ferulic acid, 1135-24-6

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Advanced Biotech is a leading manufacturer and supplier of high-quality Natural flavoring ingredients & botanical extracts for the food/beverage, cosmetic and personal care industries. With over 25 years of experience working with Fermentation processing & botanical extracts, we can help develop new innovative and functional products for today�™s competitive marketplace. Our company prides itself in the ability to cater to our customer�™s specific needs while maintaining our focus on integrity, honesty and the commitment to high quality product standards. We proudly offer our quality Natural ingredients to companies around the world.
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CODE138148 CODE138148
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1728 FERULIC ACID NATURAL
SDS

BOC Sciences

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CODE138148 CODE138148
Product(s):
1135-24-6 Ferulic Acid >98%

Glentham Life Sciences Ltd

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CODE138148 CODE138148
Product(s):
GP6734 Ferulic acid

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier
We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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CODE138148 CODE138148
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HLC-305 Ferulic Acid
HLCFD-101 Natural Ferulic Acid

M&U International LLC

Steady supply & demand
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A0065 Ferulic Acid, Kosher
N0050 Nat. Ferulic Acid, Kosher

O'Laughlin Industries Inc.

Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics
Leading the Flavor and Fragrance Industry since 1980.
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771-3051 NATURAL FERULIC ACID

Penta International Corporation

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For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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06-11000 FERULIC ACID
06-11005 FERULIC ACID NATURAL
06-11010 FERULIC ACID NATURAL 10% IN PROPYLENE GLYCOL

Sigma-Aldrich

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CODE138148 CODE138148
Product(s):
W518301 trans-Ferulic acid, ≥99%
SDS

Sunaux International

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Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
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N0055 nat.Ferulic Acid

Vigon International

Passion for Simplicity
Manufacturer and supplier of high quality flavor and fragrance ingredients.
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CODE138148 CODE138148
Product(s):
507957 FERULIC ACID NATURAL

Name:	3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
CAS Number:	1135-24-6	3D/inchi
Other(deleted CASRN):	1356408-74-6
ECHA EINECS - REACH Pre-Reg:	214-490-0
FDA UNII:	AVM951ZWST
Beilstein Number:	1570363
MDL:	MFCD00004400
CoE Number:	10113
XlogP3:	1.50 (est)
Molecular Weight:	194.18650000
Formula:	C10 H10 O4
NMR Predictor:	Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
(Z)- or (E)- isomer not specified by CASrn in Register. Mixture of E- and Z-isomers (EFFA, 2010a). Composition of stereoisomeric mixture to be specified

Category:food additive and cosmetic agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
DG SANTE Food Flavourings:	08.089 4-hydroxy-3-methoxycinnamic acid

Physical Properties:

Appearance:	pale yellow to tan powder (est)
Assay:	98.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	171.00 °C. @ 760.00 mm Hg
Boiling Point:	439.00 °C. @ 760.00 mm Hg
Vapor Pressure:	0.000003 mmHg @ 25.00 °C. (est)
Flash Point:	302.00 °F. TCC ( 150.00 °C. )
logP (o/w):	1.510
Soluble in:
	alcohol
	water, 5970 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	antimicrobial agents

Suppliers:

For experimental / research use only.

Ferulic acid 98%

BOC Sciences

For experimental / research use only.

Ferulic Acid >98%

Changsha Organic Herb

Angelica Sinensis Extract / Dong Quai Extract

Coompo

For experimental / research use only.

Ferulic Acid from Plants ≥98%

Odor: characteristic

Use: Ferulic acid is an antioxidant in vitro in the sense that it is reactive toward free radicals such as reactive oxygen species (ROS). Ferulic acid helps to prevent damage to our cells caused by ultraviolet light. Exposure to ultraviolet light actually increases the antioxidant potency of ferulic acid. Ferulic acid is often added as ingredient of anti-aging supplements. Studies have shown that ferulic acid can decrease blood glucose levels and can be of help to diabetes patients. ROS and free radicals are implicated in DNA damage, cancer, accelerated cell aging. Animal studies and in vitro studies suggest that ferulic acid may have direct antitumor activity against breast cancer and liver cancer. Ferulic acid may have pro-apoptotic effects in cancer cells, thereby leading to their destruction. Ferulic acid may be effective at preventing cancer induced by exposure to the carcinogenic compounds benzopyrene and 4-nitroquinoline 1-oxide. Note that these are not randomized controlled trials done with human participants, and therefore, the results of these studies may not be directly applicable to human use. Ferulic acid incorporation into a topical solution of 15% L-ascorbic acid and 1% -tocopherol improved chemical stability of the vitamins (C+E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

Glentham Life Sciences

Ferulic acid

Jiangyin Healthway

Ferulic Acid

New functional food ingredients

Odor: characteristic

Use: Used in skin care, sun care, hair care, after sun, color cosmetics. Possesses anti-oxidant, anti-aging and anti-inflammatory properties. Protects the skin form damage of UV light

M&U International

Ferulic Acid, Kosher

M&U International

Nat. Ferulic Acid, Kosher

Maypro Industries

Ferulic Acid

O'Laughlin Industries

NATURAL FERULIC ACID

Penta International

FERULIC ACID NATURAL 10% IN PROPYLENE GLYCOL

Santa Cruz Biotechnology

For experimental / research use only.

Ferulic Acid

Shaanxi Y-Herb Biotechnology

Raw Ferulic Acid Powder Rice Bran Extract Fumalic Acid 98% 99% CAS 1135-24-6

Sigma-Aldrich

trans-Ferulic acid, ≥99%

sds

Certified Food Grade Products

Xian Yuensun Biological Technology

Ferulic Acid, 98%

Safety Information:

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD > 350 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA BEHAVIORAL: REGIDITY Indian Journal of Pharmaceutical Sciences. Vol. 49, Pg. 77, 1987. intravenous-mouse LD50 857 mg/kg Chemical and Pharmaceutical Bulletin. Vol. 38, Pg. 1620, 1990.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
food additive and cosmetic agents
Recommendation for ferulic acid usage levels up to:
	not for fragrance use.

Maximised Survey-derived Daily Intakes (MSDI-EU):		0.097 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI):		3200 (μg/person/day)
Threshold of Concern:		1800 (μg/person/day)
Structure Class:		I

Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
		average usage mg/kg	maximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0):		3.00000	15.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0):		2.00000	10.00000
Edible ices, including sherbet and sorbet (03.0):		3.00000	15.00000
Processed fruit (04.1):		2.00000	10.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2):		-	-
Confectionery (05.0):		10.00000	50.00000
Chewing gum (05.3):		-	-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0):		5.00000	25.00000
Bakery wares (07.0):		10.00000	50.00000
Meat and meat products, including poultry and game (08.0):		2.00000	10.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0):		2.00000	10.00000
Eggs and egg products (10.0):		-	-
Sweeteners, including honey (11.0):		-	-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0):		5.00000	25.00000
Foodstuffs intended for particular nutritional uses (13.0):		10.00000	50.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1):		3.00000	15.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2):		10.00000	50.00000
Ready-to-eat savouries (15.0):		15.00000	75.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0):		5.00000	25.00000

Safety References:

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 15 (FGE.15): Aryl-substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives from chemical group 22 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 55 (FGE.55): Consideration of phenyl-substituted aliphatic alcohols and related aldehydes and esters evaluated by JECFA (63rd meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and aryl-substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives evaluated by EFSA in FGE.15 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 15, Revision 1 (FGE.15Rev1) - Aryl-substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives from chemical group 22 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 68 (FGE.68): Consideration of cinnamyl alcohol and related flavouring agents evaluated by JECFA (55th meeting) evaluated by EFSA in FGE.15Rev1 (2008)
View page or View pdf

Flavouring Group Evaluation 15, Revision 2 (FGE.15Rev2): Aryl-substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives from chemical group 22
View page or View pdf

EPI System: View

ClinicalTrials.gov:search

Daily Med:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):1135-24-6

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :709

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid

Chemidplus:0001135246

RTECS:GD9275000 for cas# 1135-24-6

References:

	3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	1135-24-6
Pubchem (cid):	709
Pubchem (sid):	134980973

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Metabolomics Database:	Search
HMDB (The Human Metabolome Database):	HMDB00954
FooDB:	FDB012801
YMDB (Yeast Metabolome Database):	YMDB01325
FDA Listing of Food Additive Status:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

antimicrobial agents

Occurrence (nature, food, other):note

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Synonyms:

	coniferic acid
4-	hydroxy-3-methoxy cinnammic acid
4-	hydroxy-3-methoxycinnamic acid
3-(4-	hydroxy-3-methoxyphenyl) acrylic acid
3-(4-	hydroxy-3-methoxyphenyl)-2-propenoic acid
3-(4-	hydroxy-3-methoxyphenyl)acrylic acid
3-(4-	hydroxy-3-methoxyphenyl)prop-2-enoic acid
3-	methoxy-4-hydroxycinnamic acid
2-	propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-