EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

bismuth subsalicylate
2-hydroxy-4H-1,3,2-benzodioxabismin-4-one

Supplier Sponsors

Name:1,3,2?2-benzodioxabismin-4-one;hydrate
CAS Number: 14882-18-9Picture of molecule3D/inchi
Other(deleted CASRN):55200-42-5
ECHA EINECS - REACH Pre-Reg:238-953-1
FDA UNII: 62TEY51RR1
MDL:MFCD00085368
Molecular Weight:362.09405000
Formula:C7 H5 Bi O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 43.97 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American Elements
Bismuth Subsalicylate 99%
Odor: characteristic
Use: Bismuth Subsalicylate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Bismuth Subsalicylate
Odor: characterisitc
Use: Used as active ingredient for liquid and tablet antacids, and antiemetics.
BOC Sciences
For experimental / research use only.
Bismuth Subsalicylate >98%
Odor: characteristic
Use: Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
George Uhe Company
BISMUTH SUBSALICYLATE POWDER USP
Penta International
BISMUTH SUBSALICYLATE USP POWDER
Sigma-Aldrich: Aldrich
For experimental / research use only.
Bismuth(III) subsalicylate 99.9% trace metals basis
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-man LDLo 60 mg/kg/26W-I
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
American Journal of Clinical Pathology. Vol. 14, Pg. 392, 1944.

intramuscular-man TDLo 17 mg/kg/5W-I
GASTROINTESTINAL: OTHER CHANGES
American Journal of Syphilis, Gonorrhea and Venereal Diseases. Vol. 26, Pg. 84, 1942.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for bismuth subsalicylate usage levels up to:
 not for fragrance use.
 
Recommendation for bismuth subsalicylate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):14882-18-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16682734
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1,3,2?2-benzodioxabismin-4-one;hydrate
Chemidplus:0008047390
EPA/NOAA CAMEO:hazardous materials
 
References:
 1,3,2?2-benzodioxabismin-4-one;hydrate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:14882-18-9
Pubchem (cid):16682734
Pubchem (sid):135354417
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07870
HMDB (The Human Metabolome Database):HMDB15408
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4H-1,3,2-benzodioxabismin-4-one, 2-hydroxy-
1,3,2?2-benzodioxabismin-4-one;hydrate
 bismukote
 bismuth oxide salicylate
 bismuth, (2-hydroxybenzoato-O1,O2)oxo-
 bismuth(III) subsalicylate
 bismuthsubsalicylate
 gastro-cote
2-hydroxy-4H-1,3,2-benzodioxabismin-4-one
 pepto-bismol
 salicylic acid bismuth basic salt
 

Articles:

PubMed:Inadvertent exaggerated anticoagulation following use of bismuth subsalicylate in an enterally fed patient receiving warfarin therapy.
PubMed:Functional diarrhea.
PubMed:Diarrhoea in adults (acute).
PubMed:Prophylaxis for travelers' diarrhea.
PubMed:Clostridium perfringens infection among inmates at a county jail--Wisconsin, August 2008.
PubMed:Traveler's diarrhea: an update on prevention and treatment.
PubMed:Systematic review: prevention of travellers' diarrhoea.
PubMed:Diarrhoea in adults (acute).
PubMed:Travellers' diarrhoea: contemporary approaches to therapy and prevention.
PubMed:Travelers' diarrhea: antimicrobial therapy and chemoprevention.
PubMed:Update in traveler's diarrhea.
PubMed:Antidiarrheal drug products for over-the-counter human use; amendment of final monograph. Final rule.
PubMed:Labeling for oral and rectal over-the-counter drug products containing aspirin and nonaspirin salicylates; Reye's Syndrome warning. Final rule.
PubMed:Travellers' diarrhoea.
PubMed:Lymphocytic and Collagenous Colitis.
PubMed:Travelers' diarrhea. Epidemiology, prevention, and self-treatment.
PubMed:Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate.
PubMed:Current FDA-approved treatments for Helicobacter pylori and the FDA approval process.
PubMed:Guidelines for the treatment of Helicobacter pylori in the pediatric population.
PubMed:Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses.
PubMed:Prevention and treatment of traveler's diarrhea: a clinical pharmacological approach.
PubMed:Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.
PubMed:Travellers' diarrhoea.
PubMed:Prevention of traveler's diarrhea.
PubMed:Treatment of diarrhea of neonatal calves.
PubMed:For your information: traveler's diarrhea.
PubMed:Emporiatrics: diarrhea in travelers.
PubMed:The efficacy of bismuth subsalicylate in relieving gastro-intestinal discomfort following excessive alcohol and food intake.
PubMed:Acute diarrhea associated with travel.
PubMed:Bismuth subsalicylate in the prevention of colonization of infant mice with Campylobacter jejuni.
PubMed:Traveler's diarrhea: methods of prevention and treatment.
PubMed:Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection.
PubMed:Control of diarrheal diseases.
PubMed:Travelers' diarrhea. NIH Consensus Development Conference.
PubMed:Travelers' diarrhea. Controversy and consensus.
PubMed:Travellers' diarrhoea: prevention by chemoprophylaxis.
PubMed:The role of location of food consumption in the prevention of travelers' diarrhea in Mexico.
 
Notes:
bismuth subsalicylate is the active ingredient of pepto-bismol and in kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with azoles and other drugs to treat helicobacter.
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