underwent suspected diagnosis of allergy to amide-type local anesthetic agents by the leukocyte migration test.

PubMed:Efficacy of articaine formulations: quantitative reviews.

PubMed:Evaluation of middle and distal esophageal diverticuli with transnasal esophagoscopy.

PubMed:Bi-hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats.

PubMed:Local and regional anesthesia in ruminants and swine.

PubMed:Factors affecting the voluntary intake of food by sheep. 5. The inhibitory effect of hypertonicity in the rumen.

PubMed:Techniques of local analgesia in ruminants and swine.

PubMed:Stability of sterile aqueous lidocaine hydrochloride and epinephrine injections submitted by U.S. hospitals.

PubMed:Evaluation of preparations of patent blue (Alphazurine 2G) dye for parenteral use.

Notes:

a local anesthetic and cardiac depressant used as an antiarrhythmia agent. its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

lidocaine hydrochloride acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)

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Articles:

lidocaine hydrochloride
acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)