|
Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 392.70 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 358.00 °F. TCC ( 181.30 °C. ) (est)
|
| logP (o/w): | 1.860 (est) |
| Soluble in: |
| | water, 1912 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 125 mg/kg
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 451, 1981.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for mellein usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for mellein flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | antibiotic AO-2 | | | antibiotic BV-1 | | 1H-2- | benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-methyl- | | iso | coumarin, 3,4-dihydro-8-hydroxy-3-methyl- | | 3,4- | dihydro-8-hydroxy-3-methyl isocoumarin | | 3,4- | dihydro-8-hydroxy-3-methylisocoumarin | | 8- | hydroxy-3-methyl-3,4-dihydro-1H-isochromen-1-one | | 8- | hydroxy-3-methyl-3,4-dihydroisochromen-1-one | | | ochracin |
Articles:
| PubMed:Lasiodiplodia sp. ME4-2, an endophytic fungus from the floral parts of Viscum coloratum , produces indole-3-carboxylic acid and other aromatic metabolites. |
| PubMed:An In planta-Expressed Polyketide Synthase Produces (R)-mellein in the Wheat Pathogen Parastagonospora nodorum. |
| PubMed:Toxicity of extracellular proteins from Diplodia seriata and Neofusicoccum parvum involved in grapevine Botryosphaeria dieback. |
| PubMed:Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain. |
| PubMed:Isolation and identification of an endophytic fungus Pezicula sp. in Forsythia viridissima and its secondary metabolites. |
| PubMed:Multifaceted defense against antagonistic microbes in developing offspring of the parasitoid wasp Ampulex compressa (Hymenoptera, Ampulicidae). |
| PubMed:Extracellular compounds produced by fungi associated with Botryosphaeria dieback induce differential defence gene expression patterns and necrosis in Vitis vinifera cv. Chardonnay cells. |
| PubMed:Exserolides A-F, new isocoumarin derivatives from the plant endophytic fungus Exserohilum sp. |
| PubMed:A new taraxerol derivative from the roots of Microcos tomentosa. |
| PubMed:A new cytotoxic phenolic derivative from the roots of Antidesma acidum. |
| PubMed:"OSMO-UT-DSAEK" using THIN-C medium. |
| PubMed:Evaluation of dihydroisocoumarins produced by the endophytic fungus Arthrinium state of Apiospora montagnei against Schistosoma mansoni. |
| PubMed:Larvae of the parasitoid wasp Ampulex compressa sanitize their host, the American cockroach, with a blend of antimicrobials. |
| PubMed:Cytotoxic activity of fungal strains isolated from the ascidian Eudistoma vannamei. |
| PubMed:The scent of bacteria: headspace analysis for the discovery of natural products. |
| PubMed:Metabolites from the mangrove-derived fungus Xylaria cubensis PSU-MA34. |
| PubMed:Bioactive secondary metabolites from Nigrospora sp. LLGLM003, an endophytic fungus of the medicinal plant Moringa oleifera Lam. |
| PubMed:Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase. |
| PubMed:[Determination of multiple constituents in Wuling capsules by HPLC simultaneously]. |
| PubMed:Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp. |
| PubMed:Guaiane sesquiterpenes from Biscogniauxia nummularia featuring potent antigerminative activity. |
| PubMed:Afritoxinones A and B, dihydrofuropyran-2-ones produced by Diplodia africana the causal agent of branch dieback on Juniperus phoenicea. |
| PubMed:A new rebound tonometer for home monitoring of intraocular pressure. |
| PubMed:A new phenolic compound with anticancer activity from the wood of Millettia leucantha. |
| PubMed:[Effects of environmental stress on secondary metabolites of Aspergillus ochraceus LCJ11-102 associated with the coral Dichotella gemmacea]. |
| PubMed:Biotransformation of bioactive (-)-mellein by a marine isolate of bacterium Stappia sp. |
| PubMed:Capsule excision and Ologen implantation for revision after glaucoma drainage device surgery. |
| PubMed:Bioactive metabolites produced by Penicillium sp. 1 and sp. 2, two endophytes associated with Alibertia macrophylla (Rubiaceae). |
| PubMed:An [11]cytochalasin derivative from the marine-derived fungus Xylaria sp. PSU-F100. |
| PubMed:Microsphaeropsisin A, a new sesquiterpenoid isolated from the mangrove endophytic fungus (No. DZ39). |
| PubMed:Synthesis and in vitro and in vivo evaluation of a series of dihydroisocoumarin derivatives conjugated with fatty acids, alcohols, and amines as potential anticancer agents. |
| PubMed:[The light-adjustable lens. Principles and clinical application]. |
| PubMed:Composition and electrophysiological activity of constituents identified in male wing gland secretion of the bumblebee parasite Aphomia sociella. |
| PubMed:Natural products as promising drug candidates for the treatment of hepatitis B and C. |
| PubMed:Aspergillus westerdijkiae polyketide synthase gene "aoks1" is involved in the biosynthesis of ochratoxin A. |
| PubMed:Use of solid phase microextraction (SPME) for profiling the volatile metabolites produced by Glomerella cingulata. |
| PubMed:A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen. |
| PubMed:Affinities of Phylacia and the daldinoid Xylariaceae, inferred from chemotypes of cultures and ribosomal DNA sequences. |
| PubMed:E-2-ethylhexenal, E-2-ethyl-2-hexenol, mellein, and 4-hydroxymellein in Camponotus species from Brunei. |
| PubMed:Weed growth inhibitors from Aspergillus fischeri TISTR 3272. |
| PubMed:Synthesis of pyran and pyranone natural products. |
| PubMed:A new dihydrobenzofuran derivative from the endophytic fungus Botryosphaeria mamane PSU-M76. |
| PubMed:Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study. |
| PubMed:Phomopsidone, a novel depsidone from an endophyte of the medicinal plant Eupatorium arnottianum. |
| PubMed:Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib. |
| PubMed:The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium. |
| PubMed:Characterization of the ability of CO2 to act as an antisolvent for ionic liquid/organic mixtures. |
| PubMed:Simulating leukocyte-venule interactions--a novel agent-oriented approach. |
| PubMed:Solvatochromic studies of ionic liquid/organic mixtures. |
| PubMed:Total synthesis of enantiopure 1,3-dimethylpyranonaphthoquinones including ventiloquinones E, G, L and eleutherin. |
| PubMed:Cytotoxic flavonoids and new chromenes from Ficus formosana f. formosana. |
| PubMed:Cardiovascular safety of lumiracoxib: a meta-analysis of all randomized controlled trials > or =1 week and up to 1 year in duration of patients with osteoarthritis and rheumatoid arthritis. |
| PubMed:Metabolites from endophytes of the medicinal plant Erythrina crista-galli. |
| PubMed:An antibacterial biphenyl derivative from Garcinia bancana MIQ. |
| PubMed:Volatile compounds of Aspergillus strains with different abilities to produce ochratoxin A. |
| PubMed:Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. |
| PubMed:Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. |
| PubMed:[Studies on antibacterial activities of secondary metabolites from fungus Cephalosporium sp. AL031]. |
| PubMed:New secondary metabolites from the marine endophytic fungus Apiospora montagnei. |
| PubMed:An experimental and theoretical analysis of ultrasound-induced permeabilization of cell membranes. |
| PubMed:Three new dihydroisocoumarins from the Greek endemic species Scorzonera cretica. |
| PubMed:Biosynthesis of ochratoxins by Aspergillus ochraceus. |
| PubMed:Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica. |
| PubMed:Mandibular gland chemistry of four Caribbean species of Camponotus (Hymenoptera: Formicidae). |
| PubMed:Safety, tolerability, and efficacy of cyclosporine microemulsion in heart transplant recipients: a randomized, multicenter, double-blind comparison with the oil-based formulation of cyclosporine--results at 24 months after transplantation. |
| PubMed:Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus. |
| PubMed:Differences in neurotoxic effects of ochratoxin A, ochracin and ochratoxin-alpha in vitro. |
| PubMed:Three new metabolites from marine-derived fungi of the genera coniothyrium and microsphaeropsis |
| PubMed:Cyclosporine microemulsion formulation (Neoral) in transplantation: pharmacokinetic/pharmacodynamic relationships. |
| PubMed:Conversion of psoriasis patients from the conventional formulation of cyclosporin A to a new microemulsion formulation: a randomized, open, multicentre assessment of safety and tolerability. |
| PubMed:New botrydial sesquiterpenoids from Hymenoscyphus epiphyllus. |
| PubMed:Safety and tolerability of Neoral in transplant recipients. |
| PubMed:Male sex pheromone of a giant danaine butterfly,Idea leuconoe. |
| PubMed:[Orchratoxin A and B: A three-dimensional molecular model for a mechanistic explanation of their toxicity] |
| PubMed:Placebo-controlled comparison of spirapril at 6, 12 and 24 mg/day in mild to severe essential hypertension. |
| PubMed:24-hour ambulatory blood pressure monitoring and spirapril in mild to severe essential hypertension: a randomized dose comparison. |
| PubMed:Compounds inhibiting prostaglandin synthesis isolated from Ipomoea pes-caprae. |
| PubMed:Chemistry of mandibular and Dufour's gland secretions of ants in genusMyrmecocystus. |
| PubMed:Randomised double blind controlled trial of cyclosporin in multiple sclerosis. |
| PubMed:Chemical composition and function of metapleural gland secretion of the ant,Crematogaster deformis smith (hymenoptera: Myrmicinae). |
| PubMed:Simultaneous quanitative determination of secondary metabolites ofAspergillus ochraceus by TLC. |
| PubMed:Isolation of secondary metabolites of Aspergillus ochraceus by HPLC. |
| PubMed:Constituents of mandibular and Dufour's glands of an australianPolyrhachis weaver ant. |
| PubMed:Hairpencil pheromone components of male oriental fruit moths,Grapholitha molesta. |
| PubMed:Close-range attraction of female oriental fruit moths to herbal scent of male hairpencils. |
| PubMed:Effect of Ethrel and Ceratocystis fimbriata on the Synthesis of Fatty Acids and 6-Methoxy Mellein in Carrot Root. |
| PubMed:Identification of mellein in the mandibular gland secretions of carpenter ants. |
| PubMed:Mellein and 4-hydroxymellein production by Aspergillus ochraceus Wilhelm. |
| PubMed:Production of 6-methoxy-mellein by Sporormia bipartis Cain. |
| PubMed:Isolation of the optical antipode of mellein from an unidentified fungus. |
|
3D/inchi