EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

lactose monohydrate
D-glucose, 4-O-beta-D-galactopyranosyl-, monohydrate

Supplier Sponsors

Name:(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
CAS Number: 64044-51-5Picture of molecule3D/inchi
FDA UNII: EWQ57Q8I5X
Beilstein Number:3768231
MDL:MFCD00166994
Molecular Weight:360.31368000
Formula:C12 H24 O12
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 667.90 °C. @ 760.00 mm Hg (est)
Flash Point: 676.00 °F. TCC ( 357.80 °C. ) (est)
logP (o/w): -3.409 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
D-Lactose monohydrate
Carbosynth
For experimental / research use only.
D-Lactose monohydrate
EMD Millipore
For experimental / research use only.
Lactose, Monohydrate
Glentham Life Sciences
D(+)-Lactose monohydrate
Indis NV
For experimental / research use only.
Lactose Monohydrate
Penta International
LACTOSE MONOHYDRATE FOOD GRADE
Penta International
LACTOSE MONOHYDRATE NF GRADE
Santa Cruz Biotechnology
For experimental / research use only.
D-Lactose Monohydrate ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
D-Lactose monohydrate BioUltra, ≥99.5% (HPLC)
Universal Preserv-A-Chem Inc.
LACTOSE MONOHYDRATE NF POWDER #312 200 MESH
Odor: characteristic
Use: Is used in direct compression of tablets (tablet binder).
Universal Preserv-A-Chem Inc.
LACTOSE MONOHYDRATE NF POWDER #315
Universal Preserv-A-Chem Inc.
LACTOSE NF MONOHYDRATE #313
Odor: characteristic
Use: Is used in direct compression of tablets (tablet binder).
Universal Preserv-A-Chem Inc.
LACTOSE NF MONOHYDRATE POWDER REAGENT
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for lactose monohydrate usage levels up to:
 not for fragrance use.
 
Recommendation for lactose monohydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62223
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
Chemidplus:0064044515
 
References:
 (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):62223
Pubchem (sid):135019847
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
D-glucose, 4-O-beta-D-galactopyranosyl-, monohydrate
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
D-lactose monohydrate
 lactose, monohydrate
 

Articles:

PubMed:Defining the Critical Material Attributes of Lactose Monohydrate in Carrier Based Dry Powder Inhaler Formulations Using Artificial Neural Networks.
PubMed:The stability of sugar solutions: A novel study of the epimerisation kinetics of lactose in water.
PubMed:Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs.
PubMed:Chemometrics applied to quantitative analysis of ternary mixtures by terahertz spectroscopy.
PubMed:Dry powders for oral inhalation free of lactose carrier particles.
PubMed:Impact of oral meloxicam administered alone or in combination with gabapentin on experimentally induced lameness in beef calves.
PubMed:Controlled-release cellulose esters matrices for water-soluble diclofenac sodium: compression and dissolution studies.
PubMed:Functionality of chitin as a direct compression excipient: an acetaminophen comparative study.
PubMed:Preparation, characterization and pulmonary pharmacokinetics of xyloglucan microspheres as dry powder inhalation.
PubMed:Taste-masked and affordable donepezil hydrochloride orally disintegrating tablet as promising solution for non-compliance in Alzheimer's disease patients.
PubMed:"Rolling" phenomenon in twin screw granulation with controlled-release excipients.
PubMed:Effects and detection of raw material variability on the performance of near-infrared calibration models for pharmaceutical products.
PubMed:Comparative evaluation of single and bilayered lamotrigine floating tablets.
PubMed:Hot-melt granulation in a twin screw extruder: effects of processing on formulations with caffeine and Ibuprofen.
PubMed:Influence of filler selection on twin screw foam granulation.
PubMed:The tableting properties of melibiose monohydrate.
PubMed:Spectroscopy of polycrystalline materials using thinned-substrate planar Goubau line at cryogenic temperatures.
PubMed:Thermal behaviour of procaine and benzocaine Part II: compatibility study with some pharmaceutical excipients used in solid dosage forms.
PubMed:[Simultaneous quantitative determination of multicomponents in tablets based on terahertz time-domain spectroscopy].
PubMed:Direct compression of cellulose and lignin isolated by a new catalytic treatment.
PubMed:Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets.
PubMed:Evaluation of some compression aids in tableting of roller compacted swellable core drug layer.
PubMed:Design expert supported mathematical optimization and predictability study of buccoadhesive pharmaceutical wafers of Loratadine.
PubMed:Controlled release of cyclosporine A self-nanoemulsifying systems from osmotic pump tablets: near zero-order release and pharmacokinetics in dogs.
PubMed:Thermodynamic study of binary system Propafenone Hydrocloride with Metoprolol Tartrate: solid-liquid equilibrium and compatibility with α-lactose monohydrate and corn starch.
PubMed:The CULTEX RFS: a comprehensive technical approach for the in vitro exposure of airway epithelial cells to the particulate matter at the air-liquid interface.
PubMed:Production and characterization of pellets using Avicel CL611 as spheronization aid.
PubMed:Zinc supplementation in pre-diabetes: study protocol for a randomized controlled trial.
PubMed:Monitoring blending of pharmaceutical powders with multipoint NIR spectroscopy.
PubMed:Effect of experimental design on the prediction performance of calibration models based on near-infrared spectroscopy for pharmaceutical applications.
PubMed:Dissolution process analysis using model-free Noyes-Whitney integral equation.
PubMed:Time-resolved near-infrared spectroscopic study of the dissolution of crystalline lactose.
PubMed:[A comparative analysis of the influence of different types of Carbopol on the release rate of lithium-carbonate from matrix tablets].
PubMed:Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study.
PubMed:Continuous twin screw granulation: influence of process variables on granule and tablet quality.
PubMed:Development of a fluid bed granulation design space using critical quality attribute weighted tolerance intervals.
PubMed:The effect of engineered mannitol-lactose mixture on dry powder inhaler performance.
PubMed:Influence of primary crystallisation conditions on the mechanical and interfacial properties of micronised budesonide for dry powder inhalation.
PubMed:Influence of peak inspiratory flow rates and pressure drops on inhalation performance of dry powder inhalers.
PubMed:An experimental evaluation of an effective medium based compaction equation.
PubMed:Hiding a realistic object using a broadband terahertz invisibility cloak.
PubMed:Characterization of critical physical and mechanical properties of freeze-dried grape powder for development of a clinical patient delivery system.
PubMed:Synthesis of galacto-oligosaccharides by β-galactosidase from Aspergillus oryzae using partially dissolved and supersaturated solution of lactose.
PubMed:To evaluate the effect of various magnesium stearate polymorphs using powder rheology and thermal analysis.
PubMed:Stress relaxation study of fillers for directly compressed tablets.
PubMed:Effect of physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach toward understanding high-shear wet granulation process, part 3: effect of binder rheological properties.
PubMed:Characterization of oral disintegrating film containing donepezil for Alzheimer disease.
PubMed:Physico-chemical aspects of lactose for inhalation.
PubMed:Hybridization induced transparency in composites of metamaterials and atomic media.
PubMed:Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery.
PubMed:Influence of the lactose grade within dry powder formulations of fluticasone propionate and terbutaline sulphate.
PubMed:Poloxamer thermogel systems as medium for crystallization.
PubMed:The measurement of the β/α anomer composition within amorphous lactose prepared by spray and freeze drying using a simple (1)H-NMR method.
PubMed:Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus.
PubMed:Acoustic assessment of mean grain size in pharmaceutical compacts.
PubMed:Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms.
PubMed:The 'stage-by-stage' deposition of drugs from commercial single-active and combination dry powder inhaler formulations.
PubMed:Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach.
PubMed:Study of radial die-wall pressure changes during pharmaceutical powder compaction.
PubMed:Near-infrared chemical imaging slope as a new method to study tablet compaction and tablet relaxation.
PubMed:Antisolvent crystallization of pharmaceutical excipients from aqueous solutions and the use of preferred orientation in phase identification by powder X-ray diffraction.
PubMed:Ultrasound transmission measurements for tensile strength evaluation of tablets.
PubMed:Complex dielectric properties of microcrystalline cellulose, anhydrous lactose, and α-lactose monohydrate powders using a microwave-based open-reflection resonator sensor.
PubMed:Theoretical and experimental investigations into the delamination tendencies of bilayer tablets.
PubMed:The impact of material attributes and process parameters on the micronisation of lactose monohydrate.
PubMed:Improved aerosolization performance of salbutamol sulfate formulated with lactose crystallized from binary mixtures of ethanol-acetone.
PubMed:The production of 'aerodynamically equivalent' drug and excipient inhalable powders using a novel fractionation technique.
PubMed:Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets.
PubMed:The influence of thermal history on the physical behavior of poly(ethylene glycol) (PEG).
PubMed:Monitoring fluidized bed drying of pharmaceutical granules.
PubMed:Photoacoustic spectroscopy using coherent synchrotron radiation: application to α-lactose monohydrate.
PubMed:In-line ultrasound measurement system for detecting tablet integrity.
PubMed:Elucidation of the internal physical and chemical microstructure of pharmaceutical granules using X-ray micro-computed tomography, Raman microscopy and infrared spectroscopy.
PubMed:Low powder mass filling of dry powder inhalation formulations.
PubMed:Inhalation performance of physically mixed dry powders evaluated with a simple simulator for human inspiratory flow patterns.
PubMed:The in-situ solid-state NMR spectroscopy investigation of alcoholic lactose suspensions.
PubMed:Amorphization of sugar hydrates upon milling.
PubMed:Determination of low levels of amorphous content in inhalation grade lactose by moisture sorption isotherms.
PubMed:Rapid formulation screening with a Multipart Microscale Fluid bed Powder processor.
PubMed:Application of crustacean chitin as a co-diluent in direct compression of tablets.
PubMed:Dry powder aerosols generated by standardized entrainment tubes from drug blends with lactose monohydrate: 2. Ipratropium bromide monohydrate and fluticasone propionate.
PubMed:Melt granulation of pharmaceutical powders: a comparison of high-shear mixer and fluidised bed processes.
PubMed:Dry powder aerosols generated by standardized entrainment tubes from drug blends with lactose monohydrate: 1. Albuterol sulfate and disodium cromoglycate.
PubMed:The effect of particle size on the dehydration/rehydration behaviour of lactose.
PubMed:[Qualitative and quantitative analyses of some saccharides by THz-TDS].
PubMed:Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products.
PubMed:Colorful drying.
PubMed:Influence of fines on the surface energy heterogeneity of lactose for pulmonary drug delivery.
PubMed:Influence of amorphous content on compaction behaviour of anhydrous alpha-lactose.
PubMed:Dual-frequency imaging using an electrically tunable terahertz quantum cascade laser.
PubMed:Influence of excipients in comilling on mitigating milling-induced amorphization or structural disorder of crystalline pharmaceutical actives.
PubMed:Quantitative X-ray diffraction determination of alpha-lactose monohydrate and beta-lactose in chocolate.
PubMed:Wet granulation in a twin-screw extruder: implications of screw design.
PubMed:Production of lactosucrose from sucrose and lactose by a levansucrase from Zymomonas mobilis.
PubMed:Mechanical properties of excipients do not affect polymer matrix formation.
PubMed:Effect of chilling on the motility and acrosomal integrity of rat sperm in the presence of various extenders.
PubMed:Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating.
PubMed:Granule size distribution of tablets.
PubMed:A structural investigation into the compaction behavior of pharmaceutical composites using powder X-ray diffraction and total scattering analysis.
PubMed:Multivariate analysis of relationships between material properties, process parameters and tablet tensile strength for alpha-lactose monohydrates.
PubMed:A combined modelling and experimental study of the surface energetics of alpha-lactose monohydrate.
PubMed:Understanding the effect of lactose particle size on the properties of DPI formulations using experimental design.
PubMed:Distribution of ethenzamide and other ingredients on granule surfaces studied by Raman microspectroscopy and mapping.
PubMed:Non-destructive determination of anisotropic mechanical properties of pharmaceutical solid dosage forms.
PubMed:Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods.
PubMed:Effective modification of particle surface properties using ultrasonic water mist.
PubMed:The rheological properties of modified microcrystalline cellulose containing high levels of model drugs.
PubMed:Evaluation of the composition of the binder bridges in matrix granules prepared with a small-scale high-shear granulator.
PubMed:Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation.
PubMed:Simulation of roller compaction with subsequent tableting and characterization of lactose and microcrystalline cellulose.
PubMed:Comparison of two twin-screw extruders for continuous granulation.
PubMed:A near-infrared spectroscopic investigation of relative density and crushing strength in four-component compacts.
PubMed:Influence of ageing, grinding and preheating on the thermal behaviour of alpha-lactose monohydrate.
PubMed:The surface characterisation and comparison of two potential sub-micron, sugar bulking excipients for use in low-dose, suspension formulations in metered dose inhalers.
PubMed:Measuring the distribution of density and tabletting force in pharmaceutical tablets by chemical imaging.
PubMed:Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients.
PubMed:Moisture sorption, compressibility and caking of lactose polymorphs.
PubMed:Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc.
PubMed:Cellactose a co-processed excipient: a comparison study.
PubMed:Differences in characteristics of pellets prepared by different pelletization methods.
PubMed:A novel method for estimating solid fraction of roller-compacted ribbons.
PubMed:Influence of loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator.
PubMed:A study of the properties of tablets from coprocessed dry binders composed of alpha-lactose monohydrate and different types of cellulose.
PubMed:Determination of figures of merit for near-infrared and Raman spectrometry by net analyte signal analysis for a 4-component solid dosage system.
PubMed:Influence of loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator.
PubMed:Studies on the influence of uniformity of particle size of powder, tapping and sample replacement for diffusion reflectance quantitative NIR spectrometric analysis.
PubMed:Characterization of pharmaceutical powder blends by NIR chemical imaging.
PubMed:The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations.
PubMed:The effect of relative humidity on electrostatic charge decay of drugs and excipient used in dry powder inhaler formulation.
PubMed:Compaction of lactose drug mixtures: quantification of the extent of incompatibility by FT-Raman spectroscopy.
PubMed:An X-ray diffraction analysis of crystallised whey and whey-permeate powders.
PubMed:Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression.
PubMed:Promising ternary dry powder inhaler formulations of cromolyn sodium: formulation and in vitro-in vivo evaluation.
PubMed:Uniformity of poorly miscible powders determined by near infrared spectroscopy.
PubMed:Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients.
PubMed:Enhancement of the dissolution of indomethacin in interactive mixtures using added fine lactose.
PubMed:Evaluation of tablet formation of different lactoses by 3D modeling and fractal analysis.
PubMed:Critical assessment of inverse gas chromatography as means of assessing surface free energy and acid-base interaction of pharmaceutical powders.
PubMed:Stress relaxation test for the characterization of the viscoelasticity of pellets.
PubMed:Effects of compression on the interaction between 1,4-dihydropyridine compounds and lactose monohydrate (II): differences in powder properties of 1,4-dihydropyridine compounds.
PubMed:The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance.
PubMed:Insensitivity of compaction properties of brittle granules to size enlargement by roller compaction.
PubMed:Influence of metronidazole particle properties on granules prepared in a high-shear mixer-granulator.
PubMed:The effects of high shear blending on alpha-lactose monohydrate.
PubMed:Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems.
PubMed:Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial.
PubMed:Nifedipine capsules may provide a viable alternative to oral powders for paediatric patients.
PubMed:Determination of amorphous content in the pharmaceutical process environment.
PubMed:Influence of realistic inspiratory flow profiles on fine particle fractions of dry powder aerosol formulations.
PubMed:Triboelectrification of pharmaceutical powders by particle impact.
PubMed:Continued investigation into the influence of loaded dose on the performance of dry powder inhalers: surface smoothing effects.
PubMed:Humidity-induced changes of the aerodynamic properties of dry powder aerosol formulations containing different carriers.
PubMed:Factorial designed experiment to study the effects of excipients on the mechanical properties of pellets.
PubMed:The effect of poloxamer viscosity on liquid-filling of solid dispersions in hard gelatin capsules.
PubMed:Electrostatic characterisation of inhaled powders: effect of contact surface and relative humidity.
PubMed:Prediction of granule physical property by a novel compression energy of wet powder.
PubMed:The effect of carrier surface treatment on drug particle detachment from crystalline carriers in adhesive mixtures for inhalation.
PubMed:The nitrogen adsorption isotherm of alpha-lactose monohydrate.
PubMed:Influence of water-cellulose binding energy on stability of acetylsalicylic acid.
PubMed:Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel.
PubMed:The Gurnham equation in characterizing the compressibility of pharmaceutical materials.
PubMed:The influence of drug-excipient and drug-polymer interactions on butt adhesive strength of ranitidine hydrochloride film-coated tablets.
PubMed:[A study of the properties of tablets from mixtures of two size degrees of alpha-lactose monohydrate and microcrystalline cellulose].
PubMed:Novel temperature controlled surface dissolution of excipient particles for carrier based dry powder inhaler formulations.
PubMed:Assessing the re-crystallization behaviour of amorphous lactose using the RH-perfusion cell.
PubMed:Determination of the surface free energy of crystalline and amorphous lactose by atomic force microscopy adhesion measurement.
PubMed:Effect of milling and sieving on functionality of dry powder inhalation products.
PubMed:Excipient selection can significantly affect solid-state phase transformation in formulation during wet granulation.
PubMed:The protective effect of lactose on lyophilization of CNK-20402.
PubMed:Comparative study of erythritol and lactose monohydrate as carriers for inhalation: atomic force microscopy and in vitro correlation.
PubMed:Tablets with high lactose content: effects of some binders and disintegrants on their properties.
PubMed:Role of cellulose ether polymers on ibuprofen release from matrix tablets.
PubMed:Effect of milling and compression on the solid-state Maillard reaction.
PubMed:Agglomerate formation and growth mechanisms during melt agglomeration in a rotary processor.
PubMed:Effect of a melt agglomeration process on agglomerates containing solid dispersions.
PubMed:Differences between eccentric and rotary tablet machines in the evaluation of powder densification behaviour.
PubMed:[A study of the properties of compacts from a mixed dry binder on the base of alpha-lactose monohydrate and microcrystalline cellulose].
PubMed:Comparison of the granulation behavior of three different excipients in a laboratory fluidized bed granulator using statistical methods.
PubMed:Highly loaded interactive mixtures for dry powder inhalers: prediction of the adhesion capacity using surface energy and solubility parameters.
PubMed:Measurement of lactose crystallinity using Raman spectroscopy.
PubMed:Effect of compression on interaction between 1,4-dihydropyridine compounds and lactose monohydrate.
PubMed:The effect of water to ethanol feed ratio on physical properties and aerosolization behavior of spray dried cromolyn sodium particles.
PubMed:Structure determination of the stable anhydrous phase of alpha-lactose from X-ray powder diffraction.
PubMed:A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates.
PubMed:The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer.
PubMed:Use of roughness maps in visualisation of surfaces.
PubMed:Development of an enteric-coated pellet formulation of F4 fimbriae for oral vaccination of suckling piglets against enterotoxigenic Escherichia coli infections.
PubMed:Crystallization and X-ray diffraction of spray-dried and freeze-dried amorphous lactose.
PubMed:Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders.
PubMed:Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution.
PubMed:Calcium sulphate dihydrate: an useful excipient for tablets containing labile actives.
PubMed:The cohesive-adhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy.
PubMed:Investigations into the use of pregelatinised starch to develop powder-filled hard capsules.
PubMed:Approaches to determine the enthalpy of crystallisation, and amorphous content, of lactose from isothermal calorimetric data.
PubMed:Aerosolisation of beclomethasone dipropionate using spray dried lactose/polyethylene glycol carriers.
PubMed:Compaction of crystallographic forms of pharmaceutical granular lactoses. II. Compacts mechanical properties.
PubMed:Compaction of crystallographic forms of pharmaceutical granular lactoses. I. Compressibility.
PubMed:Abrasive water jet cutting as a new procedure for cutting cancellous bone--in vitro testing in comparison with the oscillating saw.
PubMed:Role of excipients in hydrate formation kinetics of theophylline in wet masses studied by near-infrared spectroscopy.
PubMed:Comparison of torque measurements and near-infrared spectroscopy in characterization of a wet granulation process.
PubMed:Ab initio structure determination of the hygroscopic anhydrous form of alpha-lactose by powder X-ray diffraction.
PubMed:Quantifying low amorphous or crystalline amounts of alpha-lactose-monohydrate using X-ray powder diffraction, near-infrared spectroscopy, and differential scanning calorimetry.
PubMed:Single-step granulation/tabletting of different grades of lactose: a comparison with high shear granulation and compression.
PubMed:Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets.
PubMed:The 3D model: explaining densification and deformation mechanisms by using 3D parameter plots.
PubMed:Functionality testing of inhalation grade lactose.
PubMed:Endotoxin testing in inhalation grade lactose-a useful quality parameter?
PubMed:The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers.
PubMed:Melt pelletization with polyethylene glycol in a rotary processor.
PubMed:Twin screw granulation as a simple and efficient tool for continuous wet granulation.
PubMed:Energy-based analysis of milling alpha-lactose monohydrate.
PubMed:Characterization and taste-masking evaluation of acetaminophen granules: comparison between different preparation methods in a high-shear mixer.
PubMed:Optimization of the pelletization process in a fluid-bed rotor granulator using experimental design.
PubMed:Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets.
PubMed:Cryopreservation of spermatozoa from closed colonies, and inbred, spontaneous mutant, and transgenic strains of rats.
PubMed:Alternative sugars as potential carriers for dry powder inhalations.
PubMed:Visualization of the crystallization of lactose from the amorphous state.
PubMed:Moisture-induced surface crystallization of spray-dried amorphous lactose particles studied by atomic force microscopy.
PubMed:A novel technique for imaging film coating defects in the film-core interface and surface of coated tablets.
PubMed:The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer.
PubMed:Development of agglomerated directly compressible diluent consisting of brittle and ductile materials.
PubMed:The influence of carrier and drug morphology on drug delivery from dry powder formulations.
PubMed:The relationship between granule growth mechanism, amount of liquid binder added and properties of the wet powder mass determined using a split bed shear tester.
PubMed:Formulation design of carbamazepine fast-release tablets prepared by melt granulation technique.
PubMed:Quantitative determination of crystallinity of alpha-lactose monohydrate by Near Infrared Spectroscopy (NIRS).
PubMed:Influence of inverse gas chromatography measurement conditions on surface energy parameters of lactose monohydrate.
PubMed:Effects of excipients on hydrate formation in wet masses containing theophylline.
PubMed:Determining the compression behaviour of pharmaceutical powders from the force-distance compression profile.
PubMed:Further investigations into the use of high sensitivity differential scanning calorimetry as a means of predicting drug-excipient interactions.
PubMed:Influence of physico-chemical carrier properties on the in vitro aerosol deposition from interactive mixtures.
PubMed:The in vitro dissolution of theophylline from different types of hard shell capsules.
PubMed:Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers.
PubMed:Predicting the quality of powders for inhalation from surface energy and area.
PubMed:Wax beads as cushioning agents during the compression of coated diltiazem pellets.
PubMed:Effects of ethanol to water ratio in feed solution on the crystallinity of spray-dried lactose.
PubMed:The evaluation of the rheological properties of lactose/microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by extrusion/spheronization.
PubMed:The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations.
PubMed:Dissolution kinetics of single crystals of alpha-lactose monohydrate.
PubMed:Lactose modifications enhance its drug performance in the novel multiple dose Taifun DPI.
PubMed:Effects of droplet size and type of binder on the agglomerate growth mechanisms by melt agglomeration in a fluidised bed.
PubMed:Delivery of formoterol from a novel multi-dose inhaler Airmax.
PubMed:Investigation of excipient type and level on drug release from controlled release tablets containing HPMC.
PubMed:Clickhaler dry powder inhaler: focussed in vitro proof of principle evaluation of a new chemical entity for asthma.
PubMed:Continuous twin screw extrusion for the wet granulation of lactose.
PubMed:Dry powder inhaler: influence of humidity on topology and adhesion studied by AFM.
PubMed:Determination of indomethacin crystallinity in the presence of excipients using diffuse reflectance near-infrared spectroscopy.
PubMed:Lactose as a carrier in dry powder formulations: the influence of surface characteristics on drug delivery.
PubMed:Cold extrusion as a continuous single-step granulation and tabletting process.
PubMed:Melt agglomeration with polyethylene glycol beads at a low impeller speed in a high shear mixer.
PubMed:Generation of live rat offspring by intrauterine insemination with epididymal spermatozoa cryopreserved at -196 degrees C.
PubMed:Quantifying electrostatic interactions in pharmaceutical solid systems.
PubMed:The determination of fracture mechanics properties of pharmaceutical materials in mode III loading using an anti-clastic plate bending method.
PubMed:Alpha-lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers.
PubMed:The bulk crystallization of alpha-lactose monohydrate from aqueous solution.
PubMed:Quantifying amorphous content of lactose using parallel beam X-ray powder diffraction and whole pattern fitting.
PubMed:The influence of excipients on the stability of the moisture sensitive drugs aspirin and niacinamide: comparison of tablets containing lactose monohydrate with tablets containing anhydrous lactose.
PubMed:Characterisation and disintegration properties of irradiated starch.
PubMed:The use of inverse phase gas chromatography to study the change of surface energy of amorphous lactose as a function of relative humidity and the processes of collapse and crystallisation.
PubMed:Characterization of wet massing behavior of silicified microcrystalline cellulose and alpha-lactose monohydrate using near-infrared spectroscopy.
PubMed:Drug-fatty acid salt with wax-like properties employed as binder in melt granulation.
PubMed:The effects of carrier size and morphology on the dispersion of salbutamol sulphate after aerosolization at different flow rates.
PubMed:Crystallization of lactose from carbopol gels.
PubMed:High-resolution solid state 13C nuclear magnetic resonance spectra of 3,4-methylenedioxyamphetamine hydrochloride and related compounds and their mixtures with lactose.
PubMed:Stability study of hard gelatin capsules containing retinoic acid.
PubMed:The influence of crystallization conditions on the morphology of lactose intended for use as a carrier for dry powder aerosols.
PubMed:The influence of carrier morphology on drug delivery by dry powder inhalers.
PubMed:Direct pelletization in a rotary processor controlled by torque measurements. I. Influence of process variables.
PubMed:Partial solubility parameters of lactose, mannitol and saccharose using the modified extended Hansen method and evaporation light scattering detection.
PubMed:Pulmonary deposition of lactose carriers used in inhalation powders.
PubMed:Influence of drying temperature and granulation liquid viscosity on the inter- and intragranular drug migration in tray-dried granules and compacts.
PubMed:Influence of chopper and mixer speeds and microwave power level during the high-shear granulation process on the final granule characteristics.
PubMed:Growth mechanisms in melt agglomeration with a low viscosity binder.
PubMed:Compaction properties of composite particles consisting of lactose with sodium alginate prepared by spray-drying.
PubMed:Electrostatic charging during a melt agglomeration process.
PubMed:The application of multiple linear regression to the measurement of the median particle size of drugs and pharmaceutical excipients by near-infrared spectroscopy.
PubMed:Near-infrared mass median particle size determination of lactose monohydrate, evaluating several chemometric approaches.
PubMed:Investigations into the reduction of powder adhesion to stainless steel surfaces by surface modification to aid capsule filling.
PubMed:The use of energy indices in estimating powder compaction functionality of mixtures in pharmaceutical tableting.
PubMed:Supercritical fluid processing of materials from aqueous solutions: the application of SEDS to lactose as a model substance.
PubMed:The use of particle characteristics to elucidate mix homogeneity in binary powder blends.
PubMed:Crystallization and X-ray diffraction of crystals formed in water-plasticized amorphous lactose.
PubMed:Protein deposition from dry powder inhalers: fine particle multiplets as performance modifiers.
PubMed:Optimization of sustained-release tablet formulations: a four-component mixture experiment.
PubMed:The development of a cascade impactor simulator based on adhesion force measurements to aid the development of dry powder inhalations.
PubMed:Influence of Relative Humidity of Storage Air on the Adhesion and Autoadhesion of Micronized Particles to Particulate and Compacted Powder Surfaces
PubMed:Modeling the crystal morphology of alpha-lactose monohydrate.
PubMed:Development of a flow microcalorimetry method for the assessment of surface properties of powders.
PubMed:[Determination of partial solubility parameters of lactoses and its application to solubility evaluation].
PubMed:Correlation of extrusion forces, raw materials and sphere characteristics.
PubMed:Acoustic emission during the deformation of alpha-lactose monohydrate and anhydrous alpha-lactose monocrystals.
PubMed:Influence of tabletting speed on compactibility and compressibility of two direct compressible powders under high speed compression.
PubMed:Percolation theory and compactibility of binary powder systems.
PubMed:NTP Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CAS No. 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PubMed:Optimization of a formulation for direct compression using a simplex lattice design.
PubMed:Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline alpha-lactose monohydrate.
PubMed:Oral lactose tolerance test in foals: technique and normal values.
PubMed:Breath hydrogen test for lactose absorption capacity: importance of timing of hydrogen excretion and of high fasting hydrogen concentration.
PubMed:Increased binding capacity and flowability of alpha-lactose monohydrate after dehydration.
PubMed:A comparison of the effects of lactose and of two chemically modified waxy maize starches on mineral metabolism in the rat.
PubMed:Radiation degradation of crystalline D-fructose and alpha-lactose monohydrate.
 
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