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Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystals (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 177.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 333.80 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 2.100000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 312.00 °F. TCC ( 155.70 °C. ) (est)
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| logP (o/w): | 2.850 |
| Soluble in: |
| | water, 0.8 mg/L @ 25 °C (exp) | | | water, 47.35 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 80 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Acta Biologica et Medica Germanica. Vol. 7, Pg. 502, 1961.
oral-mouse LD50 1546 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(5), Pg. 50, 1974.
unreported-mouse LD50 750 mg/kg
Acta Biologica et Medica Germanica. Vol. 1, Pg. 450, 1958.
oral-rabbit LD50 1115 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(5), Pg. 50, 1974.
intraperitoneal-rat LD50 68400 ug/kg
Journal of Toxicology and Environmental Health. Vol. 9, Pg. 867, 1982.
oral-rat LD50 2636 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
National Technical Information Service. Vol. OTS0533649-9
unreported-rat LD50 > 10000 mg/kg
Residue Reviews. Vol. 36, Pg. 240, 1971.
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| Dermal Toxicity: |
skin-mouse LDLo 5000 mg/kg
Journal of the American College of Toxicology. Vol. 9, Pg. 642, 1991.
skin-rabbit LD50 > 22600 mg/kg
Pesticide Manual. Vol. 9, Pg. 431, 1991.
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| Inhalation Toxicity: |
inhalation-mouse LC50 > 6000 mg/m3/2H
Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
inhalation-rat LC50 > 5000 mg/m3/2H
Toxicology and Applied Pharmacology. Vol. 45, Pg. 320, 1978.
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Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for folpet usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for folpet flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Reasoned opinion on the modification of the existing MRL for folpet in table grapes
View page or View pdf
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Reasoned opinion on the review of the existing maximum residue levels (MRLs) for folpet according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
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Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
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Modification of the existing maximum residue levels for folpet in apples and pears
View page or View pdf
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Modification of the existing maximum residue levels for folpet in barley, oat, rye and wheat
View page or View pdf
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| EPI System: View |
| EPA-Iris:IRIS |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):133-07-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :8607 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 2-(trichloromethylsulfanyl)isoindole-1,3-dione |
| Chemidplus:0000133073 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:133-07-3 |
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C18860 |
| HMDB (The Human Metabolome Database): | HMDB31792 |
| FooDB: | FDB008465 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•usepaopp pesticide code 081601; trade names: phaltan; folpan; folpex.
•dusts, flowable, wettable granule, wettable powder.
•premix partners: benalaxyl; benalaxyl-m; copper hydroxide; copper sulfate; cymoxanil; dimethomorph; fosetyl-aluminum; mancozeb; metalaxyl-m; oxadixyl; prochloraz; propioconazole; triadimenol; valifenalate.
•technical grade: 88%. liquid ready-to-use 0.3 to 0.7%; wettable powder 44 to 50%.
•folpet is added to paint, stains, and caulking compounds in manufacturing settings using a variety of techniques, such as open pouring and pump-metering. folpet containing paint is subsequently applied with handheld painting equipment (e.g., paint brush, roller, compressed-air sprayer, or airless sprayer).
•semi-transparent wood preservative stain a14t5 (sherwin williams co., the): folpet 0.66%, bis(tributyltin) oxide 0.34%.
•fungitrol 11-50s fungicide (international specialty products): folpet 48%.
•olympic clear wood preservative (ppg architectural finishes, inc.): folpet 0.5%, bis(tributyltin) oxide 0.5%.
•clear wood preservative (ppg architectural finishes, inc.): folpet 0.5%, 3-lodo-2-propynyl butylcarbamate 0.5%.
•folpan folpet technical (makhteshim chemical works ltd): folpet 95.9%.
•folpan 50% w.p. (makhteshim chemical works ltd): folpet 50%.
•csi folpet technical (control solutions, inc.): folpet 95.9%.
•folpan 50w (makhteshim-agan of north america, inc.): folpet 50%.
•folpan 80 wdg (makhteshim-agan of north america, inc.): folpet 80%.
•folpan 80 wdg industrial (makhteshim-agan of north america, inc.): folpet 80%.
•folpan industrial e (makhteshim-agan of north america, inc.): folpet 95.9%.
•folpan industrial p (makhteshim-agan of north america, inc.): folpet 95.9%.
•folpan industrial bg (makhteshim-agan of north america, inc.): folpet 95%.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | faltex | | | folnit | | | folpan | | | folpel | | | fungitrol | | 1H-iso | indole-1,3(2H)-dione, 2-((trichloromethyl)thio)- | | 1H-iso | indole-1,3(2H)-dione, 2-[(trichloromethyl)thio]- | | | intercide TMP | | | murphy's rose fungicide | | | ortho phaltan 50W | | | orthophaltan | | | phaltan | | | phthalimide, N-((trichloromethyl)thio)- | | | phthalimide, N-[(trichloromethyl)thio]- | | | spolacid | | | thiophal | | 2-[( | trichlormethyl)sulfanyl]-1H-isoindol-1,3(2H)-dion | | N-( | trichlormethylthio)phthalimide | | N-( | trichloromethanesulphenyl)phthalimide | | 2-[( | trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione | | 2-(( | trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione | | 2-(( | trichloromethyl)thio)isoindoline-1,3-dione | | 2-[( | trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione | | N-( | trichloromethylmercapto)phthalimide | | 2-( | trichloromethylsulfanyl)isoindole-1,3-dione | | N-( | trichloromethylthio)phthalimide | | N- | trichloromethylthiophthalimide | | | troysan anti-mildew O | | | vinicoll |
Articles:
| PubMed:Levels and determinants of pesticide exposure in re-entry workers in vineyards: Results of the PESTEXPO study. |
| PubMed:Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease. |
| PubMed:Implementing the contamination prevention programs in the pesticide industry by infrared spectroscopy. |
| PubMed:A new alternative method for testing skin irritation using a human skin model: a pilot study. |
| PubMed:Pesticide residues in berries harvested from South-Eastern Poland (2009-2011). |
| PubMed:Development and validation of a method for the determination of 159 pesticide residues in tobacco by gas chromatography-tandem mass spectrometry. |
| PubMed:Heterogeneous ozonolysis of folpet and dimethomorph: a kinetic and mechanistic study. |
| PubMed:Extraction of imide fungicides in water and juice samples using magnetic graphene nanoparticles as adsorbent followed by their determination with gas chromatography and electron capture detection. |
| PubMed:Degradation of metalaxyl and folpet by filamentous fungi isolated from Portuguese (Alentejo) vineyard soils. |
| PubMed:Effects of temperature and purity of magnesium sulfate during extraction of pesticide residues using the QuEChERS method. |
| PubMed:Levels and determinants of pesticide exposure in operators involved in treatment of vineyards: results of the PESTEXPO Study. |
| PubMed:A multi-residue method for pesticides analysis in green coffee beans using gas chromatography-negative chemical ionization mass spectrometry in selective ion monitoring mode. |
| PubMed:Exploiting the lithiation-directing ability of oxetane for the regioselective preparation of functionalized 2-aryloxetane scaffolds under mild conditions. |
| PubMed:A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies. |
| PubMed:[Pesticides]. |
| PubMed:Toxicokinetic modeling of folpet fungicide and its ring-biomarkers of exposure in humans. |
| PubMed:Folpet-induced short term cytotoxic and proliferative changes in the mouse duodenum. |
| PubMed:Multipesticide residue analysis in maize combining acetonitrile-based extraction with dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. |
| PubMed:Multiresidue determination of 160 pesticides in wines employing mixed-mode dispersive-solid phase extraction and gas chromatography-tandem mass spectrometry. |
| PubMed:Snails as indicators of pesticide drift, deposit, transfer and effects in the vineyard. |
| PubMed:Groundwater from infiltration galleries used for small public water supply systems: contamination with pesticides and endocrine disruptors. |
| PubMed:Determination of 40 currently used pesticides in airborne particulate matter (PM 10) by microwave-assisted extraction and gas chromatography coupled to triple quadrupole mass spectrometry. |
| PubMed:Qualitative aspects in the analysis of pesticide residues in fruits and vegetables using fast, low-pressure gas chromatography-time-of-flight mass spectrometry. |
| PubMed:Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers. |
| PubMed:Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers. |
| PubMed:Gas-chromatography mass-spectrometry determination of phthalic acid in human urine as a biomarker of folpet exposure. |
| PubMed:Chiral separation of metalaxyl and benalaxyl fungicides by electrokinetic chromatography and determination of enantiomeric impurities. |
| PubMed:Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine. |
| PubMed:Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions. |
| PubMed:Genetic toxicology of folpet and captan. |
| PubMed:Carcinogenic mode of action of folpet in mice and evaluation of its relevance to humans. |
| PubMed:The effects of fungicides on non-target mites can be mediated by plant pathogens. |
| PubMed:Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables. |
| PubMed:Multiresidue analysis of 50 pesticides in grape, pomegranate, and mango by gas chromatography-ion trap mass spectrometry. |
| PubMed:Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of selected fungicides in wine. |
| PubMed:A survey of antifoulants in sediments from Ports and Marinas along the French Mediterranean coast. |
| PubMed:Analysis of captan, folpet, and captafol in apples by dispersive liquid-liquid microextraction combined with gas chromatography. |
| PubMed:Cytotoxicity of folpet fungicide on human bronchial epithelial cells. |
| PubMed:Pesticide residues in grapes from vineyards included in integrated pest management in Slovenia. |
| PubMed:Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: application to an in vivo toxicokinetic study in rats. |
| PubMed:Suitability of two laboratory testing methods to evaluate the side effects of pesticides on Typhlodromus pyri Scheuten (Acari: Phytoseiidae). |
| PubMed:Physicochemical characteristics and bronchial epithelial cell cytotoxicity of Folpan 80 WG(R) and Myco 500(R), two commercial forms of folpet. |
| PubMed:Seasonal distributions of fungicides in soils and sediments of a small river basin partially devoted to vineyards. |
| PubMed:[Simultaneous determination of captan and folpet pesticide residues in apples by solid-phase extraction and high performance liquid chromatography]. |
| PubMed:Multiresidue pesticide analysis of the medicinal plant Origanum syriacum. |
| PubMed:[Susceptibility of Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae) adults to fungicides used to control apple diseases]. |
| PubMed:Large volume cold on-column injection for gas chromatography-negative chemical ionization-mass spectrometry analysis of selected pesticides in air samples. |
| PubMed:Assessment of QoI resistance in Plasmopara viticola oospores. |
| PubMed:Residue determination of captan and folpet in vegetable samples by gas chromatography/negative chemical ionization-mass spectrometry. |
| PubMed:Residue levels of captan and trichlorfon in field-treated kaki fruits, individual versus composite samples, and after household processing. |
| PubMed:Effect of dose rate and mixtures of fungicides on selection for QoI resistance in populations of Plasmopara viticola. |
| PubMed:Quality and safety assessment of ginseng extracts by determination of the contents of pesticides and metals. |
| PubMed:Use of buffering and other means to improve results of problematic pesticides in a fast and easy method for residue analysis of fruits and vegetables. |
| PubMed:Side effects of mancozeb on Typhlodromus pyri (Acari: Phytoseiidae) in vineyards: results of multi-year field trials and a laboratory study. |
| PubMed:Evaluation of common organic solvents for gas chromatographic analysis and stability of multiclass pesticide residues. |
| PubMed:Activity of some chemicals in the control of Botrytis cinerea on roses. |
| PubMed:Phytotoxicity of diuron alone and in combination with copper or folpet on duckweed (Lemna minor). |
| PubMed:Multiresidue method using SPME for the determination of various pesticides with different volatility in confined atmospheres. |
| PubMed:Multiresidue method for the determination of pesticides in Korean domestic crops by gas chromatography/mass selective detection. |
| PubMed:Folpet permeation through nitrile gloves. |
| PubMed:Cell-cycle deregulation in BALB/c 3T3 cells transformed by 1,2-dibromoethane and folpet pesticides. |
| PubMed:Coupling solid-phase microextraction and high-performance liquid chromatography for direct and sensitive determination of halogenated fungicides in wine. |
| PubMed:Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. |
| PubMed:Induction of hsp70 in transgenic Drosophila: biomarker of exposure against phthalimide group of chemicals. |
| PubMed:A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. |
| PubMed:The effect of simulated rain on folpet and mancozeb residues on grapes and on vine leaves. |
| PubMed:Resolution by polarographic techniques of the ternary mixture of captan, captafol and folpet by using PLS calibration and artificial neuronal networks. |
| PubMed:Development of a SPME-GC-ECD methodology for selected pesticides in must and wine samples. |
| PubMed:Monitoring of antifouling agents in water samples by on-line solid-phase extraction-liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. |
| PubMed:Rapid determination of fungicides in fruit juices by micellar electrokinetic chromatography: use of organic modifiers to enhance selectivity and on-column high-salt stacking to improve sensitivity. |
| PubMed:Determination of fungicides in natural waters using solid-phase microextraction and gas chromatography coupled with electron-capture and mass spectrometric detection. |
| PubMed:Making best use of available residue data for acute intake assessment. |
| PubMed:Distribution of folpet on the grape surface after treatment. |
| PubMed:Analysis of pesticide residues in matrices with high lipid contents by membrane separation coupled on-line to a high-performance liquid chromatography system. |
| PubMed:2-trichloromethylthio-1H-isoindole-1,3(2H)-dione (Folpet). |
| PubMed:Concentrations of phthalate esters and identification of other additives in PVC children's toys. |
| PubMed:Ascorbate and glutathione contents in duckweed, Lemna minor, as biomarkers of the stress generated by copper, folpet and diuron. |
| PubMed:Cancer risk assessment of direct acting carcinogens. |
| PubMed:Chloropicrin dechlorination in relation to toxic action. |
| PubMed:Multiresidue determination of 19 fungicides in processed fruits and vegetables by capillary gas chromatography after gel permeation chromatography. |
| PubMed:Solid phase microextraction of pesticide residues from strawberries. |
| PubMed:Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine. |
| PubMed:Allergic contact and photoallergic contact dermatitis to plant and pesticide allergens. |
| PubMed:Toxic responses and catalase activity of Lemna minor L. Exposed to folpet, copper, and their combination. |
| PubMed:Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests. |
| PubMed:Evaluation of multiwavelength chromatograms for the quantification of mixtures of pesticides by high-performance liquid chromatography-diode array detection with multivariate calibration. |
| PubMed:Prevalence of dermatoses and skin sensitisation associated with use of pesticides in fruit farmers of southern Taiwan. |
| PubMed:Transgenic strains of the nematode C. elegans in biomonitoring and toxicology: effects of captan and related compounds on the stress response. |
| PubMed:Matrix solid-phase dispersion extraction procedure for multiresidue pesticide analysis in oranges. |
| PubMed:Transformation of BALB/c 3T3 cells in vitro by the fungicides captan, captafol and folpet. |
| PubMed:[Twenty-eight days repeated dose toxicity test of N-(fluorodichloromethylthio)phthalimide in rats]. |
| PubMed:Application of solid-phase partition cartridges in the determination of fungicide residues in vegetable samples. |
| PubMed:Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. |
| PubMed:Evaluation of the carcinogenic potential of pesticides. 4. Chloroalkylthiodicarboximide compounds with fungicidal activity. |
| PubMed:Safety/risk assessment of pesticides: principles, procedures and examples. |
| PubMed:The Ca(2+)-transport-ATPase of human erythrocytes as an in vitro toxicity test system--acute effects of some chlorinated compounds. |
| PubMed:Gas chromatographic determination of captan, folpet, and captafol residues in tomatoes, cucumbers, and apples using a wide-bore capillary column: interlaboratory study. |
| PubMed:A rapid in vivo bioassay for the carcinogenicity of pesticides. |
| PubMed:Induction of gastrointestinal tumors in mice fed the fungicide folpet: possible mechanisms. |
| PubMed:Comparative studies of the effects on liver and liver microsomal drug-metabolizing enzyme system by the fungicides captan, captafol and folpet in rats. |
| PubMed:Influence of bacterial growth of the overnight culture on the captan- and folpet-induced reversion in the Ames test. |
| PubMed:Mutagenic evaluation of the pesticides captan, folpet, captafol, dichlofluanid and related compounds with the mutants TA102 and TA104 of Salmonella typhimurium. |
| PubMed:Degradation behavior of captan and folpet on greenhouse tomatoes. |
| PubMed:Residues of captan and folpet on greenhouse tomatoes with emphasis on the effect of storing, washing, and cooking on their removal. |
| PubMed:Irritation and sensitization potential of pesticides. |
| PubMed:Rapid titrimetric method for the determination of captan and folpet in fungicide formulations. |
| PubMed:Comparison of the penetration of 14 pesticides through the skin of young and adult rats. |
| PubMed:Evaluation of the genetic activity profiles of 65 pesticides. |
| PubMed:A test series for pesticide dermatitis. |
| PubMed:Residues of captan and folpet in strawberries and grapes. |
| PubMed:Determination of captan, folpet, and captafol in fruits and vegetables, using two multiresidue methods. |
| PubMed:Clastogenic and physiological response of chromosomes to nine pesticides in the Vicia faba in vivo root tip assay system. |
| PubMed:[Late sequelae of prolonged phthalan exposure]. |
| PubMed:Hepatotoxicity of orally and intraperitoneally administered folpet in male rats. |
| PubMed:High-pressure liquid chromatographic determination of captan, captafol, and folpet residues in plant material. |
| PubMed:Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system). |
| PubMed:Effect of human gastric juice on the mutagenicity of chemicals. |
| PubMed:Metabolic activation and deactivation of mutagens and carcinogens. |
| PubMed:[Use of fungi as a biological test for determination of fungicide residues in plant material. II. Determination of benomyl, dichlofluanide, folpet, captane, carbendazyme, methyl thiophanate and thiram in fruit, vegetables and champignons]. |
| PubMed:Teratogenicity of the fungicides captan and folpet in the chick embryo. |
| PubMed:Effect of fungicide Folpet on growth and chromosomes of human lymphoid cell lines. |
| PubMed:Mutagenicity screening of pesticides in the microbial system. |
| PubMed:Mutagenicity studies with captan, captofol, folpet and thalidomide. |
| PubMed:Mutagenicity tests with captan and folpet in Drosophila melanogaster. |
| PubMed:Fungicide residues. II. The simultaneous determination of residues of folpet, captan and captafol in selected fruits by gas chromatography. |
| PubMed:Dominant lethal assay. II. Folpet and Difolatan. |
| PubMed:Action of the fungicides captan and folpet on rat liver mitochondria. |
| PubMed:An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates. |
| PubMed:An investigation of the teratogenic potential of captan, folpet, and difolatan. |
| PubMed:Reactions of captan and folpet with thiols. |
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3D/inchi