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ferrous fumarate
iron(2+) (2E)-2-butenedioate

Supplier Sponsors

Name:(E)-but-2-enedioate; iron(2+)
CAS Number: 141-01-5Picture of molecule3D/inchi
Other(deleted CASRN):871-44-3
ECHA EINECS - REACH Pre-Reg:205-447-7
FDA UNII: R5L488RY0Q
MDL:MFCD00058315
Molecular Weight:169.90174000
Formula:C4 H2 Fe O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1307d Ferrous fumarate View - review
FDA Mainterm (SATF):141-01-5 ; FERROUS FUMARATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart D--Special Dietary and Nutritional Additives
Sec. 172.350 Fumaric acid and salts of fumaric acid.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1307d Ferrous fumarate.
 
Physical Properties:
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1400 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
American Elements
Ferrous Fumarate 99%
Odor: characteristic
Use: Ferrous Fumarate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Ferrous Fumarate
Balchem
Ferrous Fumarate
VitaShure®
Flavor: characteristic
Vitashure is an extensive line of microencapsulated vitamins, minerals, amino acids, and bioactive substances, specifically designed for the supplementation and fortification industries.
BOC Sciences
For experimental / research use only.
ferrous fumarate
ECSA Chemicals
IRON FUMARAT
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Global Calcium
Ferrous Fumarate EP / BP
Global Calcium
Ferrous Fumarate IP
Global Calcium
Ferrous Fumarate USP
Indis NV
For experimental / research use only.
Ferrous Fumarate
Jost Chemical
Ferrous Fumarate EP Powder
Jost Chemical
Ferrous Fumarate FCC Powder
Jost Chemical
Ferrous Fumarate USP Powder
Jost Chemical
Microencapsulated Ferrous Fumarate 60%
Penta International
FERROUS FUMARATE
Qingdao Dacon Trading
Ferrous Fumarate
Santa Cruz Biotechnology
For experimental / research use only.
Ferrous Fumarate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Iron(II) fumarate ≥97.0%
sds
United International
Ferrous Fumarate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3850 mg/kg
Drugs in Japan Vol. 6, Pg. 683, 1982.

intraperitoneal-rat LD50 185 mg/kg
Drugs in Japan Vol. 6, Pg. 683, 1982.

oral-mouse LD50 1570 mg/kg
American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961.

intraperitoneal-mouse LD50 480 mg/kg
American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961.

Dermal Toxicity:
subcutaneous-rat LD50 500 mg/kg
Drugs in Japan Vol. 6, Pg. 683, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for ferrous fumarate usage levels up to:
 not for fragrance use.
 
Recommendation for ferrous fumarate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of iron compounds (E1) as feed additives for all animal species: ferrous carbonate; ferric chloride, hexahydrate; ferrous fumarate; ferrous sulphate, heptahydrate; ferrous sulphate, monohydrate; ferrous chelate of amino acids, hydrate; ferrous chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):141-01-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6433164
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(E)-but-2-enedioate; iron(2+)
Chemidplus:0000141015
RTECS:LT1950000 for cas# 141-01-5
 
References:
 (E)-but-2-enedioate; iron(2+)
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:141-01-5
Pubchem (cid):6433164
Pubchem (sid):134975091
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
KEGG (GenomeNet):D01194
HMDB (The Human Metabolome Database):Search
FooDB:FDB014094
FDA Listing of Food Additive Status:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(E)-but-2-enedioate; iron(2+)
(E)-2-butenedioic acid iron(2+) salt
2-butenedioic acid, iron(2+) salt, (2E)- (1:1)
 ferrousfumarate
 fumaric acid ferrous salt
 fumaric acid iron salt
 fumaric acid iron(2+) salt (1:1)
 fumaric acid, iron salt
 fumaric acid, iron(2+) salt
 fumaric acid, iron(2+) salt (1:1)
 iron (II) fumarate
 iron fumarate
 iron(2+) (2E)-2-butenedioate
 iron(2+) (2E)-but-2-enedioate
 iron(2+) fumarate
 iron(II) fumarate
 

Articles:

PubMed:Double-fortified salt is efficacious in improving indicators of iron deficiency in female Indian tea pickers.
PubMed:Carotenoids, but not vitamin A, improve iron uptake and ferritin synthesis by Caco-2 cells from ferrous fumarate and NaFe-EDTA.
PubMed:Bioavailability of iron, zinc, folic acid, and vitamin A from fortified maize.
PubMed:Rapid quantification of iron content in fish sauce and soy sauce: a promising tool for monitoring fortification programs.
PubMed:Iron deficiency anemia in patients with inflammatory bowel disease.
PubMed:Fortification of wheat flour and maize meal with different iron compounds: results of a series of baking trials.
PubMed:A chewable low-dose oral contraceptive: a new birth control option?
PubMed:[Effect of iron supplementation on iron deficiency anemia of childbearing age women in Shanghai].
PubMed:Iron supplementation of breastfed infants.
PubMed:Influence of organic acids on rheological and bread-making characteristics of fortified wheat flour.
PubMed:Feasibility and optimization study of using cold-forming extrusion process for agglomerating and microencapsulating ferrous fumarate for salt double fortification with iodine and iron.
PubMed:Effect of Helicobacter pylori infection on iron absorption in asymptomatic adults consuming wheat flour fortified with iron and zinc.
PubMed:Folic acid fortification through existing fortified foods: iodized salt and vitamin A-fortified sugar.
PubMed:Shelf stability, sensory qualities, and bioavailability of iron-fortified Nepalese curry powder.
PubMed:Acceptability of complementary foods and breads prepared from zinc-fortified cereal flours among young children and adults in Senegal.
PubMed:Dry cereals fortified with electrolytic iron or ferrous fumarate are equally effective in breast-fed infants.
PubMed:A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink.
PubMed:Use of ferrous fumarate to fortify foods for infants and young children.
PubMed:Orange but not apple juice enhances ferrous fumarate absorption in small children.
PubMed:Revised recommendations for iron fortification of wheat flour and an evaluation of the expected impact of current national wheat flour fortification programs.
PubMed:Iron in vitro bioavailability and iodine storage stability in double-fortified salt.
PubMed:Efficacy of pandesal baked from wheat flour fortified with iron and vitamin a in improving the iron and anthropometric status of anemic schoolchildren in the Philippines.
PubMed:FDA report: Ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease.
PubMed:Nonheme-iron absorption in first-degree relatives is highly correlated: a stable-isotope study in mother-child pairs.
PubMed:Changing the zinc:iron ratio in a cereal-based nutritional supplement has no effect on percent absorption of iron and zinc in Sri Lankan children.
PubMed:Development and optimization of iron- and zinc-containing nanostructured powders for nutritional applications.
PubMed:Periconceptional iron supplementation does not reduce anemia or improve iron status among pregnant women in rural Bangladesh.
PubMed:Regular consumption of a complementary food fortified with ascorbic acid and ferrous fumarate or ferric pyrophosphate is as useful as ferrous sulfate in maintaining hemoglobin concentrations >105 g/L in young Bangladeshi children.
PubMed:Dual fortification of salt with iodine and iron: a randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India.
PubMed:Fortifying brown bread with sodium iron EDTA, ferrous fumarate, or electrolytic iron does not affect iron status in South African schoolchildren.
PubMed:Alginate and chitosan functionalization for micronutrient encapsulation.
PubMed:Sensorial evaluation of nutritional supplements (PROGRESA) enriched with 3 different forms of iron in a rural Mexican community.
PubMed:Stability of vitamin B1 in Ultra Rice in the presence of encapsulated ferrous fumarate.
PubMed:A comparative study of iron bioavailability from cocoa supplemented with ferric pyrophosphate or ferrous fumarate in rats.
PubMed:Dialyzability of minerals in corn masa gruel (atole) fortified with different iron compounds: effects of ascorbic acid, disodium EDTA, and phytic acid.
PubMed:Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: a randomized clinical trial.
PubMed:Fortification of soy sauce using various iron sources: sensory acceptability and shelf stability.
PubMed:Iron fortification technology development: new approaches.
PubMed:Iron deficiency anemia among children: Addressing a global public health problem within a Canadian context.
PubMed:The importance of dietary composition for efficacy of iron absorption measured in a whole diet that includes rye bread fortified with ferrous fumerate: a radioisotope study in young women.
PubMed:The potential of encapsulated iron compounds in food fortification: a review.
PubMed:Iron amino acid chelates.
PubMed:Enhancers of iron absorption: ascorbic acid and other organic acids.
PubMed:Iron availability of a fortified processed wheat cereal: a comparison of fourteen iron forms using an in vitro digestion/human colonic adenocarcinoma (CaCo-2) cell model.
PubMed:Ferrous sulfate is more bioavailable among preschoolers than other forms of iron in a milk-based weaning food distributed by PROGRESA, a national program in Mexico.
PubMed:In vitro iron availability from iron-fortified whole-grain wheat flour.
PubMed:Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method.
PubMed:Stability of salt double-fortified with ferrous fumarate and potassium iodate or iodide under storage and distribution conditions in Kenya.
PubMed:A new approach to control of anemia in "at risk" infants and children around the world. 2004 Ryley-Jeffs memorial lecture.
PubMed:Helicobacter pylori infection, iron absorption, and gastric acid secretion in Bangladeshi children.
PubMed:Iron absorption from ferrous fumarate in adult women is influenced by ascorbic acid but not by Na2EDTA.
PubMed:Iron bioavailability in corn-masa tortillas is improved by the addition of disodium EDTA.
PubMed:Iron and ascorbic Acid: proposed fortification levels and recommended iron compounds.
PubMed:Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children.
PubMed:Iron bioavailability and utilization in rats are lower from lime-treated corn flour than from wheat flour when they are fortified with different sources of iron.
PubMed:Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services.
PubMed:The effect of different iron fortificants on iron absorption from iron-fortified rice.
PubMed:Bioavailability of iron from micro-encapsulated iron sprinkle supplement.
PubMed:Iodine stability in salt double-fortified with iron and iodine.
PubMed:Iron supplementation: overcoming technical and practical barriers.
PubMed:Iron bioavailability from iron-fortified Guatemalan meals based on corn tortillas and black bean paste.
PubMed:Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods.
PubMed:Multivitamin-multimineral and iron supplementation did not improve appetite of young stunted and anemic Beninese children.
PubMed:The effect of change in pH on the solubility of iron bis-glycinate chelate and other iron compounds.
PubMed:An evaluation of EDTA compounds for iron fortification of cereal-based foods.
PubMed:Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate.
PubMed:Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells.
PubMed:Iron is well absorbed by healthy adults after ingestion of double-fortified (iron and dextran-coated iodine) table salt and urinary iodine excretion is unaffected.
PubMed:Short time effect of Chemiron (a combination iron preparation), single iron, and different magnesium salts on plasma. Magnesium concentration during early pregnancy in Nigerian women. A preliminary report.
PubMed:Iron and zinc interactions in humans.
PubMed:Early response to the effect of iron fortification in the Venezuelan population.
PubMed:Bioavailability to rats of iron from fortified grain amaranth.
PubMed:[Vitamin- and iron-enriched pre-cooked corn meal].
PubMed:Ferrous fumarate fortification of a chocolate drink powder.
PubMed:Interactions between infections, malnutrition and iron nutritional status in Pakistani infants. A longitudinal study.
PubMed:Iron absorption from infant foods.
PubMed:Iron fortification of infant cereals: a proposal for the use of ferrous fumarate or ferrous succinate.
PubMed:Iron availability from infant food supplements.
 
Notes:
used in treatment of iron deficiency anemia. Nutrient supplement
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