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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 301.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 555.00 to 556.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 423.00 °F. TCC ( 217.10 °C. ) (est)
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| logP (o/w): | 3.114 (est) |
| Soluble in: |
| | water, 257.7 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Genistein 98%
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| BOC Sciences |
| For experimental / research use only. |
| Genistein >98%
Odor: characteristic Use: Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12nM or by insulin with IC50 of 19 nM. |
| Changzhou Longo Chemical |
| Genistein
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| Coompo |
| For experimental / research use only. |
| Genistein from Plants ≥96%
Odor: characteristic Use: Isoflavones genistein and daidzein bind to and transactivate all three PPAR isoforms, a, d, and ?. For example, membrane-bound PPAR?-binding assay showed that genistein can directly interact with the PPAR? ligand binding domain and has a measurable Ki of 5.7 mM.[9] Gene reporter assays showed that genistein at concentrations between 1 and 100 uM activated PPARs in a dose dependent way in KS483 mesenchymal progenitor cells, breast cancer MCF-7 cells, T47D cells and MDA-MD-231 cells, murine macrophage-like RAW 264.7 cells, endothelial cells and in Hela cells. Several studies have shown that both ERs and PPARs influenced each other and therefore induce differential effects in a dose-dependent way. The final biological effects of genistein are determined by the balance among these pleiotrophic actions.
The main known activity of genistein is tyrosine kinase inhibitor, mostly of epidermal growth factor receptor (EGFR). Tyrosine kinases are less widespread than their ser/thr counterparts but implicated in almost all cell growth and proliferation signal cascades.
Genistein may act as direct antioxidant, similar to many other isoflavones, may alleviate damaging effects of free radicals in tissues.
Genistein was subsequently demonstrated to be highly effective against intestinal parasites such as the poultry cestode Raillietina echinobothrida, the pork trematode Fasciolopsis buski, and the sheep liver fluke Fasciola hepatica. It has also been investigated in human tapeworms such as Echinococcus multilocularis and E. granulosus metacestodes that genistein and its derivatives, Rm6423 and Rm6426, are potent cestocides.
Genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis.
Genistein and other isoflavones have been identified as angiogenesis inhibitors, and found to inhibit the uncontrolled cell growth of cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors). Various studies have found that moderate doses of genistein have inhibitory effects on cancers of the prostate, cervix, brain, breast and colon. It has also been shown that genistein makes some cells more sensitive to radio-therapy.; although, timing of phytoestrogen use is also important. |
| DSM Nutritional |
| geniVida®
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| EMD Millipore |
| For experimental / research use only. |
| Genistein, Soybean
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| ExtraSynthese |
| For experimental / research use only. |
| Genistein (HPLC) ≥95%
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| Glentham Life Sciences |
| Genistein
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| Jiangyin Healthway |
| Genistein 98%
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| New functional food ingredients |
| Maypro Industries |
| Genistein
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| Nacalai USA |
| For experimental / research use only. |
| Genistein
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Genistein >98%
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| Shaanxi Y-Herb Biotechnology |
| 98% Purity Herbal Extract Powder Natural Genistein Powder Fruit Part CAS 446-72-0
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| Shaanxi Y-Herb Biotechnology |
| CAS: 446-72-0 Natural Fructus Sophorae Extract Genistein Powder 98% Manufacturer
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| Shaanxi Y-Herb Biotechnology |
| Pharmaceutical Grade Herbal Extract Powder Genistein 98% Powder C15H10O5
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| Sigma-Aldrich |
| For experimental / research use only. |
| Genistein
analytical standard |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD > 500 mg/kg
Journal of Antibiotics. Vol. 39, Pg. 606, 1986.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for genistein usage levels up to: | | | not for fragrance use.
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| Recommendation for genistein flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Preparatory work to support the risk assessment for peri- and postmenopausal women taking food supplements containing isolated isoflavones
View page or View pdf
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Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones
View page or View pdf
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| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):446-72-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5280961 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one |
| Chemidplus:0000446720 |
| RTECS:NR2392000 for cas# 446-72-0 |
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C06563 |
| HMDB (The Human Metabolome Database): | HMDB03217 |
| FooDB: | FDB011828 |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
genistein is available in a few different isoflavone formulas. a standard soy isoflavone formula contains genistein mainly in the form of genistin, as well as daidzin and glycitin. the percentages of the various isoflavones present in this soy formula reflect the percentages of these substances as found in soybeans and are: genistin, about 50%; daidzin, about 38%; and glycitin, about 12%. a 50 mg dose of soy isoflavones?a typical daily dose?provides 25 mg of genistin, 19 mg of daidzin and about 6 mg of glycitin. usually, 40% of the formula is comprised of soy isoflavones. therefore, to get a dose of 50 mg of soy isoflavones, one needs 125 mg of the soy preparation. smaller amounts of genistein as the aglycone are available in some red clover preparations.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- | | | differenol A | | 5,7- | dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-one | | 5,7- | dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone | | 5,7- | dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | | 5,7- | dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one | | 5,7- | dihydroxy-3-(4-hydroxyphenyl)chromen-4-one | | iso | flavone, 4',5,7-trihydroxy- | | | genestein | | | genisterin | | | sophoricol | | 4,5,7- | trihydroxy iso-flavone | | 4',5,7- | trihydroxy isoflavone | | 4,5,7- | trihydroxyisoflavone | | 4',5,7- | trihydroxyisoflavone |
Articles:
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an isoflavonoid derived from soy products. it inhibits protein-tyrosine kinase and topoisomerase-ii (dna topoisomerases, type ii); activity and is used as an antineoplastic and antitumor agent. experimentally, it has been shown to induce g2 phase arrest in human and murine cell lines and inhibits protein-tyrosine kinase. Genistein is a phenolic compound belonging to the isoflavonoid group. Isoflavonoids are found mainly in soybean. Genistein and daidzein (an other isoflavonoid) represent the major phytochemicals found in this plant. Health benefits (e.g. reduced risk for certain cancers and diseases of old age) associated to soya products consumption have been observed in East Asian populations and several epidemiological studies. This association has been linked to the action of isoflavonoids. With a chemical structure similar to the hormone 17-b-estradiol, soy isoflavones are able to interact with the estrogen receptor. They also possess numerous biological activities. (PMID: 15540649)
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