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perilla ketone
1-pentanone, 1-(3-furanyl)-4-methyl-

Supplier Sponsors

CAS Number:	553-84-4	3D/inchi
FDA UNII:	CV69S6Y94V
Nikkaji Web:	J69.495I
Beilstein Number:	0114624
MDL:	MFCD01939833
XlogP3:	2.80 (est)
Molecular Weight:	166.21998000
Formula:	C10 H14 O2
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:information only not used for fragrances or flavors

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Appearance:	pale yellow clear liquid (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	223.00 to 225.00 °C. @ 760.00 mm Hg
Vapor Pressure:	0.091000 mmHg @ 25.00 °C. (est)
Flash Point:	206.00 °F. TCC ( 96.67 °C. )
logP (o/w):	2.760
Soluble in:
	alcohol
	water, 281.5 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

Santa Cruz Biotechnology

For experimental / research use only.

Perilla Ketone ≥98%

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 10 mg/kg Science. Vol. 197, Pg. 573, 1977. intravenous-rabbit LD50 14 mg/kg LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA Journal of Animal Science. Vol. 60, Pg. 248, 1985. intravenous-dog LD50 106 mg/kg LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA Journal of Animal Science. Vol. 60, Pg. 248, 1985. intraperitoneal-hamster LD50 13700 ug/kg LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA Journal of Animal Science. Vol. 60, Pg. 248, 1985. intraperitoneal-mouse LD50 2500 ug/kg Science. Vol. 197, Pg. 573, 1977.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
information only not used for fragrances or flavors
Recommendation for perilla ketone usage levels up to:
	not for fragrance use.

Recommendation for perilla ketone flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :68381

National Institute of Allergy and Infectious Diseases:Data

1-furan-3-yl-4-methylpentan-1-one

Chemidplus:0000553844

References:

	1-furan-3-yl-4-methylpentan-1-one
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	68381
Pubchem (sid):	135025017

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
HMDB (The Human Metabolome Database):	HMDB35328
FooDB:	FDB013998
Typical G.C.
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
EFSA Update of results on the monitoring of furan levels in food:	Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:	Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:	Read Report

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

	patchouli oil china @ 0.02% Data GC Search Trop Picture
	perilla Search Trop Picture

Synonyms:

1-	furan-3-yl-4-methylpentan-1-one
1-(	furan-3-yl)-4-methylpentan-1-one
1-(3-	furanyl)-4-methyl-1-pentanone
b-	furyl Isoamyl Ketone
beta-	furyl isoamyl ketone
1-(3-	furyl)-4-methyl-1-pentanone
1-(3-	furyl)-4-methylpentan-1-one
1-	pentanone, 1-(3-furanyl)-4-methyl-
1-	pentanone, 1-(3-furyl)-4-methyl-

Articles:

PubMed:Inhibition of Proinflammatory Cytokine Generation in Lung Inflammation by the Leaves of Perilla frutescens and Its Constituents.

PubMed:Analogues of perillaketone as highly potent agonists of TRPA1 channel.

PubMed:Bovine atypical interstitial pneumonia.

PubMed:Characteristic aroma-active compounds of Korean perilla (Perilla frutescens Britton) leaf.

PubMed:Determination of toxic perilla ketone, secondary plant metabolites and antioxidative capacity in five Perilla frutescens L. varieties.

PubMed:Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens.

PubMed:Perilla frutescens var. frutescens in northern Laos.

PubMed:Compensated overexpression of procollagens alpha 1(I) and alpha 1(III) following perilla mint ketone-induced acute pulmonary damage in horses.

PubMed:Neutral and DEAE dextrans as tracers for assessing lung microvascular barrier permeability and integrity.

PubMed:Correlation between increased airway responsiveness and severity of pulmonary edema.

PubMed:Effect of pulmonary edema on tracheal diameter.

PubMed:Effect of cardiogenic and noncardiogenic pulmonary edema on histamine responsiveness in sheep.

PubMed:Reamed intramedullary femoral nailing after induction of an "ARDS-like" state in sheep: effect on clinically applicable markers of pulmonary function.

PubMed:Comparison of the pulmonary dysfunction caused by cardiogenic and noncardiogenic pulmonary edema.

PubMed:Evaluation of perilla ketone-induced unilateral lung injury using external gamma scanning.

PubMed:Perilla ketone increases endothelial cell monolayer permeability in vitro.

PubMed:Effects of Perilla ketone on the in situ sheep lung.

PubMed:The effects of selected bulky substituents on the pulmonary toxicity of 3-furyl ketones in mice.

PubMed:Morphology of noncardiogenic pulmonary edema induced by Perilla ketone in sheep.

PubMed:Acute bovine pulmonary emphysema caused by the fungus Fusarium semitectum.

PubMed:Perilla ketone: a model of increased pulmonary microvascular permeability pulmonary edema in sheep.

PubMed:The Essential Oil of Perilla ocimoides: A Rich Source of Rosefuran.

PubMed:Intoxication of cattle by Perilla frutescens (purple mint).

PubMed:An intestinal propulsion promoting substance from Perilla frutescens and its mechanism of action.

PubMed:Respiratory disease in adult cattle.

PubMed:Species susceptibility to the pulmonary toxicity of 3-furyl isoamyl ketone (perilla ketone): in vivo support for involvement of the lung monooxygenase system.

PubMed:Perilla ketone toxicity: a chemical model for the study of equine restrictive lung disease.

PubMed:Chemical-induced lung injury in domestic animals.

PubMed:Perilla ketone: a potent lung toxin from the mint plant, Perilla frutescens Britton.

Notes:

potent lung toxin from perilla frutescens. Isol. from the essential oil of Perilla frutescens (perilla)

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