EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ferric citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)

Supplier Sponsors

CAS Number: 3522-50-7Picture of molecule3D/inchi
Other(deleted CASRN):11084-12-1
FDA UNII: 63G354M39Z
Nikkaji Web:J1.249A
MDL:MFCD00013098
Molecular Weight:244.94525000
Formula:C6 H5 Fe O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents and indirect food additives: paper and paperboard components
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
American Elements
Ferric Citrate
BOC Sciences
For experimental / research use only.
ferric citrate
Sigma-Aldrich: Sigma
For experimental / research use only.
Ferric Citrate BioReagent, suitable for cell culture
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents and indirect food additives: paper and paperboard components
Recommendation for ferric citrate usage levels up to:
 not for fragrance use.
 
Recommendation for ferric citrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61300
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-hydroxypropane-1,2,3-tricarboxylate;iron(3+)
Chemidplus:0003522507
 
References:
 2-hydroxypropane-1,2,3-tricarboxylate;iron(3+)
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):61300
Pubchem (sid):135019896
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FooDB:FDB013680
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 citric acid, iron(3+) salt (1:1)
2-hydroxypropane-1,2,3-tricarboxylate;iron(3+)
 iron(III) citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)
 zerenex
 

Articles:

PubMed:Visual detection technique for efficient screening and isolation of Salmonella based on a novel enrichment assay using chromatography membrane.
PubMed:Microbial Metabolism Shifts Towards an Adverse Profile with Supplementary Iron in the TIM-2 In vitro Model of the Human Colon.
PubMed:Dose-related effects of ferric citrate supplementation on endoplasmic reticular stress responses and insulin signalling pathways in streptozotocin-nicotinamide-induced diabetes.
PubMed:Managing hyperphosphatemia in patients with chronic kidney disease on dialysis with ferric citrate: latest evidence and clinical usefulness.
PubMed:Novel iron-based phosphate binders in patients with chronic kidney disease.
PubMed:Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.
PubMed:Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats.
PubMed:Cultivar variability of iron uptake mechanisms in rice (Oryza sativa L.).
PubMed:Ferric citrate hydrate as a phosphate binder and risk of aluminum toxicity.
PubMed:A 13-week subchronic toxicity study of ferric citrate in F344 rats.
PubMed:Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats.
PubMed:Enhancement of non-heme iron absorption by anchovy (Engraulis japonicus) muscle protein hydrolysate involves a nanoparticle-mediated mechanism.
PubMed:Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
PubMed:Role of ferric reductases in iron acquisition and virulence in the fungal pathogen Cryptococcus neoformans.
PubMed:Dynamics in the rhizosphere and iron-uptake gene expression in peanut induced by intercropping with maize: role in improving iron nutrition in peanut.
PubMed:Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1).
PubMed:Effect of iron liposomes on anemia of inflammation.
PubMed:Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice.
PubMed:High bioavailability iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro (Caco-2 model) and in vivo (Gallus gallus).
PubMed:Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin.
PubMed:Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism.
PubMed:Iron and zinc concentrations in grain and flour of winter wheat as affected by foliar application.
PubMed:Accelerating glycolytic flux of Torulopsis glabrata CCTCC M202019 at high oxidoreduction potential created using potassium ferricyanide.
PubMed:A thioredoxin reductase-like protein from the thermophile, Thermus scotoductus SA-01, displaying iron reductase activity.
PubMed:Transport of iron bound to recombinant human lactoferrin from rice and iron citrate across Caco-2 cell monolayers.
PubMed:Effects of glyphosate application on seed iron and root ferric (III) reductase in soybean cultivars.
PubMed:Biodegradation of anthraquinone dyes by Shewanella sp. NTOU1 under anaerobic conditions.
PubMed:Ascorbic acid uptake affects ferritin, Dcytb and Nramp2 expression in Caco-2 cells.
PubMed:Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions.
PubMed:A cyclic AMP receptor protein-regulated cell-cell communication system mediates expression of a FecA homologue in Stenotrophomonas maltophilia.
PubMed:Isolation of a soluble and membrane-associated Fe(III) reductase from the thermophile, Thermus scotoductus (SA-01).
PubMed:Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.
PubMed:Rates of foliar penetration of chelated Fe(III): role of light, stomata, species, and leaf age.
PubMed:Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells.
PubMed:Oxidative stress and antioxidant status in mouse kidney: effects of dietary lipid and vitamin E plus iron.
PubMed:Physiological modulation of iron metabolism in rainbow trout (Oncorhynchus mykiss) fed low and high iron diets.
PubMed:Ferric citrate is half as effective as ferrous sulfate in meeting the iron requirement of juvenile tilapia, Oreochromis niloticus x O. aureus.
PubMed:Iron bioavailability and utilization in rats are lower from lime-treated corn flour than from wheat flour when they are fortified with different sources of iron.
PubMed:Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt.
PubMed:Molecular cloning and identification of UTR1 of a yeast Saccharomyces cerevisiae as a gene encoding an NAD kinase.
PubMed:Enhanced iron uptake of Saccharomyces cerevisiae by heterologous expression of a tadpole ferritin gene.
PubMed:The importance of the proportion of heme/nonheme iron in the diet to minimize the interference with calcium, phosphorus, and magnesium metabolism on recovery from nutritional ferropenic anemia.
PubMed:Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
PubMed:Oxidative stress and antioxidant status in mouse liver: effects of dietary lipid, vitamin E and iron.
PubMed:Effects of iron replenishment on iron, calcium, phosphorus and magnesium metabolism in iron-deficient rats.
PubMed:Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
PubMed:Reduction of exogenous ferric iron by a surface-associated ferric reductase of Listeria spp.
PubMed:Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells.
PubMed:Tumorigenicity study of ferric citrate administered orally to mice.
PubMed:Induction of oxidative single- and double-strand breaks in DNA by ferric citrate.
PubMed:Heat resistance of Listeria monocytogenes by two recovery media used with and without cold preincubation.
PubMed:Development of an improved chemically defined minimal medium for Listeria monocytogenes.
PubMed:Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: relationship between carcinoma growth and lipid peroxidation product levels.
PubMed:Development of a protein-free medium with ferric citrate substituting transferrin for the cultivation of mouse-mouse hybridomas.
PubMed:Effect of endotoxin on colonisation of Campylobacter jejuni in infant mice.
PubMed:Effect of excess dietary iron as ferrous sulfate and ferric citrate on tissue mineral composition of sheep.
PubMed:[The determination of iron in ammoniacal ferric citrate and in syrups that contain it].
 
Notes:
None found
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