EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

polyglutamic acid
poly(alpha-L-glutamic acid)

Supplier Sponsors

Name:(2S)-2-aminopentanedioic acid (poly)
CAS Number: 25513-46-6Picture of molecule3D/inchi
Other(deleted CASRN):24938-00-9
FDA UNII: Search
Formula:(C5H7NO3)n
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 339 Polyglutamic acid View - notice PDF
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 9.416e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Poly-L-Glutamic acid ≥92%
CP Kelco
AquaMAX™ HM ?-PGA
Odor: characteristic
Use: Optimal skin hydration is a critical factor to beautiful and healthy skin. AquaMAX™ represents a new class of nature-based, functional moisturizers that not only deliver improved moisturization to the skin through their excellent humectant properties, research suggests that AquaMAX may also affect a number of biological processes in the skin that can contribute to the maintenance of optimal skin health and appearance.
CP Kelco
AquaMAX™ LM ?-PGA
Jiangyin Healthway
g-Polyglutamic Acid
New functional food ingredients
Jiangyin Healthway
Gamma-polyglutamic Acid
M.C.Biotec
Polyglutamic Acid
Santa Cruz Biotechnology
For experimental / research use only.
Poly-L-Glutamic Acid ≥92%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 2050 mg/kg
German Offenlegungsschrift Patent Document. Vol. #2636091

oral-rat LD50 6000 mg/kg
German Offenlegungsschrift Patent Document. Vol. #2636091

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for polyglutamic acid usage levels up to:
 not for fragrance use.
 
Recommendation for polyglutamic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :33032
National Institute of Allergy and Infectious Diseases:Data
(2S)-2-aminopentanedioic acid (poly)
Chemidplus:0025513466
RTECS:MA1700000 for cas# 25513-46-6
 
References:
 (2S)-2-aminopentanedioic acid (poly)
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):33032
Pubchem (sid):134998253
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(2S)-2-aminopentanedioic acid (poly)
 glutamic acid polymer
alpha-L-glutamic acid polymer
L-glutamic acid, homopolymer
 poly-L-glutamate
 poly(alpha-L-glutamic acid)
 

Articles:

PubMed:Process optimization of microencapsulation of curcumin in γ-polyglutamic acid using response surface methodology.
J-Stage:The Aqueous Solubility and Thermal Stability of a-Lipoic Acid Are Enhanced by Cyclodextrin
PubMed:Effects of metabolic pathway precursors and polydimethylsiloxane (PDMS) on poly-(gamma)-glutamic acid production by Bacillus subtilis BL53.
PubMed:Biodegradable and multifunctional polymer micro-tubes for targeting photothermal therapy.
PubMed:In vitro adsorption of aluminum by an edible biopolymer poly(γ-glutamic acid).
PubMed:Calcium involved in the poly(γ-glutamic acid)-mediated promotion of Chinese cabbage nitrogen metabolism.
PubMed:Improved production of poly-γ-glutamic acid by Bacillus subtilis D7 isolated from Doenjang, a Korean traditional fermented food, and its antioxidant activity.
PubMed:Targeted poly (L-γ-glutamyl glutamine) nanoparticles of docetaxel against folate over-expressed breast cancer cells.
PubMed:The influence of process parameters in production of lipopeptide iturin A using aerated packed bed bioreactors in solid-state fermentation.
PubMed:CuInS(2) quantum dots/poly((L)-glutamic acid)-drug conjugates for drug delivery and cell imaging.
PubMed:Enhanced poly(γ-glutamic acid) fermentation by Bacillus subtilis NX-2 immobilized in an aerobic plant fibrous-bed bioreactor.
PubMed:Direct colorimetric biosensing of mercury(II) ion based on aggregation of poly-(γ-glutamic acid)-functionalized gold nanoparticles.
PubMed:Poly-γ-glutamate from Bacillus subtilis inhibits tyrosinase activity and melanogenesis.
PubMed:Anti-obesity effects of poly-γ-glutamic acid with or without isoflavones on high-fat diet induced obese mice.
PubMed:Production and optimization of poly-γ-glutamic acid by Bacillus subtilis BL53 isolated from the Amazonian environment.
PubMed:Microbial production and chemical transformation of poly-γ-glutamate.
PubMed:Poly-γ-glutamic acid attenuates angiogenesis and inflammation in experimental colitis.
PubMed:Non-sterilized fermentative co-production of poly(γ-glutamic acid) and fibrinolytic enzyme by a thermophilic Bacillus subtilis GXA-28.
PubMed:High-molecular-weight poly-gamma-glutamate protects against hypertriglyceridemic effects of a high-fructose diet in rat.
PubMed:Alkaline serine protease AprE plays an essential role in poly-γ-glutamate production during natto fermentation.
PubMed:Measuring methotrexate polyglutamates in red blood cells: a new LC-MS/MS-based method.
PubMed:Recent advances in microbial biopolymer production and purification.
PubMed:Evaluation of the probiotic potential of Bacillus polyfermenticus CJ6 isolated from Meju, a Korean soybean fermentation starter.
PubMed:In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles.
PubMed:Mutations suppressing the loss of DegQ function in Bacillus subtilis (natto) poly-γ-glutamate synthesis.
PubMed:High molecular weight poly-gamma-glutamic acid regulates lipid metabolism in rats fed a high-fat diet and humans.
PubMed:Dye adsorption characteristics of magnetite nanoparticles coated with a biopolymer poly(γ-glutamic acid).
PubMed:Complete genome sequence of Bacillus amyloliquefaciens LL3, which exhibits glutamic acid-independent production of poly-γ-glutamic acid.
PubMed:A novel glutamate transport system in poly(γ-glutamic acid)-producing strain Bacillus subtilis CGMCC 0833.
PubMed:Poly (glutamic acid)--an emerging biopolymer of commercial interest.
PubMed:The synthesis and characterization of poly(γ-glutamic acid)-coated magnetite nanoparticles and their effects on antibacterial activity and cytotoxicity.
PubMed:Glutamic acid independent production of poly-γ-glutamic acid by Bacillus amyloliquefaciens LL3 and cloning of pgsBCA genes.
PubMed:Inhibition effect of poly(γ-glutamic acid) on lead-induced toxicity in mice.
PubMed:Gamma-polyglutamic acid (gamma-PGA) produced by Bacillus amyloliquefaciens C06 promoting its colonization on fruit surface.
PubMed:Chromosomal integration of a synthetic expression control sequence achieves poly-gamma-glutamate production in a Bacillus subtilis strain.
PubMed:A poly(gamma-glutamic acid)-amphiphile complex as a novel nanovehicle for drug delivery system.
PubMed:A novel Method for the selective recovery and purification of gamma-polyglutamic acid from Bacillus licheniformis fermentation broth.
PubMed:Expression of the pgsB encoding the poly-gamma-DL-glutamate synthetase of Bacillus subtilis (natto).
PubMed:SwrAA activates poly-gamma-glutamate synthesis in addition to swarming in Bacillus subtilis.
PubMed:[Co-production of thrombolytic enzyme and gamma-polyglutamic acid by liquid-culture of Bacillus subtilis SBS].
PubMed:Enhanced production of poly (gamma-glutamic acid) from Bacillus licheniformis NCIM 2324 by using metabolic precursors.
PubMed:A statistical approach to optimization of fermentative production of poly(gamma-glutamic acid) from Bacillus licheniformis NCIM 2324.
PubMed:Effects of cultivation conditions on the production of gamma-PGA with Bacillus subtilis ZJU-7.
PubMed:Enhanced production of poly (gamma-glutamic acid) from Bacillus licheniformis NCIM 2324 in solid state fermentation.
PubMed:Phylogeny of gamma-polyglutamic acid-producing Bacillus strains isolated from a fermented locust bean product manufactured in West Africa.
PubMed:Suppressive effect of poly-gamma-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens.
PubMed:Adsorption of toxic mercury(II) by an extracellular biopolymer poly(gamma-glutamic acid).
PubMed:Microstructure of poly(gamma-glutamic acid) produced by Bacillus subtilis consisting of clusters of D- and L-glutamic acid repeating units.
PubMed:Phylogeny of gamma-polyglutamic acid-producing Bacillus strains isolated from fermented soybean foods manufactured in Asian countries.
PubMed:Acute effect of poly-gamma-glutamic acid on calcium absorption in post-menopausal women.
PubMed:Determination and characterization of IS4Bsu1-insertion loci and identification of a new insertion sequence element of the IS256 family in a natto starter.
PubMed:Effects of different carriers on the production of isoflavone powder from soybean cake.
PubMed:Encapsulation of lycopene extract from tomato pulp waste with gelatin and poly(gamma-glutamic acid) as carrier.
PubMed:Effects of temperature and pH on adsorption of basic brown 1 by the bacterial biopolymer poly(gamma-glutamic acid).
PubMed:Microbial biosynthesis of polyglutamic acid biopolymer and applications in the biopharmaceutical, biomedical and food industries.
PubMed:Characterization of gamma-glutamyl hydrolase produced by Bacillus sp. isolated from Thai Thua-nao.
PubMed:Simple improvement in freeze-tolerance of bakers' yeast with poly-gamma-glutamate.
PubMed:In vitro fermentation studies for selection and evaluation of Bacillus strains as starter cultures for the production of okpehe, a traditional African fermented condiment.
PubMed:Characterization of Bacillus subtilis strains in Thua nao, a traditional fermented soybean food in northern Thailand.
PubMed:Effect of pH on binding of mutagenic heterocyclic amines by the natural biopolymer poly(gamma-glutamic acid).
PubMed:Efficient production of poly-gamma-glutamic acid by Bacillus subtilis ZJU-7.
PubMed:Poly-gamma-glutamate in bacteria.
PubMed:Removal of cationic dyes from aqueous solution using an anionic poly-gamma-glutamic acid-based adsorbent.
PubMed:Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles.
PubMed:Characterization of Bacillus subtilis gamma-glutamyltransferase and its involvement in the degradation of capsule poly-gamma-glutamate.
PubMed:Roles and regulation of the glutamate racemase isogenes, racE and yrpC, in Bacillus subtilis.
PubMed:Glr, a glutamate racemase, supplies D-glutamate to both peptidoglycan synthesis and poly-gamma-glutamate production in gamma-PGA-producing Bacillus subtilis.
PubMed:Developments in the use of Bacillus species for industrial production.
PubMed:The production of poly-(gamma-glutamic acid) from microorganisms and its various applications.
PubMed:Natto mucilage containing poly-gamma-glutamic acid increases soluble calcium in the rat small intestine.
PubMed:Divergent structure of the ComQXPA quorum-sensing components: molecular basis of strain-specific communication mechanism in Bacillus subtilis.
PubMed:[A 90-day subchronic oral toxicity study of Bacillus subtilis gum in F344 rats].
PubMed:A new IS4 family insertion sequence, IS4Bsu1, responsible for genetic instability of poly-gamma-glutamic acid production in Bacillus subtilis.
PubMed:[Twenty-eight-day repeated dose toxicity test of Ajicoat SPG and Bionole in Wistar rat].
PubMed:Effect of various polyamino acids and D- and L-amino acids on the blood fibrinolytic system.
 
Notes:
a peptide that is a homopolymer of glutamic acid.
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