EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

polyquaternium-1
poly[(dimethylimino)-2-butene-1,4-diyl chloride], .alpha.-[4-[tris(2-hydroxyethyl)ammonium]-2-butenyl]-.omega.-[tris(2-hydroxyethyl)ammonium]-, dichloride

Supplier Sponsors

CAS Number: 75345-27-6Picture of molecule3D/inchi
FDA UNII: 6716Z5YR3G
Molecular Weight:556.99676000
Formula:C22 H48 Cl3 N3 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:film forming agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -9.896 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: film formers
 
Suppliers:
BOC Sciences
For experimental / research use only.
Polyquaternium 1 > 95%
Odor: characteristic
Use: Polyquaternium 1 is a polycationic polymer.
Stepan Company
ONAMER® M
sds
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
film forming agents
Recommendation for polyquaternium-1 usage levels up to:
 not for fragrance use.
 
Recommendation for polyquaternium-1 flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5282453
National Institute of Allergy and Infectious Diseases:Data
dimethyl-bis[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azanium;trichloride
Chemidplus:0075345276
 
References:
 dimethyl-bis[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azanium;trichloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5282453
Pubchem (sid):135192655
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 film formers
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dimethyl-bis[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azanium;trichloride
a-((E)-4-(tris(2-hydroxyethyl)ammonio)-2-butenyl-omega-(tris(2-hydroxyethyl)ammonio)poly((dimethyliminio)((E)-2-butenylene)chloride)dichloride
 onamer M
 polidronium chloride
 poly[(dimethylimino)-2-butene-1,4-diyl chloride], .alpha.-[4-[tris(2-hydroxyethyl)ammonium]-2-butenyl]-.omega.-[tris(2-hydroxyethyl)ammonium]-, dichloride
 polyquaternium 1
 

Articles:

PubMed:Confocal microscopy of epithelial and langerhans cells of the cornea in patients using travoprost drops containing two different preservatives.
PubMed:Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures.
PubMed:Short-term clinical comparison of two dual-disinfection multipurpose disinfecting solutions.
PubMed:Meta-analysis of the ocular biocompatibility of a new multipurpose lens care system.
PubMed:Relative efficacy and safety of preservative-free latanoprost (T2345) for the treatment of open-angle glaucoma and ocular hypertension: an adjusted Indirect comparison meta-analysis of randomized clinical trials.
PubMed:Effect of lens and solution choice on the comfort of contact lens wearers.
PubMed:Quantification of individual proteins in silicone hydrogel contact lens deposits.
PubMed:[Preservatives in ophthalmology].
PubMed:The effect of contact lens materials on disinfection activity of polyquaternium-1 and myristamidopropyl dimethylamine multipurpose solution against Staphylococcus aureus.
PubMed:Corneal epithelial cell viability following exposure to ophthalmic solutions containing preservatives and/or antihypertensive agents.
PubMed:Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets.
PubMed:The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells.
PubMed:Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study.
PubMed:Reduced in vivo ocular surface toxicity with polyquad-preserved travoprost versus benzalkonium-preserved travoprost or latanoprost ophthalmic solutions.
PubMed:A preservative-and-fluorescein interaction model for benign multipurpose solution-associated transient corneal hyperfluorescence.
PubMed:Cytotoxicity and effects on metabolism of contact lens care solutions on human corneal epithelium cells.
PubMed:Comparison of a travoprost BAK-free formulation preserved with polyquaternium-1 with BAK-preserved travoprost in ocular hypertension or open-angle glaucoma.
PubMed:Comparative in vitro toxicology study of travoprost polyquad-preserved, travoprost BAK-preserved, and latanoprost BAK-preserved ophthalmic solutions on human conjunctival epithelial cells.
PubMed:Ophthalmic preservatives: focus on polyquaternium-1.
PubMed:Assessment of effects of multipurpose contact lens care solutions on human corneal epithelial cells.
PubMed:Effects of benzalkonium chloride- or polyquad-preserved fixed combination glaucoma medications on human trabecular meshwork cells.
PubMed:Travoprost 0.004%/timolol 0.5%-fixed combination with and without benzalkonium chloride: a prospective, randomized, doubled-masked comparison of safety and efficacy.
PubMed:[In vitro evaluation for corneal damages by anti-glaucoma combination eye drops using human corneal epithelial cell (HCE-T)].
PubMed:Effects of benzalkonium chloride- and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells.
PubMed:Effects of glaucoma medications and preservatives on cultured human trabecular meshwork and non-pigmented ciliary epithelial cell lines.
PubMed:A preliminary study of silicone hydrogel lens material and care solution bioincompatibilities.
PubMed:Polyquad-preserved travoprost/timolol, benzalkonium chloride (BAK)-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations: a rabbit ocular surface study.
PubMed:In vitro comparative toxicology of polyquad-preserved and benzalkonium chloride-preserved travoprost/timolol fixed combination and latanoprost/timolol fixed combination.
PubMed:Effects of benzalkonium chloride-preserved, polyquad-preserved, and sofZia-preserved topical glaucoma medications on human ocular epithelial cells.
PubMed:Stability of fortified cefazolin ophthalmic solutions prepared in artificial tears containing surfactant-based versus oxidant-based preservatives.
PubMed:Interactions of lens care with silicone hydrogel lenses and effect on comfort.
PubMed:Antimicrobial efficacy assessment of multi-use solution to disinfect hydrophilic contact lens, in vitro.
PubMed:Detection of virulence factors in Serratia strains isolated from contact lens-associated corneal ulcers.
PubMed:A randomized clinical comparison of OPTI-FREE EXPRESS and ReNu MultiPLUS multipurpose lens care solutions.
PubMed:Do multipurpose solutions damage porcine corneal epithelial cells?
PubMed:Clinical evaluation of long-term users of two contact lens care preservative systems.
PubMed:[Toxicity of a new moistening agent and preservative in vitro].
PubMed:Broad spectrum of antibacterial activity of a new multipurpose disinfecting solution.
PubMed:Trabeculectomy trapdoor separation with allergic periorbital dermatitis: an unusual late-onset complication of guarded filtration surgery.
PubMed:Superficial corneal "staining"-clinical observation and risk assessment.
PubMed:Efficacy of contact lens multipurpose solutions against serratia marcescens.
PubMed:The comparative clinical performance of a new polyhexamethylene biguanide- vs a polyquad-based contact lens care regime with two silicone hydrogel contact lenses.
PubMed:Biocide uptake in contact lenses and loss of fungicidal activity during storage of contact lenses.
PubMed:Comparison of toxicological profiles of benzalkonium chloride and polyquaternium-1: an experimental study.
PubMed:The safety and intraocular pressure-lowering efficacy of brimonidine tartrate 0.15% preserved with polyquaternium-1.
PubMed:Resistance to a polyquaternium-1 lens care solution and isoelectric points of Pseudomonas aeruginosa strains.
PubMed:An investigation into the antimicrobial mechanisms of action of two contact lens biocides using electron microscopy.
PubMed:Subjective and objective measures of corneal staining related to multipurpose care systems.
PubMed:Disinfecting action of a new multi-purpose disinfection solution for contact lenses.
PubMed:Amoebicidal activity of a preserved contact lens multipurpose disinfecting solution compared to a disinfection/neutralisation peroxide system.
PubMed:Amoebicidal activity of multipurpose contact lens solutions.
PubMed:Identification of genes involved in the susceptibility of Serratia marcescens to polyquaternium-1.
PubMed:Quantitative and conformational characterization of lysozyme deposited on balafilcon and etafilcon contact lens materials.
PubMed:Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine.
PubMed:Asymptomatic corneal staining associated with the use of balafilcon silicone-hydrogel contact lenses disinfected with a polyaminopropyl biguanide-preserved care regimen.
PubMed:Rheological evaluation of the interactions between cationic celluloses and Carbopol 974P in water.
PubMed:Bacillus cereus keratitis associated with contact lens wear.
PubMed:Broad spectrum antimicrobial activity of a new multi-purpose disinfecting solution.
PubMed:Antimicrobial comparison of a new multi-purpose disinfecting solution to a 3% hydrogen peroxide system.
PubMed:Loss of bactericidal activity from contact lens storage solutions.
PubMed:Evaluating the preservative effectiveness of RGP lens care solutions.
PubMed:Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions.
PubMed:A comparative study of the microbiologic effectiveness of chemical disinfectants and peroxide-neutralizer systems.
PubMed:Artificial tear composition and promotion of recovery of the damaged corneal epithelium.
PubMed:Comparative efficacies of soft contact lens disinfectant solutions against microbial films in lens cases.
PubMed:Quantitative evaluation of the corneal epithelial barrier: effect of artificial tears and preservatives.
PubMed:Disinfecting activities of non-peroxide soft contact lens cold disinfection solutions.
PubMed:D-value determinations are an inappropriate measure of disinfecting activity of common contact lens disinfecting solutions.
PubMed:Effect of contact lens preservatives on Acanthamoeba.
PubMed:The effect of currently available contact lens disinfection systems on Acanthamoeba castellanii and Acanthamoeba polyphaga.
PubMed:Opti-Free chemical disinfectant: a safety study with various soft contact lenses.
PubMed:The margin of safety of polyquaternium-1 preserved lens care solutions: a phase I clinical study.
 
Notes:
None found
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