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Category:antimicrobial agents
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| | FDA/DG SANTE Petitions, Reviews, Notices: |
| FCN 315 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 371 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 504 | 1,2-benzisothiazolin-3-one View - notice |
| FCN 835 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 846 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1108 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1111 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1208 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1256 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1446 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1453 | 1,2-Benzisothiazolin-3-one View - notice |
| FCN 1686 | 1,2-Benzisothiazolin-3-one View - notice |
| DG SANTE Food Contact Materials: | 1,2-benzisothiazol-3(2H)-one |
| FDA Mainterm (IAUFC): | 2634-33-5 ; 1,2-BENZISOTHIAZOLIN-3-ONE |
| FDA Regulation: | FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
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Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 97.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 154.00 to 158.00 °C. @ 0.00 mm Hg
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| Boiling Point: | 204.00 to 205.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.183000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 172.00 °F. TCC ( 77.50 °C. ) (est)
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| logP (o/w): | 1.953 (est) |
| Soluble in: |
| | water, 2.143e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 1020 mg/kg
Pharmacological Research Communications. Vol. 3, Pg. 385, 1971.
oral-mouse LD50 1150 mg/kg
Pharmacological Research Communications. Vol. 3, Pg. 385, 1971.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antimicrobial agents |
| Recommendation for benzisothiazolinone usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for benzisothiazolinone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 16th list of substances for food contact materials
View page or View pdf
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on the presence of 1, 2-Benzisothiazolin-3-one as an impurity in saccharin use as a food additive
View page or View pdf
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| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):2634-33-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :17520 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WISER:UN 3077 |
| WGK Germany:2 |
| 1,2-benzothiazol-3-one |
| Chemidplus:0002634335 |
| RTECS:DE4620000 for cas# 2634-33-5 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,2- | benzisothiazol-3-one | | 1,2- | benzisothiazol-3(2H)-one | | 1,2- | benzisothiazolin-3-one | | | benzo[d]isothiazol-3(2H)-one | | 1,2- | benzothiazol-3-one | | 1,2- | benzothiazol-3(2H)-one | | | koralone | | | proxan | | | proxel PL | | | rocima | | | surcide B20 |
Articles:
| PubMed:Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries. |
| PubMed:Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase. |
| PubMed:Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets. |
| PubMed:Concomitant reactivity to methylisothiazolinone, benzisothiazolinone, and octylisothiazolinone. International Network of Departments of Dermatology data, 2009-2013. |
| PubMed:Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone. |
| PubMed:Occupations at risk of developing contact allergy to isothiazolinones in Danish contact dermatitis patients: results from a Danish multicentre study (2009-2012). |
| PubMed:Isothiazolinones in commercial products at Danish workplaces. |
| PubMed:Emission of isothiazolinones from water-based paints. |
| PubMed:Methylisothiazolinone contact allergy--growing epidemic. |
| PubMed:Cytotoxic effects of air freshener biocides in lung epithelial cells. |
| PubMed:Key role for efflux in the preservative susceptibility and adaptive resistance of Burkholderia cepacia complex bacteria. |
| PubMed:1,2-benzisothiazolin-3-one in disposable polyvinyl chloride gloves for medical use. |
| PubMed:Inhibition of human leucocyte elastase by fatty acyl-benzisothiazolinone, 1,1-dioxide conjugates (fatty acyl-saccharins). |
| PubMed:The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study. |
| PubMed:Antimicrobial allergy from polyvinyl chloride gloves. |
| PubMed:1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. |
| PubMed:Methylisothiazolinone in selected consumer products in Belgium: Adding fuel to the fire? |
| PubMed:Synthesis of some new benzisothiazolone and benzenesulfonamide derivatives of biological interest starting from saccharin sodium. |
| PubMed:Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. |
| PubMed:Chemical structure and teratogenic properties. II. Synthesis and teratogenic activity in rabbits of some derivatives of phthalmide, isoindoline-1-one, 1,2-benzisothiazoline-3-one-1,1-dioxide and 4(3H)-quinazolinone. |
| PubMed:No cross-sensitization between MCI/MI, benzisothiazolinone and octylisothiazolinone. |
| PubMed:[Aminomethyl derivatives of (benzisothiazolin-3-one-2-yl)acetic acid amides and 2-(1,2-benzisothiazoline-3-one-2-yl)propionic acid amides]. |
| PubMed:Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors. |
| PubMed:Estimation of the safe use concentrations of the preservative 1,2-benzisothiazolin-3-one (BIT) in consumer cleaning products and sunscreens. |
| PubMed:Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. |
| PubMed:Systemic allergic dermatitis following airborne exposure to 1,2-benzisothiazolin-3-one. |
| PubMed:Occupational dermatoses caused by contact with metalworking fluids in the region of central slovakia from 2000 to 2012. |
| PubMed:Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. |
| PubMed:Benzisothiazolones as modulators of macrophage migration inhibitory factor. |
| PubMed:Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. |
| PubMed:Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening. |
| PubMed:Determination of isothiazolinone preservatives in cosmetics and household products by matrix solid-phase dispersion followed by high-performance liquid chromatography-tandem mass spectrometry. |
| PubMed:Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography-tandem mass spectrometry. |
| PubMed:Determination of biocides and pesticides by on-line solid phase extraction coupled with mass spectrometry and their behaviour in wastewater and surface water. |
| PubMed:Tandem 1,5-hydride shift/1,5-S,N-cyclization with ethylene extrusion of 1,3-oxathiolane-substituted ketenimines and carbodiimides. An experimental and computational study. |
| PubMed:Kinetic migration of isothiazolinone biocides from paper packaging to Tenax and Porapak. |
| PubMed:Allergic contact dermatitis to 1,2-benzisothiazolin-3-one in the water softener manufacturing industry. |
| PubMed:One-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acids. |
| PubMed:Comparison of in vitro and ex vivo antiplatelet effects of 1,2-benzisothiazolin-3-one and its 2-amino derivative. |
| PubMed:Analysis of isothiazolinone biocides in paper for food packaging by ultra-high-performance liquid chromatography-tandem mass spectrometry. |
| PubMed:Lipophilicity of a series of 1,2-benzisothiazol-3(2H)-ones determined by reversed-phase thin-layer chromatography. |
| PubMed:A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease. |
| PubMed:Occupational asthma and rhinitis caused by 1,2-benzisothiazolin-3-one in a chemical worker. |
| PubMed:1,2-Benzisothiazolin-3-one (Proxel): irritant or allergen? A clinical study and literature review. |
| PubMed:Allergic contact dermatitis to 1,2-benzisothiazolin-3-one in the carpet industry. |
| PubMed:In vitro anti-Mycobacterium avium activity of N-(2-hydroxyethyl)-1,2-benzisothiazol-3(2H)-one and -thione carbamic esters. |
| PubMed:Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase. |
| PubMed:Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase. |
| PubMed:Bioluminescent strains of E. coli for the assay of biocides. |
| PubMed:Missed opportunities in clinical dermatology--the case of 1,2-benzisothiazolin-3-one. |
| PubMed:1,2-benzisothiazolin-3-one. |
| PubMed:Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel): a case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon CG. |
| PubMed:Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay. |
| PubMed:Chemical reactivity of some isothiazolone biocides. |
| PubMed:Inhibitors of blood platelet aggregation. Effects of some 1,2-benzisothiazol-3-ones on platelet responsiveness to adenosine diphosphate and collagen. |
| PubMed:Phototoxicity of a weedkiller: a correction. |
| PubMed:Allergic contact dermatitis due to 1,2-benzisothiazolin-3-one in gum arabic. |
| PubMed:The bactericidal mats in the pediatric intensive care unit. |
| PubMed:Contact dermatitis from benzisothiazolone in cutting oils. |
| PubMed:Occupational dermatitis due to 1,2-benzisothiazolin-3-one in the pottery industry. |
| PubMed:Contact dermatitis due to benzisothiazolone in a works analytical team. |
| PubMed:Occupational contact dermatitis to 1,2-benzisothiazolin-3-one and 5-chloro-2-methylisothiazolin-3-one/2-methylisothiazolin-3-one in paint manufacturers. |
| PubMed:Chemical analysis and genotoxicological safety assessment of paper and paperboard used for food packaging. |
| PubMed:Occupational allergic contact dermatitis caused by 1,2-benzisothiazolin-3-one in a varnish maker, followed by sensitization to benzalkonium chloride in Oilatum Plus bath additive. |
| PubMed:Re: Marchetti MG, Finzi G, Cugini P, Manfrini M, Salvatorelli G. Hospital use of decontaminating mats. J Hosp Infect 2003;55:68-72. |
| PubMed:Occupational allergic contact dermatitis from 1,2-benzisothiazolin-3-one without cross-sensitization to other isothiazolinones. |
| PubMed:ppGpp accumulation in Pseudomonas aeruginosa and Pseudomonas fluorescens subjected to nutrient limitation and biocide exposure. |
| PubMed:Occupational hand dermatitis due to 1,2-benzisothiazolin-3-one in the water-softener manufacturing industry. |
| PubMed:Solid-phase synthesis of benzisothiazolones as serine protease inhibitors. |
| PubMed:Pulpitis of the fingers from a shoe glue containing 1,2-benzisothiazolin-3-one (BIT). |
| PubMed:Biophysical characterization of zinc ejection from HIV nucleocapsid protein by anti-HIV 2,2'-dithiobis[benzamides] and benzisothiazolones. |
| PubMed:Skin symptoms and contact allergy in woodwork teachers. |
| PubMed:2,6-Disubstituted aryl carboxylic acids, leaving groups "par excellence" for benzisothiazolone inhibitors of human leukocyte elastase. |
| PubMed:Allergic contact dermatitis due to 1,2-benzisothiazolin-3-one in paint manufacture. |
| PubMed:Occupational contact allergy to 1,2-benzisothiazolin-3-one in the manufacture of air fresheners. |
| PubMed:Relationship between Legionella pneumophila and Acanthamoeba polyphaga: physiological status and susceptibility to chemical inactivation. |
| PubMed:Another isothiazolinone source. |
| PubMed:Growth inhibitory and biocidal activity of some isothiazolone biocides. |
| PubMed:Biocide patch tests. |
| PubMed:[Allergic contact eczema caused by isothiazolin-3-one derivatives]. |
| PubMed:Influence of sedatives on stress-induced trans-synaptic induction of tyrosine hydroxylase. |
| PubMed:Antagonism by supidimide of haloperidol-induced augmentation of [3H]-spiperone binding in rat striatum. |
| PubMed:Influence of supidimide on brain neurotransmitter systems of rats and mice. |
| PubMed:Analysis of isothiazolinones in environmental waters by gas chromatography-mass spectrometry. |
| PubMed:Contact urticaria from carboxymethylcellulose in white chalk. |
| PubMed:Preservatives in registered chemical products. |
| PubMed:[Contact allergies to recently introduced preservatives]. |
| PubMed:Anti-inflammatory effect of a selective inhibitor of elastase, cathepsin G and chymotrypsin on carrageenin-induced inflammation in rats. |
| PubMed:Analysis of allergens in metalworking fluids. |
| PubMed:Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG). |
| PubMed:Skin disease and contact sensitivity in house painters using water-based paints, glues and putties. |
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3D/inchi