EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

acetyl-laevo-aspartic acid
acetylaspartic acid

Supplier Sponsors

Name:(2S)-2-acetamidobutanedioic acid
CAS Number: 997-55-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:213-643-9
FDA UNII: 445Y04YIWR
Nikkaji Web:J62.824G
Beilstein Number:1726198
MDL:MFCD00020500
XlogP3:-1.10 (est)
Molecular Weight:175.14073000
Formula:C6 H9 N O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Ac-Asp-OH
Glentham Life Sciences
N-Acetyl-L-aspartic acid
Santa Cruz Biotechnology
For experimental / research use only.
N-Acetyl-L-aspartic acid ≥98%
Sigma-Aldrich
For experimental / research use only.
N-Acetyl-L-aspartic acid ≥99.0% (T)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for acetyl-laevo-aspartic acid usage levels up to:
 not for fragrance use.
 
Recommendation for acetyl-laevo-aspartic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :65065
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S)-2-acetamidobutanedioic acid
Chemidplus:0000997557
 
References:
 (2S)-2-acetamidobutanedioic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):65065
Pubchem (cas):997-55-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C01042
HMDB (The Human Metabolome Database):HMDB00812
FooDB:FDB022260
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
(2S)-2-acetamidobutanedioic acid
 acetyl aspartic acid
 acetyl-L-aspartic acid
N-acetyl-laevo-aspartic acid
 acetylaspartic acid
 aspartic acid, N-acetyl-, L- (8CI)
 

Articles:

PubMed:A multi-matrix HILIC-MS/MS method for the quantitation of endogenous small molecule neurological biomarker N-acetyl aspartic acid (NAA).
PubMed:The positive effects of high-frequency right dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation on memory, correlated with increases in brain metabolites detected by proton magnetic resonance spectroscopy in recently detoxified alcohol-dependent patients.
PubMed:Evaluation of skin firmness by the DynaSKIN, a novel non-contact compression device, and its use in revealing the efficacy of a skincare regimen featuring a novel anti-ageing ingredient, acetyl aspartic acid.
PubMed:Elevated Glutamate Levels in the Left Dorsolateral Prefrontal Cortex Are Associated with Higher Cravings for Alcohol.
PubMed:rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System.
PubMed:Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS.
PubMed:Structural activity relationship analysis (SAR) and in vitro testing reveal the anti-ageing potential activity of acetyl aspartic acid.
PubMed:In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmness.
PubMed:Pre-clinical formulation screening, development and stability of acetyl aspartic acid for cosmetic application.
PubMed:In vitro and in vivo dermal absorption assessment of acetyl aspartic acid: a compartmental study.
PubMed:Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proof.
PubMed:Safety assessment of a novel active ingredient, acetyl aspartic acid, according to the EU Cosmetics Regulation and the Scientific Committee on Consumer Safety guidelines.
PubMed:The use of gene arrays and corresponding connectivity mapping (Cmap) to identify novel anti-ageing ingredients.
PubMed:Making the White Matter Matters: Progress in Understanding Canavan's Disease and Therapeutic Interventions Through Eight Decades.
PubMed:A facile means for the identification of indolic compounds from plant tissues.
PubMed:Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study.
PubMed:Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer's disease mouse model.
PubMed:Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods.
PubMed:[Megalencephaly with dystonia revealing Canavan disease].
PubMed:[Analysis of ¹H-MRS in patients with depression after basal ganglia infarction].
PubMed:Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan's disease.
PubMed:Proton magnetic resonance spectroscopy in the evaluation of infiltration zone of cerebral alveolar echinococcosis.
PubMed:A mutation of aspartoacylase gene in a Turkish patient with Canavan disease.
PubMed:Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry.
PubMed:A missense mutation (p.G274R) in gene ASPA causes Canavan disease in a Pakistani family.
PubMed:Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry.
PubMed:Functional changes in the frontal cortex in Parkinson's disease using a rat model.
PubMed:T2 corrected quantification method of L-p-boronophenylalanine using proton magnetic resonance spectroscopy for boron neutron capture therapy.
PubMed:[Canavan disease or N-acetyl aspartic aciduria: a case report].
PubMed:[In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].
PubMed:Metabolic parameters of epilepsy: adjuncts to established antiepileptic drug therapy.
PubMed:Overexpression of a bacterial indole-3-acetyl-l-aspartic acid hydrolase in Arabidopsis thaliana.
PubMed:[Magnetic resonance spectroscopy and functional magnetic resonance images: non-invasive alternatives for identifying epileptogenic foci].
PubMed:High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid.
PubMed:Brain imaging of affective disorders and schizophrenia.
PubMed:[The EAA-ergic modulation of the brain dopaminergic system as a basis for creating new nootropic agents with stress-protective activity].
PubMed:[MRI, SPECT and MRS findings in a case of acute hemiplegia syndrome with a marked hemispheric brain edema].
PubMed:The gene for indole-3-acetyl-L-aspartic acid hydrolase from Enterobacter agglomerans: molecular cloning, nucleotide sequence, and expression in Escherichia coli.
PubMed:Metabolism of indole-3-acetic acid in Arabidopsis.
PubMed:High-resolution 1H NMR spectroscopy following experimental brain trauma.
PubMed:Methylphenidate increases rat cerebral cortex levels of N-acetyl-aspartic acid and N-acetyl-aspartyl-glutamic acid.
PubMed:Analysis of cerebral structural changes in systemic lupus erythematosus by proton MR spectroscopy.
PubMed:[The evaluation of the effects of piracetam and N-acetylaspartic acid on memory and the content of mediator amino acids in the brain in a model neurotic state in rats].
PubMed:[Effects of N-acetylasparaginic acid during frontal lobectomy in the rat: antiamnestic action and effect on monoamine level].
PubMed:[Longitudinal change of H-1 spectroscopy in cerebral infarction].
PubMed:[The effect of N-acetylaspartic acid on the processes of memory and learning in rats].
PubMed:N-acetylaspartic aciduria in Canavan disease: another proof in two infants.
PubMed:N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain.
PubMed:Effects of gibberellic Acid on endogenous indole-3-acetic Acid and indoleacetyl aspartic Acid levels in a dwarf pea.
PubMed:The influence of small direct electric currents on the transport of auxin in intact plants.
PubMed:[Transport of [(14)C] auxin from young pods of Vicia faba L].
PubMed:Studies on the movement of indole auxins in willow (Salix viminalis L.).
PubMed:The transport and metabolism of (14)C-labelled indoleacetic acid in intact pea seedlings.
PubMed:[Studies on the uptake of naphthalene-1-acetic acid and its aspartic acid conjugate into wheat coleoptile tissue].
PubMed:Growth substances from Veratrum tenuipetalum.
PubMed:Acetyl transport mechanisms. Involvement of N-acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain.
PubMed:Brain amino acid uptake: the effect of L-aspartic acid, L-N-acetyl aspartic acid, and L-asparagine administration in the rat.
PubMed:Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids.
PubMed:A method for the gas-chromatographic analysis of N-acetyl-aspartic acid in brain.
PubMed:[On the use of acetyl-aspartic acid and of citrulline in the treatment and prevention of flight fatigue].
PubMed:Studies on the function of N-acetyl aspartic acid in brain.
PubMed:FUNCTION OF N-ACETYL ASPARTIC ACID IN THE BRAIN: EFFECTS OF CERTAIN DRUGS.
PubMed:[N-ACETYL-ASPARTIC ACID IN NERVE TISSUE. QUANTITATIVE CHANGES IN THE BRAIN OF GROWING ANIMALS].
 
Notes:
N-Acetylaspartic acid is a derivative of aspartic acid. It is the second most concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartate and acetyl coenzyme A. The various functions served by N-acetylaspartic acid are still under investigation, but the primary proposed functions include: 1) A neuronal osmolyte that is involved in fluid balance in the brain 2) A source of acetate for lipid and myelin synthesis in oligodendrocytes, the glial cells that myelinate neuronal axons 3) A precursor for the synthesis of the important neuronal dipeptide N-acetylaspartylglutamate 4)N-Acetylaspartic acid may also be involved in energy production from the amino acid glutamate in neuronal mitochondria. [HMDB]
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