EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

methyl ethyl pyruvic acid
3-methyl-2-oxopentanoic acid

Supplier Sponsors

CAS Number: 1460-34-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:215-955-0
FDA UNII: 787T50HCIV
Nikkaji Web:J39.560I
Beilstein Number:3904281
MDL:MFCD00002582
CoE Number:10146
XlogP3-AA:1.10 (est)
Molecular Weight:130.14330000
Formula:C6 H10 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:632 3-methyl-2-oxopentanoic acid
FEMA Number:3870 3-methyl-2-oxopentanoic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):1460-34-0 ; 3-METHYL-2-OXOPENTANOIC ACID
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 41.00 to 42.00 °C. @ 760.00 mm Hg
Boiling Point: 233.00 °C. @ 760.00 mm Hg
Boiling Point: 84.00 °C. @ 18.00 mm Hg
Vapor Pressure:0.239000 mmHg @ 25.00 °C. (est)
Flash Point: 182.00 °F. TCC ( 83.33 °C. )
logP (o/w): 0.133 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:refrigerate in tightly sealed containers.
Soluble in:
 water, 1.676e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
3-Methyl-2-oxopentanoic acid
Parchem
methyl ethyl pyruvic acid
Penta International
3-METHYL-2-OXOPENTANOIC ACID
TCI AMERICA
For experimental / research use only.
3-Methyl-2-oxovaleric Acid >90.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for methyl ethyl pyruvic acid usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
Click here to view publication 18
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 1.0000010.00000
beverages(alcoholic): 0.500005.00000
breakfast cereal: --
cheese: 0.500005.00000
chewing gum: 1.000005.00000
condiments / relishes: 0.5000010.00000
confectionery froastings: 1.000005.00000
egg products: --
fats / oils: 0.3000010.00000
fish products: --
frozen dairy: 1.0000010.00000
fruit ices: 1.0000010.00000
gelatins / puddings: 0.500005.00000
granulated sugar: --
gravies: 1.000005.00000
hard candy: 1.000005.00000
imitation dairy: 0.500005.00000
instant coffee / tea: 0.100001.00000
jams / jellies: 1.000005.00000
meat products: --
milk products: 0.500005.00000
nut products: --
other grains: --
poultry: --
processed fruits: 0.100001.00000
processed vegetables: 0.100001.00000
reconstituted vegetables: 1.000005.00000
seasonings / flavors: 50.00000100.00000
snack foods: --
soft candy: 0.100005.00000
soups: 1.0000010.00000
sugar substitutes: 0.500005.00000
sweet sauces: 1.0000010.00000
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :47
National Institute of Allergy and Infectious Diseases:Data
3-methyl-2-oxopentanoic acid
Chemidplus:0001460340
 
References:
 3-methyl-2-oxopentanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):47
Pubchem (sid):134980342
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
Metabolomics Database:Search
KEGG (GenomeNet):C03465
HMDB (The Human Metabolome Database):HMDB00491
FooDB:FDB021447
YMDB (Yeast Metabolome Database):YMDB00168
Export Tariff Code:2918.30.0090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
FAO:3-Methyl-2-oxopentanoic acid
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 asparagus cooked white asparagus
Search Trop Picture
 cheese fontina cheese
Search PMC Picture
 cocoa
Search Trop Picture
 
Synonyms:
3-ethyl-3-methyl pyruvic acid
3-ethyl-3-methylpyruvic acid
alpha-keto-beta-methyl valeric acid
3-methyl-2-oxo-pentanoic acid
3-methyl-2-oxo-valeric acid
3-methyl-2-oxopentanoic acid
3-methyl-2-oxovaleric acid
2-oxo-3-methyl-N-valeric acid
a-keto-b-methyl-N-valeric acid
a-oxo-b-methyl-N-valeric acid
 methylethylpyruvic acid
2-oxo-3-methylpentanoic acid
a-keto-b-methylvaleric acid
a-oxo-b-methylvaleric acid
alpha-keto-beta-methylvaleric acid
 pentanoic acid, 3-methyl-2-oxo-
 

Articles:

PubMed:Metabolomics diagnostic approach to mustard airway diseases: a preliminary study.
PubMed:Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort.
PubMed:Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria.
PubMed:Examination of the superoxide/hydrogen peroxide forming and quenching potential of mouse liver mitochondria.
PubMed:A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis.
PubMed:Nontargeted LC-MS Metabolomics Approach for Metabolic Profiling of Plasma and Urine from Pigs Fed Branched Chain Amino Acids for Maximum Growth Performance.
PubMed:Application of high pressure processing for controlling Clostridium tyrobutyricum and late blowing defect on semi-hard cheese.
PubMed:Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
PubMed:A computational approach to enzyme design: predicting ω-aminotransferase catalytic activity using docking and MM-GBSA scoring.
PubMed:Effect of amino acids on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in creatinine/phenylalanine and creatinine/phenylalanine/4-oxo-2-nonenal reaction mixtures.
PubMed:Chiral bis(imidazolinyl)phenyl NCN pincer rhodium(III) catalysts for enantioselective allylation of aldehydes and carbonyl-ene reaction of trifluoropyruvates.
PubMed:Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling.
PubMed:Determination of α-keto acids in pork meat and Iberian ham via tandem mass spectrometry.
PubMed:The role of free amino acids in semen of rainbow trout Oncorhynchus mykiss and carp Cyprinus carpio.
PubMed:Joint experimental and DFT study of the gas-phase unimolecular elimination kinetic of methyl trifluoropyruvate.
PubMed:Pioglitazone enhances pyruvate and lactate oxidation in cultured neurons but not in cultured astroglia.
PubMed:S-alk(en)yl-L-cysteine sulfoxides and relative pungency measurements of photosynthetic and nonphotosynthetic tissues of Allium porrum.
PubMed:Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups--precursors to a variety of alpha-CF3-alpha-amino acid derivatives.
PubMed:The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro.
PubMed:Stereoselective biosynthesis of chloroarylpropane diols by the basidiomycete Bjerkandera adusta: exploring the roles of amino acids, pyruvate, glycerol and phenyl acetyl carbinol.
PubMed:Ethyl pyruvate: a novel anti-inflammatory agent.
PubMed:Pharmacologically active ellagitannins from Terminalia myriocarpa.
PubMed:Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis.
PubMed:Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin.
PubMed:Reactions of 4-aryl-1-hydrazinophthalazines with carbonyl compounds.
PubMed:Model studies on the analysis of pyruvic acid acetal-containing polysaccharides by the reductive-cleavage method.
 
Notes:
Flavouring ingredient. Aroma constit. of cocoa, Fontina cheese and cooked white asparagus. Also present in beer, dough preferment and pumpkin sap
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