| Name: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome |
| CAS Number: | 153-18-4 |  3D/inchi
|
| Other(deleted CASRN): | 115888-40-9 |
| ECHA EINECS - REACH Pre-Reg: | 205-814-1 |
| FDA UNII: | 5G06TVY3R7 |
| Nikkaji Web: | J818D |
| Beilstein Number: | 0075455 |
| MDL: | MFCD01319140 |
| XlogP3-AA: | -1.30 (est) |
| Molecular Weight: | 610.52330000 |
| Formula: | C27 H30 O16 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to amber powder (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 125.00 °C. @ 760.00 mm Hg
|
| logP (o/w): | -2.020 (est) |
| Soluble in: |
| | water, 125 mg/L @ 25 °C (exp) | | | water, 2.756e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| AIDP |
| Rutin 95.0%-101.5%
|
| Alfa Biotechnology |
| For experimental / research use only. |
| Rutin 98%
|
| AuNutra® Industries |
| Rutin P.E.
|
| BOC Sciences |
| For experimental / research use only. |
| Rutin
|
| Coompo |
| For experimental / research use only. |
| Rutin from Plants ≥96%
Odor: characteristic Use: Rutin has been shown to inhibit in vitro the vascular endothelial growth factor in subtoxic concentrations, so acts as an inhibitor of angiogenesis. This finding can be potentially relevant for the control of some cancers.
Rutin inhibits platelet aggregation, as well as decreases capillary permeability, making the blood thinner and improving circulation.
Rutin shows anti-inflammatory activity in some animal and in vitro models.
Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into the sugar alcohol sorbitol.
Recent studies show rutin could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes.
Some evidence also shows rutin can be used to treat hemorrhoids, varicosis, and microangiopathy. Rutin is important because it strengthens capillaries and can help people who bruise or bleed easily. Studies have demonstrated that rutin can help to stop venous edema, that is an early sign of chronic venous disease of the leg.
Rutin is also an antioxidant; compared to quercetin, acacetin, morin, hispidulin, hesperidin, and naringin, it was found to be the strongest. However, in other trials, the effects of rutin were lower or negligible compared to those of quercetin. Rutin has also the property to chelate metal ions, such as iron, thereby reducing the Fenton reaction. |
| ExtraSynthese |
| For experimental / research use only. |
| Rutin (HPLC) ≥99%
|
| Jiangyin Healthway |
| Rutin
|
| New functional food ingredients |
| Maypro Industries |
| Rutin
|
| Pangaea Sciences |
| Rutin NF
|
| Penta International |
| RUTIN USP/NF
|
| Penta International |
| RUTIN
|
| Qingdao Dacon Trading |
| Rutin
|
| Shaanxi Y-Herb Biotechnology |
| Flower Bud Part Sophora Japonica Extract Rutin Powder CAS 153-18-4 HPLC / UV Test
|
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Rutin hydrate ≥94% (HPLC), powder
|
| Sinoway Industrial |
| For experimental / research use only. |
| Troxerutin
|
| Tianjin Talent Chemical |
| Rutin
|
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 2000 mg/kg
Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980.
intravenous-mouse LD50 950 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 556, 1950.
intraperitoneal-mouse LD50 200 mg/kg
National Technical Information Service. Vol. AD277-689
intraperitoneal-guinea pig LD50 2000 mg/kg
Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | special dietary and nutritional additives |
| Recommendation for rutin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for rutin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
|
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):153-18-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5280805 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome |
| Chemidplus:0000153184 |
References:
| | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 153-18-4 |
| Pubchem (cid): | 5280805 |
| Pubchem (sid): | 134973934 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy- | | 4H-1- | benzopyran-4-one, 3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]-oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy- | | | birutan | | | c.i. 75730 | | | ci 75730 | | 3-((6-O-(6- | deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 3-[[6-O-(6- | deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one | | 2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-mannopyranoside | | | glucopyranoside, quercetin-3 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D- | | | glucopyranoside, quercetin-3 6-O-alpha-L-rhamnopyranosyl-, beta-D | | 3,3',4',5,5',7- | hexahydroxyflavone (6-O-alpha-L-rhamnosyl-beta-D-glucoside) | | | myrticolorin | | | osyritrin | | 3,3',4',5,7- | pentahydroxyflavone-3-rutinoside | | | quercetin 3-O-[beta-L-rhamnosyl-(1->6)-beta-D-glucoside] | | | quercetin 3-O-beta-delta-rutinoside | | | quercetin 3-O-rutinoside | | | quercetin 3-rutinoside | | | quercetin, 3-(6-0-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside) | | | quercetin, 3-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside) | | | quercetin, 3-(6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside) | | 3- | rhamnoglucosyl quercetin | | | rutin trihydrate | | 3- | rutinosyl quercetin | | | rutoside | | | sophorin | | | troxerutin | | | venoruton | | | violaquercitrin | | | vitamin P |
Articles:
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