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Category:viscosity controlling agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 110.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 335.12 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 314.00 °F. TCC ( 156.50 °C. ) (est)
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| logP (o/w): | 4.235 (est) |
| Soluble in: |
| | water, 27.72 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | viscosity controlling agents |
| Recommendation for lauramide usage levels up to: | | | not for fragrance use.
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| Recommendation for lauramide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | viscosity controlling agents |
Occurrence (nature, food, other): note
Synonyms:
| | dodecamide | | | dodecanamide | | | dodecylamide | | | lauric acid amide | | | lauric amide | | | lauroylamide | | | lauryl amide |
Articles:
| PubMed:Synthesis and biological evaluation of a new series of N-acyldiamines as potential antibacterial and antifungal agents. |
| PubMed:Revised stereochemistry of ceramide-trafficking inhibitor HPA-12 by X-ray crystallography analysis. |
| PubMed:Susceptibility of Gardnerella vaginalis biofilms to natural antimicrobials subtilosin, ε-poly-L-lysine, and lauramide arginine ethyl ester. |
| PubMed:Antimicrobial food packaging film based on the release of LAE from EVOH. |
| PubMed:Influence of dicephalic ionic surfactant interactions with oppositely charged polyelectrolyte upon the in vitro dye release from oil core nanocapsules. |
| PubMed:Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. |
| PubMed:Expedient and practical synthesis of CERT-dependent ceramide trafficking inhibitor HPA-12 and its analogues. |
| PubMed:Construction of an effective screening system for detection of Pseudomonas aeruginosa quorum sensing inhibitors and its application in bioautographic thin-layer chromatography. |
| PubMed:Experimental and theoretical approach to nonequivalent adsorption of novel dicephalic ammonium surfactants at the air/solution interface. |
| PubMed:Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels. |
| PubMed:Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells. |
| PubMed:Dendritic effect on supramolecular self-assembly: organogels with strong fluorescence emission induced by aggregation. |
| PubMed:DNA adsorption at liquid/solid interfaces. |
| PubMed:Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation. |
| PubMed:The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding. |
| PubMed:Highly selective enzymatic kinetic resolution of primary amines at 80 degrees C: a comparative study of carboxylic acids and their ethyl esters as acyl donors. |
| PubMed:Use of acyltransferase inhibitors to block vesicular traffic between the ER and Golgi complex. |
| PubMed:Thixotropic organogels based on a simple N-hydroxyalkyl amide: rheological and aging properties. |
| PubMed:[The molecular machinery CERT for intracellular trafficking of ceramide]. |
| PubMed:Characterization of a novel CI-976-sensitive lysophospholipid acyltransferase that is associated with the Golgi complex. |
| PubMed:Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. |
| PubMed:Stereoselective synthesis and structure-activity relationship of novel ceramide trafficking inhibitors. (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and its analogues. |
| PubMed:Catalytic, asymmetric Mannich-type reactions of N-acylimino esters: reactivity, diastereo- and enantioselectivity, and application to synthesis of N-acylated amino acid derivatives. |
| PubMed:NTP Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS NO. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies). |
| PubMed:Catalytic, asymmetric Mannich-type reactions of N-acylimino esters for direct formation of N-acylated amino acid derivatives. Efficient synthesis of a novel inhibitor of ceramide trafficking, HPA-12. |
| PubMed:A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis. |
| PubMed:pH-responsive pseudo-peptides for cell membrane disruption. |
| PubMed:Determination of fatty acid amides as trimethylsilyl derivatives by gas chromatography with mass spectrometric detection. |
| PubMed:In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats. |
| PubMed:Lauramide diethanolamine absorption, metabolism, and disposition in rats and mice after oral, intravenous, and dermal administration. |
| PubMed:Hydroxylation of lauramide diethanolamine by liver microsomes. |
| PubMed:Fatty acid discrimination and omega-hydroxylation by cytochrome P450 4A1 and a cytochrome P4504A1/NADPH-P450 reductase fusion protein. |
| PubMed:The effect of acyl CoA: cholesterol acyltransferase inhibition on the uptake, esterification and secretion of cholesterol by the hamster small intestine. |
| PubMed:Determination of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl) dodecanamide, CI-976, in rat plasma by reversed-phase high-performance liquid chromatography. |
| PubMed:Solubility predictions for solid nitriles and tertiary amides based on the mobile order theory. |
| PubMed:Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. |
| PubMed:Biodisposition studies with the acyl-coenzyme A: cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CI-976. |
| PubMed:Determination of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide, a lipid regulator, in rat plasma and mesenteric lymph by reversed-phase high-performance liquid chromatography. |
| PubMed:Facilitated transport of two model steroids by esters and amides of clofibric acid. |
| PubMed:An appraisal of povidone-iodine and wound healing. |
| PubMed:Comparison of azone and hexamethylene lauramide in toxicologic effects and penetration enhancement of cimetidine in rabbit eyes. |
| PubMed:Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. |
| PubMed:Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation. |
| PubMed:Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway. |
| PubMed:Percutaneous and systemic disposition of hexamethylene lauramide and its penetration enhancement effect on hydrocortisone in a rat sandwich skin-flap model. |
| PubMed:Rotation of nucleotide sites is not required for the enzymatic activity of chloroplast coupling factor 1. |
| PubMed:Contact allergy to cocamide DEA and lauramide DEA in shampoos. |
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3D/inchi