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hydnocarpin
5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one

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Name:5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
CAS Number: 51419-48-8Picture of molecule3D/inchi
FDA UNII: Search
XlogP3-AA:3.30 (est)
Molecular Weight:464.42720000
Formula:C25 H20 O9
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 740.00 to 741.00 °C. @ 760.00 mm Hg (est)
Flash Point: 496.00 °F. TCC ( 257.80 °C. ) (est)
logP (o/w): 3.529 (est)
Soluble in:
 water, 22.32 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Hydnocarpin 98%
Odor: characteristic
Use: Hydnocarpin is a natural compound with moderate cytotoxic on cancer cells.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for hydnocarpin usage levels up to:
 not for fragrance use.
 
Recommendation for hydnocarpin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5489114
National Institute of Allergy and Infectious Diseases:Data
5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
Chemidplus:0051419488
 
References:
 5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5489114
Pubchem (sid):135117708
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 hydnocarpus wightiana seed
Search Trop Picture
 mallotus metcalfianus
Search Trop Picture
 meconopsis quintuplinervia
Search Trop Picture
 
Synonyms:
5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
 

Articles:

PubMed:[Chemical constituents from a Tibetan medicine Meconopsis horridula].
PubMed:Hydnocarpus: an ethnopharmacological, phytochemical and pharmacological review.
PubMed:[Study on chemical constituents of Callicarpa peii].
PubMed:Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.
PubMed:Potentiating effect of the flavonolignan (-)-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line.
PubMed:[Chemical constituents from aerial parts of Fallopia dumetosum].
PubMed:NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species.
PubMed:Two new phenolic glycosides from Inula cappa.
PubMed:[Chemical constituents from stems of Lonicera japonica].
PubMed:Polyphenols isolated from antiradical extracts of Mallotus metcalfianus.
PubMed:Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam.
PubMed:Free radical scavenging, enzyme inhibitory constituents from antidiabetic Ayurvedic medicinal plant Hydnocarpus wightiana Blume.
PubMed:[Studies on chemical constituents of Meconopsis quintuplinervia Regel].
PubMed:Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species.
PubMed:Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans.
PubMed:Hypolipidemic, anti-inflammatory, and antineoplastic activity and cytotoxicity of flavonolignans isolated from Hydnocarpus wightiana seeds.
 
Notes:
isolated from hydnocarpus wightiana seeds.
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