EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

disodium etidronate
phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2)

Supplier Sponsors

Name:disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
CAS Number: 7414-83-7Picture of molecule3D/inchi
Other(deleted CASRN):187285-10-5
ECHA EINECS - REACH Pre-Reg:231-025-7
FDA UNII: M16PXG993G
MDL:MFCD00152567
Molecular Weight:249.99128256
Formula:C2 H6 Na2 O7 P2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:chelating agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: chelating agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Etidronate disodium
Odor: characteristic
Use: Etidronate disodium is a bisphosphonate agent used for the treatment of osteoporosis and Paget's disease. It binds to hydroxyap Used as a calcium regulator. A bisphosphonate bone resorptive inhibitor.
Glentham Life Sciences
Etidronate disodium salt
Santa Cruz Biotechnology
For experimental / research use only.
Etidronate Disodium ≥98%
Shiva Chemicals and Pharmaceuticals
HEDP.Na2
Sigma-Aldrich: Sigma
For experimental / research use only.
Etidronate disodium hydrate ≥97% (NMR), solid
sds
TCI AMERICA
For experimental / research use only.
Disodium Etidronate >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo 32 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Journal of Pharmaceutical Sciences. Vol. 73, Pg. 1097, 1984.

oral-dog LDLo 500 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1257, 1989.

intraperitoneal-mouse LD50 250 mg/kg
British UK Patent Application. Vol. #2096889

intravenous-mouse LD50 49 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989.

oral-mouse LD50 1900 mg/kg
Drugs in Japan Vol. -, Pg. 221, 1995.

oral-rabbit LD50 581 mg/kg
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 22, Pg. 661, 1972.

intravenous-rat LD50 35 mg/kg
British UK Patent Application. Vol. #2096889

oral-rat LD50 1340 mg/kg
KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI
Toxicology and Applied Pharmacology. Vol. 22, Pg. 661, 1972.

Dermal Toxicity:
subcutaneous-mouse LD50 260 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989.

subcutaneous-rat LD50 372 mg/kg
SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
chelating agents
Recommendation for disodium etidronate usage levels up to:
 not for fragrance use.
 
Recommendation for disodium etidronate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):7414-83-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23894
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
Chemidplus:0007414837
RTECS:SZ8562240 for cas# 7414-83-7
 
References:
 disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):23894
Pubchem (sid):134987861
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D00314
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2931.90.9047
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 didronel R
 disodium (1-hydroxyethylidene)diphosphonate
 disodium 1-hydroxyethylidene phosphonate
 disodium dihydrogen (1-hydroxyethylidene) bisphosphonate
 disodium dihydrogen (1-hydroxyethylidene)bisphosphonate
 disodium dihydrogen (1-hydroxyethylidene)diphosphonate
 disodium ethane-1-hydroxy-1,1-diphosphonate
 disodium ethanol-1,1-diphosphonate
 disodium ethydronate
 disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
 ethane-1-hydroxy-1,1-diphosphonate, disodium salt
 ethane-1-hydroxy-1,1-diphosphonic acid, disodium salt
 etidronate disodium
(1-hydroxyethane-1,1-diyl)diphosphonic acid disodium salt
1-hydroxyethylidene-1,1-diphosphonic acid disodium salt
(1-hydroxyethylidene)diphosphonic acid, disodium salt
 phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt
 phosphonic acid, (1-hydroxyethylidene)di-, disodium salt
 phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2)
 

Articles:

PubMed:Prediction of bioavailability of selected bisphosphonates using in silico methods towards categorization into a biopharmaceutical classification system.
PubMed:[Establishment of zebrafish osteopenia model induced by dexamethasone].
PubMed:Efficacy and safety of 2-year etidronate treatment in a child with generalized arterial calcification of infancy.
PubMed:Bedside ultrasound in early diagnosis of neurogenic heterotopic ossification in patients with acquired brain injury.
PubMed:WITHDRAWN: Pharmacological interventions for treating acute heterotopic ossification.
PubMed:Long-term results of disodium etidronate treatment in pulmonary alveolar microlithiasis.
PubMed:Oroantral fistula from bisphosphonate induced osteonecrosis of the jaw.
PubMed:Intracanal bisphosphonate does not inhibit replacement resorption associated with delayed replantation of monkey incisors.
PubMed:Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials.
PubMed:Application of UV-derivative spectrophotometry for determination of some bisphosphonates drugs in pharmaceutical formulations.
PubMed:Etidronate: what is its place in treatment of primary osteoporosis and other demineralizing diseases today?
PubMed:Direct stability-indicating method development and validation for analysis of etidronate disodium using a mixed-mode column and charged aerosol detector.
PubMed:Longterm effect of intermittent cyclical etidronate therapy on corticosteroid-induced osteoporosis in Japanese patients with connective tissue disease: 7-year followup.
PubMed:Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates.
PubMed:The use of eidronate disodium in the prevention of heterotopic ossification in burn patients.
PubMed:Historical perspectives on the clinical development of bisphosphonates in the treatment of bone diseases.
PubMed:Successful treatment of a patient with severe calcific uremic arteriolopathy (calciphylaxis) by etidronate disodium.
PubMed:Pseudogout attack induced during etidronate disodium therapy.
PubMed:Brain calcifications induce neurological dysfunction that can be reversed by a bone drug.
PubMed:Ossification of the Achilles tendon--a case report.
PubMed:Calcinosis universalis: a rare diagnosis.
PubMed:[Heterotopic ossification in spinal cord injured patients].
PubMed:Effect of administration of retinol and etidronate on bone histomorphometric parameters in ovariectomized rats.
PubMed:Recurrent vesical calculi, hypercalciuria, and biochemical evidence of increased bone resorption in an adult male with paraplegia due to spinal cord injury: is there a role for intermittent oral disodium etidronate therapy for prevention of calcium phosphate bladder stones?
PubMed:Pharmacological interventions for treating acute heterotopic ossification.
PubMed:Effect of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis in Japanese patients with connective tissue disease: 3 year followup.
PubMed:Spectrophotometric determination of some drugs for osteoporosis.
PubMed:Chinese herbs and bone disease.
PubMed:Pulmonary alveolar microlithiasis in childhood: clinical and radiological follow-up.
PubMed:Idiopathic calciphylaxis.
PubMed:Conventional treatment of hypercalcemia of malignancy.
PubMed:Advances in the biology and treatment of myeloma bone disease.
PubMed:Familial fibrodysplasia ossificans progressiva: trial with etidronate disodium.
PubMed:Paget's disease of the spine and its management.
PubMed:Etidronic acid and steroid therapy: new indication. No proven impact on fractures.
PubMed:Effect of intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis.
PubMed:Prevalence and determinants of osteoporosis drug prescription among patients with high exposure to glucocorticoid drugs.
PubMed:Risedronate: a clinical review.
PubMed:Complexometric determination of diphosphonic acid derivatives. Part II.
PubMed:Etidronate inhibits human osteoblast apoptosis by inhibition of pro-apoptotic factor(s) produced by activated T cells.
PubMed:Gross vertebral collapse associated with long-term disodium etidronate treatment for pelvic Paget's disease.
PubMed:Etridronate therapy in the treatment and prevention of osteoporosis.
PubMed:Acute alteration in bone mineral density and biochemical markers for bone metabolism in nephrotic patients receiving high-dose glucocorticoid and one-cycle etidronate therapy.
PubMed:36 month intermittent cyclical etidronate treatment in patients with established corticosteroid induced osteoporosis.
PubMed:A patient with Paget's disease of bone treated with etidronate disodium.
PubMed:Effects of etidronate disodium on crystallizations in synthetic urine and calcium oxalate crystal adhesion to Madin-Darby canine kidney (MDCK) cells.
PubMed:Functional improvement in a patient with cerebral calcinosis using a bisphosphonate.
PubMed:The use of cyclical etidronate in osteoporosis: changes after completion of 3 years treatment.
PubMed:A comparative study on biochemical markers of bone collagen breakdown in post-menopausal women.
PubMed:Massive osteolytic bone metastases from a primary aortic sarcoma: a case report.
PubMed:Myositis ossificans complicating severe Guillain-Barré syndrome.
PubMed:Effect of intermittent cyclical disodium etidronate therapy on bone mineral density in men with vertebral fractures.
PubMed:Analysis of selected diphosphonic acid derivatives used in treatment of osteoporosis. Part I. Complexometric determination of diphosphonic acid derivatives.
PubMed:Bisphosphonates for controlling pain from metastatic bone disease.
PubMed:Prevention of bone loss in cardiac transplant recipients. A comparison of biphosphonates and vitamin D.
PubMed:[Pseudosarcomatous osteolysis of the femur in a patient with Paget's bone disease treated with long-term etidronate disodium: apropos of a new case].
PubMed:New biochemical markers of bone resorption derived from collagen breakdown in the study of postmenopausal osteoporosis.
PubMed:Critical drug appraisal: etidronate intermittent cyclic therapy for postmenopausal osteoporosis.
PubMed:Clinical effect of etidronate disodium (EHDP) on heterotopic ossification following total hip arthroplasty.
PubMed:Direct stereological estimation of three-dimensional connectivity in rat vertebrae: effect of estrogen, etidronate and risedronate following ovariectomy.
PubMed:Myositis ossificans progressiva: a 10-year follow-up on a patient treated with etidronate disodium.
PubMed:Etretinate-induced heterotopic bone formation about the hip joint. A case report including ultrastructural study.
PubMed:Comparison of changes in bone mineral in idiopathic and secondary osteoporosis following therapy with cyclical disodium etidronate and high dose calcium supplementation.
PubMed:Determination of bisphosphonate drugs in pharmaceutical dosage formulations by ion chromatography with indirect UV detection.
PubMed:An experience of ischemic limb salvage associated with myositis ossificans of the left thigh.
PubMed:Evaluation of a 24-hour infusion of etidronate disodium for the treatment of hypercalcemia of malignancy.
PubMed:Hereditary hyperphosphatasia: 20 year follow-up and response to disodium etidronate.
PubMed:Bone histomorphometric changes after cyclic therapy with phosphate and etidronate disodium in women with postmenopausal osteoporosis.
PubMed:Antiresorptive drugs and trabecular bone turnover: validation and testing of a computer model.
PubMed:Rachitic syndrome after disodium etidronate therapy in an adolescent.
PubMed:Etidronate inhibits the thyroid hormone-induced bone loss in rats assessed by bone mineral density and messenger ribonucleic acid markers of osteoblast and osteoclast function.
PubMed:Intravenous disodium etidronate therapy in spinal cord injury patients with heterotopic ossification.
PubMed:Persistent hypercoagulation associated with heterotopic ossification in patients with spinal cord injury long after injury has occurred.
PubMed:The effects of etidronate disodium on progressive hearing loss from otosclerosis.
PubMed:Indomethacin and disodium etidronate for the prevention of recurrence of heterotopic ossification after surgical resection. Two case reports.
PubMed:Giant cell tumor arising in Paget's disease of bone. Recurrences after 36 years.
PubMed:[Indications and limitations of non-hormonal treatments of osteoporosis].
PubMed:Determination of etidronate disodium tablets by ion chromatography with indirect UV detection.
PubMed:[A one-year prospective study of disodium etidronate versus 17 beta estradiol in the prevention of postmenopausal osteoporosis].
PubMed:[A rare cause of hypercalcemia: familial hypocalciuric hypercalcemia].
PubMed:Protective effects of disodium etidronate and pamidronate against the biomechanical repercussion of betamethasone-induced osteopenia in growing rat femurs.
PubMed:Didronel PMO.
PubMed:[Osteoma cutis. Pathogenesis and therapeutic possibilities].
PubMed:Retention of etidronate in human, dog, and rat.
PubMed:Skeletal nonvisualization in a bone scan secondary to intravenous etidronate therapy.
PubMed:Warfarin in prevention of heterotopic ossification.
PubMed:Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate).
PubMed:Heterotopic bone formation in abdominal incisions.
PubMed:Gallium nitrate.
PubMed:Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia.
PubMed:Treatment of pulmonary alveolar microlithiasis with a diphosphonate--preliminary results of a case.
PubMed:Calcinosis and metastatic calcification due to vitamin D intoxication. A case report and review.
PubMed:Therapies for symptomatic primary osteoporosis.
PubMed:Duration of etidronate effect demonstrated by serial bone scintigraphy.
PubMed:Effect of daily etidronate on the osteolysis of multiple myeloma.
PubMed:Pharmacologic elevation of blood inorganic phosphate in hypoxemic patients with COPD.
PubMed:Etidronate for hypercalcemia of malignancy and osteoporosis.
PubMed:Heterotopic ossification and peripheral nerve entrapment: early diagnosis and excision.
PubMed:Estrogen and diphosphonate treatment provide long-term protection against osteopenia in ovariectomized rats.
PubMed:Treatment of hypercalcemia of malignancy with intravenous etidronate. A controlled, multicenter study. The Hypercalcemia Study Group.
PubMed:Effect of etidronate disodium on the development of bone lesions in an animal model of bone metastasis using the human prostate cancer cell line PC-3.
PubMed:Effectiveness of a 24-hour infusion of etidronate disodium in the treatment of hypercalcemia of malignant disease. A dose-ranging pilot study.
PubMed:Advances in the management of Paget's disease of bone.
PubMed:Idiopathic infantile arterial calcification in two siblings: failure of treatment with diphosphonate.
PubMed:Pseudoarthrosis in heterotopic ossification in spinal cord-injured patients.
PubMed:[A new case of pseudosarcomatous osteolysis in a patient with Paget's disease treated with disodium etidronate].
PubMed:Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats.
PubMed:Pharmacologic management of Paget's disease.
PubMed:Clinical and radiographic improvement of bone of the second lumbar vertebra in Paget's disease following therapy with etidronate disodium: a case report.
PubMed:Vitamin D in Paget's disease of bone.
PubMed:[Paget's disease: errors to be avoided].
PubMed:[Fibrodysplasia ossificans progressiva or Münchmeyer's disease].
PubMed:Cyclic therapy of osteoporosis with neutral phosphate and brief, high-dose pulses of etidronate.
PubMed:[Long-term follow-up of 88 patients with Paget's disease treated by discontinuous courses of low-dose disodium etidronate].
PubMed:Effect of etidronate disodium on bone turnover following surgical menopause.
PubMed:Treatment of painful prostatic bone metastases with oral etidronate disodium.
PubMed:Establishment of a model to evaluate inhibition of bone resorption induced by human prostate cancer cells in nude mice.
PubMed:Stabilization of hearing loss in Paget's disease with calcitonin and etidronate.
PubMed:False-negative bone imaging due to etidronate disodium therapy.
PubMed:A clinical and biochemical assessment of etidronate disodium in patients with active rheumatoid arthritis.
PubMed:[Effects of etidronate disodium (EHDP) on urogenital malignancies with bone metastasis: a multicentered collaborative evaluation].
PubMed:[Failure of cimetidine and etidronate disodium to suppress parathyroid hormone level and hypercalcemia in primary hyperparathyroidism].
PubMed:Medical treatment of primary hyperparathyroidism: effects on parathormone and vitamin D metabolites.
PubMed:Influence of disodium etidronate on Paget's disease of bone.
PubMed:Synthetic human calcitonin in refractory Paget's disease of bone.
PubMed:Heterotopic ossification and pseudoarthrosis in the shoulder following encephalitis. A case report and review of the literature.
PubMed:Low back pain in Paget's disease of bone.
PubMed:Therapy of hypercalcemia of malignancy.
PubMed:Intravenous disodium etidronate therapy in Paget's disease of bone and hypercalcemia of malignancy. Effects on biochemical parameters and bone histomorphometry.
PubMed:Effects of intravenous etidronate disodium on skeletal and calcium metabolism.
PubMed:Etidronate disodium in the management of malignancy-related hypercalcemia.
PubMed:Effect of etidronate disodium on the interactions between malignancy and bone.
PubMed:Etidronate disodium: a new therapy for hypercalcemia of malignancy. Proceedings of a symposium.
PubMed:Neoplastic hypercalcemia: physiologic response to intravenous etidronate disodium.
PubMed:The effect of 1 alpha-hydroxyvitamin D3 on the mineralization defect in disodium etidronate-treated Paget's disease--a double-blind randomized clinical study.
PubMed:Effect of disodium etidronate (EHDP) on bone ingrowth in a porous material.
PubMed:Biochemical response to combination of disodium etidronate with calcitonin in Paget's disease.
PubMed:A model of localized osteolysis induced by the MBT-2 tumor in mice and its responsiveness to etidronate disodium.
PubMed:Efficacy of oral administration of etidronate disodium in maintaining normal serum calcium levels in previously hypercalcemic cancer patients.
PubMed:Resection of heterotopic ossification and Didronel therapy--regaining wheelchair independence in the spinal cord injured patient.
PubMed:Relief of metastatic bone pain with etidronate disodium.
PubMed:Etidronate disodium for treating hypercalcaemia of malignancy: a double blind, placebo-controlled study.
PubMed:Accelerated bone formation causing profound hypocalcemia in acute leukemia.
PubMed:Immobilization hypercalcemia associated with Landry-Guillain-Barré syndrome. Successful therapy with combined calcitonin and etidronate.
PubMed:[Congenital osteoma of the skin. Attempt at diphosphonate therapy].
PubMed:Spontaneous fractures of uninvolved bones in patients with Paget's disease during unduly prolonged treatment with disodium etidronate (EHDP).
PubMed:A dynamic classification of Paget's disease.
PubMed:Effective short term treatment of Paget's disease with oral etidronate.
PubMed:Long-term follow-up of therapy with intermittent etidronate disodium in Paget's disease of bone.
PubMed:Advances in the treatment of metastatic prostatic cancer.
PubMed:Paget's disease of bone. An update on management.
PubMed:Progressive ossifying myositis in a cat.
PubMed:Dose-dependent absorption of disodium etidronate.
PubMed:Dose-dependent effect of calcium and magnesium etidronate on salicylic acid absorption in the rat.
PubMed:[Evolution of Paget's disease of bone during and after treatment with small doses of disodium etidronate (EHDP)].
PubMed:[Effect of etidronate disodium (EHDP) on calcium oxalate renal stones induced by synthetic 1 alpha(OH) vitamin D3 and ethylene glycol in rats].
PubMed:[EHDP (ethylidene-1-hydroxy-1,1-diphosphonate) in the treatment of polyosseous Paget disease].
PubMed:Comparative study of etidronate and SR 41319, a new diphosphonate, on passive cutaneous anaphylaxis and phospholipase A2 activity.
PubMed:[Treatment of Paget's disease with low dose sodium etidronate (5mg/kg/day). Occurrence of reversible transient suspected leukopenia].
PubMed:Calcinosis universalis treated with disodium etidronate.
PubMed:Intravenous etidronate in the management of malignant hypercalcemia.
PubMed:Treatment of cancer-associated hypercalcemia with mithramycin and oral etidronate disodium.
PubMed:Reduction of skeletal blood flow in Paget's disease with disodium etidronate therapy.
PubMed:[Studies of the kinetics of bone concentration of mdp-tc 99m in Paget's disease and various treatment methods].
PubMed:[Progressive myositis ossificans. Report of a case and results of treatment with disodium etidronate].
PubMed:Acute intravenous infusion of disodium dihydrogen (1-hydroxyethylidene)diphosphonate: mechanism of toxicity.
PubMed:Effect of decreased O2 affinity of hemoglobin on work performance during exercise in healthy humans.
PubMed:[Osteolysis, then fracture of the femur in a Paget's disease patient treated with high-dose disodium etidronate].
PubMed:Immobilization hypercalcemia in acute spinal cord injury treated with etidronate.
PubMed:Effects of disodium etidronate in murine tumor models.
PubMed:Alternate calcitonin and etidronate disodium therapy for Paget's bone disease.
PubMed:Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease.
PubMed:Disodium etidronate in hypercalcaemia due to immobilisation.
PubMed:Disodium etidronate (EHDP)
PubMed:[Pseudosarcomatous osteolysis in a Paget's disease patient treated with disodium etidronate (EHDP)].
PubMed:[Etidronic acid therapy in Paget's disease of bone].
PubMed:Heterotopic ossification heralded by a knee effusion.
PubMed:Disodium etidronate: its role in preventing heterotopic ossification in severe head injury.
PubMed:Diphosphonate treatment for heterotopic ossification in spinal cord injury patients.
PubMed:Treatment of hyperparathyroidism with etidronate disodium.
PubMed:Diphosphonates and painful feet.
PubMed:Review of fracture experience during treatment of Paget's disease of bone with etidronate disodium (EHDP).
PubMed:Scalp vein sign in Paget's disease of bone.
PubMed:Focal mineralization defect during disodium etidronate treatment of calcinosis.
PubMed:Etidronate disodium in the treatment of Paget's disease of bone.
PubMed:The effect of etidronate disodium (EHDP) on retinopathy in insulin-dependent diabetic patients.
PubMed:[Treatment of Paget's disease with the combined administration of calcitonin and disodium etidronate].
PubMed:Parenteral diphosphonates for treating malignant hypercalcemia.
PubMed:Three adult cases resembling hereditary bone dysplasia.
PubMed:Heterotopic ossification following hip replacement or spinal cord injury. Two clinical studies with EHDP.
PubMed:[Treatment of hypercalcemia of tumoral origin with two diphosphonates].
PubMed:Treatment of hypercalcemia with etidronate disodium.
PubMed:Effect of etidronate disodium on filterability of sickle cell erythrocytes.
PubMed:Fibrodysplasia ossificans progressiva. A survey of forty-two cases.
PubMed:Fibrodysplasia ossificans progressiva (myositis ossificans progressiva) treatment with disodium etidronate.
PubMed:Paget's disease and the nervous system.
PubMed:Etidronate disodium for Paget's disease.
PubMed:Fibrodysplasia ossificans progressiva. Biochemical changes in blood serum, urine, skin, bone, and ectopic ossification.
PubMed:Fibrodysplasia (myositis) ossificans progressiva treated with disodium etidronate.
PubMed:Use and complications of high-dose disodium etidronate therapy in fibrodysplasia ossificans progressiva.
PubMed:Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome.
PubMed:Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation.
PubMed:[Treatment of 10 cases of symptomatic Paget's disease with etidronate (EHDP)].
PubMed:Etidronate disodium in postmenopausal osteoporosis.
PubMed:In vitro stabilization of a low-tin bone-imaging agent (99mTc-Sn-HEDP) by ascorbic acid.
PubMed:Disodium etidronate in the prevention of heterotopic ossification following spinal cord injury (preliminary report).
PubMed:Effects of a diphosphonate (disodium etidronate: EHDP) on phosphate metabolism in Paget's disease of bone, primary hyperparathyroidism and type I hypophosphataemic rickets.
PubMed:Disodium etidronate in the prevention of postoperative recurrence of heterotopic ossification in spinal-cord injury patients.
PubMed:Radioimmunoassay of procollagen in serum of patients with Paget's disease of bone.
PubMed:Myositis ossificans progressiva. Clinical features of eight patients and their response to treatment.
PubMed:[Influence of disodium etidronate (EHDP) on plasma and urinary levels of sodium and potassium in humans].
PubMed:Changes in the renal and extrarenal handling of phosphate induced by disodium etidronate (EHDP) in man.
PubMed:Disodium etidronate therapy for dystrophic cutaneous calcification.
PubMed:[Study of the therapeutic effects of disodium etidronate (EHDP) on hypercholesteremia and on hypertriglyceridemia].
PubMed:Failure of disodium etidronate in calcinosis due to dermatomyositis and scleroderma.
PubMed:[Diphosphonate (disodium etidronate) lowers cholesterol and total lipid levels in the blood of humans].
PubMed:Influence of disodium etidronate on clinical and laboratory manifestations of Paget's disease of bone (osteitis deformans).
PubMed:Paget's disease of bone. Experience with a diphosphonate (disodium etidronate) in treatment.
PubMed:Intestinal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) using a deconvolution technique.
PubMed:Preliminary safety assessment of disodium etidronate as an additive to experimental oral hygiene products.
PubMed:Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey.
PubMed:The effects of disodium etidronate on the reproductive functions and embryogeny of albino rats and New Zealand rabbits.
 
Notes:
a diphosphonate which affects calcium metabolism. it inhibits ectopic calcification and slows down bone resorption and bone turnover.
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