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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear oily liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.96720 @ 25.00 °C.
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| Refractive Index: | 1.40150 @ 20.00 °C.
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| Melting Point: | -3.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 245.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.022500 mmHg @ 25.00 °C. (est) |
| Flash Point: | 256.00 °F. TCC ( 124.40 °C. ) (est)
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| Soluble in: |
| | water, 0.005007 mg/L @ 25 °C (est) | | | water, 0.0051 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor Strength:none |
| Odor Description:at 100.00 %. odorless |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| DODECAMETHYLCYCLOHEXASILOXANE >98.0%(GC)
Odor: characteristic Use: A cyclic volatile methylsiloxane (cVMS) used in cosmetic and personal care products. Used in dermal exposure |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane
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Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 50000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. OTS0572798
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for cyclohexasiloxane usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for cyclohexasiloxane flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):540-97-6 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :10911 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane |
| Chemidplus:0000540976 |
References:
| | 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 540-97-6 |
| Pubchem (cid): | 10911 |
| Pubchem (sid): | 134975746 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl- | | | cyclohexasiloxane, dodecamethyl- | | | dodecamethyl cyclohexasiloxane | | 2,2,4,4,6,6,8,8,10,10,12,12- | dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane | | | dodecamethylcyclohexasiloxan | | | dodecamethylcyclohexasiloxane |
Articles:
| PubMed:Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada. |
| PubMed:Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout. |
| PubMed:Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment. |
| PubMed:Water-in-oil emulsions prepared by peptide-silicone hybrid polymers as active interfacial modifier: effects of silicone oil species on dispersion stability of emulsions. |
| PubMed:Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation. |
| PubMed:Concentrations in ambient air and emissions of cyclic volatile methylsiloxanes in Zurich, Switzerland. |
| PubMed:Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model. |
| PubMed:Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry. |
| PubMed:Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment. |
| PubMed:Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs). |
| PubMed:Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air. |
| PubMed:Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China. |
| PubMed:Cyclic volatile methylsiloxanes in fish from the Baltic Sea. |
| PubMed:Junge relationships in measurement data for cyclic siloxanes in air. |
| PubMed:Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada. |
| PubMed:Chemical fate, latitudinal distribution and long-range transport of cyclic volatile methylsiloxanes in the global environment: a modeling assessment. |
| PubMed:Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants. |
| PubMed:Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol. |
| PubMed:Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane. |
| PubMed:Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program. |
| PubMed:Measuring chemical emissions from wet products--development of a new measurement technique. |
| PubMed:Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary. |
| PubMed:Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China. |
| PubMed:Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method. |
| PubMed:Determination of cyclic and linear siloxanes in soil samples by ultrasonic-assisted extraction and gas chromatography-mass spectrometry. |
| PubMed:Volatile siloxanes in the European arctic: assessment of sources and spatial distribution. |
| PubMed:Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures. |
| PubMed:Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure. |
| PubMed:Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products. |
| PubMed:Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants. |
| PubMed:[Residual chemicals in silicone rubber products for food contact use]. |
| PubMed:Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS. |
| PubMed:Cyclosiloxanes produce fatal liver and lung damage in mice. |
| PubMed:Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice. |
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3D/inchi