chlorothiazide, 58-94-6

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CODE130907 CODE130907
Product(s):
58-94-6 Chlorothiazide >98%
Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)

CAS Number:	58-94-6	3D/inchi
ECHA EINECS - REACH Pre-Reg:	200-467-2
FDA UNII:	77W477J15H
Nikkaji Web:	J2.807J
MDL:	MFCD00058576
XlogP3:	-0.20 (est)
Molecular Weight:	295.72462000
Formula:	C7 H6 Cl N3 O4 S2
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:pharmaceuticals / chemical synthisis

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	350.00 °C. @ 760.00 mm Hg
Boiling Point:	608.77 °C. @ 760.00 mm Hg (est)
Flash Point:	612.00 °F. TCC ( 322.00 °C. ) (est)
logP (o/w):	-0.240
Soluble in:
	water, 1854 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

Chlorothiazide >98%

Odor: characteristic

Use: Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)

Santa Cruz Biotechnology

For experimental / research use only.

Chlorothiazide

Sigma-Aldrich: Sigma

For experimental / research use only.

Chlorothiazide thiazide diuretic

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 1000 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1973. intraperitoneal-mouse LD50 1400 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961. intravenous-mouse LD50 940 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961. oral-mouse LD50 8000 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 467, 1959. intraperitoneal-rat LD50 1386 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1973. intravenous-rat LD50 200 mg/kg Toxicology and Applied Pharmacology. Vol. 1, Pg. 333, 1959. oral-rat LD50 10000 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
pharmaceuticals / chemical synthisis
Recommendation for chlorothiazide usage levels up to:
	not for fragrance use.

Recommendation for chlorothiazide flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

ClinicalTrials.gov:search

Daily Med:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):58-94-6

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :2720

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

6-chloro-1,1-dioxo-4H-1lamda6,2,4-benzothiadiazine-7-sulfonamide

Chemidplus:0000058946

EPA/NOAA CAMEO:hazardous materials

RTECS:DK9450000 for cas# 58-94-6

References:

	6-chloro-1,1-dioxo-4H-1lamda6,2,4-benzothiadiazine-7-sulfonamide
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	2720
Pubchem (sid):	134972119

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C07461
HMDB (The Human Metabolome Database):	HMDB15018
MedlinePlusSupp:	View
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

2H-1,2,4-	benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
4H-1,2,4-	benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
6-	chloro-1,1-dioxo-4H-1lamda6,2,4-benzothiadiazine-7-sulfonamide
6-	chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-	chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-	chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
6-	chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
	chlorothiazid
	chlorothiazidum
	clotride
	diurilix
	diutrid
	minzil
	salisan
	saluretil
	warduzide
	yadalan
	yadulan

Articles:

PubMed:Diuretic Exposure in Premature Infants from 1997 to 2011.

PubMed:Encapsulation of chlorothiazide in whey proteins: effects of wall-to-core ratio and cross-linking conditions on microcapsule properties and drug release.

PubMed:Isolation of a 2:1 hydrochlorothiazide-formaldehyde adduct impurity in hydrochlorothiazide drug substance by preparative chromatography and characterization by electrospray ionization LC-MS.

PubMed:Identification of chlorothiazide and hydrochlorothiazide UV-A photolytic decomposition products.

PubMed:Determination of reserpine and chlorothiazide in commercial tablets by liquid chromatography with fluorescence and UV absorbance detectors in series.

PubMed:Vasopressin and ethanol preference. II. Altered preference in two strains of diabetes insipidus rats and nephrogenic diabetes insipidus mice.

PubMed:Influence of food and fluid volume on chlorothiazide bioavailability: comparison of plasma and urinary excretion methods.

PubMed:Renin-like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli.

Notes:

a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (from martindale, the extra pharmacopoeia, 30th ed, p812)

chlorothiazide 6-chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide

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Articles:

chlorothiazide
6-chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide