| PubMed:Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology. |
| PubMed:Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy. |
| PubMed:Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70. |
| PubMed:Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel-group, multicenter, extension clinical trial. |
| PubMed:The future of atrial fibrillation therapy: intervention on heat shock proteins influencing electropathology is the next in line. |
| PubMed:HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1. |
| PubMed:Protective effect of geranylgeranylacetone against hydrogen peroxide-induced oxidative stress in human neuroblastoma cells. |
| PubMed:Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: NF-kB pathway involved. |
| PubMed:Geranylgeranylacetone suppresses colitis‑related mouse colon carcinogenesis. |
| PubMed:Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: a prospective randomized study. |
| PubMed:Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats. |
| PubMed:Comparison of teprenone and famotidine against gastroduodenal mucosal damage in patients taking low-dose aspirin. |
| PubMed:Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: HSP90 and eNOS phosphorylation involved. |
| PubMed:Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury. |
| PubMed:PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin. |
| PubMed:PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin - authors' reply. |
| PubMed:Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells. |
| PubMed:Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. |
| PubMed:Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. |
| PubMed:Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin. |
| PubMed:Modulation of human basophil degranulation by geranylgeranyl compounds. |
| PubMed:Geranylgeranylacetone blocks doxorubicin-induced cardiac toxicity and reduces cancer cell growth and invasion through RHO pathway inhibition. |
| PubMed:Induction of heat-shock protein 70 expression by geranylgeranylacetone shows cytoprotective effects in cardiomyocytes of mice under humid heat stress. |
| PubMed:Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3. |
| PubMed:Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats. |
| PubMed:Geranylgeranylacetone protects the heart via caveolae and caveolin-3. |
| PubMed:Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy. |
| PubMed:Geranylgeranylacetone, a gastromucoprotective drug, protects against NSAID-induced esophageal, gastroduodenal and small intestinal mucosal injury in healthy subjects: A prospective randomized study involving a comparison with famotidine. |
| PubMed:Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats. |
| PubMed:Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice. |
| PubMed:Protective effect of geranylgeranylacetone against methamphetamine-induced neurotoxicity in rat pheochromocytoma cells. |
| PubMed:Neuroprotective effects of geranylgeranylacetone in experimental traumatic brain injury. |
| PubMed:Evaluation of Helicobacter pylori eradication and drug therapy in patients with functional dyspepsia. |
| PubMed:The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4+ CD25+ Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney injury. |
| PubMed:Heat shock protein inducer modifies arrhythmogenic substrate and inhibits atrial fibrillation in the failing heart. |
| PubMed:Immediate induction of heat shock proteins is not protective against cryopreservation in normal human fibroblasts. |
| PubMed:Geranylgeranylacetone inhibits melanin synthesis via ERK activation in Mel-Ab cells. |
| PubMed:Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs. |
| PubMed:The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes. |
| PubMed:Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. |
| PubMed:Protective effect of geranylgeranylacetone against radiation-induced delayed effects on human keratinocytes. |
| PubMed:Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice. |
| PubMed:Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism. |
| PubMed:Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation. |
| PubMed:Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation. |
| PubMed:Poor awareness of preventing aspirin-induced gastrointestinal injury with combined protective medications. |
| PubMed:[Identification of a molecular mechanism for actions of existing medicines and its application for drug development]. |
| PubMed:Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis. |
| PubMed:Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS). |
| PubMed:Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction. |
| PubMed:A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs. |
| PubMed:Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins. |
| PubMed:Is routine stress ulcer prophylaxis of benefit for patients undergoing cardiac surgery? |
| PubMed:Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, anti-ulcer drugs and food constituents. |
| PubMed:Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome. |
| PubMed:The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis. |
| PubMed:[Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug]. |
| PubMed:Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. |
| PubMed:Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats. |
| PubMed:Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells. |
| PubMed:Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega-Study (JMMS). |
| PubMed:Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. |
| PubMed:Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans. |
| PubMed:Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes. |
| PubMed:Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea. |
| PubMed:Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation. |
| PubMed:Stimulation of gastric ulcer healing by heat shock protein 70. |
| PubMed:[The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line]. |
| PubMed:Anti-ulcer agent teprenone inhibits hepatitis C virus replication: potential treatment for hepatitis C. |
| PubMed:Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. |
| PubMed:Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. |
| PubMed:Induction of heat shock protein 70 inhibits ischemic renal injury. |
| PubMed:Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells. |
| PubMed:Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats. |
| PubMed:Isoprenoid geranylgeranylacetone inhibits human colon cancer cells through induction of apoptosis and cell cycle arrest. |
| PubMed:Geranylgeranylacetone preconditioning may attenuate heat-induced inflammation and multiorgan dysfunction in rats. |
| PubMed:An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice. |
| PubMed:Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. |
| PubMed:Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid. |
| PubMed:The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats. |
| PubMed:HSP-dependent protection against gastrointestinal diseases. |
| PubMed:HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. |
| PubMed:Influence of geranylgeranylacetone on the expression of HSP70 in retina of rats with chronic IOP elevation. |
| PubMed:Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications. |
| PubMed:Expression and function of stress (heat shock) proteins in gastrointestinal tract. |
| PubMed:Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage. |
| PubMed:Pharmacological targeting of the Hsp70 chaperone. |
| PubMed:Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study. |
| PubMed:Lysophosphatidic acid and invasion. |
| PubMed:Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model. |
| PubMed:Geranylgeranylacetone protects rat and striatum neurons against heat injury via induction of Hsp70. |
| PubMed:Induction of heat shock proteins prevents the arrhythmogenic substrate for atrial fibrillation. |
| PubMed:Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis. |
| PubMed:[Side effects of non-steroidal anti-inflammatory drugs on gastric mucosa and preventive effects of teprenone]. |
| PubMed:Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis. |
| PubMed:HSP70 confers protection against indomethacin-induced lesions of the small intestine. |
| PubMed:A role for HSP70 in protecting against indomethacin-induced gastric lesions. |
| PubMed:[Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis]. |
| PubMed:Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. |
| PubMed:Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats. |
| PubMed:Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice. |
| PubMed:Mechanism of liver regeneration after liver resection and portal vein embolization (ligation) is different? |
| PubMed:Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain. |
| PubMed:Protective effect of geranylgeranylacetone on cisplatin ototoxicity. |
| PubMed:HPLC-APCI-MS for the determination of vitamin K(1) in human plasma: method and clinical application. |
| PubMed:Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone. |
| PubMed:Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins. |
| PubMed:Mosapride in gastrointestinal disorders. |
| PubMed:Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone. |
| PubMed:HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. |
| PubMed:[Effects of teprenone on expression of heat shock protein 70 and c-fos in stomach following prednisolone ingestion: experiment with rats]. |
| PubMed:Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia. |
| PubMed:Geranylgeranylacetone ameliorates inflammatory response to lipopolysaccharide (LPS) in murine macrophages: inhibition of LPS binding to the cell surface. |
| PubMed:[Side effects of gastric muco-protective agents]. |
| PubMed:Reduction of ethanol-induced injury in portal hypertensive gastric mucosa of rats by induction of heat shock protein 72 by geranylgeranylacetone. |
| PubMed:Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions: a randomized, double-blind trial in Japan. |
| PubMed:Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response. |
| PubMed:[Role of heat shock protein in gastric mucosal protection]. |
| PubMed:Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury. |
| PubMed:Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. |
| PubMed:Geranylgeranylacetone protects the human gastric mucosa from diclofenac-induced injury via induction of heat shock protein 70. |
| PubMed:Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats. |
| PubMed:Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart. |
| PubMed:Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins. |
| PubMed:Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells. |
| PubMed:Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells. |
| PubMed:HPLC-APCI-MS for the determination of teprenone in human plasma: method and clinical application. |
| PubMed:Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB. |
| PubMed:Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo. |
| PubMed:[Effect of mucosal protective on the quality of gastric ulcer healing]. |
| PubMed:Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice. |
| PubMed:Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage. |
| PubMed:[Non-steroidal anti-inflammatory drug induced gastropathy and preventive effects of teprenone on the gastropathy in rats]. |
| PubMed:Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions. |
| PubMed:The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer). |
| PubMed:Induction of heat shock response protects the heart against atrial fibrillation. |
| PubMed:Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies. |
| PubMed:Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture. |
| PubMed:Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation. |
| PubMed:Role of protein kinase C in neuroprotective effect of geranylgeranylacetone, a noninvasive inducing agent of heat shock protein, on delayed neuronal death caused by transient ischemia in rats. |
| PubMed:[Preventive effects of teprenone on gastric mucosal lesions induced by Helicobacter pylori in mice]. |
| PubMed:Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers. |
| PubMed:Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation. |
| PubMed:Protective effects of heat shock protein 70 induced by geranylgeranylacetone on oxidative injury in rat intestinal epithelial cells. |
| PubMed:Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats. |
| PubMed:Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice. |
| PubMed:Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70. |
| PubMed:Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. |
| PubMed:[Protection of gastric mucosa against steroids-induced damage by teprenone]. |
| PubMed:Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig. |
| PubMed:Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. |
| PubMed:Oral administration of geranylgeranylacetone improves survival rate in a rat endotoxin shock model: administration timing and heat shock protein 70 induction. |
| PubMed:Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone. |
| PubMed:Oral administration of geranylgeranylacetone plus local somatothermal stimulation: a simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers. |
| PubMed:Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis. |
| PubMed:An anti-ulcer drug, geranylgeranylacetone, suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells. |
| PubMed:Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone. |
| PubMed:Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury. |
| PubMed:Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs. |
| PubMed:[Possible candidates for the compound which is expected to attenuate dioxin toxicity]. |
| PubMed:Heat shock proteins: new keys to the development of cytoprotective therapies. |
| PubMed:Upregulation of HSP by geranylgeranylacetone protects the cochlear lateral wall from endotoxin-induced inflammation. |
| PubMed:Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats. |
| PubMed:Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart. |
| PubMed:Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. |
| PubMed:Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus. |
| PubMed:Heat shock protein 70 delays gentamicin-induced vestibular hair cell death. |
| PubMed:Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. |
| PubMed:Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro. |
| PubMed:Prospective randomized trial for optimal prophylactic treatment of the upper gastrointestinal complications after open heart surgery. |
| PubMed:Neuroprotective effect of a heat shock protein inducer, geranylgeranylacetone in permanent focal cerebral ischemia. |
| PubMed:Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats. |
| PubMed:Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage. |
| PubMed:Restoration of heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase expression induced by Helicobacter pylori. |
| PubMed:Geranylgeranylacetone attenuates suppression by Helicobacter pylori extract of human umbilical vein epithelial cell growth. |
| PubMed:A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus. |
| PubMed:Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone. |
| PubMed:Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia. |
| PubMed:[Basic studies for the development of anticancer, antidementia, and taste modifier drugs]. |
| PubMed:Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines. |
| PubMed:[Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats]. |
| PubMed:Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats. |
| PubMed:Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. |
| PubMed:[Agranulocytosis due to anti-tuberculosis drugs including isoniazid (INH) and rifampicin (RFP)--a report of four cases and review of the literature]. |
| PubMed:Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. |
| PubMed:Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection. |
| PubMed:Proposed mechanism for induction of heat shock protein 70 by geranylgeranyl acetone by prenylation of Ras proteins. |
| PubMed:Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70. |
| PubMed:Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone. |
| PubMed:Cholesteryl glucoside-induced protection against gastric ulcer. |
| PubMed:Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection. |
| PubMed:Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. |
| PubMed:Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. |
| PubMed:[Molecular chaperone inducers in medicine and diseases]. |
| PubMed:Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, geranylgeranylacetone. |
| PubMed:Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells. |
| PubMed:Effects of anti-ulcer agents on ethanol-induced gastric mucosal lesions in D-galactosamine-induced hepatitis rats. |
| PubMed:Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis. |
| PubMed:Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons. |
| PubMed:Thioredoxin superfamily and thioredoxin-inducing agents. |
| PubMed:Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats. |
| PubMed:[New therapeutic approaches to peptic ulcer using mucosal protective agents]. |
| PubMed:Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells. |
| PubMed:Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes. |
| PubMed:Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression. |
| PubMed:Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart. |
| PubMed:Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced necrosis by induction of heat-shock proteins. |
| PubMed:A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol. |
| PubMed:Geranylgeranylacetone, a heat shock protein inducer, prevents primary graft nonfunction in rat liver transplantation. |
| PubMed:High dose of geranylgeranylacetone accumulate HSP72 mRNA in rat liver. |
| PubMed:Effect of teprenone on gastric mucosal injury induced by Helicobacter pylori in rats. |
| PubMed:Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. |
| PubMed:Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells. |
| PubMed:Induction of heat shock protein-70 (hsp-70) by intraarterial administration of geranylgeranylacetone. |
| PubMed:Prevention of warm ischemic injury in rat liver transplantation by geranylgeranylacetone. |
| PubMed:Efficacy of HSP72 induction in rat liver by orally administered geranylgeranylacetone. |
| PubMed:Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase. |
| PubMed:Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin. |
| PubMed:Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes. |
| PubMed:A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats. |
| PubMed:Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers. |
| PubMed:Role of heat shock proteins in gastric mucosal protection. |
| PubMed:Role of vascular endothelial growth factor in portal hypertensive gastropathy. |
| PubMed:Oral administration of geranylgeranylacetone protects rat livers from warm ischemic injury. |
| PubMed:Geranylgeranylacetone suppresses spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric pit cells. |
| PubMed:Geranylgeranylacetone induces apoptosis in HL-60 cells. |
| PubMed:Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. |
| PubMed:Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone. |
| PubMed:Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. |
| PubMed:Preventive effect of teprenone on stress-induced gastric mucosal lesions and its relation to gastric mucosal constitutive nitric oxide synthase activity. |
| PubMed:[Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats]. |
| PubMed:Geranylgeranylacetone induces heat shock protein-73 in rat small intestine. |
| PubMed:Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells. |
| PubMed:Teprenone, an anti-ulcer agent, increases gastric mucosal mucus level via nitric oxide in rats. |
| PubMed:Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients. |
| PubMed:Geranylgeranylacetone, an anti-ulcer drug, stimulates hexosamine production in a rat gastric mucosal cell line through binding to a specific cytosolic protein. |
| PubMed:Protective and preventive effects of teprenone on gastric mucosal lesions in rats. |
| PubMed:Effects of teprenone on gastric epithelial restoration in a rabbit cultured cell model. |
| PubMed:Prevention of gastric ulcer recurrence with tetraprenylacetone. |
| PubMed:[Gastric lymphoma--a case report]. |
| PubMed:Gefarnate stimulates secretion of mucin-like glycoproteins by corneal epithelium in vitro and protects corneal epithelium from desiccation in vivo. |
| PubMed:Geranylgeranylacetone and cetraxate hydrochloride increase UDP-galactosyltransferase activity in rat gastric mucosa. |
| PubMed:[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump]. |
| PubMed:Suppressive effect of tetraprenylacetone on gastric atrophy induced by short-term administration of N-methyl-N'-nitro-N-nitrosoguanidine in rats. |
| PubMed:[The effects of teprenone on the ulcer healing rate and the quality of healing in the treatment of active gastric ulcers]. |
| PubMed:Increase in hepatic tissue blood flow by teprenone. |
| PubMed:Effects of heat shock and teprenone on ethanol-induced damage to cultured rabbit gastric mucosal cells. |
| PubMed:Anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell. |
| PubMed:Gastric mucus generation in cirrhotic patients with portal hypertension. Effects of tetraprenylacetone. |
| PubMed:Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. |
| PubMed:In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori. |
| PubMed:Protective effect of teprenone on blood flow and incidence of histologic lesions in rat gastric mucosa after hemorrhage and retransfusion. |
| PubMed:Effect of the eradication of Helicobacter pylori on duodenal ulcer healing and ulcer relapse: randomized controlled study in Japan. |
| PubMed:[Teprenone in the treatment of chronic superficial gastritis, a multicentre study]. |
| PubMed:Effect of teprenone on portal hypertensive gastric mucosa. |
| PubMed:Pharmacological regulation of gastric mucous glycoprotein secretion. |
| PubMed:Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: a nationwide, multicenter clinical study. |
| PubMed:Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion. |
| PubMed:Effects of tetraprenylacetone on pancreatic exocrine secretion and acute pancreatitis in two experimental models in rats. |
| PubMed:Scanning electron microscopic observations on gastric mucus secretion in rats, and the effects of tetraprenylacetone. |
| PubMed:[Preventive effects of troxipide on a newly developed model of acute gastric mucosal lesion (AGML) induced by ischemia/reperfusion plus ammonia in the rat]. |
| PubMed:Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa. |
| PubMed:Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. |
| PubMed:Gastric subcellular organelle fragility and impaired gastric energy charge levels in rats with caerulein-induced acute pancreatitis: protective effect of anti-ulcer agent, teprenone. |
| PubMed:Gastric damage and body weight loss in LHA-lesioned rats: effects of cytoprotective geranylgeranylacetone. |
| PubMed:Effects of KB-5492, a new anti-ulcer agent with a selective affinity for the sigma-receptor, on aspirin-induced disruption of the rat gastric mucosal barrier. |
| PubMed:Antibacterial activity of teprenone, a non water-soluble antiulcer agent, against Helicobacter pylori. |
| PubMed:Role for mucous glycoprotein in protecting cultured rat gastric mucosal cells against toxic oxygen metabolites. |
| PubMed:Geranylgeranylacetone used as an antiulcer agent is a potent inducer of differentiation of various human myeloid leukemia cell lines. |
| PubMed:Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats. |
| PubMed:Effects of antiulcer drugs on phosphatidylcholine synthesis in isolated guinea pig gastric glands. |
| PubMed:Effects of a gastric mucosal protecting agent in rats with liver cirrhosis. |
| PubMed:Effect of teprenone on acute gastric mucosal lesions induced by cold-restraint stress. |
| PubMed:Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. |
| PubMed:Effects of MCI-727, a new anti-ulcer agent, on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats. |
| PubMed:Gastric mucosal hexosamine content in various liver diseases. |
| PubMed:Effects of MCI-727, a new antiulcer agent, on various gastric and duodenal lesions in experimental animals. |
| PubMed:The inhibitory effect of anti-tumor drugs on phosphatidylcholine synthesis and its reversal by geranylgeranylacetone in the isolated guinea pig gastric glands. |
| PubMed:Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat. |
| PubMed:Secretin as a potential mediator of antiulcer actions of mucosal protective agents. |
| PubMed:Changes in gastric mucosal content of adenosine, xanthine and hypoxanthine induced by restrained water immersion stress: antiulcer effects of tetraprenylacetone. |
| PubMed:[Effect of teprenone and H2-receptor antagonists on phosphatidylcholine synthesis in the isolated guinea pig gastric glands]. |
| PubMed:Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog. |
| PubMed:Effect of tetraprenylacetone, a novel anti-ulcer agent, on healing process of ethanol-induced gastric injury in rat. |
| PubMed:Effect of antiulcer agents on the physicochemical properties of gastric mucus. |
| PubMed:The measurement of gastric mucus using a computer image processing system. |
| PubMed:The anti-ulcer effect in rats of ginger constituents. |
| PubMed:Determination of tetraprenylacetone in human plasma by high-performance liquid chromatography with fluorescence derivatization using dansylhydrazine. |
| PubMed:Gastric cytoprotection by tetraprenylacetone in human subjects. |
| PubMed:[Drug administration schedule of anti-ulcer agents to prevent recurrence of peptic ulcer; administration of synergistic drugs for protective factors in peptic ulcer--criteria of drug selection according to clinical symptoms and administration methods]. |
| PubMed:Protection against alcohol-induced gastric mucosal injury by geranylgeranylacetone: effect of indomethacin. |
| PubMed:Effects of taurocholic acid/HCl alone or after pretreatment with geranylgeranylacetone on phospholipid metabolism in rat gastric mucosa. |
| PubMed:Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. |
| PubMed:Identification of urinary and microsomal metabolites of geranylgeranylacetone in rats. |
| PubMed:Incorporation of radioactivity into amino acids and fatty acids after administration of 14C-geranylgeranylacetone to rats. |
| PubMed:Advances in drug therapy for peptic ulcer disease. |
| PubMed:Effect of teprenone on the content of phospholipids in gastric secretion in man. |
| PubMed:Increasing action of teprenone, a new antiulcer agent, on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats. |
| PubMed:Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa. |
| PubMed:Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells. |
| PubMed:Healing-promoting action of teprenone, a new antiulcer agent on acetic acid ulcer in rats. |
| PubMed:Serum and stomach tissue levels of geranylgeranylacetone in patients. |
| PubMed:Effect of geranylgeranylacetone on aspirin-induced changes in gastric glycoproteins. |
| PubMed:Effect of synthetic acyclic polyisoprenoids on the cold-restraint stress induced gastric ulcer in rats. |
| PubMed:Effect of geranylgeranylacetone (GGA) on gastric lesions induced by topical aspirin plus HCl. |
| PubMed:Determination of the anti-ulcer agent geranylgeranylacetone in serum by gas chromatography-mass spectrometry. |
| PubMed:[Study on the kinetics of mucus secreting cells in the gastrointestinal tract --effects of various drugs and hormones on the cell kinetics of the generative zone in mouse gastric mucosa]. |
| PubMed:Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats. |
| PubMed:Effects of geranylgeranylacetone on gastrointestinal secretion in rats. |
| PubMed:Effect of acyclic polyisoprenoids on the biosynthesis of mannose-labeled glycolipids in rat liver microsomes. |
| PubMed:[Effect of prostaglandin E2, cimetidine and geranyl-geranyl-acetone on rat gastric mucosal damage (author's transl)]. |
| PubMed:Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats. |
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